Abstracts tagged "T cells"

Abstract Number: 2893 • 2013 ACR/ARHP Annual Meeting
Intestinal Microbiota Plays a Critical Role In The Production Of Antinuclear Antibodies In Lymphopenia-Induced Autoimmunity
Toshiki Eri¹, Kimito Kawahata¹, Mitsuru Imamura¹, Takeyuki Kanzaki², Lisa Akahira¹, Kazuya Michishita¹, Makoto Dohi¹, Takeshi Tokuhisa³ and Kazuhiko Yamamoto⁴, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Internal Medicine, Yamanashi Prefectural Central Hospital, Yamanashi, Japan, ³Development Genetics, Graduate School of Medicine, Chiba University, Chiba city, Chiba, Japan, ⁴Department of Allergy and Rhaumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Background/Purpose: Production of antinuclear autoantibodies (ANAs) is one of the major characteristics of the systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), but the…
Abstract Number: 1763 • 2013 ACR/ARHP Annual Meeting
IL4-10 Synerkine: A Novel Immunoregulatory Drug To Prevent Immunopathology In Rheumatic Diseases
Sarita Hartgring¹, Cristine Steen-louws², C.E. Hack³, Martin De Smet⁴, Floris Lafeber⁵ and J.A.G. van Roon⁶, ¹Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Rheumatology & Clinical Immunology/Lab Translational Immunology, UMC Utrecht, Utrecht, Netherlands, ³Immunology, UMC Utrecht, Utrecht, Netherlands, ⁴Lab Translational Immunology, UMC Utrecht, Utrecht, Netherlands, ⁵Rheumatology & Clinical Immunology, UMC Utrecht, Utrecht, Netherlands, ⁶Rheumatology & Clinical Immunology/Lab Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: A considerable percentage of patients shows a limited response to biologics targeting one specific inflammatory mediator, largely because of redundancy of these mediators. An…
Abstract Number: 727 • 2013 ACR/ARHP Annual Meeting
Adiponectin Promotes The Differentiation Of naïve T Cell To Th17 Cell and Aggravates Collagen-Induced Arthritis
Miaojia Zhang¹, Xiaoxuan Sun², Wenfeng Tan³, Xiaoke Feng⁴ and Ke Gan⁵, ¹Department of Rheumatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, CHINA., Nanjing, China, ²Department of Rheumatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, CHINA, Nanjing, China, ³Rheumatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ⁴Rheumatology, the First Affiliated Hospital of Nanjing Medical University, China, Nanjing, China, ⁵Rheumatology Department, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Background/Purpose: To investigate a role of Adiponectin (AD) on the differentiation of naïve T cell to Th17 cell and bone erosion in collagen-induced arthritis (CIA)…
Abstract Number: 557 • 2013 ACR/ARHP Annual Meeting
Inhibition of Calcium/Calmodulin-Dependent Protein Kinase 4 Ameliorates Th17 Related Autoimmune Disorder
Tomohiro Koga¹, Christian Hedrich¹, Masayuki Mizui², Nobuya Yoshida³, Linda Lieberman⁴, José C. Crispin¹ and George C. Tsokos⁵, ¹Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Division of Rheumatology, Department of Medicine,, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁴Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁵Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose: IL-17-producing T helper (Th17) cells have been causally linked to tissue inflammation in several autoimmune diseases including lupus and multiple sclerosis. Blockade of Th17…
Abstract Number: 2724 • 2013 ACR/ARHP Annual Meeting
cAMP Responsive Element Modulator (CREM)α Governs CD8 Expression and Contributes to the Generation of CD3⁺CD4^–CD8^– T Cells in Lupus
Christian M. Hedrich¹, José C. Crispín¹, Thomas Rauen¹, Christina Ioannidis¹, Tomohiro Koga², Noe Rodriguez Rodriguez², Sokratis A. Apostolidis³, Vasileios C. Kyttaris² and George C. Tsokos¹, ¹Medicine/Rheumatology, BIDMC, Harvard Medical School, Boston, MA, ²Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: CD3+CD4-CD8- "double negative" T cells are expanded in the peripheral blood of patients with systemic lupus erythematosus (SLE) and lupus-prone mice. Double negative T…
