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Abstracts tagged "Tumor necrosis factor (TNF)"

  • Abstract Number: 0185 • ACR Convergence 2021

    Phase 1 Study Results of GS-5718, an Oral IRAK4-Inhibitor: Pharmacodynamics of Single and Multiple Doses of GS-5718 in Healthy Subjects

    Silke Roedder1, Emily Wendt2, Chad Burris2, Jonathan Nazareon2, Grace Park3, Phil Pangilinan2, Gianna Huang2, Anubhav Mathur2, James Taylor2, Andrew Billin2 and Franziska Matzkies4, 1Gilead Sciences, Menlo Park, CA, 2Gilead Sciences, Foster City, CA, 3Gilead Sciences, Seattle, WA, 4Gilead Sciences, Inc., Foster City, CA

    Background/Purpose: Adaptive and innate immune pathways are involved in inflammation and pathogenesis of autoimmune diseases including Rheumatoid Arthritis (RA) and Lupus Erythematosus (LE). Immune complexes…
  • Abstract Number: 1891 • ACR Convergence 2021

    Variable Effects of Testosterone on Male versus Female Derived Macrophages in Inflammatory Arthritis

    Kiana Chen1, Xi Lin1, Lianping Xing2, H. Mark Kenney3, Richard Bell4, Edward Schwarz5 and Homaira Rahimi5, 1University of Rochester School of Medicine and Dentistry, Rochester, NY, 2University of Rochester Medical Center, Webster, NY, 3University of Rochester Medical Center, Rochester, NY, 4Hospital for Special Surgery, New York, NY, 5University of Rochester, Rochester, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that is female predominant. The TNF-transgenic (TNF-Tg) mouse model of RA also develops a sexually…
  • Abstract Number: 0204 • ACR Convergence 2021

    Risk of Hepatitis B Virus Reactivation in Patients with Immune-Mediated Inflammatory Diseases Receiving Biologics: Focus on the Timing of Biologics After Prophylactic Anti-viral Agents

    Soo Min Ahn1, Jonggi Choi2, Byong Duk Ye2, Suk-Kyun Yang2, Ji Seon Oh3, Yong-Gil Kim2, Chang-Keun Lee2, Bin Yoo1, Sang Hyoung Park2 and Seokchan Hong2, 1ASAN MEDICAL CENTER, Seoul, South Korea, 2Asan Medical Center, Seoul, Republic of Korea, 3Asan Medical Center, Ulsan, Republic of Korea

    Background/Purpose: Prophylactic anti-viral therapy is required in patients with hepatitis B virus (HBV) infection receiving biologics because of the high risk of HBV reactivation. However,…
  • Abstract Number: 0246 • ACR Convergence 2021

    Macrophage Activating Syndrome in Patients with Systemic Juvenile Idiopathic Arthritis Treated with Biological Drugs

    Betul Sozeri1, Kenan Barut2, Erdal Atalay3, Aysenur Pac Kisaarslan4, Semanur Ozdel5, Ozge Altug6, Ferhat Demir1, Balahan Makay7, Nuray Aktay Ayaz8, Ersen Acar9, Fatih Haslak2, Erdal Sag10, Mehmet YILDIZ2, Ummusen Kaya Akca10, Amra Adrovic2, Yelda Bilginer10, Hakan Poyrazoglu11, Erbil Unsal7, Ozgur Kasapcopur12 and Seza Ozen3, 1University of Health Sciences, Umraniye Tranining and Research Hospital Division of Pediatric Rheumatology, Istanbul, Turkey, 2Istanbul University-Cerrahpasa, Faculty of Medicine, Pediatric Rheumatology, İstanbul, Turkey, 3Hacettepe University Faculty of Medicine, Pediatric Romatology, Ankara, Turkey, 4Erciyes University Medical Faculty, Pediatric Rheumatology, Kayeri, Turkey, 5Ankara Dr.Sami Ulus Gynecology and Pediatrics Research and Training Hospital, Pediatric Rheumatology, Ankara, Turkey, 6Dr Behcet Uz Children's Hospital, Pediatric Rheumatology, Izmir, Turkey, 7Dokuz Eylul University Faculty of Medicine, Pediatric Rheumatology, Izmir, Turkey, 8Istanbul University, Faculty of Medicine, Pediatric Rheumatology, İstanbul, Turkey, 9Novartis, Istanbul, Turkey, 10Hacettepe University, Division of Pediatric Rheumatology, Department of Pediatrics, Faculty of Medicine, Ankara, Turkey, 11Erciyes University Faculty of Medicine, Pediatric Rheumatology, Kayseri, Turkey, 12Istanbul University-Cerrahpasa, Cerrahpasa Medical School, İstanbul, Turkey

