ACR Meeting Abstracts

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Abstracts tagged "tofacitinib and treatment"

  • Abstract Number: 2594 • 2018 ACR/ARHP Annual Meeting

    Median Time to Pain Improvement in Patients with Psoriatic Arthritis Treated with Tofacitinib

    Kurt de Vlam1, Alexis Ogdie2, Andrew G Bushmakin3, Joseph C Cappelleri3, Roy Fleischmann4, Peter C. Taylor5, Valderilio F Azevedo6, Lara Fallon7, Anna Maniccia8, John Woolcott9 and Philip J. Mease10, 1UZ Leuven, Leuven, Belgium, 2University of Pennsylvania, Philadelphia, PA, 3Pfizer Inc, Groton, CT, 4University of Texas Southwestern Medical Center, Dallas, TX, 5University of Oxford, Oxford, United Kingdom, 6Universidade Federal do Paraná, Curitiba, Brazil, 7Pfizer Canada, Montreal, QC, Canada, 8Pfizer Inc, New York, NY, 9Pfizer Inc, Collegeville, PA, 10Swedish Medical Center and University of Washington, Seattle, WA

    Background/Purpose: Pain is a core domain of psoriatic arthritis (PsA).1 Rapid, sustained pain reduction is a priority for patients (pts) and physicians when choosing treatment.…
  • Abstract Number: 424 • 2017 ACR/ARHP Annual Meeting

    Re-Establishment of Efficacy of Tofacitinib, an Oral Janus Kinase Inhibitor, in Rheumatoid Arthritis Patients after Temporary Discontinuation

    Jeffrey Kaine1, John Tesser2, Ryan DeMasi3, Liza Takiya3, Lisy Wang4, Mark Snyder3, Haiyun Fan4 and Jürgen Wollenhaupt5, 1Sarasota Arthritis Research Center, Sarasota, FL, 2Arizona Arthritis & Rheumatology Associates, Glendale, AZ, 3Pfizer Inc, Collegeville, PA, 4Pfizer Inc, Groton, CT, 5Schön-Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We assessed tofacitinib efficacy and safety after temporary discontinuation and…
  • Abstract Number: 596 • 2017 ACR/ARHP Annual Meeting

    Effect of Tofacitinib on Patient-Reported Outcomes in Patients with Active Psoriatic Arthritis: Results from 2 Phase 3 Studies

    Vibeke Strand1, Kurt de Vlam2, Jose A Covarrubias-Cobos3, Philip J Mease4, Dafna D Gladman5, Thijs Hendrikx6, Elizabeth Kudlacz7, Daniela Graham7, Joseph Wu7, Joseph C Cappelleri7 and Ming-Ann Hsu7, 1Stanford University, Palo Alto, CA, 2UZ Leuven, Leuven, Belgium, 3Unidad Reumatologica Las Americas S.C.P, Yucatán, Mexico, 4Swedish Medical Center and University of Washington, Seattle, WA, 5Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 6Pfizer Inc, Collegeville, PA, 7Pfizer Inc, Groton, CT

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor under investigation for the treatment of psoriatic arthritis (PsA). Safety and efficacy were investigated in 2 Phase…
  • Abstract Number: 613 • 2017 ACR/ARHP Annual Meeting

    Effect of Tofacitinib on Efficacy and Patient-Reported Outcomes in Psoriasis Patients with Baseline Psoriatic Arthritis: A Pooled Analysis of 2 Phase 3 Studies

    Hervé Bachelez1, Christopher EM Griffiths2, Kim Papp3, Stephen Hall4, Joseph F Merola5, Steven R Feldman6, Majed Khraishi7, Anna Tallman8, Huaming Tan9 and Ming-Ann Hsu9, 1Sorbonne Paris Cité Université Paris Diderot, AP-HP Hôpital St. Louis, Paris, France, 2Dermatology Centre, University of Manchester, Manchester, United Kingdom, 3Probity Medical Research and K. Papp Clinical Research Inc, Waterloo, ON, Canada, 4Emeritus Research, Melbourne, Australia, 5Harvard Medical School, Boston, MA, 6School of Medicine, Wake Forest University, Winston-Salem, NC, 7Memorial University of Newfoundland, St. John's, NF, Canada, 8Pfizer Inc, New York, NY, 9Pfizer Inc, Groton, CT

