Abstracts tagged "T-Regulatory Cells"

Abstract Number: 481 • 2016 ACR/ARHP Annual Meeting
Dual Effect of 3-Bromopyruvate on Both Th17 and Treg Cell Differentiation and Dendritic Cell Activation Ameliorates Autoimmune Arthritis in Mice
Takaichi Okano¹, Jun Saegusa², Keisuke Nishimura³, Yo Ueda⁴, Sho Sendo², Soshi Takahashi⁵, Kengo Akashi³, Akira Onishi⁶ and Akio Morinobu², ¹Rheumatology and Clinical immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ²Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ³Department of Rheumatology, Kobe University Hospital, Kobe, Japan, ⁴Kobe University Graduate School of Medicine, Kobe, Japan, ⁵Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ⁶Department for Rheumatology, Kobe University Hospital, Kobe, Japan
Background/Purpose: Recent studies have shown that cellular metabolism plays an important role in regulating immune cell function. In the process of cell differentiation, both interleukin-17-producing…
Abstract Number: 1032 • 2016 ACR/ARHP Annual Meeting
Early In Vivo Induction of Mouse Interferon-alpha1 Overexpression Triggers an Expansion of Highly Suppressive Regulatory T Lymphocytes Protecting Against Experimental Arthritis
Katarzyna Matyja^1,2, Matthieu Ribon^1,2, Roxane Hervé^1,2, Delphine Lemeiter^1,2, Ken Tsumiyama³, Natacha Bessis^1,2, Shunichi Shiozawa³, Marie-Christophe Boissier^1,2,4 and Patrice Decker^1,2, ¹Li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, ²UMR 1125, Inserm, Bobigny, France, ³Department of Medicine, Rheumatic Diseases Unit, Kyushu University Beppu Hospital, Beppu, Japan, ⁴Rheumatology Department, Assistance Publique – Hôpitaux de Paris (AP-HP), Avicenne Hospital, Bobigny, France
Background/Purpose: Type I interferons (IFN-I) can be both anti- and pro-inflammatory. Among them, IFN-α inhibits normal Th17 differentiation, whereas it is pathogenic in lupus. The…
Abstract Number: 903 • 2015 ACR/ARHP Annual Meeting
CGEN-15001, a Novel B7-like Protein, Controls Inflammation in a Translational Rheumatoid Arthritis (RA) Assay and Induces Treg Driven Long-Term Remission in an Autoimmune Disease Model
Iris Hecht¹, Ashley Gilmour², Clare Tange², Donna McIntyre², Joseph R. Podojil³, Kay McNamee⁴, Galit Rotman⁵, Eyal Neria⁵, Mariola Kurowska-Stolarska², Richard O. Williams⁴, Stephen D. Miller³ and Iain B. McInnes^2,6, ¹Therapeutic Proteins, Compugen Ltd., Tel Aviv, Israel, ²Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ³Microbiology-Immunology, Northwestern University, Chicago, IL, ⁴Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, ⁵Compugen Ltd., Tel Aviv, Israel, ⁶Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: CGEN-15001 is an Fc fusion protein composed of the extracellular domain of a novel B7-like protein. Therapeutic CGEN-15001 treatment is effective in collagen induced…
Abstract Number: 1037 • 2015 ACR/ARHP Annual Meeting
Impaired Regulatory T Cell Survival in the Pathogenesis of Autoreactive Arthritis Mediated By CD11c-Deletion of Flip
Qi Quan Huang¹, Renee E. Doyle¹, Robert Birkett², Deyu Fang³, Syamal K. Datta¹ and Richard M. Pope¹, ¹Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: We have generated a mouse line with Flip conditionally deleted in CD11c-cre expressing cells (CD11c-Flip-KO, named HUPO), which spontaneously develops erosive arthritis resembling rheumatoid…
Abstract Number: 1751 • 2015 ACR/ARHP Annual Meeting
Modulation of IRF4 Function Promotes Expansion of Effector Tregs in Lupus
Alessandra B. Pernis¹, Uma Chandrasekaran², Woelsung Yi², Sanjay Gupta³, Chien-Huan Weng⁴, Eugenia Giannopoulou², Yurii Chinenov⁵, Govind Bhagat⁶, Rolf Jessberger⁷ and Casey Weaver⁸, ¹Autoimmunity & Inflammation, Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Autoimmunity & Inflammation Research Program, Hospital for Special Surgery, New York, NY, ⁴Weill Cornell Medical College, New York, NY, ⁵Arthritis & Tissue Degeneration Program, Hospital for Special Surgery, New York, NY, ⁶Department of Pathology & Cell Biology, Columbia University, New York, NY, ⁷Dresden University of Technology, Dresden, Dresden, Germany, ⁸University of Alabama, Birmingham, AL
