Abstracts tagged "T-Regulatory Cells"

Abstract Number: 2927 • 2016 ACR/ARHP Annual Meeting
Mechanisms Regulating the Loss of Tregs in CD11c-Flip-KO Mice That Contribute to the Spontaneous Development of Inflammatory Arthritis
Qi Quan Huang¹, Renee E. Doyle², Robert Birkett¹, Deyu Fang³ and Richard M. Pope², ¹Medicine/Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: CD11c-Flip-KO (HUPO) mice spontaneously develop inflammatory, erosive arthritis. We previously demonstrated that T regulatory cells (Tregs) were reduced in HUPO mice and that the…
Abstract Number: 3040 • 2016 ACR/ARHP Annual Meeting
Th17 Migration into the Synovial Fluid of Patients with Active Psoriatic Arthritis Is Enhanced By Regulatory T Cells
Helen Baldwin¹, Amara Ezeonyeji², Mohammed Rohan Butt² and Michael R. Ehrenstein³, ¹Rheumatology, University College London, London, United Kingdom, ²Rheumatology, Medicine, University College London, London, United Kingdom, ³Medicine, University College London, London, United Kingdom
Background/Purpose: Uncontrolled migration of Th17 cells into the skin and joints is a major driver in the pathogenesis of psoriatic arthritis (PsA). Modulation of T…
Abstract Number: 3221 • 2015 ACR/ARHP Annual Meeting
Safety and Efficiency of Low-Dose Interleukin-2 Treatment in Systemic Lupus Erythematosus
Jing He¹, Xia Zhang², Yunbo Wei³, Xiaolin Sun⁴, Jianping Guo⁵, Yuebo JIn⁶, Rulin Jia⁶, Lei Zhu⁶, Zhaohua Hou⁷, Yaping Chen⁸, Yuan An⁶, Yuan Jia⁶, Xu Liu⁶, Limin Ren⁶, Ru Li⁶, HUA YE⁹, Shi Chen⁶, Xuewu Zhang¹⁰, Yin Su¹¹, Eric Morand¹², Yu Di¹³ and Zhanguo Li⁶, ¹Peking Univerisity People's Hospital, Beijing, China, ²Department of Rheumatology & immunology, Peking University People's Hospital, Beijing, China, ³Immunology for Environment and Health, Shandong Analysis and Test Center, Shandong Academy of Science, Shandong, China, ⁴People's hospital,Peking University, Beijing, China, ⁵Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, ⁶Peking University People's Hospital, Beijing, China, ⁷Shandong Analysis and Test Center, Beijing, China, ⁸Monash University, Clayton, Austria, ⁹No.11 XIZHIMENG SOUTH STREET,, Peking University People's Hospital, Beijing, China, ¹⁰Rheumatology, Peking University People's Hospital, Beijing, China, ¹¹Department of Rheumatology and Immunology,Clinical Immunology Center, Peking University People's Hospital, Beijing, China, ¹²Medicine, Monash University, Clayton, Australia, ¹³Molecular Immunomodulation Laboratory, Monash University, Clayton, Austria
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with multi-system involvement, associated with an imbalance between effector and regulatory CD4+ T cells. The…
Abstract Number: 903 • 2015 ACR/ARHP Annual Meeting
CGEN-15001, a Novel B7-like Protein, Controls Inflammation in a Translational Rheumatoid Arthritis (RA) Assay and Induces Treg Driven Long-Term Remission in an Autoimmune Disease Model
Iris Hecht¹, Ashley Gilmour², Clare Tange², Donna McIntyre², Joseph R. Podojil³, Kay McNamee⁴, Galit Rotman⁵, Eyal Neria⁵, Mariola Kurowska-Stolarska², Richard O. Williams⁴, Stephen D. Miller³ and Iain B. McInnes^2,6, ¹Therapeutic Proteins, Compugen Ltd., Tel Aviv, Israel, ²Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ³Microbiology-Immunology, Northwestern University, Chicago, IL, ⁴Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, ⁵Compugen Ltd., Tel Aviv, Israel, ⁶Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: CGEN-15001 is an Fc fusion protein composed of the extracellular domain of a novel B7-like protein. Therapeutic CGEN-15001 treatment is effective in collagen induced…
Abstract Number: 1037 • 2015 ACR/ARHP Annual Meeting
Impaired Regulatory T Cell Survival in the Pathogenesis of Autoreactive Arthritis Mediated By CD11c-Deletion of Flip
