Abstracts tagged "T-Regulatory Cells"

Abstract Number: 1455 • 2014 ACR/ARHP Annual Meeting
Ex Vivo-Expanded, but Not in Vitro-Induced, Human Regulatory T Cells Are Suitable for Cell Therapy in Rheumatological Autoimmune Diseases Thanks to Stable FOXP3 Demethylation
Maura Rossetti¹, Roberto Spreafico¹, Maryam Moshref², Jorg van Loosdregt³ and Salvatore Albani¹, ¹SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Duke-NUS Graduate Medical School, Translational Research Unit, Sanford-Burnham Medical Research Institute, Singapore, Singapore, ²Translational Research Unit, Sanford-Burnham Medical Research Institute, La Jolla, CA, ³Translational Research Unit, Sanford-Burnham Medical Research Institute, San Diego, CA
Background/Purpose: Treg cell therapy is a promising approach for transplant rejection and severe autoimmunity. Unfortunately, sufficient Treg numbers can be obtained only upon in vitroculture. Functional…
Abstract Number: 618 • 2014 ACR/ARHP Annual Meeting
A Gender Bias in Gut Microbiota of SKG Mice Colonized with a Limited Bacterial Consortium Associated with Severity of Spondyloarthritis and Ileitis Triggered By Beta-Glucan
Linda Rehaume, Olga Zbarskaya, Alicia Kang, Helen Benham, Paraic O Cuiv, Mark Morrison and Ranjeny Thomas, University of Queensland Diamantina Institute, Brisbane, Australia
Background/Purpose Beta-glucan (curdlan)-treated BALB/c ZAP-70W163C(SKG) mutant mice develop IL-23-dependent spondyloarthritis, and curdlan promotes ileitis in SKG mice housed under specific pathogen-free (SPF) but not germ-free…
Abstract Number: 449 • 2014 ACR/ARHP Annual Meeting
Citrullinated-Vimentin-Specific Regulatory T-Cell Responses Associate with ACPA Positive Individuals with Non-Specific Musculoskeletal Symptoms
Aamir Aslam¹, Jackie L. Nam¹, Laura Hunt¹, Chadi Rakieh¹, Ann W. Morgan² and Paul Emery¹, ¹NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom
Background/Purpose: The pathogenesis of RA can be conceptualised by sequential phases that precede the development of synovitis. Autoimmune antibody responses, including ACPA, can precede clinical…
Abstract Number: 335 • 2014 ACR/ARHP Annual Meeting
Interleukin-33 Suppresses Experimental Arthritis through Promoting Foxp3⁺ Regulatory T-Cells and Type-2 Immune Responses in Mice
Jerome Biton¹, Allan Thiolat¹, Sara khaleghparast Athari¹, Delphine Lemeiter², Roxanne Herve¹, Patrice Decker¹, Jean-Philippe Girard³, Stephane Roga³, André Herbelin⁴, Anais Levascot⁴, Marie-Christophe Boissier² and Natacha Bessis¹, ¹INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité and Rheumatology Department, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Bobigny, France, ²INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France, ³Centre National de la Recherche Scientifique, Institut de Pharmacologie, dUniversité de Toulouse, Université Paul Sabatier, Institut de Pharmacologie et de Biologie Structurale et de Biologie Structurale, toulouse, France, ⁴INSERM U1082, Pôle Biologie Santé,, poitiers, France
Background/Purpose Interleukin (IL)-33 is a new member of the IL-1 family that exerts pleiotropic activities in innate and adaptive immunity. With its receptor ST2, they…
Abstract Number: 2908 • 2014 ACR/ARHP Annual Meeting
Flip Deficiency in Dendritic Cells Promotes Spontaneous Arthritis Mediated By Reduced Treg and Increased Autoreactive CD4⁺t Cells
Qiquan Huang¹, Harris R. Perlman², Robert Birkett³, Renee E. Doyle⁴, Deyu Fang⁵, G Kenneth.Haines⁶, William H. Robinson⁷, Syamal K. Datta⁸, Hyewon Phee⁹ and Richard M. Pope¹⁰, ¹Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Mount Sinai Hospital School of Medicine, New York, New York, NY, ⁷VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁸Rheumatology Division, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁹Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹⁰Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose Flip (CFLAR) has been identified as a rheumatoid arthritis (RA) risk allele and is important in preventing death receptor mediated apoptosis of dendritic cells…
Abstract Number: 2347 • 2014 ACR/ARHP Annual Meeting
