Abstracts tagged "Type II collagen"

Abstract Number: 91 • 2019 ACR/ARP Annual Meeting
Histonedeacetylase 1 (HDAC1): A Key Mediator of T Cells for the Pathogenesis of Rheumatoid Arthritis
Lisa Goschl ¹, Victoria Saferding ¹, Nicole Boucheron ², Johan Backlund ³, Alexander Platzer ¹, Kiyoshi Hirahara ⁴, Han-yu Shih ⁵, Patrick Matthias ⁶, Clemens Scheinecker ¹, Günter Steiner ⁷, Wilfried Ellmeier ² and Michael Bonelli¹, ¹Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, ²Institute of Immunology, Division of Immunobiology, Medical University of Vienna, Vienna, Austria, ³Medical Inflammation Research, Karolinska Institute; Department of Medical Biochemistry and Biophysics, Stockholm, Sweden, ⁴Graduate School of Medicine, Chiba University, Chiba, Japan, ⁵National Institute of Arthritis, National Institutes of Health, Bethesda, ⁶Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland, ⁷Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Vienna, Austria, Vienna, Austria
Background/Purpose: Despite enormous efforts to develop new therapeutic strategies for treatment of rheumatoid arthritis (RA), the large number of non responding patients to currently available…
Abstract Number: 994 • 2019 ACR/ARP Annual Meeting
Increased Antibody and T-cell Responses Following Treatment of Collagen-Induced Arthritis in C57Bl/6 Mice with Organic Dust Inhalants
Michael Duryee¹, Jill Poole ¹, Amy Nelson ¹, Katherine Janike ¹, Kathryn Rentfro ¹, Lynell Klassen ¹, James O'Dell ², Bryant England ³, Geoffrey Thiele ² and Ted Mikuls ², ¹University of Nebraska Medical Center, Omaha, NE, ²VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, NE, ³VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha
Background/Purpose: Increasing evidence suggests that inhalant exposures, such as tobacco smoke or silica, are implicated in the initiation of autoimmunity leading to rheumatoid arthritis (RA).…
Abstract Number: 2087 • 2012 ACR/ARHP Annual Meeting
Regulatory Effect of the Combination of Methotrexate and 1,25-Dihydroxyvitamin D3 On the Balance of Treg and Th17 in Collagen-Induced Arthritis
Jing Luo, Department of Rheumatoloy, the Second Hospital of Shanxi Medical University, Taiyuan, China
Background/Purpose: 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) is the physiologically active metabolite of vitamin D, and it may modulate inflammatory response, cell maturation and cell differentiation. More recently,…

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