Abstracts tagged "Therapy, complementary"

Abstract Number: 2015 • ACR Convergence 2023
Synergistic Effect Between Denosumab and Immune Checkpoint Inhibitors : A Retrospective Study of 268 Patients with Bone Metastases
Emmanuel Massy¹, Etienne Mabrut¹, Sabine Mainbourg² and Cyrille Confavreux¹, ¹Centre Expert des Métastases Osseuses (CEMOS) - Service de Rhumatologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Université de Lyon, INSERM UMR 1033-LYOS, Lyon, France, ²Service de médecine interne et vasculaire, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, F-69495 Pierre-Bénite, Laboratoire de Biométrie et Biologie Evolutive, Université Lyon 1; CNRS, UMR 5558, 69622 Villeurbanne, Lyon, France
Background/Purpose: Bone is the third site of metastasis. Bone metastases are associated with poorer survival of patients and impaired quality of life with the occurrence…
Abstract Number: 2493 • ACR Convergence 2023
Renal Prognosis of Dialysis-dependent Patients at Baseline in ANCA-associated Vasculitis
Maxime Vignac¹, Dorian Nezam², François Grolleau³, Pauline Morel⁴, Dimitri Titeca-Beauport⁵, Stanislas Faguer⁶, alexandre Karras⁷, Justine Solignac⁸, Noémie Jourde-Chiche⁹, Francois Maurier¹⁰, Hamza Sakhi¹, Khalil El Karoui¹, Rafik Mesbah¹¹, Pierre Louis Carron¹², Vincent Audard¹, Didier Ducloux¹³, Romain Paule¹⁴, Jean-François Augusto¹⁵, Julien Aniort¹⁶, Aurélien Tiple¹⁶, Cédric Rafat¹, Xavier Puéchal¹⁷, Pierre Gobert¹⁸, Catherine Hanrotel¹⁹, Stéphane Bally²⁰, Nihal Martis²¹, Cécile-Audrey Durel²², Pascal Godmer²³, Aurélie Hummel²⁴, François Perrin²⁵, Antoine Néel²⁶, Claire De Moreuil²⁷, Tiphaine Goulenok²⁸, Dominique Guerrot²⁹, Aurelie Foucher³⁰, Alban DEROUX¹², Loic Guillevin³¹, Alexis REGENT³², Raphaël Porcher³ and Benjamin Terrier³³, ¹APHP, Paris, France, ²CH du Havre, Havre, France, ³Université Paris Cité, Paris, France, ⁴AURA Paris Plaisance, Paris, France, ⁵CHU Amiens, Amiens, France, ⁶CHU Toulouse, Toulouse, France, ⁷HEGP - APHP, Paris, France, ⁸APHM, Marseille, France, ⁹AP-HM, Marseille, France, ¹⁰Hôpitaux privés de Metz, Vaux / Frankreich, France, ¹¹Boulogne Hospital (CH), Boulogne, France, ¹²CHU de Grenoble, Grenoble, France, ¹³CHU de Besançon, Besançon, France, ¹⁴Hôpital Foch, Paris, France, ¹⁵CHU d'Angers, Angers, France, ¹⁶CHU de Clermont Ferrand, Clermont Ferrand, France, ¹⁷National Referral Center for Rare Systemic Autoimmune Diseases, Paris, France, ¹⁸Clinique Rhône Durance, Avignon, France, ¹⁹CHU Brest, Brest, France, ²⁰CH Métropole Savoie, Chambery, France, ²¹CHU de Nice, Nice, France, ²²CHU Lyon, Lyon, France, ²³CH Bretagne Atlantique, Vannes, France, ²⁴CHU Necker, Paris, France, ²⁵CH Saint Nazaire, Saint Nazaire, France, ²⁶CHU de Nantes, Nantes, France, ²⁷CHU de Brest, Brest, France, ²⁸Assistance Publique Hopitaux de Paris, Paris, France, ²⁹CHU Rouen, Rouen, France, ³⁰CHU de la Réunion, Saint pierre, France, ³¹University Paris Descartes, Paris, France, ³²CHU Cochin, Université Paris Cité, Paris, France, ³³Department of Internal Medicine, Hôpital Cochin, AP-HP, Paris, France
Background/Purpose: Renal involvement in ANCA-associated vasculitides (AAV) is an organ- and life-threatening manifestation and therefore an important prognostic factor. However, the identification of predictive factors…
