ACR Meeting Abstracts

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Abstracts tagged "treatment and tumor necrosis factor (TNF)"

  • Abstract Number: 620 • 2018 ACR/ARHP Annual Meeting

    Efficacy of a Second Tumor Necrosis Factor Inhibitor (TNFi) in the Treatment of Rheumatoid Arthritis (RA)

    Jennifer Reams1, Andrea Berger2, Philip Dunn2, Eva O'Connell3, William Torelli2, Jason Bankert2, Muhammed Bashir2 and Alfred Denio1, 1Rheumatology, Geisinger Medical Center, Danville, PA, 2Geisinger Medical Center, Danville, PA, 3Internal Medicine, Geisinger Medical Center, Danville, PA

    Background/Purpose: The response rate of TNFis in RA is variable and to some extent unpredictable, making treatment decision-making quite complex.  Some insurance carriers require RA…
  • Abstract Number: 2066 • 2018 ACR/ARHP Annual Meeting

    Serum IL-37 Is an Efficient Biomarker of Disease Activity and Treatment Response in Patients with Ankylosing Spondylitis

    Ga Young Ahn1, Su Man Kang2, Juyeon Kang1, Bora Nam1, Hyuk-Hee Kwon1, Tae-Hwan Kim3 and Dae-Hyun Yoo1, 1Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), 2Institute of Rheumatology, Hanyang University, Seoul, Korea, Republic of (South), 3Rheumatology, The Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea, Seoul, Korea, Republic of (South)

    Background/Purpose: The measurement of disease activity is mainly dependent on the patient-reported outcome measures in ankylosing spondylitis (AS) patients. Current inflammatory biomarkers have insufficient sensitivity…
  • Abstract Number: 1535 • 2017 ACR/ARHP Annual Meeting

    Study of Potential Clinical and Biologic Predictors of Maintaining Good Response at 1 Year Follow-up, in Patients with Ankylosing Spondylitis Under Dose Reduction of TNFi Treatment

    Mireia Moreno1, Caridad Pontes2, Ferran Torres3, Agusti Sellas-Fernandez4, Miriam Almirall5, Juan Carlos Torre-Alonso6, Teresa Clavaguera7, Carlos Rodriguez-Lozano8, Luis Francisco Linares9, Ana Urruticoechea-Arana10, Eduardo Collantes-Estevez11, Rosa Morla12, Delia Reina13, Eduardo Cuende14, Pedro Zarco15, Cruz Fernandez-Espartero16, Rosario García-Vicuña17, Jesus Sanz18, Xavier Juanola19, Antoni Vallano20, Francisco J Blanco21, Raimon Sanmarti22, Gonzalo Calvo23, Cristina Avendaño24, Eugenio De Miguel25, Roser Vives26, Raul Veroz Gonzalez27, Carlos Alberto Montilla-Morales28 and Jordi Gratacos-Masmitja29, 1Rheumatology, Parc Tauli Hospital Universitari, Sabadell, Spain, 2Clinic Pharmacology, Parc Tauli Hospital Universitari. I3PT. UAB, Sabadell, Spain, 3Hospital Clinic de Barcelona, Barcelona, Spain, 4Rheumatology, Hospital Universitario Valle Hebron, Barcelona, Spain, 5Rheumatology, Hospital del Mar, Barcelona, Spain, 6H Monte Naranco, Oviedo, Spain, 7Rheumatology. Palamós Hospital, Rheumatologist, Catalonia, Spain, 8Rheumatology, Hospital Universitario Dr. Negrin, Gran Canaria, Spain, 9Rheumatology, Hospital Virgen de la Arrixaca. Murcia. Spain, Murcia, Spain, 10Rheumatology Department. Hospital Can Misses, IBIZA, Spain, 11Rheumatology, IMIBIC-Hospital Universitario Reina Sofia, Cordoba, Spain, 12Rambla Vella, 14, Hospital La Tecla, Tarragona, Spain, 13Rheumatology, Hospital de Sant Joan Despí Moisès Broggi, Barcelona, Spain, 14University Hospital Príncipe de Asturias, Immune System Diseases, Rheumatology department, Alcalá de Henares, Madrid, Spain, 15H Fundación Alcorcón, Alcorcón, Spain, 16Rheumatology, Hospital de Mostoles, Madrid, Spain, 17Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, 18Rheumatology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain, 19Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, 20Clinic pharmacology, Hospital Universitari Bellvitge, Barcelona, Spain, 21Servicio de Reumatología. Area Genomica. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, 22Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona, Barcelona, Spain, 23Clinic pharmacology, Hospital Clinic Barcelona, Barcelona, Spain, 24Clinic pharmacology, Hospital Puerta de Hierro, Madrid, Spain, 25Medicine, Universidad Autonoma Madrid, MADRID, Spain, 26Clinic pharmacology, Parc Tauli Hospital Universitari. I3PT. UAB, Sabadell, Spain, 27Hospital de Mérida, Mérida, Spain, 28Hospital Clínico Universitario de Salamanca, Salamanca, Spain, 29Rheumatology, Parc Tauli Hospital Universitari, Sabadell, Barcelona, Spain

