Abstracts tagged "Vasculitis"

Abstract Number: 2851 • 2014 ACR/ARHP Annual Meeting
The Relationship of ARMS2 Genotype with Idiopathic Inflammatory Vasculitis
Christopher Mecoli¹, Fan Wang², Christopher Pappas³, Peter C. Grayson⁴, David Cuthbertson⁵, Simon Carette⁶, Christian Pagnoux⁶, Gary S. Hoffman⁷, Nader A. Khalidi⁸, Curry L. Koening⁹, Carol A. Langford¹⁰, Carol McAlear¹¹, Paul A. Monach¹², Larry W. Moreland¹³, Philip Seo¹⁴, Ulrich Specks¹⁵, Steven R. Ytterberg¹⁶, Rui Feng¹⁷, Gregory Hageman³ and Peter A. Merkel¹, ¹University of Pennsylvania, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, OK, ³University of Utah School of Medicine, Salt Lake City, UT, ⁴NIAMS Systemic Autoimmunity Branch, National Institutes of Health, Bethesda, MD, ⁵Department of Biostatistics, University of South Florida, Tampa, FL, ⁶Division of Rheumatology, University of Toronto, Toronto, ON, Canada, ⁷Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, OH, ⁸Division of Rheumatology, St. Joseph’s Hospital, McMaster University, Hamilton, ON, Canada, ⁹Division of Rheumatology, University of Utah, Salt Lake City, UT, ¹⁰Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, ¹¹Division of Rheumatology, Vasculitis Center, University of Pennsylvania, Philadelphia, PA, ¹²Section of Rheumatology, Vasculitis Center, Boston University School of Medicine, Boston, MA, ¹³Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹⁴Rheumatology Division, Johns Hopkins Vasculitis Center, Johns Hopkins University, Baltimore, MD, ¹⁵Frederichs Dr NW, Mayo Clinic, Rochester, MN, ¹⁶Division of Rheumatology, Mayo Clinic, Rochester, MN, ¹⁷Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Patients with age-related macular degeneration (AMD), a leading cause of irreversible blindness, have a 10-fold increased prevalence of abdominal aortic aneurysms. Single nucleotide polymorphisms…
Abstract Number: 2764 • 2014 ACR/ARHP Annual Meeting
S100B Astrocyte Protein May Serve As a Prognostic Factor in Reversible Cerebral Vasoconstrictive Syndromes
Juan J. Maya¹, Vikram Puvenna^2,3,4, Chanda Brennan^2,3,5, Seby John⁶, Ken Uchino⁷, Leonard H. Calabrese⁸, Damir Janigro^2,4,9,10 and Rula Hajj-Ali¹¹, ¹Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH, ²Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, ³Neurosurgery, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, ⁴Cleveland Clinic Lerner College of Medicine, Cleveland, OH, ⁵Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, ⁶9500 Euclid Avenue S10-C, Cleveland Clinic Foundation, Cleveland, OH, ⁷Neurology, Cleveland Clinic Foundation, Cleveland, OH, ⁸Cleveland Clinic Foundation, Cleveland, OH, ⁹Department of Neurosurgery, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, ¹⁰Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, ¹¹Rheumatology, Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Reversible Cerebral Vasoconstriction Syndromes (RCVS) are a group of disorders characterized by acute onset of recurrent thunderclap headaches with or without neurologic deficits. Radiologically,…
Abstract Number: 1788 • 2014 ACR/ARHP Annual Meeting
Association of HLA-B*41 with Henoch-Schönlein Purpura in Spanish Individuals Irrespective of the HLA-DRB1 Status
