Abstracts tagged "Urinary Biomarkers"

Abstract Number: 123 • 2016 ACR/ARHP Annual Meeting
A Panel of Urinary Biomarkers to Assess Renal Involvement in Latin American Patients with Systemic Lupus Erythematosus
José A. Gómez-Puerta^1,2, Blanca L Ortiz Reyes¹, Tomás Urrego¹, Adriana L Vanegas^2,3, Carlos Horacio Muñoz^3,4, Mauricio Restrepo², Wilmer Rojas-Zuleta², Sofia Arteaga², Luis Alonso Gonzalez⁴ and Gloria Vásquez^1,4, ¹Grupo de Inmunología Celular e Inmunogenética, Universidad de Antioquia, Medellín, Colombia, ²Rheumatology Unit, Universidad de Antioquia, Medellín, Colombia, ³Hospital Universitario de San Vicente Fundación, Medellín, Colombia, ⁴Rheumatology Unit, Universidad de Antioquia, Medellin, Colombia
Background/Purpose: Some previous studies in Caucasian, Asian, and African-american patients have shown promising results for several urinary biomarkers in patients with lupus nephritis (LN). However,…
Abstract Number: 963 • 2016 ACR/ARHP Annual Meeting
Treatment of Homocysteine Improves Urine Protein/Cr Ratio in SLE
Wei Fu¹ and Michelle Petri², ¹Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Homocysteine is a proven prospective risk factor for stroke and arterial thrombosis in SLE. However, checking for homocysteine and treating high levels is actually…
Abstract Number: 716 • 2015 ACR/ARHP Annual Meeting
Urinary Proteomics Identifies Three Novel Biomarkers for Lupus Nephritis Activity: Retinol Binding Protein, Alpha-1-Antichymotrysin and Haptoglobin
Amita Aggarwal¹, Sudhir sinha², Ranjan Gupta³, Liza Rajasekhar⁴, Akhilesh Yadav³, Ramnath Misra¹ and Virsingh Negi⁵, ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Department of Biochemistry, CSIR-central drug research institute, Lucknow, India, ³Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ⁴Department of Rheumatology, Nizam Institute of Medical Sciences, Hyderabad, India, ⁵Department of Clinical Immunology, JIPMER, Puducherry, India
Background/Purpose: Urinary biomarkers have a potential for identification, follow-up and assessment of response to treatment in patients with lupus nephritis. Urinary proteomics can help in…
Abstract Number: 722 • 2015 ACR/ARHP Annual Meeting
Biomarkers/Pathways Discovery of Lupus Nephritis By Urine Proteomics
Michelle Petri¹, Wei Fu², Adnan Kiani¹, Lauren DeVine¹, Conover Talbot Jr.¹ and Robert Cole¹, ¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: We have previously validated several urine proteomic biomarkers for Lupus Nephritis (osteoprotegerin, MCP-1, VCAM-1 and urine TWEAK). In this discovery effort we looked for…
Abstract Number: 755 • 2015 ACR/ARHP Annual Meeting
Validating the RAIL Algorithm in Adult Lupus Nephritis Patients
Gaurav Gulati¹, Khalid Abulaban², Jun Ying³, Xiaolan Zhang⁴, Huijuan Song⁵, Qing Ma⁶, Christopher Haffner⁶, Kasha Wiley⁷, Michael Bennett⁸, Brad H. Rovin⁵ and Hermine I. Brunner⁹, ¹Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH, ²Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³University of Cincinnati, Cincinnati, OH, ⁴Ohio State University, Columbus, OH, ⁵Ohio State University Medical Center, Columbus, OH, ⁶Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, ⁷Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁸Division of Nephrology, Cincinnati Children`s Hospital Medical Center, Cincinnati, OH, ⁹Pediatric Rheumatology Collaborative Study Group, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Lupus Nephritis (LN) significantly contributes to morbidity and mortality among Systemic Lupus Erythematosus (SLE) patients. We have established the Renal Activity Index for Lupus…
Abstract Number: 2070 • 2015 ACR/ARHP Annual Meeting
Urinary Biomarker Based “a-RAIL”� Study in Adults with Lupus Nephritis
Gaurav Gulati¹, Khalid Abulaban², Jun Ying³, Huijuan Song⁴, Xiaolan Zhang⁵, Qing Ma⁶, Christopher Haffner⁶, Kasha Wiley⁷, Michael Bennett⁸, Brad H. Rovin⁴ and Hermine I. Brunner⁹, ¹Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH, ²Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³University of Cincinnati, Cincinnati, OH, ⁴Ohio State University Medical Center, Columbus, OH, ⁵Ohio State University, Columbus, OH, ⁶Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, ⁷Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁸Division of Nephrology, Cincinnati Children`s Hospital Medical Center, Cincinnati, OH, ⁹Pediatric Rheumatology Collaborative Study Group, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: The present study was aimed at developing an adult Renal Activity In Lupus (A-RAIL) algorithm for Lupus Nephritis (LN) activity assessment using urinary biomarkers…
Abstract Number: 2071 • 2015 ACR/ARHP Annual Meeting
Urinary Osteoprotegerin As Biomarker of Lupus Nephritis Disease Activity: Cross Sectional and Longitudinal Study
