Abstracts tagged "T cells"

Abstract Number: 201 • 2012 ACR/ARHP Annual Meeting
High Rate of Autoimmune Manifestations During Idiopathic CD4 Lymphocytopenia
Alexis Régent¹, Brigitte Autran², Guislaine Carcelain², Benjamin Terrier³, Alain Krivitzky⁴, Eric Oksenhendler⁵, Nathalie Costedoat-Chalumeau⁶, Pascale Hubert², Olivier Lortholary⁷, Nicolas Dupin⁸, Patrice Debré², Loic Guillevin⁹ and Luc Mouthon¹, ¹Internal Medicine, Hopital Cochin, Paris, France, ²INSERM, UMR945, AP-HP, Hôpital Pitié-Salpêtrière, Laboratoire d'Immunologie Cellulaire Et Tissulaire, Paris, France, ³National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France, ⁴Département de médecine interne, Hôpital Avicenne, AP-HP, Bobigny, France, ⁵Département d'Immunologie Clinique, Hôpital Saint-Louis, AP-HP, Paris, France, ⁶Internal Medicine, Assistance Publique-Hôpitaux de Paris, Hopital Pitié-Salpétrière, Paris, France, ⁷Service de maladies infectieuses, Hôpital Necker-Enfants malades, AP-HP, Paris, France, ⁸Service de Dermatologie, Hôpital Cochin, AP-HP, Paris, France, ⁹Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France
Background/Purpose: When first described by the Center for Disease Control, idiopathic CD4 lymphocytopenia (ICL) was characterized by opportunistic infections in patients with a CD4 count≤300/mm3…
Abstract Number: 2335 • 2012 ACR/ARHP Annual Meeting
Increased TSLP Expression in Joints of Rheumatoid Arthritis Patients Causes Increased Activation of Intra-Articular Myeloid Dendritic Cells with Enhanced Th1 and Th17 Cell Activity
F.M. Moret¹, C.E. Hack², T.R.D.J. Radstake³, J.W.J. Bijlsma¹, F.P.J.G. Lafeber¹ and J.A.G. van Roon⁴, ¹Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Immunology, UMC Utrecht, Utrecht, Netherlands, ³Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Rheumatology & Clinical Immunology/Lab Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Thymic stromal lymphopoietin (TSLP) is well known for its potent activation of myeloid dendritic cells (mDCs) to induce Th2-mediated immune responses. Administration of TSLP…
Abstract Number: 2150 • 2012 ACR/ARHP Annual Meeting
Action of Tofacitinib Via Human Dendritic Cells
Satoshi Kubo¹, Kunihiro Yamaoka², Shigeru Iwata¹ and Yoshiya Tanaka¹, ¹First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
Background/Purpose: Tofacitinib, an oral Janus Kinase (JAK) inhibitor, has gathered attention in treatment of Rheumatoid arthritis (RA). Although JAKs are well known for its importance…
Abstract Number: 1055 • 2012 ACR/ARHP Annual Meeting
Sec61 Is Indispensable for Antigen Cross-Presentation and the Development of Lupus Nephritis: A Novel ‘Self-Organized Criticality Theory’ Explaining the Cause of Systemic Lupus Erythematosus (SLE)
Ken Tsumiyama and Shunichi Shiozawa, Department of Medicine, Kyushu University Beppu Hospital, Beppu, Japan
Background/Purpose: We found that systemic lupus erythematosus (SLE) was induced experimentally by repeatedly immunizing the mice normally not prone to autoimmune diseases by any exogenous…
Abstract Number: 2336 • 2012 ACR/ARHP Annual Meeting
Elevated Frequency of Synovial Interleukin-21⁺ CD4⁺ T Cells Co-Expressing Tumor Necrosis Factor-a in Rheumatoid Arthritis
Maria C. Lebre¹, Pedro L. Vieira², Saïda Aarrass³, Thomas Newsom-Davis², Paul P. Tak⁴ and Gavin R. Screaton², ¹Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam The Netherlands, Amsterdam, Netherlands, ²Department of Immunology, Imperial College London, London, United Kingdom, ³Clinical Immunology and Rheumatology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam The Netherlands, Amsterdam, Netherlands, ⁴Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting synovial tissue in multiple joints. The inflammatory process in RA is regulated by several cytokines,…
Abstract Number: 2090 • 2012 ACR/ARHP Annual Meeting
Orchestrating the Orchestrators: Blockade of Flt3L Signaling-Dependent Dendritic Cells Protects Against Collagen Induced Arthritis
Maria I. Martins Ramos¹, Karpus O.N. Karpus², Pleun Broekstra², Saïda Aarrass³, Paul P. Tak⁴ and Maria C. Lebre³, ¹Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Clinical Immunology and Rheumatology & Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁴Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands
Background/Purpose: Autoimmune diseases often result from inappropriate or unregulated activation of autoreactive T cells. The induction and maintenance of T cell tolerance to tissue antigens…
Abstract Number: 1060 • 2012 ACR/ARHP Annual Meeting
Protein Kinase C Inhibitor Generates Human Tolerogenic Dendritic Cells That Induce Tr1 and Foxp3⁺ Regulatory T Cells
Takuya Matsumoto, Hitoshi Hasegawa, Jun Ishizaki, Koichiro Suemori, Sachiko Onishi and Masaki Yasukawa, Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Toon, Japan
Background/Purpose: Tolerogenic dendritic cells (tDCs) play a critical role in immune tolerance and are involved in the pathogenesis of autoimmune diseases such as rheumatoid arthritis.…
Abstract Number: 2675 • 2012 ACR/ARHP Annual Meeting
Oral and Gut Microbiota Influence Immune Responses to Sjogren’s Syndrome Associated Antigen Ro60
Agnieszka Szymula¹, Barbara Szczerba¹, Harini Bagavant¹, Shu-Man Fu² and Umesh Deshmukh³, ¹Department of Medicine, University of Virginia, Charlottesville, VA, ²University of Virginia, Charlottesville, VA, ³Medicine, University of Virginia, Charlottesville, VA
Background/Purpose: Autoantibodies reactive against Ro60 protein are often found in patients with Sjogren’s syndrome. This study was undertaken to investigate the role of oral and…
Abstract Number: 2529 • 2012 ACR/ARHP Annual Meeting
Molecular Mechanism of IgG4 Class Switch Recombination in IgG4-Related Disease
Hiroto Tsuboi¹, Mana Iizuka¹, Hiromitsu Asashima¹, Sayaka Tsuzuki¹, Yuya Kondo¹, Akihiko Tanaka², Masafumi Moriyama², Isao Matsumoto¹, Seiji Nakamura² and Takayuki Sumida¹, ¹Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Faculty of Dental Science, Kyushu University, Fukuoka, Japan
Background/Purpose: IgG4-related disease (IgG4-RD) is a new disease entity characterized by high serum IgG4 levels, IgG4-positive plasmacytic infiltration and fibrosis in various organs. Although the…
Abstract Number: 2338 • 2012 ACR/ARHP Annual Meeting
1,25(OH)₂D₃ Modulates the Migration Pattern of Th17 Cells From Patients with Rheumatoid Arthritis
Wendy Dankers¹, Jan Piet van Hamburg², Patrick S. Asmawidjaja¹, Nadine Davelaar¹, Hoyan Wen³, Anne-Marie Mus¹, Edgar Colin², Johannes van Leeuwen⁴, Johanna M.W. Hazes⁵ and Erik Lubberts¹, ¹Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ²Rheumatology, Erasmus MC, Rotterdam, Netherlands, ³Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁴Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁵Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands
Background/Purpose: Vitamin D has suppressive effects on autoimmune diseases, such as rheumatoid arthritis (RA). Within these diseases, T-helper-17 (Th17) cells have been implicated to play…
Abstract Number: 2070 • 2012 ACR/ARHP Annual Meeting
Myeloid-Derived Suppressor Cells Accumulated in Spleens of Mice with Collagen-Induced Arthritis and Inhibited Immune Response of CD4⁺ T Cells
Wataru Fujii¹, Eishi Ashihara², Hideyo Hirai³, Hidetake Nagahara¹, Kazuki Fujioka¹, Ken Murakami¹, Kaoru Nakamura¹, Takahiro Seno¹, Aihiro Yamamoto¹, Hidetaka Ishino¹, Masataka Kohno¹, Taira Maekawa³ and Yutaka Kawahito¹, ¹Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan, ²Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan, ³Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan
Background/Purpose: Myeloid-derived suppressor cells (MDSCs), firstly reported in patients with cancer, have a myeloid origin and an ability to suppress T cell responses. MDSCs are…
Abstract Number: 1061 • 2012 ACR/ARHP Annual Meeting
Generation of Myeloid-Derived Suppressor Cells in Vitro From Murine Bone Marrow Precursors
Julia Kurko¹, Beata Tryniszewska¹, Tibor A. Rauch¹, Colt Egelston², Tibor T. Glant¹ and Katalin Mikecz¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Immunology, Rush University Medical Center, Chicago, IL
Background/Purpose: Myeloid-derived suppressor cells (MDSCs) are innate immune cells that expand under pathological conditions (such as cancer and autoimmune diseases) in response to local growth…
Abstract Number: 2682 • 2012 ACR/ARHP Annual Meeting
Calcium/Calmodulin-Dependent Protein Kinase IV Suppresses IL-2 Production and Regulatory T Cell Activity in Systemic Lupus Erythematosus
Tomohiro Koga¹, Kunihiro Ichinose², Masayuki Mizui³, José C. Crispín⁴ and George C. Tsokos⁴, ¹Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Department of Immunology and Rheumatology, Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Division of Rheumatology, Department of Medicine,, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁴Medicine/Rheumatology, BIDMC, Harvard Medical School, Boston, MA
Background/Purpose: T cells from patients with SLE exhibit abnormal signaling upon TCR engagement and have an altered gene expression profile. Accordingly, the regulation of several transcription factors…
Abstract Number: 2506 • 2012 ACR/ARHP Annual Meeting
Expression of Helios Facilitates Distinction Between FoxP3⁺ Treg and FoxP3⁺ Activated T Conventional Cells in Patients with Systemic Lupus Erythematosus
Amit Golding¹, Sarfaraz A. Hasni², Gabor G. Illei³ and Ethan M. Shevach⁴, ¹Medicine/Rheumatology and Clinical Immunology, Baltimore VA and University of Maryland School of Medicine, Baltimore, MD, ²Rheumatology, National Institutes of Health, Bethesda, MD, ³Sjogren's Clinic, NIDCR/ NIH, Bethesda, MD, ⁴Laboratory of Immunology, NIAID/NIH, Bethesda, MD
Background/Purpose: FoxP3 is not a reliable marker for distinguishing regulatory T (Treg) cells in humans due to the fact that FoxP3 may be up-regulated in…
Abstract Number: 2339 • 2012 ACR/ARHP Annual Meeting
Lowering Fli1 Levels Decreases the Levels of Lipid Mediators in the Kidneys and T Cells of MRL/Lpr Lupus Prone Mice
Marlene Bunni¹, Zainab Amani², Andrew Mather³, Jennifer Berglind Schepp³, Leah Siskind³ and Tamara K. Nowling⁴, ¹Medicine, Medical University of South Carolina, Charleston, SC, ²Medicine/Rheumatology, Medical University of South Carolina, Charleston, SC, ³Pharmaceutical & Biomedical Sciences, Medical University of South Carolina, Charleston, SC, ⁴Medicine/Rheumatology, Medical University of South Carolina and Ralph H. Johnson VA Medical Center, Charleston, SC
Background/Purpose: The Ets factor Fli1 is implicated as a key modulator of lupus disease expression. Over-expressing Fli1 in healthy mice, results in the development of…

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