ACR Meeting Abstracts

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Abstracts tagged "T-Regulatory Cells"

  • Abstract Number: 1920 • 2016 ACR/ARHP Annual Meeting

    Vitamin D Induces a Type 1 Regulatory T Cell (Tr1)-like Phenotype in Human C-C Chemokine Receptor Type 6 (Ccr6)+ th Cells and Promotes Their Migration to an Inflammatory Environment

    Wendy Dankers1, Jan Piet van Hamburg1, Nadine Davelaar1, Patrick Asmawidjaja1, Hoyan Wen1, Johannes van Leeuwen2, Edgar Colin3 and Erik Lubberts1, 1Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 2Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 3Rheumatology, ZGT, Almelo, Netherlands

    Background/Purpose: The active vitamin D metabolite 1,25(OH)2D3 suppresses various experimental autoimmune diseases. In addition, serum vitamin D levels, vitamin D intake and polymorphisms in the…
  • Abstract Number: 2072 • 2016 ACR/ARHP Annual Meeting

    Fli1-Haploinsufficient Dermal Fibroblasts Promote Skin-Localized Transdifferentiation of Th2- and Th17-like Regulatory T Cells

    Ryosuke Saigusa1, Yoshihide Asano2, Takuya Miyagawa2, Megumi Hirabayashi2, Kouki Nakamura1, Shunsuke Miura3, Takashi Yamashita2, Yohei Ichimura1, Takehiro Takahashi1, Tetsuo Toyama2, Takashi Taniguchi1, Ayumi Yoshizaki2, Maria Trojanowska4 and Shinichi Sato1, 1Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan, 2Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, 3University of Tokyo Graduate School of Medicine, Tokyo, Japan, 4Arthritis Center, Boston University, Arthritis Center, Boston, MA

    Background/Purpose:  Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by autoimmunity/inflammation, vasculopathy, and tissue fibrosis. Fli1 is a member of Ets family transcription…
  • Abstract Number: 2581 • 2015 ACR/ARHP Annual Meeting

    TNF-Alpha Receptor II Signaling Plays an Important Role in Maintaining the Expression of Forkhead Box P3 in Murine Regulatory T Cells

    Wen-Yi Tseng1,2, Kay McNamee1, Adam Cribbs3, Anviti Vyas1 and Richard O. Williams1, 1Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, 2Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan, 3Computational Genomics and Training Centre, MRC Functional Genomics Unit, University of Oxford, Oxford, United Kingdom

    Background/Purpose: TNF-α is a key regulator of inflammation, which induces signal transduction by binding to two structurally and functionally distinct receptors on target cells: TNF…
  • Abstract Number: 3020 • 2015 ACR/ARHP Annual Meeting

    IL-21 Abrogates CD4+CD25+FOXP3+ Treg Differentiation in Part By Suppressing Treg GATA-3 Expression in SLE

    Hiroshi Kato1 and Andras Perl2, 1Division of Rheumatology/Internal Medicine, SUNY Upstate Medical University, Syracuse, NY, 2Department of Medicine, SUNY Upstate Medical University, Syracuse, NY

    Background/Purpose: Previous studies point to qualitative and quantitative Treg insufficiencies underlying aberrant T-cell activation in SLE. GATA-3 is critical in lineage commitment and functions of…
  • Abstract Number: 3022 • 2015 ACR/ARHP Annual Meeting

    Characterizing a Novel Gene, Mosaic, and Its Role in Mediating a Multisystem Autoimmunity

    Alice Chan1, Emily Brown2, Oded Foreman3, Anita Oberbauer4, Angela Hughes5, Shelly Burton6, Hong-Erh Liang7, Mark Anderson8 and Danika Bannasch9, 1Pediatric Rheumatology, University of California San Francisco, San Francisco, CA, 2Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA, 3Genentech, Inc, South San Francisco, CA, 4Department of Animal Science, School of Veterinary Medicine, University of California Davis, Davis, CA, 5Mars Veterinary, Gaithersburg, MD, 6Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE, Canada, 7Medicine, University of California San Francisco, San Francisco, CA, 8Diabetes Center, University of California San Francisco, San Francisco, CA, 9Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA

    Background/Purpose:  A novel candidate gene, Mosaic (Multi-Organ System Autoimmunity in Canines), was identified as the culprit causing an early and severe multiorgan autoimmunity in a…
  • Abstract Number: 3142 • 2015 ACR/ARHP Annual Meeting

    Tocilizumab Enhances Regulatory T-Cell Activation and Proliferation in Giant Cell Arteritis

    Chie Miyabe1, Klemen Strle2, Yoshishige Miyabe1, John H. Stone1,3, Andrew D. Luster1,4 and Sebastian Unizony1,5, 1Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 3Rheumatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 4Massachusetts General Hospital, Charlestown, MA, 5Rheumatology, Massachusetts General Hospital, Boston, MA

