Abstracts tagged "Tofacitinib"

Abstract Number: 2900 • 2019 ACR/ARP Annual Meeting
Interferon Signature Predicts Response to Tofacitinib in Haploinsufficiency of A20
Sarah Blackstone¹, Daniella Schwartz ¹, Natalia Sampaio Moura ¹, Deborah Stone ¹, Meryl Waldman ¹, Patrycja Hoffmann ¹, Anne Jones ¹, Tina Romeo ¹, Karyl Barron ¹, Joshua Milner ¹, Daniel Kastner ¹ and Amanda Ombrello ¹, ¹National Institutes of Health, Bethesda, MD
Background/Purpose: The protein A20, encoded by TNFAIP3, represses signaling upstream of the inflammatory transcription factor nuclear factor (NF)-kB by regulating ubiquitination. Heterozygous loss-of-function mutations in…
Abstract Number: L09 • 2018 ACR/ARHP Annual Meeting
Comparative Risk of Venous Thromboembolism with Tofacitinib Versus Tumor Necrosis Factor Inhibitors: A Cohort Study of Rheumatoid Arthritis Patients
Rishi J. Desai¹, Ajinkya Pawar², Michael E Weinblatt³ and Seoyoung C. Kim⁴, ¹Division of Pharmacoepidemiology and Pharmacoeconimics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁴Rheumatology, Brigham and Women's Hospital, Boston, MA
Background/Purpose: A potentially increased risk of venous thromboembolism (VTE) was noted in pre-marketing trials of baricitinib, which is a Janus kinase inhibitor (JAK-I). This led…
Abstract Number: 522 • 2017 ACR/ARHP Annual Meeting
Tofacitinib, an Oral Janus Kinase Inhibitor, in the Treatment of Rheumatoid Arthritis: Safety and Efficacy in Open-Label, Long-Term Extension Studies over 9 Years
Jürgen Wollenhaupt¹, Joel Silverfield², Eun Bong Lee³, Ketti Terry⁴, Kenneth Kwok⁵, Sander Strengholt⁶, Ryan DeMasi⁷ and Lisy Wang⁴, ¹Schoen-Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany, ²Healthpoint Medical Group, Tampa, FL, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ⁴Pfizer Inc, Groton, CT, ⁵Pfizer Inc, New York, NY, ⁶Pfizer Inc, Capelle aan den IJssel, Netherlands, ⁷Pfizer Inc, Collegeville, PA
Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). Here, we report tofacitinib safety and tolerability up to 114…
Abstract Number: 1609 • 2016 ACR/ARHP Annual Meeting
Efficacy of Tofacitinib in Patients Who Are Inadequate Responders to Disease-Modifying Antirheumatic Drugs According to Early Versus Late Duration of Rheumatoid Arthritis: Post-Hoc Analysis of Data from Phase 3 Trials
Stephen Hall¹, Peter Nash², Maureen Rischmueller³, Zirke Wiid⁴, David Witcombe⁵, David Gruben⁶, Ryan DeMasi⁷ and Tatjana Lukic⁷, ¹Cabrini Medical Centre, Monash University, Melbourne, Australia, ²University of Queensland, Brisbane, Australia, ³The Queen Elizabeth Hospital, Adelaide, Australia, ⁴Pfizer Australia, Sydney, Australia, ⁵Pfizer Australia, Sydney, NSW, Australia, ⁶Pfizer Inc, Groton, CT, ⁷Pfizer Inc, New York, NY
Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. This post-hoc analysis of data from Phase 3 studies investigated the efficacy…
Abstract Number: 3024 • 2016 ACR/ARHP Annual Meeting
Major Adverse Cardiovascular Events: Risk Factors in Patients with RA Treated with Tofacitinib
Christina Charles-Schoeman¹, Hernan Valdez², Koshika Soma², Lie-Ju Hwang², Ryan DeMasi², Mary Boy³ and Iain B McInnes⁴, ¹University of California, Los Angeles, Los Angeles, CA, ²Pfizer Inc, New York, NY, ³Pfizer Inc, Groton, CT, ⁴Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: RA patients (pts) are at increased risk of myocardial infarction (MI) and stroke that cannot be completely explained by traditional cardiovascular (CV) risk factors.…

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