Abstract Number: PP01 • ACR Convergence 2023
You Can’t Get This from a Doctor: The Role of Support Groups for Adults Aged 25-55 Living with Arthritis
Eileen Davidson, Global Healthy Living Foundation, Burnaby, BC, Canada
Background/Purpose: Living with a rheumatic condition comes with unique concerns specific to mental and social health like struggling with fatigue, anxiety, depression, and isolation, all…
Abstract Number: 2040 • ACR Convergence 2022
Metformin Improves Objective Measures of Dry Eyes and Focus Score in Sjögren′s Disease: A Retrospective Observational Study
Astrid Rasmussen¹, R. Hal Scofield², Kiely Grundahl¹, Lida Radfar², Christopher Lessard¹ and A. Darise Farris¹, ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Metformin (dimethyl biguanide, Met) is a widely used, first-line antidiabetic drug with AMPK-dependent anti-inflammatory and immunomodulatory effects. In vitro studies and human trials in…
Abstract Number: 0038 • ACR Convergence 2022
STING Antagonist (IFM4490) Inhibits STING Activation and STING Dependent Signal Transduction in Patients with STING-associated Vasculopathy with Onset in Infancy (SAVI)
Sachin Gaurav¹, Bin Lin², Sophia Park³, Shankar Venkatraman⁴, David Winkler⁴ and Raphaela Goldbach-Mansky⁵, ¹Translational Autoinflammatory Diseases Section, LCIM, NIAID,, Bethesda, MD, ²NIH, Bethesda, MD, ³NIAID, Bethesda, MD, ⁴IFM Therapeutics, Boston, MA, ⁵NIH/NIAID, Potomac, MD
Background/Purpose: SAVI is a rare, autoinflammatory type I interferonopathy caused by gain-of-function mutations that cause STING activation and excessive production of type I interferons and…
Abstract Number: 0206 • ACR Convergence 2022
Differences in Medicinal Cannabis Use According to Demography, Rationale, and Patient-Physician Interactions Between the United States and Canada
kevin boehnke¹, Ying He¹, Tristin Smith¹, marc martel², david williams¹ and Mary-Ann Fitzcharles³, ¹University of Michigan, Ann Arbor, MI, ²McGill University, Montréal-Ouest, Canada, ³McGill University, Montréal, QC, Canada
Background/Purpose: Medical cannabis (MC) is increasingly used by persons with rheumatic conditions worldwide, although legal status varies by country. In Canada, MC has been federally…
Abstract Number: 0288 • ACR Convergence 2022
Comparison of the Effect of Different Janus Kinase Inhibitors on Activation, Function and Property of NK Cells to Control Cancer Cell Lines Proliferation: An Ex Vivo and in Vitro Study
Loïc Meudec¹, Pauline Richebé¹, Juliette Pascaud², Xavier Mariette³ and Gaetane Nocturne⁴, ¹Université Paris-Saclay, AP-HP-Hôpital Bicêtre, Le Kremlin Bicêtre, France, ²Université Paris-Saclay, INSERM U1184, Le Kremlin Bicêtre, France, ³Paris-Saclay University, Rueil Malmaison, Ile-de-France, France, ⁴APHP, Le Kremlin Bicêtre, France
Background/Purpose: Janus kinase inhibitors (JAKi) are effective treatments licensed in rheumatoid arthritis (RA). Concerns about a risk of cancer may arise with JAKi as in…
Abstract Number: 0551 • ACR Convergence 2022
Medical Cannabis Use by Rheumatology Patients According to Inflammatory versus Non-Inflammatory Condition
