Abstracts tagged "TCR"

Abstract Number: 90 • 2019 ACR/ARP Annual Meeting
SLAMF6 Clustering Is Required to Augment Autoimmune T Cell Activation
Matthew Dragovich¹ and Adam Mor ², ¹Columbia University, New York, NY, ²Columbia University School of Medicine, New York, NY
Background/Purpose: The signaling lymphocytic activation molecule (SLAM) family is encompassed by nine distinct receptors that are hematopoietic restricted. Among these, SLAMF6 is highly expressed in…
Abstract Number: 123 • 2019 ACR/ARP Annual Meeting
Blockade of Antigen-specific T Cell Activation by a Non-Depleting Anti-HLA-DR Monoclonal Antibody with a Unique Binding Epitope
Fang Shen¹, Karen Duffy ¹, Stephane Becart ², Robert Kuhn ¹, Melissa Swiecki ¹, Brian Jones ¹, Yawei Li ¹, Jeffrey Hall ¹, Ravi Malaviya ¹, Nathan Felix ¹, Mimi Zhou ², Sunil Nagpal ¹ and Navin Rao ¹, ¹Janssen R&D, Spring House, PA, ²Janssen R&D, La Jolla, CA
Background/Purpose: The activation of T helper cells requires cognate recognition of antigen-derived peptides presented by Major Compatibility Complex Class II (MHC II) molecules, which are…

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