ACR Meeting Abstracts

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Abstracts tagged "TH17 Cells"

  • Abstract Number: 0068 • ACR Convergence 2024

    Enhanced Expression of GPR65 in Inflammatory Sites and Bone Formation Regions in Ankylosing Spondylitis: Evidence from ScRNA-seq Analysis

    Yong-Wook Park1, Ki-Jeong Park2, Sungsin Jo3, Tae-Hwan Kim4 and Tae-Jong Kim1, 1Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea, 2Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea, 3Hanyang University Institute for Rheumatology Research, Seoul, Republic of Korea, 4Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea

    Background/Purpose: Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the axial skeleton. T helper 17 (Th17) cells play a pivotal role in the…
  • Abstract Number: 0081 • ACR Convergence 2024

    The Axial Spondyloarthritis Risk Variant CARD9 S12N Enhances Neutrophil-mediated Th Responses

    Hillary Struthers1, Kofi Asare-Konadu2, Emily Vance1 and Ruth Napier3, 1Oregon Health & Science University, Portland, OR, 2Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, 3Department of Molecular Microbiology and Immunology and Division of Arthritis and Rheumatic Disease, Oregon Health & Science University, VA Portland Health Care System, Portland, OR

    Background/Purpose: Axial spondyloarthritis (axSpA) is a type of inflammatory arthritis that primarily affects the entheses of the spine and/or sacroiliac joints. The cause of axSpA…
  • Abstract Number: 0873 • ACR Convergence 2024

    Epigenetic Control of Pathogenic CD4 T Cell Polarization During Progression to Rheumatoid Arthritis (RA)

    Ziyuan He1, Pravina Venkatesan1, Adam Savage1, Marla Glass1, Lauren Okada2, Upaasana Krishnan2, Christy Bennett1, Nhung Tran2, Yudong He2, Samir Rachid Zaim1, Padmapriyadarshini Ravisankar2, Jessica Garber2, Palak Genge2, Kevin Lee2, Regina Mettey2, Cole Phalen2, Sugandhika Khosa2, Marie Feser3, Fan Zhang4, David Boyle5, Kristine Kuhn4, Kristen Demoruelle6, Cate Speake7, Jane Buckner8, Ananda Goldrath1, Thomas Bumol9, V. Michael Holers10, Peter Skene1, Gary Firestein11, Xiaojun Li1, Kevin Deane12, Troy Torgerson13 and Mark Gillespie1, 1Allen Institute for Immunology, Seattle, WA, 2Allen Institute for Immunology, Seattle, 3Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 4University of Colorado, Aurora, CO, 5UCSD, La Jolla, CA, 6University of Colorado Anschutz Medical Campus, Golden, CO, 7Benaroya Research Institute at Virginia Mason, Seattle, 8Benaroya Research Institute, Seattle, WA, 9Allen Institute for Immunology, San Diego, CA, 10University of Colorado, Denver, CO, 11University of California, San Diego, San Diego, CA, 12University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 13Allen Institute for Immunology, Enumclaw, WA

    Background/Purpose: Multiple T cell subsets, including Th1, Th17 cells, and Tfh/Tph, contribute to rheumatoid arthritis (RA) pathology. Clinical trials have shown efficacy of T cell…
  • Abstract Number: 0878 • ACR Convergence 2024

    YY1 a Potential Modulator of IL17/IL23 Axis in Psoriasis Disease

    vinod kumar, Tammana Sharma, Rahul Mahajan, Tarun Narang, Sunil Dogra and Sanjeev handa, PGIMER, Chandigarh, Chandigarh, India

    Background/Purpose: Psoriasis is an inflammatory skin disease that progresses and worsens if left unattended. IL17 plays a pivotal role as a pathogenic trigger. Despite Th17…
  • Abstract Number: 0885 • ACR Convergence 2024

    Reproducible Single Cell Annotation of Programs Underlying T-cell Subsets, Activation States, and Functions

    Dylan Kotliar1, Michelle Curtis1, Ryan Agnew1, Kathryn Weinand1, Aparna Nathan2, Yuriy Baglaenko1, Yu Zhao1, Pardis Sabeti3, Deepak Rao4 and Soumya Raychaudhuri1, 1Brigham and Women's Hospital, Boston, MA, 2Harvard Medical School, Boston, MA, 3Broad Institute, Boston, MA, 4Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: T-cells play a key role in the pathogenesis of autoimmune disease and in protection against cancer and infection. Consequently, there is widespread interest in…
  • Abstract Number: 0938 • ACR Convergence 2024

    Group 2 Innate Lymphoid Cells Promote T Cell Activation and Development of Autoimmune Arthritis

    Agnieszka Lastowska1, Anders Nguyen2, Miriam Bollmann2 and Mattias Svensson3, 1University of Gothenburg, Goteborg, Sweden, 2University of Gothenburg, Göteborg, Sweden, 3University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Innate Lymphoid Cells (ILCs) are the innate counterparts to T cells and can be divided into three functionally distinct subpopulations: Group 1 (ILC1), Group…
  • Abstract Number: 0947 • ACR Convergence 2024

    REX-7117 Is a Highly Potent and Selective Oral STAT3 Inhibitor That Demonstrated Potential Efficacy and Safety Differentiation versus JAK/TYK2 Targeting in Preclinical Models of Inflammatory Arthritis

    Alexandra Gardino1, Neil Bifulco1, Jeremy Hunt2, Rishi Vaswani1, Donglim Park2, Patrick Metz2, Ksenya Cohen-Katsenelson2, Jeong-Ho Kim2, Xia Tian2, Aryan Alavi2, Ajay Nirula2, Daniel Treiber2, Brian Hodous1, Seong Kim3 and Paul Smith2, 1Recludix Pharma, Cambridge, MA, 2Recludix Pharma, San Diego, CA, 3Department of Microbiology and Immunology, LSU Health Shreveport, Shreveport, LA