    Background/Purpose: Some clinical guidance recommends empirical TNFi dose reductions in AS patients despite lack of robust supportive evidence. Recently, we communicated that a strategy of…
  • Abstract Number: 633 • 2016 ACR/ARHP Annual Meeting

    High Similarity Between Ex-Vivo Inhibited Cytokine Profiling By Golimumab and Adalimumab As a Putative Explanation for Inferior Treatment Response to Golimumab after Adalimumab Failure in Rheumatoid Arthritis

    L. Tweehuysen1, K. Schraa2, M.G. Netea3, F.H.J. van den Hoogen4,5, L.A.B. Joosten3 and A.A. den Broeder4, 1Sint Maartenskliniek, Nijmegen, Netherlands, 2Internal Medicine, Radboudumc, Nijmegen, Netherlands, 3Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands, 4Department of Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, 5Rheumatology, Radboudumc, Nijmegen, Netherlands

    Background/Purpose: Better prediction of treatment response to biologics in rheumatoid arthritis (RA) would contribute to optimal individualized treatment. Clinical data suggest that the response of…
  • Abstract Number: 1617 • 2016 ACR/ARHP Annual Meeting

    Treatment with Sirukumab, an Anti-IL6 Cytokine Monoclonal Antibody, Improves Fatigue and Health-Related Physical and Emotional Well Being in Patients with Active Rheumatoid Arthritis Refractory to Conventional or Biologic Therapy: Results of 2 Global, Placebo-Controlled, Phase 3 Trials

    Clifton Bingham III1, Yoshiya Tanaka2, George Karpouzas3, Tsutomu Takeuchi4, Daniel Aletaha5, Carter Thorne6, Shihong Sheng7, Weichun Xu7, Ravi Rao8, Kaiyin Fei7, Benjamin Hsu7, Prasheen Agarwal7, Sharon Popik7, Regina Kurrasch9, Steve Peterson7, Rita Ganguly9, Chenglong Han7 and Kelly McQuarrie7, 1Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 2University of Occupational and Environmental Health, Kitakyushu, Japan, 3Division of Rheumatology, Harbor-UCLA Medical Center, Torrance, CA, 4Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan, 5Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 6University of Toronto and Southlake Regional Health Centre, Newmarket, ON, Canada, 7Janssen Research & Development, LLC, Spring House, PA, 8GSK Medicines Research Centre, Stevenage, Hertfordshire, United Kingdom, 9GlaxoSmithKline, Collegeville, PA

    Background/Purpose: Patients (pts) with rheumatoid arthritis (RA) often experience both substantial fatigue and a decline in their health-related physical and emotional well-being. Sirukumab is a…
  • Abstract Number: 2495 • 2016 ACR/ARHP Annual Meeting

    The Prevalence of Loss of Response to Treatment with a Tumor Necrosis Factor Inhibitor and/or Methotrexate in Patients with Rheumatoid Arthritis

    Josef Smolen1, Yihan Li2, Iain Sainsbury2, Stefan Florentinus2, Kershnie Rambalee2 and GR Burmester3, 1Internal Medicine III, Div. of Rheumatology, Medical University of Vienna, Vienna, Austria, 2AbbVie Inc., North Chicago, IL, 3Charité – University Medicine Berlin, Berlin, Germany

    Background/Purpose: Patients (pts) with rheumatoid arthritis (RA) who achieve disease control in response to treatment with a tumor necrosis factor inhibitor (TNFi) may lose that…
  • Abstract Number: 3011 • 2016 ACR/ARHP Annual Meeting

    Long-Term Outcomes after Disease Activity Guided Tapering of Tumor Necrosis Factor Inhibition in Rheumatoid Arthritis: 3 Year Data of a Randomised Controlled Pragmatic Non Inferiority Strategy Study

    Alfons A. den Broeder1, Chantal A.M. Bouman1, Frank H.J. van den Hoogen1,2, Jaap Fransen2, Ronald F. van Vollenhoven3, Johannes W.J. Bijlsma4, Aatke van der Maas1 and Noortje van Herwaarden1, 1Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, 2Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, 3Amsterdam Rheumatology and Immunology Center ARC, Amsterdam, Netherlands, 4Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Long-term Outcomes After Disease Activity Guided Tapering of TNF Inhibitors in Rheumatoid Arthritis: 3 Year Data of a Randomized Controlled Pragmatic Non Inferiority Strategy Study…
  • Abstract Number: 14L • 2015 ACR/ARHP Annual Meeting

