ACR Meeting Abstracts

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Abstracts tagged "treatment and tumor necrosis factor (TNF)"

  • Abstract Number: 1145 • 2014 ACR/ARHP Annual Meeting

    Evaluation of Biologic Treatment Patterns, Clinical Outcomes, and Healthcare Resource Utilization Post-Tumor Necrosis Factor Inhibitor Discontinuation in Rheumatoid Arthritis

    J. Harnett1, D. Wiederkehr1, R. Gerber2, D. Gruben2, A. Koenig3 and J. Bourret3, 1Pfizer Inc, New York, NY, 2Pfizer Inc, Groton, CT, 3Pfizer Inc, Collegeville, PA

    Background/Purpose: For rheumatoid arthritis (RA) patients (pts) with inadequate response to a TNF inhibitor (TNFi), limited evidence exists from observational studies and indirect comparisons of…
  • Abstract Number: 472 • 2013 ACR/ARHP Annual Meeting

    Clinical Efficacy Rate Of The Non-Specific Effect (the placebo effect) In The Tumour Necrosis Factor Inhibitors For Rheumatoid Arthritis Treatment After Methotrexate Failure: Meta-Analysis

    Julie Azaïs1, Thomas Barnetche2, Pascale Vergne-Salle3, Christine Bonnet4, Carine Dufauret-Lombard5, Richard Treves6 and Philippe Bertin7, 1Rheumatology department, CHU Dupuytren Limoges, Limoges, France, 2Rheumatology, CHU Bordeaux Pellegrin, Bordeaux, France, 3Rheumatology, CHU Dupuytren Limoges, limoges, France, 4department of Rheumatology, CHU Dupuytren Limoges, Limoges, France, 5Rheumatology, CHU Dupuytren Limoges, Limoges, France, 6Department of Rheumatology, CHU Dupuytren Limoges, Limoges, France, 7Service De Rhumatologie, CHU Dupuytren Limoges, Limoges, France

    Background/Purpose: Therapeutics generate non-specific effects (the placebo effect), and specific ones, like the 5 tumor necrosis factor (TNF) inhibitors used in the treatment of Rheumatoid…
  • Abstract Number: L12 • 2013 ACR/ARHP Annual Meeting

    Cetrorelix, a Gonadotropin-Releasing Hormone Antagonist, Demonstrates Efficacy and Significantly Reduces Proinflammatory Cytokines in Patients with Active Longstanding Rheumatoid Arthritis with High Gonadotropin Levels: A Proof-of-Concept, Double-Blind, Randomized Trial

    Anita Kåss1,2, Ivana Hollan3, Peter Torjesen4, Hans Christian Gulseth5 and Øystein T. Førre6, 1Faculty of Medicine, University of Oslo, Oslo, Norway, 2Dept. of Rheumatology, Betanien Hospital, Skien, Norway, 3Rheumatology, Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, 4Department of Endocrinology, Oslo University Hospital, Oslo, Norway, 5Rheumatology, Betanien Hospital, Skien, Norway, 6Oslo University Hospital, Oslo, Norway

    Background/Purpose: The pathogenesis of rheumatoid arthritis (RA) is unclear, and treatment options can be improved. Gonadotropin-releasing hormone (GnRH) stimulates immune responses (1). Inhibiting GnRH, by…
  • Abstract Number: 2801 • 2013 ACR/ARHP Annual Meeting

    Comparative Longitudinal Analysis Of Periarticular Bone Structure In Patients Treated With Methotrexate In Combination Of Either TNF Blockers Or Tocilizumab

    Sebastian Kraus1, Matthias Englbrecht1, Juergen Rech2, Roland Kocijan1, Georg A. Schett1 and Stephanie Finzel1, 1Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose: Inhibition of tumor necrosis factor alpha (TNFi) and interleukin-6 receptor (IL6Ri, tocilzumab) are among the most potent therapeutic strategies in patients with rheumatoid arthritis…
  • Abstract Number: 2354 • 2013 ACR/ARHP Annual Meeting

    Drug Survival Rates Of Anti-Tumor Necrosis Factor Therapies In Patients With Rheumatoid Arthritis and Ankylosing Spondylitis

    Dong-Jin Park1, Kyung-Eun Lee1, Ji-Hyoun Kang2, Jeong-Won Lee2, Tae-Jong Kim3, Yong-Wook Park1 and Shin-Seok Lee4, 1Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, 2Chonnam National University Medical School, Gwangju, South Korea, 3Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea, 4Dept of Int Med/Rheumatology, Chonnam National University Medical School, Gwangju, South Korea

    Background/Purpose: We investigated the compliance of Korean patients using anti-tumor necrosis factor (TNF) agents to treat rheumatoid arthritis (RA) and anklyosing spondylitis (AS), and identified…
  • Abstract Number: 2558 • 2012 ACR/ARHP Annual Meeting

    Clinical Response, Drug Survival and Predictors Thereof Among 548 Switchers of Tumor Necrosis Factor Alpha Inhibitor Therapy in Psoriatic Arthritis. Results From the Danish Nationwide Danbio Registry