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor under investigation for the treatment of psoriatic arthritis (PsA). Up to 42% of patients (pts) with psoriasis…
  • Abstract Number: 619 • 2017 ACR/ARHP Annual Meeting

    Integrated Efficacy Analysis of Tofacitinib, an Oral Janus Kinase Inhibitor, in Patients with Active Psoriatic Arthritis

    Peter Nash1, Laura C Coates2, Roy Fleischmann3, Kim Papp4, Juan J. Gomez-Reino5, Keith S Kanik6, Cunshan Wang6, Joseph Wu6, Thijs Hendrikx7 and William C Ports6, 1Department of Medicine, University of Queensland, St Lucia, Brisbane, Australia, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 3Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX, 4Probity Medical Research and K. Papp Clinical Research Inc, Waterloo, ON, Canada, 5Fundacion Ramon Dominguez, Hospital Clinico Universitario, Santiago de Compostela, Spain, 6Pfizer Inc, Groton, CT, 7Pfizer Inc, Collegeville, PA

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor under investigation for treatment of psoriatic arthritis (PsA). We examined tofacitinib efficacy in patients (pts) with active…
  • Abstract Number: 620 • 2017 ACR/ARHP Annual Meeting

    Safety and Efficacy of Tofacitinib, an Oral Janus Kinase Inhibitor, up to 36 Months in Patients with Active Psoriatic Arthritis: Data from the Second Interim Analysis of OPAL Balance, an Open‑Label, Long-Term Extension Study

    Peter Nash1, Laura C Coates2, Alan J. Kivitz3, Philip J Mease4, Dafna D Gladman5, Jose A Covarrubias-Cobos6, Dona Fleishaker7, Cunshan Wang7, Elizabeth Kudlacz7, Sujatha Menon7, Thijs Hendrikx8 and Keith S Kanik7, 1Department of Medicine, University of Queensland, St Lucia, Brisbane, Australia, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 3Department of Rheumatology, Altoona Center for Clinical Research, Duncansville, PA, 4Swedish Medical Center and University of Washington, Seattle, WA, 5Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 6Unidad Reumatologica Las Americas S.C.P, Yucatán, Mexico, 7Pfizer Inc, Groton, CT, 8Pfizer Inc, Collegeville, PA

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor under investigation for psoriatic arthritis (PsA). Interim data up to January 2017 (database not locked) report the…
  • Abstract Number: 623 • 2017 ACR/ARHP Annual Meeting

    Tofacitinib Improves Composite Endpoint Measures of Disease in Patients with Psoriatic Arthritis

    Philip S. Helliwell1, Laura C Coates1, Oliver FitzGerald2, Peter Nash3, Enrique R Soriano4, M. Elaine Husni5, Ming-Ann Hsu6, Keith S Kanik6, Thijs Hendrikx7, Joseph Wu6 and Elizabeth Kudlacz6, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2ASRI, Dublin, Ireland, Dublin, Ireland, 3Department of Medicine, University of Queensland, St Lucia, Brisbane, Australia, 4Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 5Cleveland Clinic Lerner Research Institute, Cleveland, OH, 6Pfizer Inc, Groton, CT, 7Pfizer Inc, Collegeville, PA

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor under investigation for the treatment of psoriatic arthritis (PsA). PsA is a heterogeneous disease and composite endpoints…
  • Abstract Number: 880 • 2017 ACR/ARHP Annual Meeting

    Tofacitinib Treatment in Patients with Psoriatic Arthritis and Rates of Radiologic Progression According to Baseline CRP Levels: Results from a Phase 3 Clinical Study

    Désirée van der Heijde1, Dafna D Gladman2, Oliver FitzGerald3, Arthur Kavanaugh4, Daniela Graham5, Cunshan Wang5 and Lara Fallon6, 1Leiden University Medical Center, Leiden, Netherlands, 2Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 3Department of Rheumatology, St Vincent's University Hospital, Dublin, Ireland, 4University of California San Diego School of Medicine, La Jolla, San Diego, CA, 5Pfizer Inc, Groton, CT, 6Pfizer Canada, Montreal, QC, Canada

