Abstract Number: 0014 • ACR Convergence 2026
PsoriAxis Reveals Continuous Molecular Healing and Residual Disease States in Psoriasis
Background/Purpose: Psoriasis is a chronic IL-23/IL-17-driven inflammatory disease. Yet, despite highly effective targeted biologics, lesions commonly recur after treatment withdrawal, and systemic manifestations such as…Abstract Number: 1055 • ACR Convergence 2026
Homocitrulline-Specific Th1 and Th17 Cells Are Expanded in Rheumatoid Arthritis
Background/Purpose: In rheumatoid arthritis (RA), B and T cells contribute to disease pathogenesis through immune responses directed against post-translationally modified self-antigens. One such modification, carbamylation,…Abstract Number: 1067 • ACR Convergence 2026
Spatial Transcriptomics Reveals Diffuse Th17/IL-17 Synovial Inflammation Outside Tertiary Lymphoid Structures in Refractory Pediatric Arthritis with a Heterozygous STAT5B Loss-of-Function Variant
Background/Purpose: STAT5B signaling maintains regulatory T cells (Tregs) and restrains Th17 differentiation. We integrated single-cell spatial transcriptomics with genetic and functional immune profiling to determine…Abstract Number: 1958 • ACR Convergence 2026
TH17 and ExTH17 Cells in Rheumatoid Arthritis-related Interstitial Lung Disease (RA-ILD)
Background/Purpose: Interleukin (IL)-17-expressing CD4+ T cells (TH17) are known to drive autoimmune responses and morph into IL-17-negative cells (hereafter exTH17) in response to microenvironmental stimuli.…Abstract Number: 1960 • ACR Convergence 2026
Amplification of the Th17/IL-17 Pathway Activation Marks the Transition from Very Early Systemic Sclerosis (VEDOSS) to Established Systemic Sclerosis: A Multi-Omics Analysis
Background/Purpose: Systemic sclerosis (SSc) carries the highest mortality among rheumatic diseases, underscoring the need to identify immunological drivers before irreversible organ damage occurs. The Very…Abstract Number: 2941 • ACR Convergence 2026
FTB-918: A Dual Targeting Antibody With TRBV9+ T Cell Depletion and IL-17A Neutralization for the Treatment of Axial Spondyloarthritis
Background/Purpose: Axial spondyloarthritis (axSpA) is a chronic immune-mediated condition strongly associated with HLA-B27. The prevailing hypothesis for the role of HLA-B27 in disease initiation is…Abstract Number: 0070 • ACR Convergence 2026
Dual IL-17A/IL-17F Inhibition Modulates Entheseal Stromal Inflammatory Networks and Reveals a Role for IL-17F in Neutrophil Recruitment in Human Entheseal Inflammation
Background/Purpose: The importance of controlling IL-17 signalling in spondyloarthropathies has been well demonstrated through the successful use of biological drugs targeting IL-17, IL-23 and TNF. Additionally, dual IL-17A/IL-17F blockade has shown superiority in psoriasis compared to IL-17A blockade.1 Therapeutic control of…Abstract Number: 0094 • ACR Convergence 2026
Arginase 1-Driven Arginine Metabolism Boosts Th17 Cell Responses to Exacerbate Rheumatoid Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disorder, and aberrant overactivation of Th17 cells acts as a central pathogenic contributor to disease progression. Our…Abstract Number: 0135 • ACR Convergence 2026
Novel Signal Transducer and Activator of Transcription 3 (STAT3) Mutation Mimicking Systemic Juvenile Idiopathic Arthritis (sJIA) is Linked to Unique Immune Cell Characteristics
Background/Purpose: Signal transducer and activator of transcription 3 (STAT3) mutations with either a loss or gain of function can result in clinical phenotypes. We characterize…Abstract Number: 0919 • ACR Convergence 2026
Elevated Indole Metabolism Associates with Progression to Rheumatoid Arthritis and Promotes Dendritic Cell-Mediated Th17 Responses
Background/Purpose: Microbial tryptophan metabolites regulate host immunity and may contribute to progression from preclinical autoimmunity to rheumatoid arthritis (RA). Indole, a bacterial tryptophan metabolite, has…Abstract Number: 0939 • ACR Convergence 2026
Loss of T cell-Intrinsic NOD2 Immune Restraint Drives IL-17-Mediated Inflammation in Blau Syndrome
Background/Purpose: Mutations in the innate immune receptor NOD2 cause Blau syndrome, an early-onset inflammatory disease characterized by arthritis, dermatitis, and uveitis. Blau syndrome has long…Abstract Number: 0940 • ACR Convergence 2026
PD-1 Blockade Unleashes Pathogenic TH17 Differentiation That Mediates Inflammatory Arthritis
Background/Purpose: Inflammatory arthritis is a common immune-related adverse event (irAE) associated with immune checkpoint inhibitor (ICI) therapy. Although its development is closely linked to pre-existing…Abstract Number: 1040 • ACR Convergence 2026
Berberine alleviates rheumatoid arthritis by selectively targeting mitochondrial complex I to restore Th17/Treg immune homeostasis
Background/Purpose: Growing evidence indicates that mitochondrial dysfunction plays an important role in the pathogenesis of rheumatoid arthritis (RA), yet whether berberine (BBR) exerts its anti-arthritic…Abstract Number: 1049 • ACR Convergence 2026
TL1A defines a focused inflammatory signaling axis in rheumatoid arthritis synovium
Background/Purpose: Tumor necrosis factor-like ligand 1A (TL1A; TNFSF15) is a pro-inflammatory cytokine implicated in autoimmune-mediated diseases and is thought to be biologically distinct from TNF…Abstract Number: LB15 • ACR Convergence 2025
Dietary Fiber Supplementation Enhances Methotrexate Response and Restores Th17/Treg Balance in Rheumatoid Arthritis: Results from the Superfibre Randomized Trial
Background/Purpose: Gut dysbiosis and Th17/Treg imbalance contribute to rheumatoid arthritis (RA). Additionally, methotrexate (MTX) efficacy depends on gut microbiota composition, especially on the presence of B.…
ACR Meeting Abstracts