Abstracts tagged "Uric Acid, Urate"

Abstract Number: 1130 • ACR Convergence 2025
Novel Anti-Obesity Medications and Serum Urate Change Among Patients with Gout and Baseline Hyperuricemia
Kiara Tan¹, Jiaqi Wang¹, Saiajay Chigurupati², Gregory Challener³, Natalie McCormick¹, Sharan Rai⁴, Florence Porterfield⁵, Chika Anekwe¹, Dong Wook Kim⁶, Fatima Stanford⁷, Caroline Apovian⁸, Hyon K. Choi⁹ and Chio Yokose¹⁰, ¹Massachusetts General Hospital, Boston, ²Massachusetts General Hospital, Boston, MA, ³Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, ⁴Massachusetts General Hospital/Harvard Medical School, Boston, MA, ⁵Division of Endocrinology, Massachusetts General Hospital, Boston, ⁶Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital, Boston, ⁷Neuroendocrine Unit, Pediatric Endocrinology, Massachusetts General Hospital, Boston, ⁸Brigham and Women's Hospital, Boston, ⁹MASSACHUSETTS GENERAL HOSPITAL, Lexington, MA, ¹⁰Massachusetts General Hospital, Waltham, MA
Background/Purpose: Obesity affects >50% of individuals with gout and is the most important modifiable risk factor for gout. Thus, novel anti-obesity medications (AOM, e.g., semaglutide…
Abstract Number: 1129 • ACR Convergence 2025
Effectiveness of sodium-glucose cotransporter type 2 inhibitors and urate-lowering agents in patients with gout: data from a single-center specialised clinic
Jose Doménech Serrano¹, Ivana García Loiseau², Cristina RodrÍguez-Alvear³, Pablo Riesgo Sanchis¹, Oscar Moreno Pérez¹ and Mariano Andrés¹, ¹Dr Balmis Alicante General University Hospital-ISABIAL, Alicante, Spain, ²Miguel Hernández University, Alicante, Spain, ³Virgen de la Peña General Hospital, Fuerteventura, Spain
Background/Purpose: Sodium-glucose cotransporter type 2 inhibitors (SGLT2I) proved substantial benefits in diabetes mellitus (DM), heart failure (HF) and kidney disease (KD). In pivotal trials, SGLT2Is…
Abstract Number: 2588 • ACR Convergence 2025
Nanoencapsulated Sirolimus plus Pegadricase (NASP) Demonstrates a Reduction in Gout Flares: Results from the Phase 3 DISSOLVE Studies
Angelo Gaffo¹, Herbert Baraf², Anand Patel³, Tuhina Neogi⁴, Rehan Azeem⁵, Wesley DeHaan⁶, Ben Peace⁷, Hugues Santin-Janin⁸, Bhavisha Desai⁹ and Naomi Schlesinger¹⁰, ¹Division of Rheumatology and Clinical Immunology, University of Alabama, Birmingham, AL, USA; Birmingham VA Medical Center, Birmingham, AL, USA, Birmingham, AL, ²The Center for Rheumatology and Bone Research, Rheumatology, Wheaton, Maryland, USA; Division of Rheumatology, The George Washington University, Washington, DC, ³Conquest Research, Winter Park, FL, USA, Winter Park, FL, ⁴Boston University School of Medicine, Boston, MA, ⁵Global MACD, Sobi Inc., Waltham, MA, ⁶Sobi, Inc, Waltham, MA, ⁷Statistical Science, Sobi, Stockholm, Sweden, ⁸Sobi, BASEL, Switzerland, ⁹Sobi, Glastonbury, CT, ¹⁰Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT, USA, Salt Lake City, UT
Background/Purpose: Urate-lowering therapy is recommended to lower serum urate (sUA) and for long-term prevention of gout flares (FitzGerald et al. Arthritis Care Res (Hoboken) 2020;…
Abstract Number: 1125 • ACR Convergence 2025
Validation of an Allopurinol Dose Prediction Tool to Achieve Goal Serum Urate Among Patients with Gout