Therapeutic Effect of a Novel Histone Deacetylase 6 Inhibitor, CKD-L, on Collagen Induced Arthritis and Peripheral Blood Mononuclear Cells from Patients with Rheumatoid Arthritis
Bo Ram Oh¹, Hyojin Lim², Daekwon Bae², Nina Ha², Young il Choi², Hyun Jung Yoo^3,4, Jin Kyun Park³, Eun Young Lee⁵, Eun Bong Lee³ and Yeong Wook Song^3,4, ¹Division of Rheumatology, Department of Molecular Medicine and Biophamaceutical Sciences, BK 21 plus Graduate School of Convergence Science Technology, Colleage of Medicine, Seoul National University, Seoul, South Korea, ²Department of Pharmacology and Toxicology, CKD Research Institute, CKD Pharmaceutical Company, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, ⁴Department of Molecular Medicine and Biophamaceutical Sciences, BK 21 plus Graduate School of Convergence Science Technology, Colleage of Medicine, Seoul National University, Seoul, South Korea, ⁵Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
Background/Purpose Epigenetic regulation plays an important role in inflammatory arthritis, including rheumatoid arthritis (RA). Histone deacetylase inhibitor (HDACi) has been recently reported to have therapeutic…
Abstract Number: 2164 • 2014 ACR/ARHP Annual Meeting
Self-Phospholipids Regulate Inflammation Via Activation of CD1d-Restricted T-cells and Induction of ‘anti-inflammatory’ Myeloid-Derived Suppressor Cells (MDSC)
Ram Raj Singh^1,2,3,4, Cynthia Tran¹, Priti Prasad¹, Jing Wang⁵, Dirk Zajonc⁵ and Ramesh Halder¹, ¹Autoimmunity and Tolerance Laboratory, Department of Medicine/Rheumatology, UCLA, Los Angeles, CA, ²Interdepartmental Program in Molecular Toxicology, UCLA, Los Angeles, CA, ³Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, ⁴Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, ⁵La Jolla Institute of Allergy and Immunology, La Jolla, CA
Background/Purpose Self-lipids play an increasingly appreciated role in immunity and inflammation. Lipid antigens are presented by CD1d and CD1a-d molecules in mouse and human, respectively,…
Abstract Number: 1799 • 2014 ACR/ARHP Annual Meeting
Elevated Indoleamine-2,3-Dioxygenase (IDO) Activity and Kynurinene-3-Monooxygenase (KMO) Expression in Interferon Positive Primary Sjogrens Syndrome Patients Is Associated with Increased CD25^hiFoxP3⁺regulatory Tcells: A Skew Towards Neurotoxicity or an Attempt to Rescue?
Naomi I Maria¹, Cornelia G. van Helden-Meeuwsen¹, Zana Brkic¹, Sandra M.J. Paulissen^1,2, Virgil A. Dalm¹, Paul L. van Daele¹, P. Martin van Hagen¹, Sinead M. Gibney^1,3, Andrew Harkin³, Hemmo A. Drexhage¹, Erik Lubberts^1,2 and Marjan A. Versnel¹, ¹Erasmus Medical Center, Immunology, Rotterdam, Netherlands, ²Erasmus Medical Center, Rheumatology, Rotterdam, Netherlands, ³Trinity College Institute of Neuroscience, Neuropsychopharmacology, Dublin, Ireland
Background/Purpose: A role for indoleamine-2,3-dioxygenase (IDO) in suppression of effector T-cell function and promotion of regulatory T-cell (Treg) differentiation has been described. IDO - the…
Abstract Number: 1750 • 2014 ACR/ARHP Annual Meeting
The Effect of a Pro-Inflammatory Milieu on Tregalizumab (BT-061)-Induced Regulatory T-Cell Activity
Jan Kubach¹, Faiza Rharbaoui², Martin Koenig², Jörg Schüttrumpf², Silke Aigner², Benjamin Dälken² and Helmut Jonuleit¹, ¹Department of Dermatology, University of Mainz Medical Center, Mainz, Germany, ²Biotest AG, Dreieich, Germany
Background/Purpose Regulatory T cells (Tregs) are essential for maintaining normal immune homeostasis. We have previously reported that tregalizumab is a humanized, non-depleting, CD4 agonistic antibody…
Abstract Number: 1737 • 2014 ACR/ARHP Annual Meeting
Altered Phenotype and Function of Senescent Regulatory T Cells in Rheumatoid Arthritis
Johannes Fessler¹, Chrsitine Schwarz¹, Anja C. Ficjan¹, Rusmir Husic², Evelyne Höller³, Angelika Lackner¹, Winfried B. Graninger⁴ and Christian Dejaco^1,5, ¹Rheumatology and Immunology, Medical University Graz, Graz, Austria, ²Rheumatology, Medical University Graz, Graz, Austria, ³Endocrinology, Medical University Graz, Graz, Austria, ⁴Internal medicine/Rheumatology and Immunology, Medical University Graz, Graz, Austria, ⁵Department of Rheumatology and Immunology, Medical University Graz, Graz A-8036, Austria
