Abstracts tagged "Tumor necrosis factor (TNF)"

Abstract Number: 94 • 2019 ACR/ARP Annual Meeting
Tumor Necrosis Factor Receptor 2 Signaling Potentiates Proliferation and Suppressive Activities of Follicular Regulatory T Cells
Shotaro kawano¹, Hiroki Mitoma ², Shoichiro Inokuchi ³, Masahiro Ayano ², Yasutaka Kimoto ⁴, Mitsuteru Akahoshi ², Yojiro Arinobu ², Koichi Akashi ², Takahiko Horiuchi ⁵ and Hiroaki Niiro ⁶, ¹Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ²Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Fukuoka, Japan, Fukuoka, Japan, ³Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Fukuoka, Japan, Fukuoka, Fukuoka, Japan, ⁴Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, ⁵Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, Beppu, Japan, ⁶Clinical Education Centre, Kyushu University Hospital, Fukuoka, Japan, Fukuoka, Japan
Background/Purpose: Tumor Necrosis Factor (TNF) α is a multifunctional cytokine with pro-inflammatory and anti-inflammatory characteristics. Regulatory T cells (Treg) express a remarkably high level of…
Abstract Number: 106 • 2019 ACR/ARP Annual Meeting
Increased T Cell Polyreactivity with Marked Accumulation of TNF-α DP (CD4+CD8+) in the Synovial Tissue of pre-RA, Arthralgia Subjects
Achilleas Floudas¹, Douglas Veale ² and Ursula Fearon ³, ¹Trinity Biomedical Sciences Institu, DUBLIN, Ireland, ²EULAR Centre For Arthritis And Rheumatic Diseases and The Conway Institute, Dublin, Ireland, ³Molecular Rheumatology, Trinity Biomedical Sciences Institute, TCD, Dublin, Ireland
Background/Purpose: Effective treatment of Rheumatoid arthritis (RA) patients is achievable within a short window of opportunity following diagnosis. Identification of pathogenic immune mechanisms at a…
Abstract Number: 614 • 2019 ACR/ARP Annual Meeting
Tapering of Tumor Necrosis Factor Inhibitor and Healthcare Cost Differences in Patients with Ankylosing Spondylitis: A Retrospective Analysis of Korean National Health Insurance Data
Bon San Koo¹, Yu-Cheol Lim ², Min-Young Lee ³, Ja-Young Jeon ⁴, Hyun-Jeong Yoo ⁵, In-Sun Oh ², Ju-Young Shin ² and Tae-Hwan Kim ⁶, ¹Department of Internal Medicine, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea, ²School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea, ³VIAplus, Siheung, Republic of Korea, ⁴Pfizer Inc, Seoul, Republic of Korea, ⁵Pfizer Korea, Seoul, Republic of Korea, ⁶Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea
Background/Purpose: Tapering of tumor necrosis factor (TNF) inhibitors may be considered in patients with ankylosing spondylitis (AS) with low disease activity. However, there is still…
Abstract Number: 752 • 2019 ACR/ARP Annual Meeting
Drug Retention and Discontinuation Reasons Between Seven Biologics in Patients with Takayasu Arteritis
Corrado Campochiaro¹, Alessandro Tomelleri ², Silvia Sartorelli ³, Giulio Cavalli ², De Luca Giacomo ⁴, Elena Baldissera ² and Lorenzo Dagna ², ¹Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy, ²Unit of Immunology, Rheumatology, Allergy and Rare Diseases. IRCCS San Raffaele Hospital. Vita-Salute San Raffaele University., Milan, Italy, ³Vita-Salute San Raffaele University, IRCCS San Raffaele Hospital, Milan, Italy, ⁴Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Milan, Italy
Background/Purpose: Takayasu's arteritis (TA) is a large vessel vasculitis affecting mainly young women. Biologic agents are currently use to treat refractory TA patients but no…
Abstract Number: 772 • 2019 ACR/ARP Annual Meeting
The Study of the Novel G87V Mutation in the TNFRSF1A Gene Identified in a Family with TNF Receptor-Associated Periodic Syndrome (TRAPS)