kevin boehnke¹, Tristin Smith¹, Ying He¹, marc martel², david williams¹ and Mary-Ann Fitzcharles³, ¹University of Michigan, Ann Arbor, MI, ²McGill University, Montréal-Ouest, Canada, ³McGill University, Montréal, QC, Canada
Background/Purpose: Persistent pain and poor sleep are common symptoms experienced by patients with rheumatic diseases. Medical cannabis (MC) may offer symptomatic relief and is increasingly…
Abstract Number: 0912 • ACR Convergence 2022
Associations Between Fatty Acid Amide Hydrolase Variants and Response to Cannabis Use for Pain Management in Rheumatoid Arthritis
Kristin Wipfler¹, Joanna Zeiger², Teresa Simon³, Stuart Kassan⁴ and Kaleb Michaud⁵, ¹FORWARD, The National Databank for Rheumatic Diseases, Omaha, NE, ²Canna Research Foundation, Boulder, CO, ³Physicians Research Center Consultant to ForWard, Toms River, NJ, ⁴Colorado Arthritis Associates, Lakewood, CO, ⁵University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Fatty acid amide hydrolase (FAAH) is a serine hydrolase that breaks down the endocannabinoid/cannabinoid receptor agonist anandamide. Variants in the FAAH gene have been…
Abstract Number: 0922 • ACR Convergence 2022
Alteration of the Cardiometabolic and Cardiovascular Proteome in Rheumatoid Arthritis. Modulation by Methotrexate and Tofacitinib
Nuria Barbarroja¹, Carlos Pérez-Sánchez¹, Laura Cuesta-Lopez¹, Miriam Ruiz-Ponce¹, Ivan Arias-de la Rosa¹, Antonio Gonzalez², Eva Perez Pampin³, Chamaida Plasencia-Rodriguez⁴, Ana Martinez-Feito⁴, Rafaela Ortega-Castro¹, Jerusalem Calvo-Gutierrez⁵, Alejandro Balsa⁶, Alejandro Escudero-Contreras¹, Eduardo Collantes¹ and Chary López-Pedrera⁷, ¹IMIBIC/University of Cordoba/Reina Sofia Hospital, Cordoba, Spain, ²Experimental and Observational Rheumatology and Rheumatology Unit, Instituto de Investigacion Sanitaria-Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain, ³Experimental and Observational Rheumatology and Rheumatology Unit, Instituto de Investigacion Sanitaria-Hospital Clínico Universitario de Santiago, Cordoba, Spain, ⁴Rheumatology Department, La Paz University Hospital, Madrid, Spain, ⁵IMIBIC/University of Cordoba/Reina Sofia Hospital, Córdoba, Spain, ⁶Hospital La Paz Institute for Health Research, Madrid, Spain, ⁷Maimonides Institute for Biomedical Research of Córdoba, Cordoba, Spain
Background/Purpose: Patients with rheumatoid arthritis (RA) have a high risk of suffering cardiovascular disease. The analysis of the cardiovascular and cardiometabolic proteome in RA patients…
Abstract Number: 0930 • ACR Convergence 2022
Delayed Response to Methotrexate Treatment in Rheumatoid Arthritis Patients Receiving Folic Acid Supplementation
Alberto Sulli, Tamara Vojinovic, Lercara Adriano, Emanuele Gotelli, sabrina Paolino, Alessandri Elisa and Maurizio Cutolo, Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino Polyclinic Hospital, Genova, Italy
Background/Purpose: MTX is the first line conventional synthetic DMARD (csDMARD) for the treatment of rheumatoid arthritis (RA), and folic acid (FA) supplementation is frequently co-prescribed…
Abstract Number: 1044 • ACR Convergence 2022
Combined Biological or Targeted Therapy in Spondyloarthritis: Experience from a Multicenter Case Series in Spain
