Abstracts tagged "takayasu arteritis and vasculitis"

Abstract Number: 888 • 2016 ACR/ARHP Annual Meeting
Prevalence of Takayasu Arteritis in Young Women Presenting with Acute Ischemic Heart Disease
Giulio Cavalli, Alessandro Tomelleri, Elena Baldissera and Lorenzo Dagna, Internal Medicine and Clinical Immunology, Vita-Salute San Raffaele University, Milan, Italy
Background/Purpose: Ischemic heart disease (IHD) is classically considered a disease of older men. However, 10% of myocardial infarctions occur in patients aged <45; also, in…
Abstract Number: 889 • 2016 ACR/ARHP Annual Meeting
The Utility of Patient-Reported Outcomes in Predicting Disease Activity in Patients with Takayasu’s Arteritis
Antoine G. Sreih¹, Tanaz A. Kermani², Gunnar Tomasson³, Joshua F. Baker⁴, David Cuthbertson⁵, Renee Borchin⁶, Simon Carette⁷, Lindsy J. Forbess⁸, Gary S. Hoffman⁹, Nader A. Khalidi¹⁰, Curry L. Koening¹¹, Carol A. McAlear¹², Paul A. Monach¹³, Larry W. Moreland¹⁴, Christian Pagnoux¹⁵, Philip Seo¹⁶, Robert F. Spiera¹⁷, Kenneth J. Warrington¹⁸, Steven R. Ytterberg², Carol A. Langford¹⁹ and Peter A. Merkel²⁰, ¹Department of Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Rheumatology, Mayo Clinic, Rochester, MN, ³Dept of Public Health Sciences, University of Iceland, Reykjavik, IS, ⁴Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁵Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, ⁶University of South Florida, Tampa, FL, ⁷Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁸Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁹Rheumatology, Cleveland Clinic, Cleveland, OH, ¹⁰Division of Rheumatology, McMaster University, Hamilton, ON, Canada, ¹¹Rheumatology, University of Utah, Salt Lake City, UT, ¹²University of Pennsylvania, Philadelphia, PA, ¹³Rheumatology, Boston University School of Medicine, Boston, MA, ¹⁴Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹⁵Division of Rheumatology, Mount Sinai Hospital, University Health Network, University of Toronto, Toronto, Canada, Toronto, ON, Canada, ¹⁶Medicine, Johns Hopkins University, Baltimore, MD, ¹⁷Hospital for Special Surgery, Cornell, New York, NY, ¹⁸Rheumatology, University of California Los Angeles, CA, USA Mayo, Rochester, MN, ¹⁹Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, ²⁰Division of Rheumatology, Univ of Pennsylvania; Perelman School of Med, Philadelphia, PA
Background/Purpose: Takayasu’s arteritis (TAK) is a relapsing large vessel vasculitis. There are currently no reliable predictors of disease relapse. This study explored whether changes in…
Abstract Number: 890 • 2016 ACR/ARHP Annual Meeting
Health-Related Domains of Importance to Patients with Takayasu’s Arteritis
Antoine G. Sreih¹, Fatma Alibaz-Oner², Ebony Easley³, Trocon Davis³, Gonca Mumcu⁴, Nataliya Milman⁵, Joanna C. Robson⁶, Peter F. Cronholm³, Haner Direskeneli⁷ and Peter A. Merkel⁸, ¹Rheumatology, The University of Pennsylvania, Philadelphia, PA, ²Department of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, ³Department of Family Medicine and Community Health, The University of Pennsylvania, Philadelphia, PA, ⁴Department of Health Management, Marmara University, Faculty of Health Sciences, Istanbul, Turkey, ⁵Department of Medicine, University of Ottawa, Ottawa, ON, Canada, ⁶Faculty of Health and Applied Science, University of the West of England, Bristol, United Kingdom, ⁷Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, ⁸Division of Rheumatology, Univ of Pennsylvania; Perelman School of Med, Philadelphia, PA
Background/Purpose: The need to include patients’ perspectives as key outcomes in clinical research is now widely recognized. This project was designed to describe the experience…
Abstract Number: 3054 • 2015 ACR/ARHP Annual Meeting
Takayasu’s Arteritis Associated with Behçet’s Syndrome: A Case Series of 8 Patients
Sinem Nihal Esatoglu¹, Emire Seyahi², Serdal Ugurlu², Gulen Hatemi², Melike Melikoglu², Vedat Hamuryudan³ and Sebahattin Yurdakul¹, ¹Rheumatology, Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Turkey, Istanbul, Turkey, ²Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Turkey, Istanbul, Turkey, ³Rheumatology, Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
Background/Purpose: Takayasu's arteritis (TA) and Behçet's syndrome (BS) are both systemic vasculitis of an unknown etiology, each with unique involvement pattern. TA affects aorta and…
Abstract Number: 3059 • 2015 ACR/ARHP Annual Meeting
Abnormal Body Composition in Takayasu Arteritis Patients: Role of Inflammatory Cytokines and Adipokines