Brian Coburn¹, Daniel Wright², Jeff Newcomb³, Mary Brophy⁴, Anne Davis-Karim⁵, Ryan Ferguson⁴, Michael Pillinger⁶, Tuhina Neogi⁷, Paul Palevsky⁸, Bryant England³, James O'Dell³, Lisa Stamp⁹, Ted Mikuls³ and Joshua Baker¹⁰, ¹Hospital of the University of Pennsylvania, Philadelphia, PA, ²University of Otago, Dunedin, New Zealand, ³University of Nebraska Medical Center, Omaha, NE, ⁴VA Cooperative Studies Program Coordinating Center, Boston, MA, ⁵VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM, ⁶New York University Grossman School of Medicine, New York,, NY, ⁷Boston University School of Medicine, Boston, MA, ⁸VA Pittsburgh Healthcare System, Pittsburgh, PA, ⁹University of Otago, Christchurch, Christchurch, New Zealand, ¹⁰University of Pennsylvania, Philadelphia, PA
Background/Purpose: Despite evidence-based recommendations, allopurinol dose escalation to goal serum urate (SU) is frequently suboptimal. The EasyAllo tool was developed to facilitate pre-planned allopurinol dose…
Abstract Number: 2105 • ACR Convergence 2025
Stratification for elevated urate identifies a pro-inflammatory synovial fluid proteome in knee osteoarthritis: a pilot study
Tuhina Neogi¹, Sayali Dhamne², Robert Terkeltaub³, Virginia Kraus⁴, Simon Dillon⁵ and Towia Libermann⁵, ¹Boston University School of Medicine, Boston, MA, ²Boston University Chobanian & Avedisian School of Medicine, Boston, MA, ³Retired, San Diego, CA, ⁴Duke University, Durham, NC, ⁵Beth Israel Deaconess Medical Center, Boston, MA
Background/Purpose: The causes of inflammation, pain fluctuations, and disease progression in osteoarthritis (OA) are not well understood. Soluble urate is a “danger signal”, and synovial…
Abstract Number: 1123 • ACR Convergence 2025
Nanoencapsulated Sirolimus plus Pegadricase (NASP) Demonstrates Long Term Efficacy and Safety in Patients with Uncontrolled Gout: Results from the 24-week Double-blind Extension of the Phase 3 DISSOLVE I Study
Alan Kivitz¹, Atul Singhal², Anand Patel³, Rehan Azeem⁴, Ben Peace⁵, Bhavisha Desai⁶ and Herbert Baraf⁷, ¹Altoona Center for Clinical Research, Duncansville, PA, ²SouthWest Arthritis Research Group, Mesquite, TX, ³Conquest Research, Winter Park, FL, USA, Winter Park, FL, ⁴Global MACD, Sobi Inc., Waltham, MA, ⁵Statistical Science, Sobi, Stockholm, Sweden, ⁶Sobi, Glastonbury, CT, ⁷The Center for Rheumatology and Bone Research, Rheumatology, Wheaton, Maryland, USA; Division of Rheumatology, The George Washington University, Washington, DC
Background/Purpose: Uncontrolled gout (UG) occurs when serum uric acid (sUA) levels remain persistently elevated despite use of oral urate-lowering therapies and can result in progressively…
Abstract Number: 2007 • ACR Convergence 2025
Machine Learning-Based Prediction of Gout Onset in Individuals with Asymptomatic Hyperuricemia Using a Common Data Model
Min Jung Kim¹, Sang Min Lee², Jun Seok Kim², Borim Ryu² and Kichul Shin³, ¹Seoul Metropolitan Government Boramae Medical center, Dongjak-gu, Seoul, South Korea, ²Center for Data Science, Biomedical Research Institute, Seoul Metropolitan Government–Seoul National University Hospital Boramae Medical Center, Seoul, Republic of Korea, ³Seoul National University, Seoul, South Korea
Background/Purpose: Long-term hyperuricemia is essential for the development of gout. However, only 9.9% of individuals with asymptomatic hyperuricemia (AHU) develop gout within 10 years. Identifying…
Abstract Number: 1076 • ACR Convergence 2025
Racial Differences in Real-World Use of Urate-Lowering and Adjunctive Therapies for Gout: A 10-Year Propensity-Matched Cohort Study