Abstract Number: 1643 • 2013 ACR/ARHP Annual Meeting
Ex Vivo Suppression Of RA Effector T Cells (Teff) By Mapc Media Is Synergistic With Treg
Gali Malul¹, David Soler², Donald D. Anthony³, Hillard M. Lazarus⁴, Nicholas Lehman⁵, Thomas McCormick², Julia M. Sugalski⁶, Anthony E. Ting⁵ and Nora G. Singer⁷, ¹Rheumatology, MetroHealth Medical Center, Cleveland, OH, ²Dermatology, Case Medical Center, Cleveland, OH, ³Medicine, Case Western Reserve University, Cleveland, OH, ⁴Comprehensive Cancer Center, Case Medical Center, Cleveland, OH, ⁵Athersys, Inc., Cleveland, OH, ⁶Medicine/infectious disease, Case Western Reserve University, Cleveland, OH, ⁷Medicine, Division of Rheumatology, MetroHealth Medical Center, Cleveland, OH
Background/Purpose: Use of mesenchymal/multipotent stem cells (MSCs/MAPCs) is an emerging immune modulatory therapeutic strategy promising for a number of human diseases. Multipotent adult progenitor cells…
Abstract Number: 728 • 2013 ACR/ARHP Annual Meeting
Unraveling The Identity Of FoxP3⁺ Regulatory T-Cells In Gpa-Patients
WH Abdulahad¹, Coen A. Stegeman², MG Huitema¹, Pieter C. Limburg³, Abraham Rutgers¹, Peter Heeringa⁴ and Cees G.M. Kallenberg¹, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Nephrology, University Medical Center Groningen, Groningen, Netherlands, ³Department of Laboratory Medicine, University Medical Center Groningen, Groningen, Netherlands, ⁴Pathology and Medical Biology, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Human FoxP3+ Th-cells are heterogeneous in function and include not only suppressive cells (TRegs) but also non-suppressive cells that abundantly secrete proinflammatory cytokines. We…
Abstract Number: 531 • 2013 ACR/ARHP Annual Meeting
Influenza Infection Of MHC-I Transgenic Mice Reveals That Erap Is Necessary and Sufficient For Generation Of The B27-Specific Immunodominant Epitope
Ali Akram¹ and Robert Inman², ¹Institute of Medical Science and Department of Immunology, University of Toronto and University Health Network (UHN), Toronto, ON, Canada, ²Immunlogy and Institute of Medical Science, University of Toronto and Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Although HLA-B27 and ERAP are known to confer susceptibility to spondyloarthritis (SpA), the role of these elements in modulating host response to infection is…
Abstract Number: 2725 • 2013 ACR/ARHP Annual Meeting
Regulation Of Aberrant CD4 T Cell Activation By Suppressor Of Cytokine Signaling-1 (SOCS1) Mimetic Peptide, Has Relevance To Human Systemic Lupus Erythematosus
Tenisha Wilson¹, Cristina Armbruster², Simone Bedoya², Howard M. Johnson², Westley H. Reeves³, Yi Li⁴, Ying Yi Zheng⁵, Laurence Morel⁶ and Joseph Larkin III², ¹Division of Rheumatology & Clinical Immunology, University of Florida, Gainesville, FL, ²Microbiology and Cell Science, University of Florida, Gainesville, FL, ³Rheumatology & Clinical Imm, University of Florida, Gainesville, FL, ⁴Medicine, University of Florida, Gainesville, FL, ⁵Pathology, University of Florida, Gainesville, FL, ⁶Pathology/Immunology/Lab Medical, University of Florida, Gainesville, FL
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease, mediated by aberrantly activated CD4 T cells. Notably, suppressor of cytokine signaling-1 (SOCS1) regulates CD4 T…
Abstract Number: 1645 • 2013 ACR/ARHP Annual Meeting
Circulating CD4+CD161+ T Lymphocytes Are Increased In Seropositive Arthralgia Patients But Decreased In Patients With Newly Diagnosed Rheumatoid Arthritis
Paulina Chalan¹, Bart-Jan Kroesen², Kornelis S.M. van der Geest¹, Minke G. Huitema¹, Wayel H. Abdulahad³, Elisabeth Brouwer¹ and Annemieke M.H. Boots⁴, ¹Dept. of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Dept. of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ⁴Dept. of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Improved understanding of the immune events discriminating between seropositive arthralgia and clinical synovitis is of key importance in rheumatology research. Ample evidence suggests a…
Abstract Number: 711 • 2013 ACR/ARHP Annual Meeting
1,25(OH)₂D₃ Inhibits Th17 Cytokine Production and RORγt Expression Through GATA3/IL4-Dependent and -Independent Mechanisms
Wendy Dankers¹, Jan Piet van Hamburg^2,3, Anne-Marie Mus¹, Patrick S. Asmawidjaja¹, Johannes van Leeuwen⁴, Rudi W. Hendriks⁵, Louis Boon⁶, Edgar Colin⁷ and Erik Lubberts^1,8, ¹Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ²Rheumatology, Erasmus MC, Rotterdam, Netherlands, ³Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁴Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁵Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁶Bioceros, Utrecht, Netherlands, ⁷Department of Rheumatology, ZGT, Almelo, Netherlands, ⁸Erasmus Medical Center, Rheumatology, Rotterdam, Netherlands
Background/Purpose: Vitamin D has suppressive effects on autoimmune diseases, such as rheumatoid arthritis (RA). One important mechanism of disease suppression by vitamin D is inhibition…
Abstract Number: 540 • 2013 ACR/ARHP Annual Meeting
Exploration Of a Novel Therapeutic Target In a Murine Model Of Systemic Lupus Erythematosus: Targeting Sphingosine-1-Phosphate (S1P) Receptors
Christopher Tracy¹, Jess Edison², S. Frattalone² and C. Moratz³, ¹Internal Medicine-Rheumatology, Walter Reed National Military Medical Center, Bethesda, MD, ²Department of Rheumatology, Walter Reed National Military Medical Center, Bethesda, MD, ³Department of Medicine, Uniformed Services University of Health Sciences, Bethesda, MD
Background/Purpose: Systemic lupus erythematous (SLE) is an autoimmune disease characterized by symptomatic flares that often result in terminal organ failure. The pathogenesis is characterized by…
Abstract Number: 2699 • 2013 ACR/ARHP Annual Meeting
Transcription Factor RFX1 Regulates Th17 Differentiation and Its Role In The Pathogenesis Of Systemic Lupus Erythematosus
Ming Zhao¹, Gongping Liang¹, Qian Tang², Yang Yang¹, Yixin Tan¹ and Qianjin Lu¹, ¹Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China, ²Second Xiangya Hospital, Central South University, Changsha, China
Background/Purpose: Recently, evidence is emerging that abnormal regulation of Th17 differentiation plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). However, the…
Abstract Number: 1648 • 2013 ACR/ARHP Annual Meeting
PD-1⁺CD45RB^lo122^lo Autoantibody-Inducing CD4 T Cells (aiCD4 T cells) As a Key In The Pathogenesis Of Systemic Lupus Erythematosus (SLE)
Yumi Miyazaki¹, Ken Tsumiyama² and Shunichi Shiozawa¹, ¹Department of Medicine, Kyushu University Beppu Hospital, Beppu, Japan, ²Department of Rheumatology, Kyushu University Beppu Hospital, Beppu, Japan
Background/Purpose: We found that systemic lupus erythematosus (SLE) was induced experimentally by repeatedly immunizing the mice normally not prone to autoimmune diseases by any exogenous…
Abstract Number: 714 • 2013 ACR/ARHP Annual Meeting
Combination Blocking Of Interleukin-6 and Interleukin-21 In Experimental Arthritis Inhibits Their Redundant Role In T Helper 17-Driven Joint Pathology
Debbie M. Roeleveld¹, Marije I. Koenders², Renoud J. Marijnissen^1,3, Cheryl L. Nickerson-Nutter⁴, Fons A. van de Loo¹ and Wim B. van den Berg⁵, ¹Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, ³Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, Netherlands, ⁴Immunology and Autoimmunity, Pfizer, Cambridge, MA, ⁵Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Both IL-6 and IL-21 have been described to drive in vitro Th17 differentiation in the presence of TGF-β. We explored whether also in vivo…

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