Background/Purpose Immunosenescence accompanied by accumulation of senescent T cells is a hallmark feature in the pathogenesis of rheumatoid arthritis (RA). Here we characterize a novel senescent…
Abstract Number: 2696 • 2013 ACR/ARHP Annual Meeting
Impaired Bacterial Clearance and An Exuberant Inflammatory Response Promote Chlamydia-Induced Reactive Arthritis In SKG Mice
Athan Baillet¹, Linda Rehaume², Helen Benham², Connor O'Meara³, Charles Armitage⁴, Marina Harvie⁴, Geraldine Brizard⁵, Jared Velasco², John V. Forrester⁶, Mariapia Degli-Esposti⁵, Kenneth Beagley⁴ and Ranjeny Thomas², ¹Diamantina Institute, The University of Queensland, Brisbane, Australia, ²University of Queensland Diamantina Institute, Brisbane, Australia, ³Institute of Health & Biomedical Innovation, Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Australia, ⁴Institute of Health & Biomedical Innovation, Brisbane, Australia, ⁵Lions Eye Institute, Nedlands, Australia, ⁶Lions Eye Institute, Nedlands, Bahrain
Background/Purpose: The sterile inflammatory arthritis associated with spondylitis, uveitis and rash, known as reactive arthritis, commences weeks after certain gastrointestinal or genitourinary infections, including Salmonella…
Abstract Number: 2698 • 2013 ACR/ARHP Annual Meeting
The Treg/Th17 Imbalance Of Patients With Systemic Lupus Erythematosus Were Mediated By Mir-663 Through Down-Regulating TGF-β1 Secretion Of Bone Marrow-Derived Mesenchymal Stem Cells
Lingyu Geng¹, Xia Li¹, Xuebing Feng² and Lingyun Sun³, ¹Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ²Department of Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ³the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: Systemic lupus erythematosus (SLE) patients exist an imbalance between CD4+CD25+FoxP3+ T regulatory (Treg) and IL-17-producing cells (Th17). Correction of this Treg/Th17 imbalance may have…
Abstract Number: 2711 • 2013 ACR/ARHP Annual Meeting
Self-Specific Polyclonal CD4 T Cells Enter a FR4^hi CD73^hi Anergic State To Prevent Immunopathology and Serve As a Reservoir For The Differentiation Of Protective Foxp3⁺ Tregs
Lokesh Kalekar¹ and Daniel L. Mueller², ¹University of Minnesota Medical School, Minneapolis, MN, ²Medicine/Rheumatic and Autoimmune Diseases, University of Minnesota Medical School, Minneapolis, MN
Background/Purpose: Clonal anergy has been proposed as a mechanism to allow for peripheral recognition of self antigens, without the consequence of immunopathology. Model systems have…
Abstract Number: 2713 • 2013 ACR/ARHP Annual Meeting
IL-21 Inhibited Follicular Regulatory T Cells To Promote Autoreactive Germinal Center Development In Autoimmune BXD2 Mice
Yanna Ding¹, Hui-Chen Hsu^2,3, Jun Li⁴, PingAr Yang⁴, Qi Wu⁴, Allan J. Zajac⁵ and John D. Mountz^3,6, ¹University of Alabama at Birmingham, Birmingham, AL, ²Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Birmingham VA Medical Center, Birmingham, AL, ⁴Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁵Microbiology, University of Alabama at Birmingham, Birmingham, AL, ⁶Dept of Med/Rheumatology Div, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Follicular T helper (Tfh) cells have been correlated with germinal center (GC) formation, autoantibody production and disease severity in human systemic lupus erythematosus (SLE).…
Abstract Number: 2215 • 2013 ACR/ARHP Annual Meeting
Apoptotic Cell-Based Therapy To Treat Collagen-Induced Experimental Arthritis. Rationale For The Use Of Apoptotic Cells In The Treatment Of Rheumatoid Arthritis
Sylvain Perruche¹, Amandine Clauzon¹, Francis Bonnefoy¹, Eric Toussirot² and Philippe Saas³, ¹UMR1098 INSERM, EFS Bourgogne Franche Comté, Besançon, France, ²Université de Franche Comté , CHRU, CIC Biotherapy 506 and Rheumatology and EA 4266 Pathogens and Inflammation, Besançon, France, ³Etablisement Français du Sang ; Université de Franche Comté, INSERM UMR1098, Besançon, France
Background/Purpose: Most of the currently available biological agents used in the treatment of rheumatoid arthritis (RA) target a cellular or soluble factor involved in the…

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