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor under investigation for the treatment of psoriatic arthritis (PsA). Here, we evaluate radiographic progression in PsA patients…
  • Abstract Number: 884 • 2017 ACR/ARHP Annual Meeting

    Changes in Lipid Levels and Incidence of Cardiovascular Events Following Tofacitinib Treatment in Patients with Psoriatic Arthritis: An Integrated Analysis across Phase 3 and Long-Term Extension Studies

    Dafna D Gladman1, Christina Charles-Schoeman2, Iain B. McInnes3, Douglas J. Veale4, Bruce Thiers5, Daniela Graham6, Cunshan Wang6, Thomas Jones7, Robert Wolk6 and Ryan DeMasi7, 1Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2University of California, Los Angeles, Los Angeles, CA, 3Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom, 4St. Vincent’s University Hospital and University College Dublin, Dublin, Ireland, 5Medical University of South Carolina, Charleston, SC, 6Pfizer Inc, Groton, CT, 7Pfizer Inc, Collegeville, PA

    Background/Purpose: Cardiovascular (CV) disease and cardiometabolic syndrome are common comorbidities/causes of mortality in patients (pts) with psoriatic arthritis (PsA). Tofacitinib is an oral Janus kinase…
  • Abstract Number: 10L • 2016 ACR/ARHP Annual Meeting

    Efficacy and Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Patients with Active Psoriatic Arthritis and an Inadequate Response to Tumor Necrosis Factor Inhibitors: OPAL Beyond, a Randomized, Double Blind, Placebo-Controlled, Phase 3 Trial

    Dafna D Gladman1, William Rigby2, Valderilio F Azevedo3, Frank Behrens4, Ricardo Blanco5, Andrzej Kaszuba6, Elizabeth Kudlacz7, Cunshan Wang7, Sujatha Menon7, Thijs Hendrikx8 and Keith S Kanik7, 1University of Toronto, Toronto, ON, Canada, 2Rheumatology, Dartmouth-Hitchcock Med Ctr, Lebanon, NH, 3Federal University of Parana and Edumed Health Research Center and Biotech, Curitiba, Brazil, 4Johann Wolfgang Goethe University, Frankfurt, Germany, 5Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 6Specialstyczne Gabinety Lerkarskie "DERMED", Lodz, Poland, 7Pfizer Inc, Groton, CT, 8Pfizer Inc, Collegeville, PA

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor under investigation for treatment of PsA. In this first study of tofacitinib in patients (pts) with active…
  • Abstract Number: 1647 • 2016 ACR/ARHP Annual Meeting

    Tofacitinib, an Oral Janus Kinase Inhibitor, in the Treatment of Rheumatoid Arthritis: Safety and Efficacy in Open-Label, Long-Term Extension Studies over 8 Years

    Jürgen Wollenhaupt1, Joel Silverfield2, Eun Bong Lee3, Ketti Terry4, Kenneth Kwok5, Staci Abramsky5, Min Wang5, Chudy Nduaka6, Ryan DeMasi5 and Lisy Wang4, 1Schoen-Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany, 2Healthpoint Medical Group, Tampa, FL, 3Seoul National University, Seoul, South Korea, 4Pfizer Inc, Groton, CT, 5Pfizer Inc, New York, NY, 6Pfizer Inc, Collegeville, PA

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. The objective of this analysis was to report tofacitinib safety and tolerability…
  • Abstract Number: 2983 • 2016 ACR/ARHP Annual Meeting

    Efficacy and Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, or Adalimumab in Patients with Active Psoriatic Arthritis and an Inadequate Response to Conventional Synthetic Dmards: A Randomized, Placebo‑Controlled, Phase 3 Trial