Thiago Ferreira da Silva, Mauricio Levy Neto, Valéria Caparbo, Liliam Takayama and Rosa M R Pereira, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Chronic inflammatory conditions including rheumatic diseases may alter body composition, especially lean and fat mass. In this process, adipokines and inflammatory cytokines appear to…
Abstract Number: 3068 • 2015 ACR/ARHP Annual Meeting
Damage Assessment in Takayasu’s Arteritis
Antoine G. Sreih¹, Tanaz A. Kermani², David Cuthbertson³, Simon Carette⁴, Gary S. Hoffman⁵, Nader A. Khalidi⁶, Curry L. Koening⁷, Carol A. Langford⁵, Carol McAlear⁸, Paul A. Monach⁹, Larry W. Moreland¹⁰, Christian Pagnoux¹¹, Philip Seo¹², Kenneth J. Warrington¹³, Steven R. Ytterberg¹⁴ and Peter A. Merkel⁸, ¹Department of Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Rheumatology, University of California Los Angeles, Santa Monica, CA, ³Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, ⁴Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁵Rheumatology, Cleveland Clinic, Cleveland, OH, ⁶McMaster University, Hamilton, ON, Canada, ⁷Division of rheumatology, George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City and University of Utah, University of Utah School of Medicine, Salt Lake City, UT, ⁸Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁹Section of Rheumatology, Vasculitis Center, Boston University School of Medicine, Boston, MA, ¹⁰Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹¹Rheumatology, Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, ¹²Division of Rheumatology, Johns Hopkins, Baltimore, MD, ¹³Rheumatology, Mayo Clinic, Rochester, MN, ¹⁴Rheumatology Division, Mayo Clinic, Rochester, MN
Background/Purpose: This study aimed to describe disease-related damage in Takayasu's arteritis (TAK) and evaluate damage assessment tools using data from a large longitudinal cohort. …
Abstract Number: 3227 • 2015 ACR/ARHP Annual Meeting
Identification of Novel Protein-Coding Genetic Variants Associated with Takayasu Arteritis
Paul Renauer¹, Patrick Coit¹, Peter A. Merkel² and Amr H. Sawalha¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Takayasu arteritis is a rare large vessel vasculitis of unclear etiology. Previous studies identified associations between Takayasu arteritis and genetic variants within HLA class…
Abstract Number: 2786 • 2014 ACR/ARHP Annual Meeting
Aortitis: Outcomes from a Cohort of 196 Patients
Alison Clifford¹, Amr Arafat², Jahanzaib Idrees², Eric Roselli², Carmela D. Tan³, E. Rene Rodriguez³, Lars Svensson², Eugene Blackstone² and Gary S. Hoffman¹, ¹Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, OH, ²Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Cleveland, OH, ³Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Idiopathic aortitis is a rare diagnosis that may occur in the context of a primary systemic vasculitis, as part of a systemic autoimmune disease,…
Abstract Number: 804 • 2014 ACR/ARHP Annual Meeting
Vasculitis and Inflammatory Bowel Diseases: A Study of 32 Patients with Both Conditions and Systematic Review of the Literature
Alice Sy¹, Natasha Dehghan², Nader A. Khalidi³, Lillian Barra⁴, Simon Carette⁵, David Cuthbertson⁶, Gary S. Hoffman⁷, Curry L Koening⁸, Carol A. Langford⁹, Carol McAlear¹⁰, Paul A. Monach¹¹, Larry W. Moreland¹², Philip Seo¹³, Ulrich Specks¹⁴, Steven R. Ytterberg¹⁵, Gert Van Assche¹⁶, Peter A. Merkel¹⁰ and Christian Pagnoux⁵, ¹Medicine Division, London, ON, Canada, ²Rheumatology Division, Vancouver, BC, Canada, ³Internal Medicine/Rheumatology, McMaster University, Hamilton, ON, Canada, ⁴Rheumatology, St. Joseph's Health Care, London, ON, Canada, ⁵Division of Rheumatology, University of Toronto, Toronto, ON, Canada, ⁶Department of Biostatistics, University of South Florida, Tampa, FL, ⁷Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, OH, ⁸Division of rheumatology, George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City and University of Utah, University of Utah School of Medicine, Salt Lake City, UT, ⁹Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, ¹⁰University of Pennsylvania, Philadelphia, PA, ¹¹Rheumatology, Boston University, Boston, MA, ¹²Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹³Johns Hopkins Vasculitis Center, Rheumatology Division, Johns Hopkins University, Baltimore, MD, ¹⁴Mayo Clinic, Rochester, MN, ¹⁵Rheumatology Division, Mayo Clinic, Rochester, MN, ¹⁶Mount Sinai Hospital, Toronto, ON, Canada
Background/Purpose: Small case series suggested that vasculitis and inflammatory bowel disease (IBD; Crohn’s disease [CD] or ulcerative colitis [UC]) can co-occur more commonly than the…
Abstract Number: 813 • 2014 ACR/ARHP Annual Meeting
Long-Term Outcomes of Takayasu’s Arteritis Patients with Renal Artery Involvement