    Background/Purpose : CD4+ T helper (Th) 17 cells, Th1 cells, and regulatory T-cells (Treg) contribute to the pathogenesis of giant cell arteritis (GCA). Interleukin (IL)-6,…
  • Abstract Number: 3221 • 2015 ACR/ARHP Annual Meeting

    Safety and Efficiency of Low-Dose Interleukin-2 Treatment in Systemic Lupus Erythematosus

    Jing He1, Xia Zhang2, Yunbo Wei3, Xiaolin Sun4, Jianping Guo5, Yuebo JIn6, Rulin Jia6, Lei Zhu6, Zhaohua Hou7, Yaping Chen8, Yuan An6, Yuan Jia6, Xu Liu6, Limin Ren6, Ru Li6, HUA YE9, Shi Chen6, Xuewu Zhang10, Yin Su11, Eric Morand12, Yu Di13 and Zhanguo Li6, 1Peking Univerisity People's Hospital, Beijing, China, 2Department of Rheumatology & immunology, Peking University People's Hospital, Beijing, China, 3Immunology for Environment and Health, Shandong Analysis and Test Center, Shandong Academy of Science, Shandong, China, 4People's hospital,Peking University, Beijing, China, 5Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, 6Peking University People's Hospital, Beijing, China, 7Shandong Analysis and Test Center, Beijing, China, 8Monash University, Clayton, Austria, 9No.11 XIZHIMENG SOUTH STREET,, Peking University People's Hospital, Beijing, China, 10Rheumatology, Peking University People's Hospital, Beijing, China, 11Department of Rheumatology and Immunology,Clinical Immunology Center, Peking University People's Hospital, Beijing, China, 12Medicine, Monash University, Clayton, Australia, 13Molecular Immunomodulation Laboratory, Monash University, Clayton, Austria

    Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with multi-system involvement, associated with an imbalance between effector and regulatory CD4+ T cells. The…
  • Abstract Number: 903 • 2015 ACR/ARHP Annual Meeting

    CGEN-15001, a Novel B7-like Protein, Controls Inflammation in a Translational Rheumatoid Arthritis (RA) Assay and Induces Treg Driven Long-Term Remission in an Autoimmune Disease Model

    Iris Hecht1, Ashley Gilmour2, Clare Tange2, Donna McIntyre2, Joseph R. Podojil3, Kay McNamee4, Galit Rotman5, Eyal Neria5, Mariola Kurowska-Stolarska2, Richard O. Williams4, Stephen D. Miller3 and Iain B. McInnes2,6, 1Therapeutic Proteins, Compugen Ltd., Tel Aviv, Israel, 2Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, 3Microbiology-Immunology, Northwestern University, Chicago, IL, 4Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, 5Compugen Ltd., Tel Aviv, Israel, 6Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: CGEN-15001 is an Fc fusion protein composed of the extracellular domain of a novel B7-like protein. Therapeutic CGEN-15001 treatment is effective in collagen induced…
  • Abstract Number: 1037 • 2015 ACR/ARHP Annual Meeting

    Impaired Regulatory T Cell Survival in the Pathogenesis of Autoreactive Arthritis Mediated By CD11c-Deletion of Flip

    Qi Quan Huang1, Renee E. Doyle1, Robert Birkett2, Deyu Fang3, Syamal K. Datta1 and Richard M. Pope1, 1Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose:  We have generated a mouse line with Flip conditionally deleted in CD11c-cre expressing cells (CD11c-Flip-KO, named HUPO), which spontaneously develops erosive arthritis resembling rheumatoid…
  • Abstract Number: 1751 • 2015 ACR/ARHP Annual Meeting

    Modulation of IRF4 Function Promotes Expansion of Effector Tregs in Lupus

    Alessandra B. Pernis1, Uma Chandrasekaran2, Woelsung Yi2, Sanjay Gupta3, Chien-Huan Weng4, Eugenia Giannopoulou2, Yurii Chinenov5, Govind Bhagat6, Rolf Jessberger7 and Casey Weaver8, 1Autoimmunity & Inflammation, Hospital for Special Surgery, New York, NY, 2Hospital for Special Surgery, New York, NY, 3Autoimmunity & Inflammation Research Program, Hospital for Special Surgery, New York, NY, 4Weill Cornell Medical College, New York, NY, 5Arthritis & Tissue Degeneration Program, Hospital for Special Surgery, New York, NY, 6Department of Pathology & Cell Biology, Columbia University, New York, NY, 7Dresden University of Technology, Dresden, Dresden, Germany, 8University of Alabama, Birmingham, AL