Shoko Tsuji¹, Hidenori Matsuzaki ², Masanori Iseki ³, Akiko Nagasu ¹, Hiroyasu Hirano ¹, Katsuhiko Ishihara ⁴, Naoyasu Ueda ⁵, Yoshitaka Honda ⁶, Takahiko Horiuchi ⁷, Ryuta Nishikomori ⁸, Yoshitaka Morita ¹ and Tomoyuki Mukai ⁹, ¹Department of Rheumatology, Kawasaki Medical School, Kurashiki, Okayama, Japan, ²Department of Life Sciences, Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, shobara, Hiroshima, Japan, ³Department of Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki, Okayama, Japan, ⁴Department of Immunology and Molecular Genetics, Kurashiki, Okayama, Japan, ⁵Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan, ⁶Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁷Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, Beppu, Japan, ⁸Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Fukuoka, Japan, ⁹Department of Rheumatology, Kawasaki medical School, Kurashiki, Okayama, Okayama, Japan
Background/Purpose: TNF Receptor-Associated Periodic Syndrome (TRAPS) is one of the autoinflammatory diseases. TRAPS is caused by heterozygous mutations in the TNFRSF1A gene. Although more than…
Abstract Number: 1871 • 2013 ACR/ARHP Annual Meeting
Progranulin Directly Binds To The CRD 2 and CRD3 Of TNFR Extracellular Domains
Jinlong Jian¹, Shuai Zhao¹, Qingyun Tian¹, Elena Gonzalez Gugel², Jyoti Mundra², Sardar MZ Uddin², Ben Liu³, Brendon Richbourgh², Ryan Brunetti², Gerald Chan⁴, Carolyn Green⁵ and Chuanju Liu¹, ¹Orthopaedic Surgery, NYU Hospital for Joint Diseases, New York, NY, ²NYU Hospital for Joint Diseases, New York, NY, ³NYU Hospital for Joint Diseases, New York Univerity, NY, ⁴Atreaon, Boston, MA, ⁵Atreaon, Boston, NY
Background/Purpose: We previously reported that Progranulin (PGRN) bound to TNF receptors (TNFR) and was therapeutic in inflammatory arthritis (Tang, W., et al, Science, 2011). PGRN…
Abstract Number: 1365 • 2012 ACR/ARHP Annual Meeting
Double-Blind, Placebo-Controlled, 28-Week Trial of Efficacy and Safety of Infliximab Plus Naproxen Vs Naproxen Alone: Results From the Infliximab As First Line Therapy in Patients with Early, Active Axial Spondyloarthritis Trial, Part I
Joachim Sieper¹, Jan Lenaerts², Jürgen Wollenhaupt³, Vadim Mazurov⁴, L. Myasoutova⁵, Sung-Hwan Park⁶, Yeong W. Song⁷, Ruji Yao⁸, Denesh Chitkara⁸ and Nathan Vastesaeger⁹, ¹Charité, University Medicine Berlin, Berlin, Germany, ²Reuma-instituut, Hasselt, Belgium, ³Schön-Klinik, Hamburg, Germany, ⁴St. Petersburg Medical Academy, St. Petersburg, Russia, ⁵Kazan State Medical University, Kazan, Russia, ⁶Catholic University of Korea, Seoul, South Korea, ⁷Seoul National University, Seoul, South Korea, ⁸Merck Sharp and Dohme, Kenilworth, NJ, ⁹Merck Sharp & Dohme, Brussels, Belgium
Background/Purpose: Efficacy of anti–tumor necrosis factor (TNF) therapy in patients with axial spondyloarthritis (SpA) has been tested only in patients who are refractory to NSAIDs.…
Abstract Number: 834 • 2012 ACR/ARHP Annual Meeting
Cetrorelix, a Gonadotropin-Releasing Hormone Antagonist, Significantly Reduces Tumour-Necrosis-Factor-Alpha and Demonstrates Efficacy in Patients with Active Rheumatoid Arthritis: A Proof-of-Concept, Double-Blind, Randomised Trial
Anita Kåss¹, Øystein T. Førre², Morten Fagerland³, Hans Christian Gulseth⁴, Peter Torjesen⁵ and Ivana Hollan⁶, ¹University of Oslo, Oslo, Norway, ²Oslo University Hospital, Oslo, Norway, ³Department of Biostatistics, Oslo University Hospital, Oslo, Norway, ⁴Rheumatology, Betanien Hospital, Skien, Norway, ⁵Department of Endocrinology, Oslo University Hospital, Oslo, Norway, ⁶Rheumatology, Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway
Background/Purpose: The pathogenesis of rheumatoid arthritis (RA) is unclear, and treatment options can be improved. Gonadotropin-releasing hormone (GnRH) stimulates immune responses (1) and therefore might…
Abstract Number: 779 • 2012 ACR/ARHP Annual Meeting
Changes in Active Inflammatory Lesions Assessed by Magnetic Resonance Imaging: Results of the Infliximab As First Line Therapy in Patients with Early Active Axial Spondyloarthritis Trial