    Safety and Efficacy of ABT-494, a Novel Selective JAK1 Inhibitor, in Patients with Active Rheumatoid Arthritis and Inadequate Response or Intolerance to Anti-TNF Biologic Therapy

    Joel M. Kremer1, Edward C. Keystone2, Paul Emery3, Heidi S. Camp4, Alan Friedman4, Li Wang4, Ahmed A. Othman4, Nasser Khan4 and Steven Jungerwirth4, 1Albany Medical College, Albany, NY, 2Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 3NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom, 4AbbVie Inc., North Chicago, IL

    Background/Purpose: The safety, efficacy, and dose response of ABT-494, a novel selective JAK1 inhibitor, were characterized vs placebo (PBO) in patients (pts) with moderately to…
  • Abstract Number: 433 • 2015 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis (RA) Biologic Switching and Cycling in a Large US Managed Care Population

    Machaon Bonafede1, Jeffrey R. Curtis2, Donna McMorrow1, Chieh-I Chen3 and George J. Joseph4, 1Truven Health Analytics, Cambridge, MA, 2Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 3Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 4Global Health Economics & Outcomes Research (HEOR), Sanofi, Bridgewater, NJ

    Background/Purpose: A majority of RA patients who switch from a tumor necrosis factor inhibitor (TNFi) to another biologic disease-modifying anti-rheumatic drug (DMARD) are TNFi cyclers…
  • Abstract Number: 1655 • 2015 ACR/ARHP Annual Meeting

    Effectiveness of Monotherapy in Rheumatoid Arthritis (RA) Patients Initiating a Tumor Necrosis Factor Inhibitor (TNFi) Vs a Non-TNFi in a Large US Commercial and Medicare Advantage Plan

    Benjamin Chastek1, Jeffrey R. Curtis2, Laura K. Becker3, George J. Joseph4 and Chieh-I Chen5, 1Optum Insight, Eden Prairie, MN, 2University of Alabama at Birmingham, Birmingham, AL, 3Optum, Eden Prairie, MN, 4Global Health Economics & Outcomes Research (HEOR), Sanofi, Bridgewater, NJ, 5Regeneron Pharmaceuticals, Inc., Tarrytown, NY

    Background/Purpose: Monotherapy accounts for approximately 30% of biologic disease-modifying anti-rheumatic drug (DMARD) use in RA (Emery P et al. Ann Rheum Dis 2013;72:1897-904). A validated…
  • Abstract Number: 2842 • 2015 ACR/ARHP Annual Meeting

    Tumor Necrosis Factor Alpha Inhibition in Ankylosing Spondylitis and Non Radiographic Axial Spondyloarthritis: Treatment Response, Drug Survival and Patient Outcome

    Justine Corli1, Rene-Marc Flipo1, Peggy Philippe2, Anne Bera-Louville2, Cecile Wibaux2 and Julien Paccou2, 1Rheumatology, Hopital R Salengro CHRU, Lille, France, 2Hopital R Salengro CHRU, Lille, France

    Background/Purpose: Several studies have demonstrated that Tumor Necrosis Factor Inhibitors (TNFi) are efficient in non-radiographic axial spondyloarthritis (Nr-AxSpA). However, few investigations have directly compared ankylosing…
  • Abstract Number: 2927 • 2014 ACR/ARHP Annual Meeting

    Baseline Serum Interferon Beta/Alpha Ratio Predicts Response to Tumor Necrosis Factor Alpha Inhibition in Rheumatoid Arthritis

    Priyanka Vashisht1, Jessica M. Dorschner2, Mark A. Jensen3, Beverly Chrabot4, Theresa Wampler Muskardin5, Marlena Kern6, Tetrad Investigators7, ABCoN Consortium8, S. Louis Bridges Jr.9,10, P.K. Gregersen11 and Timothy B. Niewold2, 1Division of Rheumatology and Department of Immunology, University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, 3Divsion of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, 4Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, 5Div of Rheumatology, Mayo Clinic, Rochester, MN, 6North Shore Univ Hospital, Feinstein Institute for Medical Research, Manhasset, NY, 7AL, 8NY, 9University of Alabama at Birmingham, Birmingham, AL, 10Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 11The Feinstein Institute for Medical Research, Manhasset, NY

    Background/Purpose Response to tumor necrosis factor alpha (TNF-α) inhibition is variable in rheumatoid arthritis (RA).  Previous studies have suggested that circulating type I interferon (IFN)…
  • Abstract Number: 2477 • 2014 ACR/ARHP Annual Meeting