    Background/Purpose: Systemic Juvenile Idiopathic Arthritis (SJIA) is the most acute and severe form of JIA. Despite the substantial evidence supporting the effectiveness of biologic drugs…
  • Abstract Number: 0451 • ACR Convergence 2021

    Tumor Necrosis Factor Inhibitors Show a Delayed Effect on Radiographic Sacroiliitis Progression in Patients with Early Axial Spondyloarthritis: 10-Year Results from the German Spondyloarthritis Inception Cohort

    Murat Torgutalp1, Valeria Rios Rodriguez1, Maryna Verba2, Mikhail Protopopov1, Fabian Proft1, Judith Rademacher1, Hildrun Haibel3, Martin Rudwaleit4, Joachim Sieper3 and Denis Poddubnyy5, 1Charité University Medicine Berlin, Berlin, Germany, 2Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Berlin, Germany, 3Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, 4University of Bielefeld, Klinikum Bielefeld, Bielefeld, Germany, 5Department of Rheumatology, Charité – Universitätsmedizin, Berlin, Germany

    Background/Purpose: Observational cohort studies have shown that there is low, but still detectable progression level in radiographic sacroiliitis, which might also have an impact on…
  • Abstract Number: 0511 • ACR Convergence 2021

    Tumor Necrosis Factor-α Modulates Endothelial-to-mesenchymal Transition and Increases Protein Tyrosine Phosphatase 1B

    Jorge Romo-Tena1, Jose Esparza-Lopez2, Carmelo Carmona-Rivera3, Luz P blanco3, Mariana Kaplan4 and María de Jesús Ibarra-Sánchez2, 1INNSZ / NIAMS, Mexico City, Mexico, 2INNSZ, Mexico City, Mexico, 3NIAMS, Bethesda, MD, 4National Institutes of Health, Bethesda, MD

    Background/Purpose: Endothelial dysfunction is a hallmark in the pathogenesis of many inflammatory diseases. The endothelial-to-mesenchymal transition (EndoMT) is a process where endothelial cells lose their…
  • Abstract Number: 0514 • ACR Convergence 2021

    Extracellular Sulfatase-2 Mediates TNF-α Inflammatory Signaling in Human Rheumatoid Arthritis Synovial Fibroblasts

    Ruby Siegel1, Anil singh1, Judy Vinh1, H. Mark Kenney2, Edward Schwarz3, David Fox4, Sadik Khuder5 and Salah-uddin Ahmed1, 1Washington State University, Spokane, WA, 2University of Rochester Medical Center, Rochester, NY, 3University of Rochester, Rochester, NY, 4Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI, 5Department of Medicine and Public Health, University of Toledo,, Toledo, OH

    Background/Purpose: TNF-α drives RA synovial fibroblast (RASF)-mediated hyperplasia and joint tissue destruction. Extracellular sulfatase-2 (Sulf-2) influences receptor/ligand binding and subsequent signaling of chemokines, cytokines, and…
  • Abstract Number: 0515 • ACR Convergence 2021

    The Extracellular Sulfatase-2 Inhibitor OKN-007 Abrogates TNF-α-induced Inflammatory Mediators in Human Rheumatoid Arthritis Synovial Fibroblasts

    Ruby Siegel, Sang Han and Salah-uddin Ahmed, Washington State University, Spokane, WA

    Background/Purpose: Recent unpublished findings from our lab show that the extracellular enzyme sulfatase-2 (Sulf-2) facilitates pro-inflammatory TNF-α signaling which activates rheumatoid arthritis synovial fibroblasts (RASFs).…
  • Abstract Number: 0527 • ACR Convergence 2021

    Role of Terminal Uridylyl Transferase 7 in TNF-α-Induced Inflammation in Rheumatoid Arthritis Synovial Fibroblasts In Vitro

    Anil singh, farheen Shaikh and Salah-uddin Ahmed, Washington State University, Spokane, WA

    Background/Purpose: Terminal uridylyl transferase 7 (TUT7), also known as Zcchc6, is a zinc finger domain-containing protein responsible for terminal uridylation of miRNA, implicated in pre-miRNA…
  • Abstract Number: 0931 • ACR Convergence 2021