    Philip J Mease1, Stephen Hall2, Oliver FitzGerald3, Désirée van der Heijde4, Joseph F Merola5, Francisco Avila-Zapata6, Dorata Cieślak7, Daniela Graham8, Cunshan Wang9, Sujatha Menon9, Thijs Hendrikx8 and Keith Kanik9, 1Swedish Medical Center and University of Washington, Seattle, WA, 2Cabrini Health and Monash University, Melbourne, VIC, Australia, 3Department of Rheumatology, St Vincent’s University Hospital and Conway Institute, University College, Dublin, Ireland, 4Leiden University Medical Center, Leiden, Netherlands, 5Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 6Centro Multidisciplinario para el Desarrollo Especializado de la Investigacion Clinica en Yucatan S.C.P., Yucatán, Mexico, 7Poznan University, Poznan, Poland, 8Pfizer Inc, Collegeville, PA, 9Pfizer Inc, Groton, CT

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor under investigation for treatment of psoriatic arthritis (PsA). This study evaluated tofacitinib efficacy and safety vs placebo…
  • Abstract Number: 1645 • 2015 ACR/ARHP Annual Meeting

    Tofacitinib, an Oral Janus Kinase Inhibitor, in the Treatment of Rheumatoid Arthritis: Safety and Clinical and Radiographic Efficacy in Open-Label, Long-Term Extension Studies over 7 Years

    Jürgen Wollenhaupt1, Joel Silverfield2, Eun Bong Lee3, Ketti Terry4, Kenneth Kwok5, Irina Lazariciu6, Chudy Nduaka7, Carol A. Connell4, Ryan DeMasi5 and Lisy Wang4, 1Schoen-Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany, 2Healthpoint Medical Group, Tampa, FL, 3Seoul National University, Seoul, South Korea, 4Pfizer Inc, Groton, CT, 5Pfizer Inc, New York, NY, 6Quintiles, Saint-Laurent, QC, Canada, 7Pfizer Inc, Collegeville, PA

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We report tofacitinib safety, tolerability, and clinical response over 84 months…
  • Abstract Number: 2742 • 2015 ACR/ARHP Annual Meeting

    Efficacy and Safety of Tofacitinib Monotherapy Versus Combination Therapy in a Latin American Subpopulation of Patients with Rheumatoid Arthritis: A Pooled Phase 3 Analysis

    Cristiano Zerbini1, Sebastiao Radominski2, Mario H. Cardiel3, Oswaldo Castañeda4, Ferope Romero5, Gustavo Citera6, Oscar Neira7, Dario Ponce de Leon8, Elaine Hoffman9 and Ricardo Rojo10, 1Centro Paulista de Investigação Clinica, São Paulo, Brazil, 2Universidade Federal do Paraná, Curitiba, Brazil, 3Centro de Investigacion Clinica de Morelia, Morelia, Mexico, 4Clínica Angloamericana, Lima, Peru, 5Hospital Arzobispo Loayza, Lima, Peru, 6Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 7Hospital del Salvador, Clínica Alemana, Santiago, Chile, 8Pfizer Inc, Lima, PA, Peru, 9Pfizer Inc, Groton, CT, 10Pfizer Inc, New York, NY

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. This post-hoc pooled analysis was designed to assess the efficacy and safety…
  • Abstract Number: 1639 • 2015 ACR/ARHP Annual Meeting

    Clinical Outcomes for Rheumatoid Arthritis Patients Receiving Tofacitinib Monotherapy in the Open-Label Long-Term Extension over 6 Years

    Roy Fleischmann1, Yusuf Yazici2, Jürgen Wollenhaupt3, Lisy Wang4, Anna Maniccia5, Kenneth Kwok4, Liza Takiya5 and Ronald van Vollenhoven6, 1Rheumatology, Metroplex Clinical Research Center, Dallas, TX, 2New York University Hospital for Joint Diseases, New York, NY, 3Teaching Hospital of the University of Hamburg, Schoen-Klinik Hamburg-Eilbek, Hamburg, Germany, 4Pfizer Inc, Groton, CT, 5Pfizer Inc, New York, NY, 6The Karolinska Institute, Stockholm, Sweden

    Background/Purpose: Treatment options delivering sustained efficacy when given as monotherapy in RA are limited.1 Tofacitinib is an oral Janus kinase inhibitor for the treatment of…
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