ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstracts tagged "T-Regulatory Cells"

  • Abstract Number: 2908 • 2014 ACR/ARHP Annual Meeting

    Flip Deficiency in Dendritic Cells Promotes Spontaneous Arthritis Mediated By Reduced Treg and Increased Autoreactive CD4+t Cells

    Qiquan Huang1, Harris R. Perlman2, Robert Birkett3, Renee E. Doyle4, Deyu Fang5, G Kenneth.Haines6, William H. Robinson7, Syamal K. Datta8, Hyewon Phee9 and Richard M. Pope10, 1Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Northwestern University Feinberg School of Medicine, Chicago, IL, 3Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 4Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 5Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, 6Mount Sinai Hospital School of Medicine, New York, New York, NY, 7VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, 8Rheumatology Division, Northwestern University Feinberg School of Medicine, Chicago, IL, 9Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, 10Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL

    Background/Purpose Flip (CFLAR) has been identified as a rheumatoid arthritis (RA) risk allele and is important in preventing death receptor mediated apoptosis of dendritic cells…
  • Abstract Number: 2347 • 2014 ACR/ARHP Annual Meeting

    Therapeutic Effect of a Novel Histone Deacetylase 6 Inhibitor, CKD-L, on Collagen Induced Arthritis and Peripheral Blood Mononuclear Cells from Patients with Rheumatoid Arthritis

    Bo Ram Oh1, Hyojin Lim2, Daekwon Bae2, Nina Ha2, Young il Choi2, Hyun Jung Yoo3,4, Jin Kyun Park3, Eun Young Lee5, Eun Bong Lee3 and Yeong Wook Song3,4, 1Division of Rheumatology, Department of Molecular Medicine and Biophamaceutical Sciences, BK 21 plus Graduate School of Convergence Science Technology, Colleage of Medicine, Seoul National University, Seoul, South Korea, 2Department of Pharmacology and Toxicology, CKD Research Institute, CKD Pharmaceutical Company, Seoul, South Korea, 3Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, 4Department of Molecular Medicine and Biophamaceutical Sciences, BK 21 plus Graduate School of Convergence Science Technology, Colleage of Medicine, Seoul National University, Seoul, South Korea, 5Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea

    Background/Purpose Epigenetic regulation plays an important role in inflammatory arthritis, including rheumatoid arthritis (RA). Histone deacetylase inhibitor (HDACi) has been recently reported to have therapeutic…
  • Abstract Number: 2164 • 2014 ACR/ARHP Annual Meeting

    Self-Phospholipids Regulate Inflammation Via Activation of CD1d-Restricted T-cells and Induction of ‘anti-inflammatory’ Myeloid-Derived Suppressor Cells (MDSC)

    Ram Raj Singh1,2,3,4, Cynthia Tran1, Priti Prasad1, Jing Wang5, Dirk Zajonc5 and Ramesh Halder1, 1Autoimmunity and Tolerance Laboratory, Department of Medicine/Rheumatology, UCLA, Los Angeles, CA, 2Interdepartmental Program in Molecular Toxicology, UCLA, Los Angeles, CA, 3Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, 4Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, 5La Jolla Institute of Allergy and Immunology, La Jolla, CA

    Background/Purpose Self-lipids play an increasingly appreciated role in immunity and inflammation. Lipid antigens are presented by CD1d and CD1a-d molecules in mouse and human, respectively,…
  • Abstract Number: 1799 • 2014 ACR/ARHP Annual Meeting

    Elevated Indoleamine-2,3-Dioxygenase (IDO) Activity and Kynurinene-3-Monooxygenase (KMO) Expression in Interferon Positive Primary Sjogrens Syndrome Patients Is Associated with Increased CD25hiFoxP3+ regulatory Tcells: A Skew Towards Neurotoxicity or an Attempt to Rescue?

