ACR Meeting Abstracts

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Abstracts tagged "T cells"

  • Abstract Number: 1442 • 2012 ACR/ARHP Annual Meeting

    IRF-1 Deficient Lupus-Prone MRL/Lpr Mice Show Reduced Glomerulonephritis but Develop Severe Interstitial Nephritis, Renal Vasculitis and Pulmonary Granulomas with Propensity for Th2 Polarity

    Hidemaru Sekine1, Takeshi Machida1, Natsumi Sakamoto1, Eiji Suzuki2, Xian Zhang3, Christopher Reilly4 and Gary S. Gilkeson5, 1Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan, 2Medicine, Medical University of South Carolina, Charleston, SC, 3Medicine, Medical University of South Carolina and Ralph H. Johnson VA Medical Center, Charleston, SC, 4Virginia Tech, Blacksburg, VA, 5Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC

    Background/Purpose: The transcription factor interferon regulatory factor-4 (IRF-4) and -1 (IRF-1) are members of the IRF family of transcription regulators and involved in the development…
  • Abstract Number: 519 • 2012 ACR/ARHP Annual Meeting

    Sex-Specific Regulatory T Cell Dysfunction in a Mouse Model of Sjögren Syndrome

    Scott M. Lieberman1, Portia A. Kreiger2 and Gary A. Koretzky3, 1Pediatrics, Div Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, 2Pathology, Nemours/A.I. DuPont Hospital for Children, Wilmington, DE, 3Medicine, University Pennsylvania, Philadelphia, PA

    Background/Purpose: CD4+Foxp3+ regulatory T cells (Tregs) are a specialized population of lymphocytes which prevent autoimmunity in normal hosts. Treg dysfunction has been implicated in autoimmunity; however results…
  • Abstract Number: 2331 • 2012 ACR/ARHP Annual Meeting

    The Effects of Anti–Tumor Necrosis Factor Agents On the Expansion of T Helper-Type 17 Cells Driven by Lipopolysaccharide-Stimulated Monocytes

    Gianluca Fossati1, Louise Healy1 and Andrew Nesbitt2, 1UCB Pharma, Slough, United Kingdom, 2UCB Pharma, SLough, United Kingdom

    Background/Purpose: T helper-type 17 (Th17) cells are proinflammatory CD4+ cells characterized by the production of Interleukin-17 (IL-17).There is evidence that IL-17 and other cytokines which…
  • Abstract Number: 2320 • 2012 ACR/ARHP Annual Meeting

    Superantigen Induces IL-17 Production From Extremely Polarized Th1 Clones

    Kentaro Yomogida1, Yuan K. Chou1 and Cong-Qiu Chu2, 1Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR, 2Rheumatology, Oregon Health & Science Univ and Portland VA Medical Center, Portland, OR

    Background/Purpose: Differentiation of naïve CD4+ T cells is considered to be an irreversible event and, in particular, the plasticity is thought to be completely lost…
  • Abstract Number: 1447 • 2012 ACR/ARHP Annual Meeting

    A Synthetic Triterpenoid CDDO-Me Prevents and Reverses Murine Lupus Nephritis

    Tianfu Wu1, Yujin Ye1, Mei Yan1, Xin J. Zhou2, Michael Andreef3 and Chandra Mohan1, 1Division of Rheumatology/Internal Medicine, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX, 2Internal Medicine - Rheumatic Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, 3Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M. D. Anderson Cancer Center, Houston, TX

    Background/Purpose: Current treatment options for lupus are far from optimal. Previously, we have reported that PI3K/AKT/mTOR, MEK1/Erk1,2, p38, STAT3, STAT5, NF-κB, multiple Bcl-2 family members,…
  • Abstract Number: 521 • 2012 ACR/ARHP Annual Meeting

    Differences in Genome-Wide DNA Methylation Profiles Across Multiple Cell and Tissue Types in Sjögren’s Syndrome (SS)

    Lindsey A. Criswell1, Diana Quach2, Hong L. Quach2, Emon Elboudwarej2 and Lisa F. Barcellos2, 1Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, Division of Rheumatology, University of California San Francisco, San Francisco, CA, 2Epidemiology, University of California, Berkeley, Berkeley, CA

    Background/Purpose: Increasing evidence supports a role for epigenetic factors, including DNA methylation status, in autoimmune disease risk and severity. Our goal is to characterize DNA…
  • Abstract Number: 2332 • 2012 ACR/ARHP Annual Meeting

    Suppression of PP2Ac Causes DNA Hypermethylation Through Enhanced Pmek/Perk Activity in T Cells

    Katsue S. Watanabe1, Kamalpreet Nagpal2 and George C. Tsokos3, 1Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan, 2Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 3Medicine/Rheumatology, BIDMC, Harvard Medical School, Boston, MA

    Background/Purpose: Although many reports have focused on the impaired MEK-ERK signaling pathway in T cells from systemic lupus erythematosus (SLE) patients which results in suppression…
  • Abstract Number: 2322 • 2012 ACR/ARHP Annual Meeting

    Dynamic Regulation of T Follicular Helper Cell Differentiation Through STAT Signaling

    Shingo Nakayamada1, Yuka Kanno2, Golnaz Vahedi2, John J. O'Shea2 and Yoshiya Tanaka1, 1First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, 2National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD

    Background/Purpose: T follicular helper (Tfh) cells are a new subset of T cells that regulate B cell function and exert an important role in the…
  • Abstract Number: 1453 • 2012 ACR/ARHP Annual Meeting