cristina Valero-Martinez¹, Judith Font Urguelles², Meritxell Sallés³, BEATRIZ E. JOVEN⁴, Felipe Julio Ramirez Garcia⁵, Xavier Juanola⁶, Raquel Almodóvar⁷, ana Laiz⁸, Mireia Moreno⁹, Manel Pujol¹⁰, Luis Sala-Icardo¹¹, Santos Castañeda¹² and Rosario Garcia-Vicuña¹, ¹Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Spain, ²Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ³Althaia Xarxa Assistencial Universitària, Manresa, Spain, ⁴Hospital Universitario 12 de Octubre, Madrid, Spain, ⁵Hospital Clínic, Barcelona, Spain, ⁶Hospital Universitari Bellvitge, Hospitalet de Llobregat, Barcelona, Spain, ⁷Hospital Universitario Fundación Alcorcón, Madrid, Spain, ⁸Unitat Territorial de Reumatologia Sant Pau-Dos de Maig, Barcelona, Spain, ⁹Hospital Universitari Parc Taulí, Sabadell, Spain, ¹⁰Hospital Universitario MútuaTerrassa, Terrassa, Spain, ¹¹Hospital Universitario de Torrejón de Ardoz, Madrid, Spain, ¹²Division of Rheumatology, Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Spain
Background/Purpose: Combined biological or targeted therapy (CBTT) is rarely considered in clinical practice due to contraindication in guidelines, potential safety concerns and high costs. However,…
Abstract Number: 1174 • ACR Convergence 2022
Cellular Immunotherapy for Systemic Sclerosis
Chanhyuk Park¹, Rajan Bhandari², Jason Gunn³, Timothy Sullivan², Gretel Torres², Joana Murad³, Michael Whitfield⁴ and Patricia Pioli², ¹Geisel School of Medicine at Dartmouth, West Lebanon, NH, ²Geisel School of Medicine at Dartmouth, Lebanon, NH, ³Celdara Medical, Lebanon, ⁴Geisel School of Medicine, Lebanon, NH
Background/Purpose: Pro-fibrotic macrophages (MØs) are implicated in the pathogenesis of systemic sclerosis (SSc). In prior work, we and others have shown that MØs derived from…
Abstract Number: 1227 • ACR Convergence 2022
Impact of Pain Sensitivity and Expectations on Predicting Response to Acupuncture in Fibromyalgia
Anne Murphy¹, Henry Buchtel¹, Erin Zhan¹, Steven E Harte¹, Ishtiaq Mawla¹, Eric Ichesco¹, Tony Larkin¹, Vitaly Napadow² and Richard E Harris¹, ¹University of Michigan, Ann Arbor, MI, ²Harvard Medical School, Boston, MA
Background/Purpose: Fibromyalgia (FM) is a common chronic pain condition for which acupuncture treatment is increasingly utilized. However, there is no universally accepted measure to predict…
Abstract Number: 1294 • ACR Convergence 2022
Translation and Cross-cultural Adaptation of the CORS into Spanish
Victoria Navarro-Compán¹, Diego Benavent², Andrea Jochems³, Dora Pascual-Salcedo³, Gijs Jochems⁴, Sofia Ramiro⁵, Wim van Lankveld⁶ and Chamaida Plasencia-Rodriguez⁷, ¹Department of Rheumatology, La Paz University Hospital, IdiPaz, Madrid, Spain, ²La Paz University Hospital, Madrid, Spain, ³Immuno-Rheumatology Group, Hospital Universitario La Paz, Madrid, Spain, ⁴Promega Biotech Ibérica, Madrid, Spain, ⁵Leiden University Medical Center, Leiden, Netherlands, ⁶NA, Amsterdam, Netherlands, ⁷Rheumatology Department, La Paz University Hospital, Madrid, Spain
Background/Purpose: Rheumatic diseases substantially affect the lives of patients, with complex associations between disease severity and self-perceived health status. In this regard, the Coping with…

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