Qi Quan Huang¹, Renee E. Doyle¹, Robert Birkett², Deyu Fang³, Syamal K. Datta¹ and Richard M. Pope¹, ¹Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: We have generated a mouse line with Flip conditionally deleted in CD11c-cre expressing cells (CD11c-Flip-KO, named HUPO), which spontaneously develops erosive arthritis resembling rheumatoid…
Abstract Number: 1751 • 2015 ACR/ARHP Annual Meeting
Modulation of IRF4 Function Promotes Expansion of Effector Tregs in Lupus
Alessandra B. Pernis¹, Uma Chandrasekaran², Woelsung Yi², Sanjay Gupta³, Chien-Huan Weng⁴, Eugenia Giannopoulou², Yurii Chinenov⁵, Govind Bhagat⁶, Rolf Jessberger⁷ and Casey Weaver⁸, ¹Autoimmunity & Inflammation, Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Autoimmunity & Inflammation Research Program, Hospital for Special Surgery, New York, NY, ⁴Weill Cornell Medical College, New York, NY, ⁵Arthritis & Tissue Degeneration Program, Hospital for Special Surgery, New York, NY, ⁶Department of Pathology & Cell Biology, Columbia University, New York, NY, ⁷Dresden University of Technology, Dresden, Dresden, Germany, ⁸University of Alabama, Birmingham, AL
Background/Purpose: Acquisition of an effector phenotype is critical for Treg function in chronic inflammatory settings such as those encountered in autoimmune diseases like lupus. Although…
Abstract Number: 1938 • 2015 ACR/ARHP Annual Meeting
Engaging PD-1 Resuscitates Synovial Treg Cells and Dampens the Joint Infiltrating T Cells in Rheumatoid Arthritis
Dipendra Kumar Mitra¹ and Kaustav Chowdhury², ¹Transplant Immunology & Immunogenetics, All India Institute of Medical Sciences, Delhi, India, ²TRANSPLANT IMMUNOLOGY AND IMMUNOGENETICS, ALL INDIA INSTITUTE OF MEDICAL SCIENCES, New Delhi, India
Background/Purpose: Enrichment of regulatory T cells (Treg) has been reported in the synovial fluid (SF) of RA patients, although they fail to alleviate the joint…
Abstract Number: 1947 • 2015 ACR/ARHP Annual Meeting
Hypermethylation of Treg-Specific Demethylated Regions in the Ikaros Transcription Factor Family Members, Helios and Eos, in Rheumatoid Arthritis Tregs
Alla Skapenko¹, Viktoria Soentgerath¹, Sonja Haupt², Jan Leipe¹ and Hendrik Schulze-Koops¹, ¹Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany, ²Division of Rheumatology and Clinical Immunology, Med.Klinik und Poliklinik IV, University of Munich, Munich, Germany
Background/Purpose: Foxp3 is the signature transcription factor of regulatory T cells (Tregs) and facilitates many of the characteristic functions of Tregs. Members of the Ikaros…
Abstract Number: 1950 • 2015 ACR/ARHP Annual Meeting
Methylation-Dependent Interference of Two Promoters for the Treg-Specific Protein, Garp, Contributes to Altered Treg Function in Rheumatoid Arthritis
Viktoria Soentgerath¹, Sonja Haupt², Jan Leipe³, Hendrik Schulze-Koops¹ and Alla Skapenko¹, ¹Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany, ²Division of Rheumatology and Clinical Immunology, Med.Klinik und Poliklinik IV, University of Munich, Munich, Germany, ³Division of Rheumatology, University of Munich, Munich, Germany
Background/Purpose: Recently, genome-wide studies identified several Treg-specific genes containing hypomethylated regions that are critical for their expression, so called Treg-specific demethylated regions (TSDR). For example,…
Abstract Number: 2581 • 2015 ACR/ARHP Annual Meeting
TNF-Alpha Receptor II Signaling Plays an Important Role in Maintaining the Expression of Forkhead Box P3 in Murine Regulatory T Cells
Wen-Yi Tseng^1,2, Kay McNamee¹, Adam Cribbs³, Anviti Vyas¹ and Richard O. Williams¹, ¹Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, ²Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan, ³Computational Genomics and Training Centre, MRC Functional Genomics Unit, University of Oxford, Oxford, United Kingdom