Michael Hamilton¹, Justin Riley Lam², Emmanuel Otabor³, Laith Alomari³, Maxim Barnett³, Arthur Lau⁴ and Irene Tan⁵, ¹Jefferson Einstein Hospital, Philadelphia, Philadelphia, PA, ²Jefferson Einstein Hospital, Philadelphia, PA, ³Jefferson Einstein Hospital Philadelphia, Philadelphia, PA, ⁴Jefferson Einstein Hospital, Maple Glen, PA, ⁵Einstein Healthcare Network Philadelphia - Jefferson Health, Bala Cynwyd, PA
Background/Purpose: Although achieving target serum urate (SU) and reducing cardiovascular events are cornerstones of gout management, little is known about contemporary treatment patterns across racial…
Abstract Number: 2005 • ACR Convergence 2025
Elevated Serum Uric Acid as an Independent Risk Factor for Multiple Stent Placement in Non-Hypertensive, Non-Diabetic Patients with Coronary Artery Disease: A Retrospective Cohort Analysis
qingyan li¹, Jianguo Li¹, Mengwen Niu¹, Tianshu chu¹ and lemei an², ¹Henan Provincial People's Hospital, zhengzhou, China (People's Republic), ²Henan Provincial People's Hospital, zhengzhou
Background/Purpose: While the relationship between serum uric acid (SUA) and coronary artery disease (CAD) remains controversial, emerging evidence suggests a particularly significant association in patients…
Abstract Number: 1043 • ACR Convergence 2025
The Care Pathway and Treatment Patterns in Patients with Uncontrolled Gout: A Real-World Survey of Physicians In The United States
Gordon Lam¹, Menaka Bhor², James Hawthorne², Arinola Dada³, Molly Edwards⁴, Emily Goddard⁴ and John Albert⁵, ¹Arthritis & Osteoporosis Consultants of the Carolinas, Charlotte, NC, ²Sobi Inc, Waltham, MA, ³Overlake Arthritis and Osteoporosis Center, Bellevue, WA, ⁴Adelphi Real World, Bollington, United Kingdom, ⁵Rheumatic Disease Center, Glendale, WI
Background/Purpose: Uncontrolled gout (UG) is a chronic, progressive, and systemic disease characterized by serum uric acid (sUA) >6 mg/dl and clinical manifestations such as tophi,…
Abstract Number: 2004 • ACR Convergence 2025
Characteristics and Management of Gout Patients Under Rheumatologist Care from Low-Income and Middle-Income Asia-Pacific Countries: Data from the APLAR Gout Registry
Kanon Jatuworapruk¹, Binit Vaidya², ANA MONICA ESTRELLA³, MA. HANNA MONICA SOLLANO³, Ronaldo De Vera⁴, Ida Ayu Ratih Wulansari Manuaba⁵, Rakhma Hellmi⁶, Panchalee Satpanich⁷, Nittayawadee Aeamsaard⁸, MAHABALESHWAR MAMADAPUR⁹, Mustafa Alhayali¹⁰, Chang-Nam Son¹¹, Syahrul Sazliyana Shaharir¹², Galymzhan Togizbayev¹³ and Jose Paulo Lorenzo³, ¹Thammasat University, Pathumthani, Thailand, ²National Center for Rheumatic Diseases, Kathmandu, Nepal, ³Makati Medical Center, Makati, Philippines, ⁴Tricity Medical Center in Pasig City, Pasig, Philippines, ⁵Bali International University, Bali, Indonesia, ⁶Kariadi Hospital Medical Center, Semarang, Indonesia, ⁷Faculty of Medicine Vajira Hospital, bangkok, Thailand, ⁸Saraburi Hospital, Saraburi, Thailand, ⁹JSS MEDICAL COLLEGE AND HOSPITAL, Mysore, Karnataka, India, ¹⁰Baghdad Teaching Hospital, Baghdad, Iraq, ¹¹UIJEONGBU EULJI MEDICAL CENTER, EULJI UNIVERSITY, UIJEONGBU, Republic of Korea, ¹²Universiti Kebangsaan Malaysia, Selangor, Malaysia, ¹³Qazaq College of Rheumatology, Almaty, Kazakhstan
Background/Purpose: The burden of gout is rising in low-income and middle-income countries in the Asia-Pacific region. However, individuals with gout in this region remain underrepresented…