    Naomi I Maria1, Cornelia G. van Helden-Meeuwsen1, Zana Brkic1, Sandra M.J. Paulissen1,2, Virgil A. Dalm1, Paul L. van Daele1, P. Martin van Hagen1, Sinead M. Gibney1,3, Andrew Harkin3, Hemmo A. Drexhage1, Erik Lubberts1,2 and Marjan A. Versnel1, 1Erasmus Medical Center, Immunology, Rotterdam, Netherlands, 2Erasmus Medical Center, Rheumatology, Rotterdam, Netherlands, 3Trinity College Institute of Neuroscience, Neuropsychopharmacology, Dublin, Ireland

    Background/Purpose: A role for indoleamine-2,3-dioxygenase (IDO) in suppression of effector T-cell function and promotion of regulatory T-cell (Treg) differentiation has been described. IDO - the…
  • Abstract Number: 1750 • 2014 ACR/ARHP Annual Meeting

    The Effect of a Pro-Inflammatory Milieu on Tregalizumab (BT-061)-Induced Regulatory T-Cell Activity

    Jan Kubach1, Faiza Rharbaoui2, Martin Koenig2, Jörg Schüttrumpf2, Silke Aigner2, Benjamin Dälken2 and Helmut Jonuleit1, 1Department of Dermatology, University of Mainz Medical Center, Mainz, Germany, 2Biotest AG, Dreieich, Germany

    Background/Purpose Regulatory T cells (Tregs) are essential for maintaining normal immune homeostasis. We have previously reported that tregalizumab is a humanized, non-depleting, CD4 agonistic antibody…
  • Abstract Number: 1737 • 2014 ACR/ARHP Annual Meeting

    Altered Phenotype and Function of Senescent Regulatory T Cells in Rheumatoid Arthritis

    Johannes Fessler1, Chrsitine Schwarz1, Anja C. Ficjan1, Rusmir Husic2, Evelyne Höller3, Angelika Lackner1, Winfried B. Graninger4 and Christian Dejaco1,5, 1Rheumatology and Immunology, Medical University Graz, Graz, Austria, 2Rheumatology, Medical University Graz, Graz, Austria, 3Endocrinology, Medical University Graz, Graz, Austria, 4Internal medicine/Rheumatology and Immunology, Medical University Graz, Graz, Austria, 5Department of Rheumatology and Immunology, Medical University Graz, Graz A-8036, Austria

    Background/Purpose Immunosenescence accompanied by accumulation of senescent T cells  is a hallmark feature in the pathogenesis of rheumatoid arthritis (RA). Here we characterize a novel senescent…
  • Abstract Number: 1732 • 2014 ACR/ARHP Annual Meeting

    Attenuation of Sclerodermatous Graft Versus Host Disease (sclGVHD) in IL4RA Receptor-Deficient Mice

    Katia Urso1, Kelly Tsang2, Robert Lafyatis3 and Antonios O. Aliprantis2, 1Rheumatology, Brigham and Women's Hospital, Boston, MA, 2Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 3Rheumatology, Boston University School of Medicine, Boston, MA

    Background/Purpose Scleroderma is a rare autoimmune disease characterized by the accumulation of fibrotic tissue in multiple organs including the skin, gut and lungs. To date,…
  • Abstract Number: 1642 • 2014 ACR/ARHP Annual Meeting

    A Prospective Study of Vitamin D Effects on T Cells Phenotype in Patients with Systemic Lupus Erythematosus Treated with Different Regimens of Supplementation for Two Years

    Silvia Piantoni, Laura Andreoli, Alessandra Zanola, Francesca Dall'Ara, Mirko Scarsi and Angela Tincani, Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy

    Background/Purpose Vitamin D (VD) receptor is constitutively expressed on the membrane of multiple cells, including lymphocytes. Recent studies highlight that VD may have an action…
  • Abstract Number: 1455 • 2014 ACR/ARHP Annual Meeting