    Estrogen Receptor Alpha Impacts Th17 Expansion in Murine Lupus

    Melissa A. Cunningham1, Osama S. Naga2, Jackie G. Eudaly3 and Gary S. Gilkeson4, 1Med/Rheumatology, MUSC, Charleston, SC, 2Medicine/Rheumatology, Medical University of South Carolina, Charleston, SC, 3Med/Rheumatology, Medical University of SC, Charleston, SC, 4Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC

    Background/Purpose: Systemic lupus erythematosus is a disease that disproportionately affects females. The mechanisms underlying the female predominance in this disease are largely unknown. We previously…
  • Abstract Number: 509 • 2012 ACR/ARHP Annual Meeting

    IL-7 and Toll-Like Receptor 7 Synergistically Increase Th1/Th17/Th22 Cytokine Secretion and Activity of B Cells

    A. Bikker1, A.a. Kruize1, F. Redegeld2, W. de Jager3, F.P.J.G. Lafeber4 and J.A.G. van Roon5, 1Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Dept Pharmacology UU, Utrecht, Netherlands, 3Dept Immunology, UMC Utrecht, Utrecht, Netherlands, 4Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 5Rheumatology & Clinical Immunology/Lab Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose:  IL-7 is a potent T cell activating cytokine that has been shown to cause proliferation, survival and differentiation of T cells as well as…
  • Abstract Number: 2333 • 2012 ACR/ARHP Annual Meeting

    A Novel Subset of CD4 T Cells That Provides Help for Human Memory B Cell Responses

    Sang T. Kim, Jin Young Choi, Begona Lainez and Joseph E. Craft, Internal Medicine, Section of Rheumatology, Yale University School of Medicine, New Haven, CT

    Background/Purpose: Follicular helper T (Tfh) cells provide help to B cells in germinal centers (GCs) of secondary lymphoid organs (SLOs) following primary antigen (Ag) challenge,…
  • Abstract Number: 2323 • 2012 ACR/ARHP Annual Meeting

    A Genetic Polymorphism on New Zealand Black Chromosome 1 Is Associated with Abnormal Dendritic Cell Function Leading to Expansion of TH1, TH17 and T Follicular Helper (TFH) Cells

    Nafiseh Talaei1, Carolina Landolt-Marticorena2, Babak Noamani1, Evelyn Pau3, Nan-Hua Chang4 and Joan E. Wither5, 1Genetics and developmental biology, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, 2Rheumatology, University Health Network, Toronto, ON, Canada, 3Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, 4Genetics and Development, Toronto Western Research Institute, Toronto Western Hospital, Toronto, ON, Canada, 51E420/Div of Rheumatology, Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada

    Background/Purpose: We have previously shown that B6 mice with an introgressed homozygous New Zealand Black chromosome (c) 1 interval (70 to 100 cM) develop high titres…
  • Abstract Number: 1195 • 2012 ACR/ARHP Annual Meeting

    Identification of Follicular Helper T Cells As a Novel Cell Population Potentially Involved in the Pathogenesis of Rheumatoid Arthritis

    Sharon Ing1, Anika Alarakhia1, Elvira Lindwall1, Austin Fraser1, Jerald M. Zakem1, William E. Davis1, Tamika A. Webb-Detiege1, Robert Quinet1 and Xin Zhang2, 1Rheumatology, Ochsner Medical Center, New Orleans, LA, 2Institute of Translational Research, Ochsner Medical Center, New Orleans, LA

    Background/Purpose: Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the synovium, causing progressive joint destruction and reduction in quality of life…
  • Abstract Number: 407 • 2012 ACR/ARHP Annual Meeting

    The I50V IL4R SNP Is Associated with Increased Th17 Cell Frequency and Poor Clinical Outcome in Rheumatoid Arthritis

    Jan Leipe1, Iryna Prots2, Markus A. Schramm1, Matthias Witt1, Axel P. Nigg1, Christiane S. Reindl1, Claudia Dechant1, Mathias Grunke1, Hendrik Schulze-Koops1 and Alla Skapenko3, 1Division of Rheumatology and Clinical Immunology, Med. Klinik und Poliklinik IV, University of Munich, Munich, Germany, 2Friedrich-Alexander-University Erlangen-Nürnberg, Junior Research Group III, Interdisciplinary Center for Clinical Research Nikolaus-Fiebiger Center for Molecular Medicine, Erlangen, 3Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany

    Background/Purpose: A single nucleotide polymorphism (SNP) in the IL4R gene (I50V, rs 1805010) has previously been associated with an aggressive destructive course of rheumatoid arthritis…
  • Abstract Number: 2334 • 2012 ACR/ARHP Annual Meeting

    T-Cell Cross Reactivity with Citrullinated Antigen and P. Gingivalis Membrane Antigen Following Infection with P. Gingavalis and/or Injection of Citrullinated Mouse Type II Collagen in DBA/1J Mice

    Michael J. Duryee1, Anand Dusad2, Carlos D. Hunter1, Ke Ren3, Dong Wang4, James R. O'Dell5, Lynell W. Klassen5, Ted R. Mikuls6 and Geoffrey M. Thiele7, 1Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 2Rheumatology, University of Nebraska Medical Center, Omaha, NE, 3College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, 4Pharmaceutical Sciences, Univ of Nebraska Medical Ctr, Omaha, NE, 5Dept of Internal Medicine, Univ of Nebraska Med Ctr, Omaha, NE, 6Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 7Int Med/Sec of Rheum/Immun, Univ of Nebraska Med Ctr, Omaha, NE

    Background/Purpose: Recently, periodontal disease (PD) has been associated with the risk and progression of RA.  Patients with RA complicated by PD have been shown to…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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