    Background/Purpose: Inhibition of JAK family signaling has translated into clinically meaningful efficacy in rheumatoid arthritis, psoriatic arthritis and other inflammatory diseases. However, small molecule JAK/TYK2…
  • Abstract Number: 1790 • ACR Convergence 2024

    Response Gene to Complement-32 Expression Is Upregulated in Lupus T Cells and Promotes Th17 Differentiation

    Violeta Rus1, Vinh Nguyen1, Alexandru Tatomir1, Cornelia Cudrici2 and Horea Rus1, 1University of Maryland at Baltimore, Baltimore, MD, 2National Institute of Health, Bethesda, MD

    Background/Purpose: RGC (Response Gene to Complement)-32 is a cell cycle regulator expressed in normal tissues, tumors and a variety of cell lines.  RGC-32 plays a…
  • Abstract Number: 1848 • ACR Convergence 2024

    Characterization of Treg Phenotype, Function and Its Transcriptome Signatures in Treatment-naïve Rheumatoid Arthritis

    Vallayyachari Kommoju1, Sree Nethra Bulusu2, Shruthi S Vembar3, Chengappa Kavadichanda4, Molly Thabah5, Christina Mary Mariaselvam2 and Vir Singh Negi6, 1JIPMER, Pondicherry, India, 2JIPMER, Pondicherry, Puducherry, India, 3IGIB, Bengalore, India, 4Jawaharlal Institute of Postgraduate Medical Education and Research, pondicherry, Puducherry, India, 5Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, Puducherry, India, 6AIIMS, Bilaspur, Puducherry, Puducherry, India

    Background/Purpose: Inflammatory cytokines in the periphery can affect Treg stability and function by altering its molecular signatures. We aimed to characterize Treg phenotype, function and…
  • Abstract Number: 1851 • ACR Convergence 2024

    Aberrant Tfh Cells Generated by Th17 Cell Plasticity in the Gut Promote Autoimmune Arthritis

    Joyce Wu, The Ohio State University, Columbus, OH

    Background/Purpose: Much remains unknown regarding T follicular helper 17 (Tfh17) cells in autoimmunity. We previously showed, and here ask why, egress of gut segmented filamentous…
  • Abstract Number: 1853 • ACR Convergence 2024

    Mutated Nod2 Enhances Pathogenic Th17 Responses That Promote Experimental Blau Syndrome

    Leah Huey1, Emily Vance1, Kofi Asare-Konadu2 and Ruth Napier3, 1Oregon Health & Science University, Portland, OR, 2Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, 3Department of Molecular Microbiology and Immunology and Division of Arthritis and Rheumatic Disease, Oregon Health & Science University, VA Portland Health Care System, Portland, OR

    Background/Purpose: Blau syndrome, a pediatric rheumatological disease characterized by uveitis, arthritis, and dermatitis, is caused by a single point mutation in the gene NOD2. Nod2…
  • Abstract Number: 0084 • ACR Convergence 2023

    Excess IL-18 Protects from Experimental Autoimmune Encephalomyelitis Mainly via Preferential Augmentation of Suppressor/Regulatory over Autoreactive T-cell Function

    Jeremy Morrissette1, Vinh Dang2, Jemy Varghese2, Zachary Lanzar1, Junior Nguyen2, Emily Landy3, Anastasia Frank-Kamenetskii4 and Scott Canna2, 1University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, 2Children's Hospital of Philadelphia, Philadelphia, PA, 3University of Pittsburgh, Pittsburgh, PA, 4CHOP/UPENN, Philadelphia, PA

    Background/Purpose: Interleukin 18 (IL-18) is an inflammasome-activated cytokine that canonically amplifies interferon-gamma (IFNg) production and cytotoxicity by CD8 T-cells (CD8Ts) and Th1 CD4 T-cells (CD4Ts).…
  • Abstract Number: 0279 • ACR Convergence 2023

    Therapeutic Exploration of Immune Checkpoint Inhibitor Induced Inflammatory Arthritis In Vivo

    Sang Kim1, Rene Rico2, Naimah Turner2, Trupti Trivedi2, Theresa Guise2 and Roza Nurieva2, 1The Univesrity of Texas MD Andesron Cancer Center, Pearland, TX, 2The University of Texas, MD Anderson Cancer Center, Houston, TX

    Background/Purpose: Despite unprecedented clinical success, immune checkpoint inhibitors (ICIs) are associated with immune-related adverse events (irAEs), including arthritis (ICI-arthritis). Management of ICI-arthritis is challenging because…
  • Abstract Number: 0699 • ACR Convergence 2023

    T Cell Subset Analysis in Patients with Large-Vessel Vasculitis

    Rebecca Kuan1, Christopher Redmond1, McKella Sylvester2, Mary Maclean1, Francoise Meylan1, Marcela Ferrada1, Kaitlin Quinn1 and Peter Grayson3, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 2Colgate University, Bethesda, MD, 3National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Chevy Chase, MD

    Background/Purpose: Large-vessel vasculitis (LVV) is characterized by granulomatous inflammation of the aorta and its major branches. The two major forms are giant cell arteritis (GCA)…
  • Abstract Number: 0801 • ACR Convergence 2023

    LncRNA PIGL-217 Regulates Th17 Differentiation by Targeting miR-5008-5p and Suppressing FoxO1 in Behçet’s Disease

    Zhimian Wang, Xin Yu, Hua Chen and Wenjie Zheng, Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing, China

    Background/Purpose: Dysregulated Th17 cells are implicated in Behçet's disease (BD). However, the underlying mechanism remains unclear. Here we aim to elucidate the mechanism of forkhead…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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