Background/Purpose: TNF-α is a key regulator of inflammation, which induces signal transduction by binding to two structurally and functionally distinct receptors on target cells: TNF…
Abstract Number: 3020 • 2015 ACR/ARHP Annual Meeting
IL-21 Abrogates CD4+CD25+FOXP3+ Treg Differentiation in Part By Suppressing Treg GATA-3 Expression in SLE
Hiroshi Kato¹ and Andras Perl², ¹Division of Rheumatology/Internal Medicine, SUNY Upstate Medical University, Syracuse, NY, ²Department of Medicine, SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Previous studies point to qualitative and quantitative Treg insufficiencies underlying aberrant T-cell activation in SLE. GATA-3 is critical in lineage commitment and functions of…
Abstract Number: 3022 • 2015 ACR/ARHP Annual Meeting
Characterizing a Novel Gene, Mosaic, and Its Role in Mediating a Multisystem Autoimmunity
Alice Chan¹, Emily Brown², Oded Foreman³, Anita Oberbauer⁴, Angela Hughes⁵, Shelly Burton⁶, Hong-Erh Liang⁷, Mark Anderson⁸ and Danika Bannasch⁹, ¹Pediatric Rheumatology, University of California San Francisco, San Francisco, CA, ²Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA, ³Genentech, Inc, South San Francisco, CA, ⁴Department of Animal Science, School of Veterinary Medicine, University of California Davis, Davis, CA, ⁵Mars Veterinary, Gaithersburg, MD, ⁶Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE, Canada, ⁷Medicine, University of California San Francisco, San Francisco, CA, ⁸Diabetes Center, University of California San Francisco, San Francisco, CA, ⁹Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA
Background/Purpose: A novel candidate gene, Mosaic (Multi-Organ System Autoimmunity in Canines), was identified as the culprit causing an early and severe multiorgan autoimmunity in a…
Abstract Number: 3142 • 2015 ACR/ARHP Annual Meeting
Tocilizumab Enhances Regulatory T-Cell Activation and Proliferation in Giant Cell Arteritis
Chie Miyabe¹, Klemen Strle², Yoshishige Miyabe¹, John H. Stone^1,3, Andrew D. Luster^1,4 and Sebastian Unizony^1,5, ¹Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Rheumatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Massachusetts General Hospital, Charlestown, MA, ⁵Rheumatology, Massachusetts General Hospital, Boston, MA
Background/Purpose : CD4+ T helper (Th) 17 cells, Th1 cells, and regulatory T-cells (Treg) contribute to the pathogenesis of giant cell arteritis (GCA). Interleukin (IL)-6,…
Abstract Number: 1732 • 2014 ACR/ARHP Annual Meeting
Attenuation of Sclerodermatous Graft Versus Host Disease (sclGVHD) in IL4RA Receptor-Deficient Mice
Katia Urso¹, Kelly Tsang², Robert Lafyatis³ and Antonios O. Aliprantis², ¹Rheumatology, Brigham and Women's Hospital, Boston, MA, ²Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Rheumatology, Boston University School of Medicine, Boston, MA
Background/Purpose Scleroderma is a rare autoimmune disease characterized by the accumulation of fibrotic tissue in multiple organs including the skin, gut and lungs. To date,…
Abstract Number: 1642 • 2014 ACR/ARHP Annual Meeting
A Prospective Study of Vitamin D Effects on T Cells Phenotype in Patients with Systemic Lupus Erythematosus Treated with Different Regimens of Supplementation for Two Years
Silvia Piantoni, Laura Andreoli, Alessandra Zanola, Francesca Dall'Ara, Mirko Scarsi and Angela Tincani, Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy
Background/Purpose Vitamin D (VD) receptor is constitutively expressed on the membrane of multiple cells, including lymphocytes. Recent studies highlight that VD may have an action…

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