Abstracts tagged "vasculitis and mitochondrial dna"

Abstract Number: 2626 • 2019 ACR/ARP Annual Meeting
Cell-free Mitochondrial DNA Levels in Granulomatosis with Polyangiitis
Lindsay Lally¹, Sebastian E. Sattui ², Jackie Finik ³, Augustine Choi ⁴, Rennie Rhee ⁵, Peter Merkel ⁶, W. Joseph McCune ⁷, E William St. Clair ⁸, Ulrich Specks ⁹, John Stone ¹⁰ and Robert Spiera ¹, ¹Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, ³Hospital for Special Surgery, New York, NY, New York, NY, ⁴Weill Cornell Medicine, New York, ⁵University of Pennsylvania, Division of Rheumatology, Philadelphia, PA, ⁶University of Pennsylvania, Philadelphia, PA, ⁷University of Michigan, Ann Arbor, MI, ⁸Duke, Raleigh, ⁹Mayo Clinic College of Medicine, Rochester, MN, ¹⁰Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA
Background/Purpose: Circulating cell-free mitochondrial DNA (mtDNA) is released during non-apoptotic processes such as NETosis. Increased levels of mtDNA are associated with autophagic dysfunction and inflammasome…

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