    Ex Vivo-Expanded, but Not in Vitro-Induced, Human Regulatory T Cells Are Suitable for Cell Therapy in Rheumatological Autoimmune Diseases Thanks to Stable FOXP3 Demethylation

    Maura Rossetti1, Roberto Spreafico1, Maryam Moshref2, Jorg van Loosdregt3 and Salvatore Albani1, 1SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Duke-NUS Graduate Medical School, Translational Research Unit, Sanford-Burnham Medical Research Institute, Singapore, Singapore, 2Translational Research Unit, Sanford-Burnham Medical Research Institute, La Jolla, CA, 3Translational Research Unit, Sanford-Burnham Medical Research Institute, San Diego, CA

    Background/Purpose: Treg cell therapy is a promising approach for transplant rejection and severe autoimmunity. Unfortunately, sufficient Treg numbers can be obtained only upon in vitroculture. Functional…
  • Abstract Number: 618 • 2014 ACR/ARHP Annual Meeting

    A Gender Bias in Gut Microbiota of SKG Mice Colonized with a Limited Bacterial Consortium Associated with Severity of Spondyloarthritis and Ileitis Triggered By Beta-Glucan

    Linda Rehaume, Olga Zbarskaya, Alicia Kang, Helen Benham, Paraic O Cuiv, Mark Morrison and Ranjeny Thomas, University of Queensland Diamantina Institute, Brisbane, Australia

    Background/Purpose Beta-glucan (curdlan)-treated BALB/c ZAP-70W163C(SKG) mutant mice develop IL-23-dependent spondyloarthritis, and curdlan promotes ileitis in SKG mice housed under specific pathogen-free (SPF) but not germ-free…
  • Abstract Number: 2215 • 2013 ACR/ARHP Annual Meeting

    Apoptotic Cell-Based Therapy To Treat Collagen-Induced Experimental Arthritis. Rationale For The Use Of Apoptotic Cells In The Treatment Of Rheumatoid Arthritis

    Sylvain Perruche1, Amandine Clauzon1, Francis Bonnefoy1, Eric Toussirot2 and Philippe Saas3, 1UMR1098 INSERM, EFS Bourgogne Franche Comté, Besançon, France, 2Université de Franche Comté , CHRU, CIC Biotherapy 506 and Rheumatology and EA 4266 Pathogens and Inflammation, Besançon, France, 3Etablisement Français du Sang ; Université de Franche Comté, INSERM UMR1098, Besançon, France

    Background/Purpose: Most of the currently available biological agents used in the treatment of rheumatoid arthritis (RA) target a cellular or soluble factor involved in the…
  • Abstract Number: 1643 • 2013 ACR/ARHP Annual Meeting

    Ex Vivo Suppression Of RA Effector T Cells (Teff) By Mapc Media Is Synergistic With Treg

    Gali Malul1, David Soler2, Donald D. Anthony3, Hillard M. Lazarus4, Nicholas Lehman5, Thomas McCormick2, Julia M. Sugalski6, Anthony E. Ting5 and Nora G. Singer7, 1Rheumatology, MetroHealth Medical Center, Cleveland, OH, 2Dermatology, Case Medical Center, Cleveland, OH, 3Medicine, Case Western Reserve University, Cleveland, OH, 4Comprehensive Cancer Center, Case Medical Center, Cleveland, OH, 5Athersys, Inc., Cleveland, OH, 6Medicine/infectious disease, Case Western Reserve University, Cleveland, OH, 7Medicine, Division of Rheumatology, MetroHealth Medical Center, Cleveland, OH

    Background/Purpose: Use of mesenchymal/multipotent stem cells (MSCs/MAPCs) is an emerging immune modulatory therapeutic strategy promising for a number of human diseases. Multipotent adult progenitor cells…
  • Abstract Number: 1641 • 2013 ACR/ARHP Annual Meeting

    Bispecific Antibodies For Redirection Of Human Regulatory T Cells To Surface-Inducible Autoantigen La/SS-B