Fernanda Genre¹, Raquel López-Mejías¹, Belén Sevilla Pérez², Santos Castañeda³, Norberto Ortego-Centeno², Javier Llorca⁴, Begoña Ubilla¹, Trinitario Pina Murcia¹, Vanesa Calvo-Río⁵, Ana Márquez⁶, Luis Sala-Icardo⁷, Jose A. Miranda-Filloy⁸, Marta Conde-Jaldón⁹, Lourdes Ortiz-Fernández⁹, Juan María Blanco-Madrigal¹⁰, Eva Galindez-Agirregoikoa¹⁰, Francisca González Escribano⁹, Javier Martin¹¹, Ricardo Blanco¹² and MA González-Gay¹, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, ²Medicine Department, Hospital Universitario San Cecilio, Granada, Spain, ³Rheumatology, Hospital Universitario de La Princesa, IISP, Madrid, Spain, ⁴Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, ⁵Av. Cardenal Herrera Oria s/n - Lab. 201, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, ⁶Instituto de Parasitologia y Biomedicina López-Neyra (IPBLN-CSIC) and Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, ⁷Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, ⁸Hospital Universitario Lucus Augusti, Rheumatology Division, Lugo, Spain, ⁹Immunology department, Hospital Universitario Virgen del Rocío, Sevilla, Spain, ¹⁰Rheumatology Department. Basurto University Hospital, Bilbao, Spain, ¹¹Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, ¹²Hospital Marques de Valdecilla, Santander, Spain
Background/Purpose: Henoch-Schönlein purpura (HSP), the most common type of primary small-sized blood vessel leukocytoclastic vasculitis, is characterized by infiltration of the small blood vessels with…
Abstract Number: 1780 • 2014 ACR/ARHP Annual Meeting
Outcomes of Triple Therapy (Plasma Exchange, Cyclophosphamide and Systemic Corticosteroid) for Anti-Neutrophil Cytoplasm Antibody (ANCA)-Associated Vasculitis
Joanna Ueng¹, Katerina Pavenski² and Laurence Rubin³, ¹Rheumatology/Medicine, University of Toronto, Toronto, ON, Canada, ²Transfusion Medicine, St. Michael's Hospital, Toronto, ON, Canada, ³Rheumatology, St. Michael Hospital, Toronto, ON, Canada
Background/Purpose Microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA), and Churg-Strauss Syndrome (CSS) are syndromes known as ANCA-associated vasculitis (AAV). In addition to immunosuppressive therapy, plasma…
Abstract Number: 2787 • 2013 ACR/ARHP Annual Meeting
The Effect Of Smoking On The Clinical Expression Of ANCA-Associated Vasculitis
Neil Basu¹, Aladdin Mohammad², Richard A. Watts³, Paul Gatenby⁴, Luis F. Flores-Suarez⁵ and Alfred Mahr⁶, ¹Musculoskeletal Research Collaboration (Epidemiology Group), University of Aberdeen, Aberdeen, United Kingdom, ²Department of Rheumatology, Skåne University Hospital, Lund, Sweden, ³Rheumatology Department Ipswich Hospital and University of East Anglia, Ipswich, United Kingdom, ⁴ANU Medical School, The Canberra Hospital, Canberra, Australia, ⁵Primary Systemic Vasculitides Clinic, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico, ⁶Department of Internal Medicine, Hospital Saint-Louis, Paris, France
Background/Purpose: It is well recognized that smoking has immuno-modulatory effects in several chronic inflammatory disorders. For ANCA-associated vasculitis (AAV), which includes granulomatosis with polyangiitis (GPA)…
Abstract Number: 2633 • 2013 ACR/ARHP Annual Meeting
Clinical Spectrum Of Cutaneous Vasculitis
Javier Loricera¹, Vanesa Calvo-Río¹, Francisco Ortiz-Sanjuan², Héctor Fernández-Llaca³, Marcos A. González-López⁴, Lino Álvarez⁵, M. Carmen González-Vela⁶, Domingo González-Lamuño⁷, Cristina Mata², Javier Rueda-Gotor⁸, Víctor M. Martínez-Taboada⁹, Miguel Angel González-Gay² and Ricardo Blanco¹⁰, ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ²Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, ³Dermatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, ⁴Dermatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, ⁵Pediatrics, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ⁶Pathology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, ⁷Pediatrics, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander, Santander, Spain, ⁸Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, ⁹Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV., Santander, Spain, ¹⁰Hospital Marques de Valdecilla, Santander, Spain
Background/Purpose: Cutaneous vasculitis (CV) encompasses a large and heterogeneous set of syndromes characterized by inflammation of the skin vessels. The most common clinical manifestation is…
Abstract Number: 1657 • 2013 ACR/ARHP Annual Meeting
Enothelin-1 Plays a Role In The Pathogenesis Of Reversible Cerebral Vasoconstriction Syndrome
Tariq Hammad¹, Leonard H. Calabrese², Ken Uchino³, Seby John³, Mark Stillman⁴, Stewart Tepper⁴, Colin O'Rourke⁵, Allison Janocha¹, Serpil Erzurum¹ and Rula Hajj-Ali⁴, ¹Cleveland Clinic, Cleveland, OH, ²Rheumatic & Immunologic Dis, Cleveland Clinic, Cleveland, OH, ³Neurology, Cleveland Clinic Foundation, Cleveland, OH, ⁴Cleveland Clinic Foundation, Cleveland, OH, ⁵Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH
Background/Purpose: Cerebral vasoconstriction is thought to be the underlying pathogenetic mechanism of Reversible Cerebral Vasoconstriction Syndromes (RCVS). However, mediators of the syndrome at molecular levels…
Abstract Number: 1660 • 2013 ACR/ARHP Annual Meeting
Primary Central Nervous System Vasculitis: Treatment and Course
Carlo Salvarani¹, Robert D. Brown Jr.², Teresa J. H. Christianson², John Huston III², Kenneth Calamia³, Caterina Giannini² and Gene G. Hunder⁴, ¹Rheumatology, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ²Mayo Clinic, Rochester, MN, ³Mayo Clinic, Jacksonville, FL, ⁴Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: To determine the response to therapy and long-term outcome of PCNSV we reviewed all cases of PCNSV seen over a 29-year period. Methods:…
Abstract Number: 854 • 2013 ACR/ARHP Annual Meeting
Aortic Wall Thickness In Patients Without Aortitis: a Computed Tomography-Based Study Of 100 Patients
Afif Nakhleh¹, Irina Rukhkyan², Vladimir Wolfson³, Itzhak A. Rosner⁴, Majed Odeh⁴ and Gleb Slobodin⁵, ¹Internal Medicine, Bnai Zion Medical Center, Haifa, Israel, ²Rehabilition, Bnai Zion Medical Center, Haifa, Israel, ³Radiology, Bnai Zion Medical Center, Haifa, Israel, ⁴Bnai Zion Medical Center, Haifa, Israel, ⁵Rheumatology, Bnai Zion Medical Center, Haifa, Israel
Background/Purpose: Thickening of the aortic wall, probably the earliest CT sign of aortitis, is frequently missed as there are no accepted criteria for normal aortic…
Abstract Number: 2566 • 2012 ACR/ARHP Annual Meeting
Aβ-Related Angiitis: Comparison with Patients with Amyloid Cerebral Angiopathy without Inflammation
Carlo Salvarani¹, Caterina Giannini², Robert D. Brown Jr.², Teresa J. H. Christianson² and Gene G. Hunder³, ¹Rheumatology, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ²Mayo Clinic, Rochester, MN, ³Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: Coexistence of sporadic cerebral amyloid angiopathy (CAA) and primary central nervous system vasculitis (PCNSV) has been reported, particularly in patients with granulomatous vasculitis. This…
Abstract Number: 2388 • 2012 ACR/ARHP Annual Meeting
Urticarial Vasculitis: Clinical Study
Javier Loricera¹, Vanesa Calvo-Rio², Francisco Ortiz Sanjuan², Marcos Antonio Gonzalez-Lopez³, Hector Fernandez-Llaca³, Javier Rueda-Gotor², Carmen Gonzalez-Vela⁴, Cristina Mata-Arnaiz⁵, Jose Luis Peña-Sagredo², Miguel A. Gonzalez-Gay² and Ricardo Blanco², ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, ²Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, ³Dermatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, ⁴Pathology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, ⁵Rheumatology, Hospital Laredo, Santander, Spain
Background/Purpose: Urticarial vasculitis is an infrecuent subset of vasculitis described by McDuffy et al, in 1973, characterized clinically by urticarial skin lesions of more than…
Abstract Number: 2391 • 2012 ACR/ARHP Annual Meeting
New Disease Manifestations After Diagnosis in Six Types of Vasculitis
Peter C. Grayson¹, David Cuthbertson², Simon Carette³, Gary S. Hoffman⁴, Nader A. Khalidi⁵, Curry L. Koening⁶, Carol A. Langford⁷, Kathleen Maksimowicz-McKinnon⁸, Paul A. Monach⁹, Philip Seo¹⁰, Ulrich Specks¹¹, Steven R. Ytterberg¹² and Peter A. Merkel¹³, ¹Section of Rheumatology & the Clinical Epidemiology Unit, Boston University School of Medicine, Vasculitis Center, Boston, MA, ²Department of Biostatistics, University of South Florida, Tampa, FL, ³Div of Rheum/E1-422, UHN/MSH, Toronto, ON, Canada, ⁴Rheumatic & Immunologic Dis, Cleveland Clinic, Cleveland, OH, ⁵Internal Medicine/Rheumatology, McMaster University, Hamilton, ON, Canada, ⁶Internal Medicine, Salt Lake City Veterans Administration, Salt Lake City, UT, ⁷Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, ⁸Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁹Rheumatology, Boston University, Boston, MA, ¹⁰Rheumatology Division, Johns Hopkins Vasculitis Center, Johns Hopkins University, Baltimore, MD, ¹¹Mayo Clinic, Rochester, MN, ¹²Rheumatology Division, Mayo Clinic, Rochester, MN, ¹³University of Pennsylvania, Philadelphia, PA
Background/Purpose: The proportion of patients who experience new manifestations of vasculitis after diagnosis is unknown. Our objectives were to quantify the occurrence of new…
Abstract Number: 2365 • 2012 ACR/ARHP Annual Meeting
Asymptomatic Myocardial Ischemic Disease in Takayasu’s Arteritis
Chloe Comarmond¹, Odile Dessault², jean-Yves Devaux², Nathalie Costedoat-Chalumeau³, Mathieu Resche Rigon⁴, Richard Isnard⁵, Fabien Koskas⁶, Patrice Cacoub Sr.⁷ and David Saadoun⁸, ¹Internal Medicine, Hôpital Pitié Salpétrière, Paris, France, ²Department of Nuclear Medicine, Groupe Hospitalier Saint-Antoine, Paris, France, ³Internal Medicine, Assistance Publique-Hôpitaux de Paris, Hopital Pitié-Salpétrière, Paris, France, ⁴Department of Internal Medicine and Laboratory I3 “Immunology, Immunopathology, Immunotherapy”, UMR CNRS 7211, INSERM U959, Groupe Hospitalier Pitié-Salpetrière, Université Pierre et Marie Curie, Paris 6, Paris, France, Paris, France, ⁵Cardiology, CHU Pitié-Salpêtrière, 47-83 Boulevard de l'hôpital, 75651 Paris Cedex 13, Paris, France, Paris, France, ⁶Department of Internal Medicine and 2Laboratory I3 « Immunology, Immunopathology, Immunotherapy », UMR CNRS 7211, INSERM U959, Groupe Hospitalier Pitié-Salpetrière, Université Pierre et Marie Curie, Paris 6, Paris, France, Paris, France, ⁷Department of Internal Medicine 2., CHU Pitié-Salpêtrière, Paris, France, ⁸DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, Paris, France
Background/Purpose: Cardiac involvement in Takayasu's arteritis (TA) is a leading cause of death. Previous studies reported a high incidence of myocardial involvement using exercise thallium-201…

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