    Bente Glintborg1, Mikkel Østergaard2, Niels Steen Krogh3, Martin Dehn Andersen4, Ulrik Tarp4, Anne Gitte Loft4, Hanne M. Lindegaard5, Mette Holland-Fischer6, Henrik Nordin4, Dorte Vendelbo Jensen4 and Merete L. Hetland2, 1Copenhagen University Hospital Gentofte, Copenhagen, Denmark, 2Copenhagen University Hospital Glostrup, Copenhagen, Denmark, 3ZiteLab ApS, Copenhagen, Denmark, 4DANBIO, On behalf of Depts of Rheumatology, North, South, Central, Zealand and Capital Region, Copenhagen, Denmark, 5Department of Rheumatology, Odense University Hospital, Odense, Denmark, 6Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark

    Background/Purpose: Treatment with tumor-necrosis-factor-alpha inhibitors (TNFi) has improved the outcome in patients with psoriatic arthritis (PsA) who have failed treatment with synthetic disease modifying antirheumatic…
  • Abstract Number: 2540 • 2012 ACR/ARHP Annual Meeting

    Prescription of Tumour Necrosis Factor α Antagonists Is Strongly Associated with a Reduction in Hospital Admissions and in Musculoskeletal Surgical Procedures for Rheumatoid Arthritis Based On a 16 Year Analysis of Nationwide Data

    Leonard C. Harty1, Gary O'Toole2, Kathleen Bennett3 and Oliver M. FitzGerald4, 1Department of Rheumatology, St. Vincent's University Hospital, Dublin, Ireland, 2Department of Orthopaedic Surgery, St. Vincent's University Hospital, Dublin, Ireland, 3Trinity Centre for Health Sciences, Department of Pharmacology & Therapeutics, Dublin, Ireland, 4Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland

    Background/Purpose: Comorbidities, joint destruction leading to orthopaedic intervention and physical disability are predictable outcomes of uncontrolled Rheumatoid Arthritis (RA). Synthetic DMARDS have a slow mechanism…
  • Abstract Number: 2152 • 2012 ACR/ARHP Annual Meeting

    Inhibition of Fucose Incorporation Abrogates the Development of Arthritis by Suppressing the Inflammatory Macrophage Development and TNF-α Production

    Jun Li1, Hui-Chen Hsu2, PingAr Yang1, Qi Wu1, David M. Spalding3, W. Winn Chatham4, Robert P. Kimberly5, S. Louis Bridges Jr.6 and John D. Mountz7, 1Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 2Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 3Clinical Immunology and Rheum, University of Alabama at Birmingham, Birmingham, AL, 4University of Alabama at Birmingham, Birmingham, AL, 5Clinical Immun & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 6Clinical Immunology & Rheum, University of Alabama at Birmingham, Birmingham, AL, 7Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham and Birmingham VA Medical center, Birmingham, AL

    Background/Purpose: Fucosylation, catalyzed by fucosyltransferases (Futs), is an important glycosylation process involved in inflammation, cell death, and differentiation. We have observed an extremely high positive correlation…
  • Abstract Number: 1827 • 2012 ACR/ARHP Annual Meeting

    Factors That Impact Work Productivity in the Preserve Trial: A Randomized Controlled Trial of Combination Etanercept-Methotrexate Therapy in Patients with Moderately Active Rheumatoid Arthritis

    Vibeke Strand1, Thomas V. Jones2, Wenzhi Li3, Andrew S. Koenig4 and Sameer Kotak5, 1Adjunct, Division of Immunology / Rheumatology, Stanford University, Portola Valley, CA, 2Inflammation Specialty Care, Pfizer, Inc, Collegeville, PA, 3Pfizer Inc., Collegeville, PA, 4Specialty Care Business Unit, Pfizer Inc., Collegeville, PA, 5Specialty Care, Pfizer Inc., New York, NY

    Background/Purpose: Active joint inflammation and structural damage in patients with rheumatoid arthritis (RA) often result in impaired physical function and ultimately work disability.1,2 Lost productivity…
  • Abstract Number: 1669 • 2012 ACR/ARHP Annual Meeting

    Infection Risk After Orthopaedic Surgery in Patients with Inflammatory Rheumatic Diseases, with Focus On Discontinuation of TNF-Alpha-Inhibitors

    Catrina B. Scherrer1, Anne AF Mannion2, Diego Kyburz3, Markus Vogt4 and Ines A. Kramers-de Quervain1, 1Rheumatology, Schulthess Clinic, Zürich, Switzerland, 2Research Department, Schulthess Clinic, Zürich, Switzerland, 3Department of Rheumatology, University Hospital of Zurich, Zurich, Switzerland, 4Infectious Diseases Service, Cantonal Hospital Zug, Baar, Switzerland

    Background/Purpose: Infections after orthopaedic surgeries are feared complications, leading to costly treatments and successive interventions. A higher postoperative infection risk is discussed in patients with…
  • Abstract Number: 1338 • 2012 ACR/ARHP Annual Meeting

    Anti-Tumor Necrosis Factor Therapy Reduces Serum Levels of Chemerin in Rheumatoid Arthritis: A New Mechanism by which Anti-Tumor Necrosis Factor Might Reduce Inflammation

    M.M. Herenius1, A.S.F. Oliveira1, C.A. Wijbrandts1, D. Gerlag1, Paul P. Tak2 and Maria C. Lebre3, 1Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 2Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands, 3Clinical Immunology and Rheumatology & Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands

    Background/Purpose: Chemerin is a specific chemoattractant for macrophages and dendritic cells (DC). In addition, it can rapidly stimulate macrophage adhesion to extracellular matrix proteins and…
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