    Stefanie Koristka1, Marc Cartellieri2, Claudia Arndt2, Anja Feldmann2, Irene Michalk2, Claudia C. Bippes2, Nicole Berndt2, Anne Hermsdorf2, Slava Stamova2, Biji T. Kurien3, Robert Hal Scofield4, A. Darise Farris5, Judith A. James6, Holger Bartsch7 and Michael Bachmann2, 1Carl Gustav Carus TU-Dresden, Dresden, Germany, 2Inst. Immunology, Carl Gustav Carus TU-Dresden, Dresden, Germany, 3College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 4Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation; Department of Medicine, University of Oklahoma Health Sciences Center; US Department of Veterans Affairs Medical Center, Oklahoma City, OK, 5Arthritis & Immunology Program, Oklahoma Medical Research Foun, Oklahoma City, OK, 6Oklahoma Medical Research Foundation, Oklahoma City, OK, 7Inst. Immunol., Carl Gustav Carus TU-Dresden, Dresden, Germany

    Background/Purpose: Adoptive transfer of regulatory T cells (Tregs)  represents a promising strategy for treatment of auto- and alloimmunity. However, it is difficult to obtain therapeutically…
  • Abstract Number: 1412 • 2013 ACR/ARHP Annual Meeting

    Use Of a Biologic Marker For An Integrated Pharmacodynamic and Clinical Analysis To Inform Further Clinical Development, Including Dose Selection For The Phase 2b Trial – Treat 2b – Of Tregalizumab In Rheumatoid Arthritis

    Eva Dokoupilova1, Slawomir Jeka2, Jiri Vencovsky3, Janusz Badurski4, Klaas Prins5, Vibeke Strand6, Edward C. Keystone7, Ronald F van Vollenhoven8, Jurgen Wollenhaupt9, Andrea Wartenberg-Demand10, Gabriele Niemann10, Ahmed Abufarag10, Silke Aigner10, Sibylle Kaiser10, Faiza Rharbaoui10, Niklas Czeloth11, Ralf Wolter10, Benjamin Dälken10 and Thorsten Holzkämper10, 1Medical Plus s.r.o, Uherske Hradiste, Czech Republic, 2Clinic of Rheumatology and Connective Tissue Diseases University Hospital No 2 in Bydgoszcz Collegium Medicum UMK in Torun, Bydgoszcz, Poland, 3Institute of Rheumatology, Department of Clinical and Experimental Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 4Center of Osteoporosis and Osteo-articular Diseases, Bialystock, Poland, 5qPharmetra, Nijmegen, Netherlands, 6Adjunct, Division of Immunology / Rheumatology, Stanford University, Portola Valley, CA, 7Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 8ClinTRID, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 9Schoen-Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany, 10Biotest AG, Dreieich, Germany, 11Global Research Immunology, Biotest AG, Dreieich, Germany

    Background/Purpose: In patients with rheumatoid arthritis (RA) reduced numbers and functional impairment of regulatory T cells (Tregs) have been observed. Tregalizumab is a humanized, agonistic…
  • Abstract Number: 719 • 2013 ACR/ARHP Annual Meeting

    Mammalian Target Of Rapamycin (mTOR) Skews T Cell Lineage Development In Systemic Lupus Erythematosus (SLE)

    Hiroshi Kato1 and Andras Perl2, 1Internal Medicine, Division of Rheumatology, SUNY Upstate Medical University, Syracuse, NY, 2Dept of Medicine, SUNY Upstate Medical University, Syracuse, NY

    Background/Purpose: mTOR activity is increased in SLE T cells and its blockade has therapeutic efficacy in SLE. Murine studies showed essential roles of mTORC1 in…
  • « Previous Page
  • 1
  • …
  • 3
  • 4
  • 5
  • 6
  • Next Page »
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

Copyright Policy

View ACR Policies.

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology