Abstracts tagged "T cells"

Abstract Number: 2075 • 2012 ACR/ARHP Annual Meeting
CCR6⁺Foxp3⁺ Regulatory T Cells Regulate the Development of Collagen Induced Arthritis in T Cell Specific RORγt Transgenic Mice
Yuya Kondo¹, Masahiro Tahara¹, Mana Iizuka¹, Hiroto Tsuboi¹, Satoru Takahashi², Isao Matsumoto¹ and Takayuki Sumida¹, ¹Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Department of Anatomy and Embryology, Faculty of Medicine,, University of Tsukuba, Tsukuba, Japan
Background/Purpose: Recent studies reported that IL-17 producing Th-17 cells appear to play an important role in the generation of several autoimmune arthritis models. We previously…
Abstract Number: 1064 • 2012 ACR/ARHP Annual Meeting
CD1c-Expressing Myeloid Dendritic Cells From Joints of Rheumatoid Arthritis Patients Produce Increased Levels of T Cell-Attracting Chemokines and Strongly Activate Autologous T Cells
F.M. Moret¹, C.E. Hack², F.P.J.G. Lafeber¹, T.R.D.J. Radstake¹ and J.A.G. van Roon¹, ¹Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Immunology, UMC Utrecht, Utrecht, Netherlands
Background/Purpose: Myeloid dendritic cells (mDCs) are potent T cell-activating antigen-presenting cells that have been implicated to play a crucial role in the regulation of tolerance…
Abstract Number: 2508 • 2012 ACR/ARHP Annual Meeting
miR142-3p Interfers with T Cell Proliferation by Targeting the Expression of Garp in Patients with Rheumatoid Arthritis
Qihui Zhou¹, Sonja Haupt¹, Johannes Thomas Kreuzer¹, Hendrik Schulze-Koops¹ and Alla Skapenko², ¹Division of Rheumatology and Clinical Immunology, Med.Klinik und Poliklinik IV, University of Munich, Munich, Germany, ²Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany
Background/Purpose: Rheumatoid arthritis (RA) is a systematic chronic inflammatory disorder, characterized by severe joint destruction. Regulatory T cells (Tregs) have been implicated to be important…
Abstract Number: 2340 • 2012 ACR/ARHP Annual Meeting
A Numeric Expansion of Invariant Natural Killer T Cells Protects Against the Progression of Fatal Autoimmunity in Lupus-Prone Mice
Yuriy Baglaenko¹, Nan-Hua Chang², Evelyn Pau³, Christina Loh⁴ and Joan E. Wither⁵, ¹Immunology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ²Genetics and Development, Toronto Western Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ³Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ⁴Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, ⁵1E420/Div of Rheumatology, Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Previous studies from our lab have shown that the introgression of a NZB chromosome 1 (c1) interval extending from 135 to179 Mb onto the…
Abstract Number: 1783 • 2012 ACR/ARHP Annual Meeting
TNFα Influences RasGRP1 and RasGRP3 Expression Levels in PBMC, B and T Cells
Marie-Laure Potier¹, Martine Hiron¹, Clément Guillou¹, Céline Derambure², Olivier Boyer³, Xavier Le Loët⁴, Olivier Vittecoq⁵ and Thierry Lequerré⁶, ¹Inserm 905 & Institute for Biomedical Research, University of Rouen, Rouen, France, ²Inserm 905 & Institute for Biomedical Research, University of Rouen, Rouen, France, Rouen, France, ³Immunology, Inserm 905, Institute for Biomedical research, University of Rouen, Rouen, France, ⁴Rheumatology Department, Department of Rheumatology, Rouen University Hospital & Inserm 905, Institute for Biomedical Research, University of Rouen, Rouen Cedex, France, ⁵Rheumatology, Department of Rheumatology, Rouen University Hospital & Inserm 905, Institute for Biomedical Research, University of Rouen, Rouen Cedex, France, ⁶Rheumatology Department & Inserm 905, Department of Rheumatology, Rouen University Hospital & Inserm 905, Institute for Biomedical Research, University of Rouen, Rouen Cedex, France
Background/Purpose: Rheumatoid arthritis (RA) is the most common inflammatory arthritis. B and T lymphocytes play a central role in the pathophysiology of RA. RasGRP is…
Abstract Number: 896 • 2012 ACR/ARHP Annual Meeting
Tyro3, Axl, MerTK-Receptor Activation by Gas6 or Pros1 Gene Delivery, ameliorates Collagen-induced arthritis
Fons A.J. van de Loo¹, Ben T. van Den Brand², Shahla Abdollahi-Roodsaz³, Eline A. Vermeij⁴, Miranda B. Bennink⁴, Onno J. Arntz⁵ and Wim B. van den Berg⁶, ¹Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁴Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁵Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Nijmegen, Netherlands, ⁶Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Insufficient controlled activation of innate immunity by cytokines and pattern recognition receptors could develop into auto-immune diseases. Stimulation of dendritic cells via the Axl receptor…
Abstract Number: 2523 • 2012 ACR/ARHP Annual Meeting
Periodontal Pathogens Directly Promote Autoimmune Experimental Arthritis by Inducing a Toll-Like Receptor 2 and Interleukin-1 Driven Th17 Response
Shahla Abdollahi-Roodsaz¹, Sabrina Garcia de Aquino², Marije I. Koenders³, Fons A. van de Loo⁴, Ger J. Pruijn⁵, Mario J. Avila Campos⁶, Fernando Q. Cunha⁷, Joni A. Cirelli² and Wim B. van den Berg¹, ¹Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Department of Diagnosis and Oral Surgery, Periodontic Division, Araraquara Dental School, Sao Paolo, Brazil, ³Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, ⁴Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁵Department of Biomolecular Chemistry, Radboud University, Nijmegen, Netherlands, ⁶Department of Microbiology, Institute of Biomedical Sciences—ICB/USP, Sao Paulo, Brazil, ⁷Department of Pharmacology, School of Medicine of Ribeirao Preto, Sao Paolo, Brazil
Background/Purpose: The periodontal pathogen Porphyromonas gingivalishas been associated with the pathogenesis of rheumatoid arthritis (RA) because of its ability to citrullinate mammalian proteins and to…
Abstract Number: 2342 • 2012 ACR/ARHP Annual Meeting
Synovial Tissue Analysis in the Pre-Clinical Phase of Arthritis: T-Cell Infiltration Preceding the Development of Arthritis
Maria J. H. de Hair¹, Marleen G. H. van de Sande¹, Tamara H. Ramwadhdoebe², Robert B. M. Landewé³, Christiaan van der Leij⁴, Mario Maas⁵, Dirkjan van Schaardenburg⁶, Danielle Marie Gerlag¹, Lisa G.M. van Baarsen² and Paul P. Tak⁷, ¹Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ²Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology , Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ³Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam & Atrium Medical Center, Amsterdam, Netherlands, ⁴Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁵Department of Radiology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ⁶Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ⁷Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands
Background/Purpose: We have previously shown in a pilot study that there is no evident synovial inflammation in autoantibody-positive individuals who are at risk of developing…
Abstract Number: 1788 • 2012 ACR/ARHP Annual Meeting
TSLP Induces TNFα Production by CD1c Myeloid Dendritic Cells and Myeloid DC-Activated T Cells From Rheumatoid Arthritis Patients
F.M. Moret¹, T.R.D.J. Radstake², J.W.J. Bijlsma¹, F.P.J.G. Lafeber¹ and J.A.G. van Roon³, ¹Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Rheumatology & Clinical Immunology/Lab Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Thymic stromal lymphopoietin (TSLP) is well known for its potent activation of myeloid dendritic cells (mDCs) to induce Th2-mediated immune responses. Fibroblasts from rheumatoid arthritis…
Abstract Number: 885 • 2012 ACR/ARHP Annual Meeting
Interferon α and Self-Organized Criticality Theory