    Background/Purpose: Acquisition of an effector phenotype is critical for Treg function in chronic inflammatory settings such as those encountered in autoimmune diseases like lupus. Although…
  • Abstract Number: 1938 • 2015 ACR/ARHP Annual Meeting

    Engaging PD-1 Resuscitates Synovial Treg Cells and Dampens the Joint Infiltrating T Cells in Rheumatoid Arthritis

    Dipendra Kumar Mitra1 and Kaustav Chowdhury2, 1Transplant Immunology & Immunogenetics, All India Institute of Medical Sciences, Delhi, India, 2TRANSPLANT IMMUNOLOGY AND IMMUNOGENETICS, ALL INDIA INSTITUTE OF MEDICAL SCIENCES, New Delhi, India

    Background/Purpose: Enrichment of regulatory T cells (Treg) has been reported in the synovial fluid (SF) of RA patients, although they fail to alleviate the joint…
  • Abstract Number: 1947 • 2015 ACR/ARHP Annual Meeting

    Hypermethylation of Treg-Specific Demethylated Regions in the Ikaros Transcription Factor Family Members, Helios and Eos, in Rheumatoid Arthritis Tregs

    Alla Skapenko1, Viktoria Soentgerath1, Sonja Haupt2, Jan Leipe1 and Hendrik Schulze-Koops1, 1Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany, 2Division of Rheumatology and Clinical Immunology, Med.Klinik und Poliklinik IV, University of Munich, Munich, Germany

    Background/Purpose: Foxp3 is the signature transcription factor of regulatory T cells (Tregs) and facilitates many of the characteristic functions of Tregs. Members of the Ikaros…
  • Abstract Number: 1950 • 2015 ACR/ARHP Annual Meeting

    Methylation-Dependent Interference of Two Promoters for the Treg-Specific Protein, Garp, Contributes to Altered Treg Function in Rheumatoid Arthritis

    Viktoria Soentgerath1, Sonja Haupt2, Jan Leipe3, Hendrik Schulze-Koops1 and Alla Skapenko1, 1Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany, 2Division of Rheumatology and Clinical Immunology, Med.Klinik und Poliklinik IV, University of Munich, Munich, Germany, 3Division of Rheumatology, University of Munich, Munich, Germany

    Background/Purpose: Recently, genome-wide studies identified several Treg-specific genes containing hypomethylated regions that are critical for their expression, so called Treg-specific demethylated regions (TSDR). For example,…
  • Abstract Number: 2164 • 2014 ACR/ARHP Annual Meeting

    Self-Phospholipids Regulate Inflammation Via Activation of CD1d-Restricted T-cells and Induction of ‘anti-inflammatory’ Myeloid-Derived Suppressor Cells (MDSC)

    Ram Raj Singh1,2,3,4, Cynthia Tran1, Priti Prasad1, Jing Wang5, Dirk Zajonc5 and Ramesh Halder1, 1Autoimmunity and Tolerance Laboratory, Department of Medicine/Rheumatology, UCLA, Los Angeles, CA, 2Interdepartmental Program in Molecular Toxicology, UCLA, Los Angeles, CA, 3Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, 4Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, 5La Jolla Institute of Allergy and Immunology, La Jolla, CA

    Background/Purpose Self-lipids play an increasingly appreciated role in immunity and inflammation. Lipid antigens are presented by CD1d and CD1a-d molecules in mouse and human, respectively,…
  • Abstract Number: 1799 • 2014 ACR/ARHP Annual Meeting

    Elevated Indoleamine-2,3-Dioxygenase (IDO) Activity and Kynurinene-3-Monooxygenase (KMO) Expression in Interferon Positive Primary Sjogrens Syndrome Patients Is Associated with Increased CD25hiFoxP3+ regulatory Tcells: A Skew Towards Neurotoxicity or an Attempt to Rescue?

    Naomi I Maria1, Cornelia G. van Helden-Meeuwsen1, Zana Brkic1, Sandra M.J. Paulissen1,2, Virgil A. Dalm1, Paul L. van Daele1, P. Martin van Hagen1, Sinead M. Gibney1,3, Andrew Harkin3, Hemmo A. Drexhage1, Erik Lubberts1,2 and Marjan A. Versnel1, 1Erasmus Medical Center, Immunology, Rotterdam, Netherlands, 2Erasmus Medical Center, Rheumatology, Rotterdam, Netherlands, 3Trinity College Institute of Neuroscience, Neuropsychopharmacology, Dublin, Ireland

    Background/Purpose: A role for indoleamine-2,3-dioxygenase (IDO) in suppression of effector T-cell function and promotion of regulatory T-cell (Treg) differentiation has been described. IDO - the…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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