Corisande Baldwin¹, Aladdin Mohammad² and David Jayne³, ¹Rheumatology, University of British Columbia, Vancouver, BC, Canada, ²Dept. of Rheumatology, Lund University Hospital, Lund University, Lund, Lund, Sweden, ³Vasculitis and Lupus Clinic, Addenbrookes Hospital University of Cambridge, Cambridge, United Kingdom
Background/Purpose: Takayasu's Arteritis (TAK) is a chronic inflammatory large vessel vasculitis characterized by granulomatous inflammation of the aorta and its branches. TAK incidence is 2.6/million…
Abstract Number: 88 • 2014 ACR/ARHP Annual Meeting
Microbiomes of Inflammatory and Non-Inflammatory Thoracic Aortic Aneurysms
Pauline Funchain*^1,2,3, Gary S. Hoffman*⁴, Lars Svensson⁵, Eric Roselli⁵, Gosta Pettersson⁶, Douglas Johnston⁶, Edward Soltesz⁶, Ritu Chakravarti⁷, Alison Clifford⁸ and Charis Eng², ¹Genomic Medicine Institute, Lerner Research Institute, Cleveland, OH, ²Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, ³Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH, ⁴Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, ⁵Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Cleveland, OH, ⁶Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Cleveland, OH, ⁷Lerner Research Institure, Cleveland Clinic, Cleveland, OH, ⁸Rheumatic and Immunologic Diseases, Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Aortitis may occur in the context of multifocal large and medium-sized vessel diseases such as giant cell arteritis (GCA) or Takayasu arteritis (TAK) and…
Abstract Number: 1766 • 2013 ACR/ARHP Annual Meeting
Role Of IL33 In The Inflammation Of Takayasu Arteritis
David Saadoun¹, Marlène Garrido², Julien Gaudric³, Cloé Comarmond⁴, Michele Rosenzwacjg⁵ and Patrice Cacoub⁶, ¹Groupe Hospitalier Pitié Salpétrière, Service de Médecine Interne, DHU i2B, Paris, France, ²I3 laboratory, Pitié-Salpétrière, Paris, France, ³Department of Vascular surgery GHPS, Paris, France, ⁴Internal Medicine and Clinical Imunology, Referal Center for Autoimmune diseases, Internal Medicine and Clinical Imunology, Hôpital Pitié Salpétrière, Paris, France, ⁵Department of Immunology GHPS, Paris, France, ⁶Médecine Interne 2, Hopital Pitié-Salpétrière, Paris, France
Background/Purpose: Interleukin (IL)-33, a member of the IL-1 cytokine family, is a recently described novel activator of endothelial cells, which promotes adhesion molecules and proinflammatory…
Abstract Number: 1702 • 2013 ACR/ARHP Annual Meeting
Identification of Multiple Genetic Susceptibility Loci in Takayasu’s Arteritis
Guher Saruhan-Direskeneli¹, Travis Hughes², Patrick S. Coit², Joel M. Guthridge³, Judith A. James⁴, Peter A. Merkel of behalf of the Vasculitis Clinical Research Consortium⁵, Haner Direskeneli on behalf of the Turkish Takayasu Study Group⁶ and Amr H. Sawalha², ¹Department of Physiology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ²Division of Rheumatology, University of Michigan, Ann Arbor, MI, ³Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁶Department of Rheumatology, Marmara University, Faculty of Medicine, Istanbul, Turkey
Background/Purpose: Takayasu’s arteritis is a rare inflammatory disease of large arteries. The etiology of Takayasu’s arteritis remains poorly understood, but genetic contribution to the disease…
Abstract Number: 1678 • 2013 ACR/ARHP Annual Meeting
How Similar Are Extracranial Giant Cell Arteritis and Takayasu Arteritis?
Tanaz A. Kermani¹, Cynthia S. Crowson², Francesco Muratore³, Jean Schmidt⁴, Eric L. Matteson⁵ and Kenneth J. Warrington⁶, ¹Rheumatology, University of California Los Angeles, Los Angeles, CA, ²Department of Health Sciences Research, Mayo Clinic, Rochester, MN, ³Rheumatology Service, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ⁴Internal Medicine and RECIF, CHU Nord, Amiens, France, ⁵Rheumatology, Mayo Clinic, Rochester, MN, ⁶Division of Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: The clinical and radiographic features of giant cell arteritis (GCA) with extracranial (large-vessel) involvement can be similar to those of Takayasu arteritis (TAK)…
Abstract Number: 1684 • 2013 ACR/ARHP Annual Meeting
Early Combination Immunosuppression and Serial Non-Invasive Imaging Improves Outcome In Takayasu Arteritis
Taryn Youngstein¹, Michael Quinn¹, James Peters¹ and Justin C. Mason², ¹Rheumatology Unit, Hammersmith Hospital, Imperial College London, London, United Kingdom, ²Rheumatology and Vascular Sciences, Hammersmith Hospital, Imperial College London, London, United Kingdom
Background/Purpose: Takayasu arteritis (TA) affects the aorta and its branches, pre-disposing to stenoses and aneurysmal dilatation. While morbidity remains high, evidence for efficacy of immunosuppressive…

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