    Early Improvement in Disease Activity Indices Predicts Achievement of Long-term Clinical Remissions, ASDAS Inactive Disease and Low BASDAI with Normal CRP, During TNF-α-inhibitor Therapy in Patients with Ankylosing Spondylitis

    Sang Jin Lee, Na Ri Kim and Eon Nam, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea

    Background/Purpose: As biologic agents including tumor necrosis factor (TNF)-α inhibitors (TNFi) have been proven to improve enormously clinical outcomes for patients with ankylosing spondylitis (AS),…
  • Abstract Number: 0947 • ACR Convergence 2021

    Cytokine Competent Gut-joint Migratory T Cells Contribute to Inflammation in the Joint

    Adam Lefferts1, David Claypool1, Eric Norman1, Uma Kantheti1 and Kristine Kuhn2, 1University of Colorado, Anschutz Medical Campus, Aurora, CO, 2University of Colorado Anschutz Medical Campus, Aurora, CO

    Background/Purpose: Although studies have identified the presence of gut-associated cells in the enthesis of joints affected by spondyloarthritis, a direct link through cellular transit between…
  • Abstract Number: 0978 • ACR Convergence 2021

    Immunological and Clinical Features of Untreated Juvenile Dermatomyositis Patients with Elevated Neopterin

    Amer Khojah1, Gabrielle Morgan2 and Lauren Pachman3, 1Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 2Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, IL, 3Northwestern's Feinberg School of Medicine. Ann and Robert H. Lurie Children's Hospital of Chicago; Stanley Manne Children's Research Institute of Chicago, Lake Forest, IL

    Background/Purpose: Neopterin is a metabolic product of guanosine triphosphate, which is produced by macrophages upon stimulation with interferon-gamma from activated T helper cells. Despite the…
  • Abstract Number: 1016 • ACR Convergence 2021

    Assessment of Pre-Inflammatory Mesenchymal (PRIME) Cells as a Biomarker of Tumor Necrosis Factor-Induced Arthritis in Mice

    Kiana Chen1, Xi Lin1, Lianping Xing2, H. Mark Kenney3, Richard Bell4, Edward Schwarz5 and Homaira Rahimi5, 1University of Rochester School of Medicine and Dentistry, Rochester, NY, 2University of Rochester Medical Center, Webster, NY, 3University of Rochester Medical Center, Rochester, NY, 4Hospital for Special Surgery, New York, NY, 5University of Rochester, Rochester, NY

    Background/Purpose: Recently, CD45−CD31−Podoplanin (PDPN)+ synovial fibroblast-like cells, termed pre-inflammatory mesenchymal (PRIME) cells were found to be differentially expressed and circulate in the blood of rheumatoid…
  • Abstract Number: 1219 • ACR Convergence 2021

    Machine Learning Based Prediction Model for Responses of bDMARDs in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis

    Seulkee Lee, Seonyoung Kang, Yeonghee Eun, Hyungjin Kim, Jaejoon Lee, Eun-Mi Koh and Hoon-Suk Cha, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

    Background/Purpose: Few studies on rheumatoid arthritis (RA) have generated machine learning models to predict biologic disease-modifying antirheumatic drugs (bDMARDs) responses; however, these studies included insufficient…
  • Abstract Number: 1338 • ACR Convergence 2021

    Bimekizumab in Patients with Psoriatic Arthritis: 3-Year Results for Overall and Tumor Necrosis Factor Inhibitor (TNFi)-Naïve Populations from a Phase 2b Open-Label Extension Study

    Philip Mease1, Atul Deodhar2, Joseph Merola3, Iain McInnes4, Deepak Assudani5, Rajan Bajracharya5, Jason Coarse6, Barbara Ink7 and Georg Schett8, 1Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, WA, 2Oregon Health & Science University, Portland, OR, 3Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 4University of Glasgow, School of Medicine, Glasgow, Scotland, United Kingdom, 5UCB Pharma, Slough, United Kingdom, 6UCB Pharma, Raleigh, NC, 7UCB Celltech, Slough, UK, Slough, United Kingdom, 8Universitätsklinikum Erlangen, Department of Internal Medicine 3 – Rheumatology and Immunology, Erlangen, Germany, Erlangen, Germany

    Background/Purpose: Bimekizumab (BKZ) is a monoclonal IgG1 antibody that selectively inhibits interleukin (IL)-17F and IL-­17A, and has demonstrated clinical improvements in joint and skin outcomes…
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ACR Pediatric Rheumatology Symposium 2020

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