Joachim Sieper¹, Jan Lenaerts², Jürgen Wollenhaupt³, Vadim Mazurov⁴, L. Myasoutova⁵, Sung-Hwan Park⁶, Yeong W. Song⁷, Ruji Yao⁸, Denesh Chitkara⁹ and Nathan Vastesaeger¹⁰, ¹Charité, University Medicine Berlin, Berlin, Germany, ²Reuma-instituut, Hasselt, Belgium, ³Schön-Klinik, Hamburg, Germany, ⁴St. Petersburg Medical Academy, St. Petersburg, Russia, ⁵Kazan State Medical University, Kazan, Russia, ⁶Catholic University of Korea, Seoul, South Korea, ⁷Seoul National University, Seoul, South Korea, ⁸Merck Sharp & Dohme, Kenilworth, NJ, ⁹Merck Sharp and Dohme, Kenilworth, NJ, ¹⁰Merck Sharp & Dohme, Brussels, Belgium
Background/Purpose: Few studies have evaluated changes in active inflammation of spine and sacroiliac (SI) joints by MRI during long-term treatment for axial SpA, and no…
Abstract Number: 549 • 2012 ACR/ARHP Annual Meeting
A Randomized, Open-Label Study of Maintenance of Partial Remission with Naproxen Vs No Treatment: Results of the Infliximab As First Line Therapy in Patients with Early Active Axial Spondyloarthritis Trial, Part II
Joachim Sieper¹, Jan Lenaerts², Jürgen Wollenhaupt³, Vadim Mazurov⁴, L. Myasoutova⁵, Sung-Hwan Park⁶, Yeong W. Song⁷, Ruji Yao⁸, Denesh Chitkara⁹ and Nathan Vastesaeger¹⁰, ¹Charité, University Medicine Berlin, Berlin, Germany, ²Reuma-instituut, Hasselt, Belgium, ³Schön-Klinik, Hamburg, Germany, ⁴St. Petersburg Medical Academy, St. Petersburg, Russia, ⁵Kazan State Medical University, Kazan, Russia, ⁶Catholic University of Korea, Seoul, South Korea, ⁷Seoul National University, Seoul, South Korea, ⁸Merck Sharp & Dohme, Kenilworth, NJ, ⁹Merck Sharp and Dohme, Kenilworth, NJ, ¹⁰Merck Sharp & Dohme, Brussels, Belgium
Background/Purpose: In patients with axial SpA who have achieved partial remission, it is unclear whether continuous treatment with NSAIDs is superior to stopping treatment. Objectives:…
Abstract Number: 471 • 2012 ACR/ARHP Annual Meeting
Efficacy and Safety of Golimumab As Add-On Therapy to Disease-Modifying Antirheumatic Drugs
Bernard Combe¹, Bhaskar Dasgupta², Ingrid Louw³, Sarvajeet Pal⁴, Jürgen Wollenhaupt⁵, Cristiano Zerbini⁶, Andre D. Beaulieu⁷, Hendrik Schulze-Koops⁸, Patrick Durez⁹, Ruji Yao¹⁰, Nathan Vastesaeger¹¹ and Holly Weng¹⁰, ¹Hôpital Lapeyronie-Service d'Immuno-rhumatologie, Montpellier, France, ²Rheumatology, Southend University Hospital, Westcliff-on-Sea, United Kingdom, ³Panorama Medical Centre, Cape Town, South Africa, ⁴Advance Rheumatology Clinic, Hyderabad, India, ⁵Schön-Klinik, Hamburg, Germany, ⁶Centro Paulista de Investigações, Sao Paulo, Brazil, ⁷Bureau 140, Centre de Rhumatologie, St. Louis, QC, Canada, ⁸University of Munich, Munich, Germany, ⁹UCL Saint-Luc, Brussels, Belgium, ¹⁰Merck Sharp & Dohme, Kenilworth, NJ, ¹¹Merck Sharp & Dohme, Brussels, Belgium
Background/Purpose: This study evaluated golimumab (GLM) as add-on therapy in patients with active RA despite treatment with non-biologic DMARDs. Two GLM treatment strategies (subcutaneous [SC]…
Abstract Number: 472 • 2012 ACR/ARHP Annual Meeting
More Positive Expectations of Treatment with Golimumab for Rheumatoid Arthritis Are Associated with Greater Improvement in Clinical Outcomes
Bhaskar Dasgupta¹, Bernard Combe², Ingrid Louw³, Sarvajeet Pal⁴, Jürgen Wollenhaupt⁵, Cristiano Zerbini⁶, Andre D. Beaulieu⁷, Hendrik Schulze-Koops⁸, Patrick Durez⁹, W. Bensen¹⁰, V. Wolff¹¹, Ruji Yao¹², Holly Weng¹² and Nathan Vastesaeger¹³, ¹Southend University Hospital, Westcliff-on-Sea, United Kingdom, ²Hôpital Lapeyronie-Service d'Immuno-rhumatologie, Montpellier, France, ³Panorama Medical Centre, Cape Town, South Africa, ⁴Advance Rheumatology Clinic, Hyderabad, India, ⁵Schön-Klinik, Hamburg, Germany, ⁶Centro Paulista de Investigações, Sao Paulo, Brazil, ⁷Bureau 140, Centre de Rhumatologie, St. Louis, QC, Canada, ⁸University of Munich, Munich, Germany, ⁹UCL Saint-Luc, Brussels, Belgium, ¹⁰St. Joseph's Hospital and McMaster University, Hamilton, ON, Canada, ¹¹Hospital del Salvador, Santiago, Chile, ¹²Merck Sharp & Dohme, Kenilworth, NJ, ¹³Merck Sharp & Dohme, Brussels, Belgium
Background/Purpose: Little is known about how patient and physician expectations relate to clinical outcomes. This study investigated the expectations that patients and physicians have at…

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