Abstracts tagged "T cells"

Abstract Number: 2678 • 2014 ACR/ARHP Annual Meeting
UC-MSCs Inhibit T Cell Autophagy and Apoptosis in Patients with Systemic Lupus Erythematosus through Mitochondrial Transfer
Jinyun Chen¹, Xuebing Feng² and Lingyun Sun², ¹The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ²Department of Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose This study is aimed to investigate the role of umbilical cord derived mesenchymal stem cells (UC-MSCs) on autophagy and apoptosis in T cells from…
Abstract Number: 1741 • 2014 ACR/ARHP Annual Meeting
Anti-TNFα Treatment Increases IL-17A+ and IL-22+ T Cells in Spondyloarthritis Regardless of Concomittant Gut Inflammation
Thomas Andersen¹, René Østgård^1,2, Bent Deleuran^1,2, Malene Hvid³ and Henning Glerup⁴, ¹Dept. of Biomedicine, Aarhus University, Aarhus, Denmark, ²Dept. of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ³Dept. of Clinical Medicine, Aarhus University, Aarhus, Denmark, ⁴Dept. of Gastroenterology, Regional Hospital of Silkeborg, Silkeborg, Denmark
Background/Purpose The pro-inflammatory Th17 associated cytokines IL-17A and IL-22 have been proposed as important mediators of the inflammation seen in spondyloarthritis (SpA) and inflammatory bowel…
Abstract Number: 1048 • 2014 ACR/ARHP Annual Meeting
Oncostatin M Suppresses Activation of IL-17/Th17 Via Suppressor of Cytokine signaling3 (SOCS3) Regulation in CD4+ T Cells
Young Ok Jung^1,2, seon Yeong Lee³, Sung Yeon Lee⁴, Mi-La Cho³ and Hea-Jin Son⁵, ¹Rheumatology dept, Internal medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, South Korea, ²Rheumatology dept, Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, South Korea, ³Rheumatism Research Center, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul, South Korea, ⁴Department of Internal Medicine, Hallym University Sacred Heart Hospital, Gyeonggi-do, South Korea, ⁵Rheumatism Research Center, Catholic Institutes of Medical Science, The Catholic University of Korea, Seoul, South Korea
Background/Purpose Oncostatin M (OSM) is a pleiotropic cytokine that belongs to the interleukin(IL)-6 group of cytokines. High level of OSM were detected in synoviums of…
Abstract Number: 336 • 2014 ACR/ARHP Annual Meeting
The Additive Inflammatory in Vivo and in Vitro Effects of Thymic Stromal Lymphopoietin (TSLP) and IL-7 in Arthritis Underscore the Therapeutic Rationale for blockade of Their Common Receptor Subunit
M.R. Hillen^1,2, S.A.Y. Hartgring^1,2, T.R.D.J. Radstake^2,3, C.E. Hack^1,2, F.P.J.G. Lafeber¹ and J.a.G. van Roon^1,2, ¹Rheumatology & Clinical Immunology, UMC Utrecht, Utrecht, Netherlands, ²Laboratory for Translational Immunology, UMC Utrecht, Utrecht, Netherlands, ³Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose Interleukin (IL)-7 and thymic stromal lymphopoietin (TSLP) are cytokines that signal through the IL-7Ra subunit and play proinflammatory roles in experimental arthritis and rheumatoid…
Abstract Number: 2846 • 2014 ACR/ARHP Annual Meeting
CaMK4 Inhibition Ameliorates the Development of Th17 Driven Inflammatory Diseases By Preventing Recruitment of IL-17 Producing Cells to Target Organs
Tomohiro Koga^1,2, Kotaro Otomo², Masayuki Mizui³, Nobuya Yoshida⁴, José C. Crispin², Atsushi Kawakami¹ and George C. Tsokos⁵, ¹Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Division of Rheumatology, Department of Medicine,, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁴Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁵Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose: IL-17 producing T helper (Th17) cells have been closely associated with the development of organ damage in inflammatory and autoimmune diseases. We have previously…
Abstract Number: 2460 • 2014 ACR/ARHP Annual Meeting
Phospho-STAT1/3 and Gene Expression Measurement in Circulating CD4⁺ T Cells As Diagnostic Tools in Early Autoantibody-Negative Rheumatoid Arthritis
Amy E. Anderson¹, Arthur G Pratt¹, Mamdouh Sedhom², Nisha Nair³, Jonathan Massey³, Christine Routledge¹, Ben Hargreaves¹, Philip Brown¹, Anne Barton⁴, John D Isaacs¹ and Ranjeny Thomas², ¹Institute of Cellular Medicine (Musculoskeletal Research Group), NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom, ²Translational Research Institute, The University of Queensland Diamantina Institute, Queensland, Australia, ³NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, United Kingdom, ⁴NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, United Kingdom
Background/Purpose Early diagnosis of rheumatoid arthritis (RA) improves outcomes but is challenging, particularly amongst anti-citrullinated peptide auto-antibody (ACPA) negative individuals. Previously we identified an IL-6…
Abstract Number: 1738 • 2014 ACR/ARHP Annual Meeting
Prominent Role of CCR6+ T Helper Cells in the Pathogenesis of ACPA+ Patients with Early RA