Background/Purpose: Acquisition of an effector phenotype is critical for Treg function in chronic inflammatory settings such as those encountered in autoimmune diseases like lupus. Although…
Abstract Number: 1938 • 2015 ACR/ARHP Annual Meeting
Engaging PD-1 Resuscitates Synovial Treg Cells and Dampens the Joint Infiltrating T Cells in Rheumatoid Arthritis
Dipendra Kumar Mitra¹ and Kaustav Chowdhury², ¹Transplant Immunology & Immunogenetics, All India Institute of Medical Sciences, Delhi, India, ²TRANSPLANT IMMUNOLOGY AND IMMUNOGENETICS, ALL INDIA INSTITUTE OF MEDICAL SCIENCES, New Delhi, India
Background/Purpose: Enrichment of regulatory T cells (Treg) has been reported in the synovial fluid (SF) of RA patients, although they fail to alleviate the joint…
Abstract Number: 1947 • 2015 ACR/ARHP Annual Meeting
Hypermethylation of Treg-Specific Demethylated Regions in the Ikaros Transcription Factor Family Members, Helios and Eos, in Rheumatoid Arthritis Tregs
Alla Skapenko¹, Viktoria Soentgerath¹, Sonja Haupt², Jan Leipe¹ and Hendrik Schulze-Koops¹, ¹Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany, ²Division of Rheumatology and Clinical Immunology, Med.Klinik und Poliklinik IV, University of Munich, Munich, Germany
Background/Purpose: Foxp3 is the signature transcription factor of regulatory T cells (Tregs) and facilitates many of the characteristic functions of Tregs. Members of the Ikaros…
Abstract Number: 1950 • 2015 ACR/ARHP Annual Meeting
Methylation-Dependent Interference of Two Promoters for the Treg-Specific Protein, Garp, Contributes to Altered Treg Function in Rheumatoid Arthritis
Viktoria Soentgerath¹, Sonja Haupt², Jan Leipe³, Hendrik Schulze-Koops¹ and Alla Skapenko¹, ¹Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany, ²Division of Rheumatology and Clinical Immunology, Med.Klinik und Poliklinik IV, University of Munich, Munich, Germany, ³Division of Rheumatology, University of Munich, Munich, Germany
Background/Purpose: Recently, genome-wide studies identified several Treg-specific genes containing hypomethylated regions that are critical for their expression, so called Treg-specific demethylated regions (TSDR). For example,…
Abstract Number: 2581 • 2015 ACR/ARHP Annual Meeting
TNF-Alpha Receptor II Signaling Plays an Important Role in Maintaining the Expression of Forkhead Box P3 in Murine Regulatory T Cells
Wen-Yi Tseng^1,2, Kay McNamee¹, Adam Cribbs³, Anviti Vyas¹ and Richard O. Williams¹, ¹Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, ²Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan, ³Computational Genomics and Training Centre, MRC Functional Genomics Unit, University of Oxford, Oxford, United Kingdom
Background/Purpose: TNF-α is a key regulator of inflammation, which induces signal transduction by binding to two structurally and functionally distinct receptors on target cells: TNF…
Abstract Number: 3020 • 2015 ACR/ARHP Annual Meeting
IL-21 Abrogates CD4+CD25+FOXP3+ Treg Differentiation in Part By Suppressing Treg GATA-3 Expression in SLE
Hiroshi Kato¹ and Andras Perl², ¹Division of Rheumatology/Internal Medicine, SUNY Upstate Medical University, Syracuse, NY, ²Department of Medicine, SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Previous studies point to qualitative and quantitative Treg insufficiencies underlying aberrant T-cell activation in SLE. GATA-3 is critical in lineage commitment and functions of…
Abstract Number: 3022 • 2015 ACR/ARHP Annual Meeting
Characterizing a Novel Gene, Mosaic, and Its Role in Mediating a Multisystem Autoimmunity
Alice Chan¹, Emily Brown², Oded Foreman³, Anita Oberbauer⁴, Angela Hughes⁵, Shelly Burton⁶, Hong-Erh Liang⁷, Mark Anderson⁸ and Danika Bannasch⁹, ¹Pediatric Rheumatology, University of California San Francisco, San Francisco, CA, ²Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA, ³Genentech, Inc, South San Francisco, CA, ⁴Department of Animal Science, School of Veterinary Medicine, University of California Davis, Davis, CA, ⁵Mars Veterinary, Gaithersburg, MD, ⁶Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE, Canada, ⁷Medicine, University of California San Francisco, San Francisco, CA, ⁸Diabetes Center, University of California San Francisco, San Francisco, CA, ⁹Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA
Background/Purpose: A novel candidate gene, Mosaic (Multi-Organ System Autoimmunity in Canines), was identified as the culprit causing an early and severe multiorgan autoimmunity in a…
Abstract Number: 3142 • 2015 ACR/ARHP Annual Meeting
Tocilizumab Enhances Regulatory T-Cell Activation and Proliferation in Giant Cell Arteritis
Chie Miyabe¹, Klemen Strle², Yoshishige Miyabe¹, John H. Stone^1,3, Andrew D. Luster^1,4 and Sebastian Unizony^1,5, ¹Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Rheumatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Massachusetts General Hospital, Charlestown, MA, ⁵Rheumatology, Massachusetts General Hospital, Boston, MA
Background/Purpose : CD4+ T helper (Th) 17 cells, Th1 cells, and regulatory T-cells (Treg) contribute to the pathogenesis of giant cell arteritis (GCA). Interleukin (IL)-6,…
Abstract Number: 3221 • 2015 ACR/ARHP Annual Meeting
Safety and Efficiency of Low-Dose Interleukin-2 Treatment in Systemic Lupus Erythematosus
Jing He¹, Xia Zhang², Yunbo Wei³, Xiaolin Sun⁴, Jianping Guo⁵, Yuebo JIn⁶, Rulin Jia⁶, Lei Zhu⁶, Zhaohua Hou⁷, Yaping Chen⁸, Yuan An⁶, Yuan Jia⁶, Xu Liu⁶, Limin Ren⁶, Ru Li⁶, HUA YE⁹, Shi Chen⁶, Xuewu Zhang¹⁰, Yin Su¹¹, Eric Morand¹², Yu Di¹³ and Zhanguo Li⁶, ¹Peking Univerisity People's Hospital, Beijing, China, ²Department of Rheumatology & immunology, Peking University People's Hospital, Beijing, China, ³Immunology for Environment and Health, Shandong Analysis and Test Center, Shandong Academy of Science, Shandong, China, ⁴People's hospital,Peking University, Beijing, China, ⁵Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, ⁶Peking University People's Hospital, Beijing, China, ⁷Shandong Analysis and Test Center, Beijing, China, ⁸Monash University, Clayton, Austria, ⁹No.11 XIZHIMENG SOUTH STREET,, Peking University People's Hospital, Beijing, China, ¹⁰Rheumatology, Peking University People's Hospital, Beijing, China, ¹¹Department of Rheumatology and Immunology,Clinical Immunology Center, Peking University People's Hospital, Beijing, China, ¹²Medicine, Monash University, Clayton, Australia, ¹³Molecular Immunomodulation Laboratory, Monash University, Clayton, Austria
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with multi-system involvement, associated with an imbalance between effector and regulatory CD4+ T cells. The…
Abstract Number: 449 • 2014 ACR/ARHP Annual Meeting
Citrullinated-Vimentin-Specific Regulatory T-Cell Responses Associate with ACPA Positive Individuals with Non-Specific Musculoskeletal Symptoms
Aamir Aslam¹, Jackie L. Nam¹, Laura Hunt¹, Chadi Rakieh¹, Ann W. Morgan² and Paul Emery¹, ¹NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom
Background/Purpose: The pathogenesis of RA can be conceptualised by sequential phases that precede the development of synovitis. Autoimmune antibody responses, including ACPA, can precede clinical…
Abstract Number: 335 • 2014 ACR/ARHP Annual Meeting
Interleukin-33 Suppresses Experimental Arthritis through Promoting Foxp3⁺ Regulatory T-Cells and Type-2 Immune Responses in Mice
Jerome Biton¹, Allan Thiolat¹, Sara khaleghparast Athari¹, Delphine Lemeiter², Roxanne Herve¹, Patrice Decker¹, Jean-Philippe Girard³, Stephane Roga³, André Herbelin⁴, Anais Levascot⁴, Marie-Christophe Boissier² and Natacha Bessis¹, ¹INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité and Rheumatology Department, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Bobigny, France, ²INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France, ³Centre National de la Recherche Scientifique, Institut de Pharmacologie, dUniversité de Toulouse, Université Paul Sabatier, Institut de Pharmacologie et de Biologie Structurale et de Biologie Structurale, toulouse, France, ⁴INSERM U1082, Pôle Biologie Santé,, poitiers, France
Background/Purpose Interleukin (IL)-33 is a new member of the IL-1 family that exerts pleiotropic activities in innate and adaptive immunity. With its receptor ST2, they…

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