Shunichi Shiozawa¹, Yumi Miyazaki² and Ken Tsumiyama³, ¹Department of Medicine, Kyushu University Beppu Hospital, Beppu, Japan, ²Kyushu University Beppu Hospital/ Kobe University Graduate School of Health Sciences, Beppu/ Kobe, Japan, ³Department of Rheumatology, Kyushu University Beppu Hospital, Beppu, Japan
Background/Purpose: One of the biggest obstacle we face in elucidating the pathogenesis of autoimmunity today is the mechanism how autoreactive lymphocyte clones could survive or…
Abstract Number: 2504 • 2012 ACR/ARHP Annual Meeting
SOCS1 Is One of the Key Molecules to Prevent the Plasticity of Regulatory T Cells and the Development of Autoimmunity
Reiko Takahashi¹, Kenji Itoh¹, Fumihiko Kimura¹ and Akihiko Yoshimura², ¹Division of Rheumatology, Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan, ²Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Suppression of autoimmunity or inflamation by regulatory T cells (Tregs) is now well established, recently, natural Foxp3+T cells have been shown to be a…
Abstract Number: 2343 • 2012 ACR/ARHP Annual Meeting
The Therapeutic Antibody Tregalizumab (BT-061) Induces Activation of Regulatory T Cells by Engaging a Unique CD4 Mediated Signaling That Strongly Differs From Signaling Events Induced by Standard Anti-CD4 Antibodies
Bianca Helling¹, Benjamin Daelken¹, Holger Wallmeier², Silke Aigner¹, Chantal Zuber¹, Martin Koenig¹, Andre Engling¹, Frank Osterroth¹, Niklas Czeloth³ and Christoph Uherek¹, ¹Biotest AG, Dreieich, Germany, ²Condor Scientific Computing & Consulting, Sulzbach, Germany, ³Global Research Immunology, Biotest AG, Dreieich, Germany
Background/Purpose: The humanized CD4 specific monoclonal antibody (mAb) tregalizumab is currently being tested in phase II clinical trials in Rheumatoid Arthritis. In contrast to other…
Abstract Number: 1793 • 2012 ACR/ARHP Annual Meeting
The Cyclooxygenase/Prostaglandin-E₂ Pathway Is Critical for Autocrine IL-17A Production by Th17 Cells Upon Synovial Fibroblast Interaction
Sandra M.J. Paulissen¹, Jan Piet van Hamburg², Nadine Davelaar³, Patrick S. Asmawidjaja³, Johanna M.W. Hazes⁴ and Erik Lubberts³, ¹Immunology, Erasmus Medical Center, Immunology, Rotterdam, Netherlands, ²Rheumatology, Erasmus MC, Rotterdam, Netherlands, ³Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁴Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands
Background/Purpose: Recently, we have shown that Th17, but not Th1 cells, from patients with early rheumatoid arthritis (RA) are potent activators of RA synovial fibroblasts…
Abstract Number: 857 • 2012 ACR/ARHP Annual Meeting
Impairment of the Inhibitory PD-1-PD-L1 Axis in Giant Cell Arteritis (GCA)
Mazen Nasrallah¹, Augusto Vaglio², Shalini Mohan¹, Bjorn Hartmann³, Joyce Liao⁴, Kenneth J. Warrington⁵, Jorg J. Goronzy³ and Cornelia M. Weyand⁶, ¹Medicine: Immunology and Rheumatology, Stanford University, Stanford, CA, ²Unit of Nephrology, University Hospital of Parma, Parma, Italy, ³Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁴Byers Eye Institute at Stanford, Stanford University, Palo Alto, CA, ⁵Division of Rheumatology, Mayo Clinic, Rochester, MN, ⁶Medicine, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Giant cell arteritis (GCA) is an autoimmune syndrome characterized by granuloma formation in the media of medium and large arteries. In a healthy immune…
Abstract Number: 2325 • 2012 ACR/ARHP Annual Meeting
PD-1 Signaling Promotes Suppressive Function of CD4⁺ Regulatory T Cells in (New Zealand Black x New Zealand White )F₁ Lupus-Prone Mice in a Dose-Dependent Manner
Maida Wong¹, Antonio La Cava² and Bevra H. Hahn³, ¹Internal Medicine/Rheumatology, University of California, Los Angeles, Los Angeles, CA, ²Internal Medicine/Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ³Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: Programmed death-1 (PD-1) has been regarded as a negative regulatory signal in T cells. Our laboratory has shown that PD-1 is important in T…

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