Ranjan Gupta¹, Amita Aggarwal², Sudhir sinha³, Liza Rajasekhar⁴, Akhilesh Yadav¹, Priyanka Gaur¹, Ramnath Misra² and Virsingh Negi⁵, ¹Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ³Department of Biochemistry, CSIR-central drug research institute, Lucknow, India, ⁴Department of Rheumatology, Nizam Institute of Medical Sciences, Hyderabad, India, ⁵Department of Clinical Immunology, JIPMER, Puducherry, India
Background/Purpose: Urinary biomarkers may help in identification, treatment and assessment of response to therapy in patients with lupus nephritis (LN). Osteoprotegerin (OPG) is produced by…
Abstract Number: 2898 • 2015 ACR/ARHP Annual Meeting
Erythrocytes, Acanthocytes, and Proteins in Urine Reflect Lupus Nephritis Histology
Marco Ulises Martinez-Martinez¹, Lilia Llamazares-Azuara², David Martínez-Galla³, Francisco Valadez-Castillo⁴, Peter Mandeville⁴, Jaime Antonio Borjas García⁵ and Carlos Abud-Mendoza¹, ¹Unidad de Investigaciones Reumatológicas, Hospital Central & Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico, ²Laboratorio Renal, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico, ³Patología, Hospital Central & Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico, ⁴Faculty of Medicine, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico, ⁵Regional Unit of Rheumatology and Osteoporosis, Faculty of Medicine, Universidad Autónoma de San Luis Potosí and Hospital Central, San Luis Potosí, Mexico
Background/Purpose: Hematuria in lupus nephritis (LN) is secondary to the passage of red blood cells (RBCs) through glomerular abnormalities. Dysmorphic RBCs are associated with glomerulonephritis,…
Abstract Number: 2603 • 2014 ACR/ARHP Annual Meeting
Short-Term Non-Steroidal Anti-Inflammatory Drug (NSAID) Use Induces Subclinical-Kidney-Injury in Spondyloarthritis Patients: Urinary Biomarker Study
Anuj Shukla¹, Mohit kumar Rai¹, Narayan Prasad² and Vikas Agarwal¹, ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose NSAIDs are the first-line therapy for spondyloarthritis (SpA) patients and are associated with the risk of kidney injury. Long-term NSAID use is known to…
Abstract Number: 2097 • 2014 ACR/ARHP Annual Meeting
Identification of Diagnostic and Activity Metabolomic Urine Biomarkers in Six Immune-Mediated Inflammatory Diseases
Arnald Alonso¹, Jesús Tornero², Antonio Fernandez Nebro³, Juan D. Cañete⁴, Eugeni Domènech⁵, Javier P. Gisbert⁶, Carlos Ferrándiz⁵, Eduardo Fonseca⁷, Valle García⁸, Francisco Blanco⁷, Jesus Rodriguez⁹, Jordi Gratacós¹⁰, Patricia Carreira¹¹, Toni Julia¹, Raül Tortosa¹, María América López-Lasanta¹, Xavier Correig¹² and Sara Marsal¹, ¹Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ²Hospital Universitario Guadalajara, Guadalajara, Spain, ³Rheumatology, Hospital Regional Carlos Haya, Biomedical Research Institute of Malaga (IBIMA), Malaga, Spain, ⁴Rheumatology, Hospital Clinic, Barcelona, Spain, ⁵Hospital Universitari Germans Trias I Pujol, Badalona, Spain, ⁶Hospital Universitario de la Princesa, Madrid, Spain, ⁷Complejo Hospitalario Juan Canalejo, A Coruña, Spain, ⁸Hospital Universitario Reina Sofía, Córdoba, Spain, ⁹Rheumatology, Hospital Universitari de Bellvitge, Barcelona, Spain, ¹⁰Hospital Parc Taulí, Sabadell, Spain, ¹¹Hospital Universitario 12 de Octubre, Department of Rheumatology, Madrid, Spain, ¹²CIBERDEM, Metabolomics Platform, Reus, Spain
Background/Purpose: Metabolomics is an emergent research field within the omics sciences aimed at characterizing the metabolome in complex biological samples. It provides a powerful approach…
Abstract Number: 2416 • 2013 ACR/ARHP Annual Meeting
Discovery Of Novel Biomarkers In Rheumatoid Urine : Significance Of Urinary CD14
Yune-Jung Park¹, Hyun-Sook Kim², Seung-Ah Yoo³, Susanna Choi³, Dong-Ho Kim⁴, Chul-Soo Cho⁵ and Wan-Uk Kim⁶, ¹Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Soonchunhyang University of Korea, Seoul, South Korea, ³Research Institute of Immunobiology, The Catholic University of Korea, Seoul, South Korea, ⁴Research Institute of Immunobiology, Catholic Research Institute of Medical Science, Seoul, Korea., Seoul, South Korea, ⁵Internal Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea, ⁶Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea
Background/Purpose: Current serum measures for assessing rheumatoid arthritis (RA) are invasive and are not highly sensitive to changes in disease activity. Thus, there is a…
Abstract Number: 247 • 2013 ACR/ARHP Annual Meeting
Associations Between Levels Of Urinary C-Telopeptide Fragments Of Type II Collagen and Knee Structure In Asymptomatic Middle-Aged Women
Binghui Wang¹, Hans Kurniawan Pramono², Flavia Cicuttini³, Anita Wluka³, Fahad Hanna², Susan Davis², Robin Bell², Andrew Teichtahl¹ and Yuanyuan Wang², ¹Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia, ²Monash University, Melbourne, Australia, ³Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
Background/Purpose: There is evidence for an association between levels of urinary C-telopeptide fragments of type II collagen (uCTX-II) and the risk of knee osteoarthritis. The…

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