Abstract Number: 2001 • ACR Convergence 2025
Characteristics of Gout Flares Over Time with Treat-to-Target Urate-Lowering Therapy Use
Jason Yang¹, Ted Mikuls², Harlan Sayles², Michael Pillinger³, Jeff Newcomb², Bridget Kramer², Anne Davis-Karim⁴, Mary Brophy⁵, Ryan Ferguson⁵, Paul Palevsky⁶, James O'Dell² and Tuhina Neogi⁷, ¹Boston Medical Center, Boston, MA, ²University of Nebraska Medical Center, Omaha, NE, ³New York University Grossman School of Medicine, New York,, NY, ⁴VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM, ⁵VA Cooperative Studies Program Coordinating Center, Boston, MA, ⁶VA Pittsburgh Healthcare System, Pittsburgh, PA, ⁷Boston University School of Medicine, Boston, MA
Background/Purpose: Gout flares are an important treatment outcome in gout. Although flares are typically assessed by occurrence (yes/no) or a simple count in trials of…
Abstract Number: 1998 • ACR Convergence 2025
Reduction in Tophi Observed in Patients with Uncontrolled Gout Treated with NASP: Results from Phase 3 DISSOLVE Studies
Herbert Baraf¹, Puja Khanna², Frédéric Lioté³, Rehan Azeem⁴, Wesley DeHaan⁵, Ben Peace⁶, Hugues Santin-Janin⁷, Bhavisha Desai⁸ and Alan Kivitz⁹, ¹The Center for Rheumatology and Bone Research, Rheumatology, Wheaton, Maryland, USA; Division of Rheumatology, The George Washington University, Washington, DC, ²Division of Rheumatology, University of Michigan, Ann Arbor, MI, ³Université Paris Cité-Inserm UMR¹¹³² & Rheumatology Department, GH Paris Saint Joseph & Institut Arthur Vernes, Paris, France, ⁴Global MACD, Sobi Inc., Waltham, MA, ⁵Sobi, Inc, Waltham, MA, ⁶Statistical Science, Sobi, Stockholm, Sweden, ⁷Sobi, BASEL, Switzerland, ⁸Sobi, Glastonbury, CT, ⁹Altoona Center for Clinical Research, Duncansville, PA
Background/Purpose: Patients (pts) with uncontrolled gout (UG) and tophi experience joint pain, impaired function and poor quality of life (Schlesinger et al. Semin Arthritis Rheum…
Abstract Number: 1994 • ACR Convergence 2025
Pharmacokinetics of Ready-to-Use Pegloticase Formulation Compared to Standard Pegloticase Dosing: Data from the AGILE Study
Orrin Troum¹, John Botson², Afroz S. Mohammad³, Xiaoqing Yang⁴, Nathan Roe⁵, Supra Verma⁶ and Brian Lamoreaux⁷, ¹Providence Health Care/Doctor's of St John's (MDSJ) Santa Monica, CA, Santa Monica, CA, ²Orthopedic Physicians Alaska, Anchorage, AK, ³Amgen Inc, Deerfield, ⁴Amgen, Seattle, WA, ⁵Horizon Therapeutics, Boise, ID, ⁶Horizon Therapeutics, Newport Beach, CA, ⁷Amgen, Inc., Deerfield, IL
Background/Purpose: Pegloticase is approved for uncontrolled gout as 8-mg infusions admixed in 250 cc of normal saline over 120 minutes or more administered every 2…
Abstract Number: 1992 • ACR Convergence 2025
Tolerance of Methotrexate Coadministered with Pegloticase in Patients with Uncontrolled Gout: Findings from MIRROR RCT
Vinicius Domingues¹, Alexis Woods², Xiaoqing Yang³, Brian Lamoreaux⁴ and Michael Weinblatt⁵, ¹Rheumatology, Allergy, Asthma & Arthritis Center, Daytona beach, FL, ²Amgen, Detroit, MI, ³Amgen, Seattle, WA, ⁴Amgen, Inc., Deerfield, IL, ⁵Brigham and Women's Hospital/ Harvard Medical School, Waban, MA
Background/Purpose: Methotrexate (MTX) coadministered with pegloticase attenuates anti-drug antibody formation, leading to higher response rates and markedly reduced infusion reaction risk compared with pegloticase +…

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