    Integrating Treatment Goals of Physicians, Patients, and Payers during Treatment with Golimumab in Patients with Rheumatoid Arthritis

    B Combe1, DJ Veale2, R Burgos-Vargas3, G Szűcs4, M Leirisalo-Repo5, R Yao6, S Huyck6, R Lyu6, M Govoni7, N Vastesaeger8 and HH Weng6, 1Monpellier University Hospital, Montpellier, France, 2Consultant Rheumatologist, St. Vincent’s University Hospital, Dublin, Ireland, 3Cliditer S.A. de C.V. and Hospital General de Mexico, Mexico City, Mexico, 4University of Debrecen Faculty of Medicine, Debrecen, Hungary, 5Department of Medicine, Division of Rheumatology, Helsinki University Central Hospital, Helsinki, Finland, 6Merck & Co., Inc., Whitehouse Station, NJ, 7MSD Italy, Rome, Italy, 8MSD Belgium, Brussels, Belgium

    Background/Purpose Physicians, patients, and payers may have different ideas about what constitutes successful treatment and how treatment goals should be defined for rheumatoid arthritis (RA).…
  • Abstract Number: 2279 • 2014 ACR/ARHP Annual Meeting

    Evidence Based Recommendations for Diagnosis and Management of Tumor Necrosis Factor Receptor-1 Associated Periodic Syndrome (TRAPS)

    Nienke ter Haar1, Paul Brogan2, Gilles Grateau3, Jordi Anton4, Karyl Barron5, Luca Cantarini6, Joost Frenkel7, Caroline Galeotti8, Veronique Hentgen9, Michael Hofer10, Tilmann Kallinich11, Isabelle Kone-Paut12, Jasmin Kuemmerle-Deschner13, Huri Ozdogan14, Seza Ozen15, Ricardo Russo16, Anna Simon17, Yosef Uziel18, Carine Wouters19, Brian Feldman20, Bas Vastert7, Nico Wulffraat21, Helen Lachmann22 and Marco Gattorno23, 1Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Rheumatology Unit, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom, 3Service De Médecine Interne, Hopital Tenon, Paris, France, 4Pediatric Rheumatology Unit. Hospital Sant Joan de Déu. Universitat de Barcelona, Barcelona, Spain, 5NIH, Bethesda, MD, 6University of Siena, Siena, Italy, 7University Medical Center Utrecht, Utrecht, Netherlands, 8Bicêtre Hospital, University of Paris SUD, Paris, France, 9Versailles Hospital, Le Chesnay Cedex, France, 10Centre Multisite Romand de Rhumatologie Pediatrique, Lausanne, Switzerland, 11Charite, University Medicine Berlin, Berlin, Germany, 12Department of Pediatric Rheumatology, Reference Centre for Autoinflammatory Disorders CEREMAI, Bicêtre Hospital, University of Paris SUD, Paris, France, 13Pediatrics, University Hospital Tuebingen, Tuebingen, Germany, 14Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, 15Deptartment. of Pediatric Rheumatology, Hacettepe University, Ankara, Turkey, 16Immunology & Rheumatology, Hospital De Pediatria, Buenos Aires, Argentina, 17Radboudumc, Nijmegen, Netherlands, 18Tel-Aviv University, Sackler School of Medicine, Tel-Aviv, Israel, 19University of Leuven, Laboratory of Pediatric Immunology, University Hospital Leuven, Leuven, Belgium, 20Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 21Pediatric rheumatology, Wilhelmina Children's Hospital/ UMC Utrecht, Utrecht, Netherlands, 22UK National Amyloidosis Centre, University College London Medical School, London, United Kingdom, 23Istituto Giannina Gaslini, Genova, Italy

    Background/Purpose Tumor necrosis factor receptor-1 associated periodic syndrome (TRAPS) is a rare hereditary autoinflammatory syndrome that can lead to significant morbidity. Evidence-based guidelines are lacking…
  • Abstract Number: 1491 • 2014 ACR/ARHP Annual Meeting

    Discovery and Characterization of COVA322, a Clinical Stage Bispecific TNF/IL-17A Inhibitor for the Treatment of Inflammatory Diseases

    Dragan Grabulovski, Michela Silacci, Wibke Lembke, Wenjuan Zha, Richard Woods, Roger Santimaria, Julian Bertschinger and Mathias Locher, Covagen AG, Schlieren, Switzerland

    Background/Purpose: Biologics such as TNF inhibitors have revolutionized the treatment of inflammatory diseases including rheumatoid arthritis (RA), psoriasis and psoriatic arthritis. However, recent data suggest that…
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