Sandra M.J. Paulissen¹, Jan Piet van Hamburg², Nadine Davelaar², Heleen Vroman³, Johanna MW Hazes⁴, P.H.P. de Jong⁵ and Erik Lubberts², ¹Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands, ²Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ³Rheumatology and Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁴Rheumatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands, ⁵Department of Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands
Background/Purpose: Presence of serum anti-citrullinated protein antibodies (ACPAs) in patients with rheumatoid arthritis (RA) predicts worse disease course and a more erosive disease. In the…
Abstract Number: 1033 • 2014 ACR/ARHP Annual Meeting
Stat3 Promotes IL-10 Expression in SLE T Cells through Trans-activation and Chromatin Remodeling
Christian Hedrich¹, Thomas Rauen², Sokratis Apostolidis³, Alexandros P. Grammatikos⁴, Noe Rodriguez Rodriguez⁴, Christina Ioannidis³, Vasileios C. Kyttaris⁴, José C. Crispin⁴ and George C. Tsokos⁵, ¹Children's Hospital, Dresden, Germany, ²Medicine/Rheumatology, BIDMC, Harvard Medical School, Boston, MA, ³Medicine, Rheumatology, BIDMC, Boston, MA, ⁴Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁵Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose: IL-10 is an immune-regulatory cytokine that is expressed by a wide range of cells and tissues. It plays a central role in the regulation…
Abstract Number: 37 • 2014 ACR/ARHP Annual Meeting
Regulation of Osteoclast and T Cell Differentiation By DC-STAMP and TRAF3
Yahui Grace Chiu¹, Jinbo Li², Dongge Li¹, Brendan Boyce² and Christopher T. Ritchlin³, ¹Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ²Pathology, University of Rochester, Rochester, NY, ³Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose DC-STAMP (Dendritic Cell-Specific Transmembrane Protein) is a 7-pass transmembrane protein essential for cell-to-cell fusion during OC differentiation. We have previously shown that DC-STAMP is…
Abstract Number: 2847 • 2014 ACR/ARHP Annual Meeting
Survivin Co-Ordinates Formation of Follicular T-Cells in Rheumatoid Arthritis
Maria Bokarewa¹, Karin Andersson², Malin Erlandsson², Mattias Svensson², Nicola Cavallini³ and Mikael Brisslert², ¹Guldhedsgatan 10, University of Goteborg, Goteborg, Sweden, ²Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden, ³Rheumatology and Inflammation Research, University of Göteborg, Göteborg, Sweden
Background/Purpose Survivin is a proto-oncogene that regulates cell division and apoptosis. Recently, survivin has emerged as a biomarker of persistently active and joint destructive rheumatoid…
Abstract Number: 2346 • 2014 ACR/ARHP Annual Meeting
Specific Overexpression of FPR2(FPRL-1) on Th1 Cells in GPI-Induced Arthritis and Patients with Rheumatoid Arthritis
Yuki Tanaka¹, Isao Matsumoto², Asuka Inoue³, Naoto Umeda⁴, Chinatsu Takai⁵, Yuko Kurashima⁶, Hoshimi Kawaguchi⁶ and Takayuki Sumida⁷, ¹Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba city, Ibaraki, Japan, ²Department of Interenal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ³Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, University of Tsukuba, Tsukuba city, Ibaraki, Japan, ⁴Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba City, Japan, ⁵University of Tsukuba, Ibaraki, Japan, ⁶University of Tsukuba, Tsukuba, Japan, ⁷Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
【Background/Purpose 】 CD4+T cell are critical to the pathogenesis of rheumatoid arthritis (RA). In glucose-6-phosphate isomerase (GPI) induced-arthritis (GIA), Th1 and Th17 cells are indispensable…
Abstract Number: 1736 • 2014 ACR/ARHP Annual Meeting
Immune Related Adverse Events Associated with Anti-CTLA-4 Antibodies: Systematic Review and Meta-Analysis
Anne Bertrand, Marie Kostine, Thomas Barnetche and Thierry Schaeverbeke, Rheumatology, Bordeaux University Hospital, Bordeaux, France
Background/Purpose CTLA-4 is a costimulatory molecule that downregulates T-cell activation and promotes an immunotolerance, well known by rheumatologist since the use of Abatacept. Targeting CTLA-4…
Abstract Number: 939 • 2014 ACR/ARHP Annual Meeting
Prenatal Methyl-Rich Diet Decreases Inflammation in Collagen Induced Arthritis
Sanjay Garg¹, Dipak R. Patel² and Raymond Yung³, ¹Internal Medicine, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, ²Internal Medicine, University of Michigan, Ann Arbor, MI, ³Internal Med-Univ Michigan, University of Michigan, Ann Arbor, MI
Background/Purpose: Early-life nutrition can have a profound effect on late-life disease development. Most current studies focus on macro-nutrition (calorie, carbohydrate, fat, and protein), and much…
Abstract Number: L24 • 2014 ACR/ARHP Annual Meeting
A Progressive Increase in T Follicular Helper Cells Marks the Transition from Benign to Symptomatic Autoimmunity
Sina Rusta-Sallehy¹, Babak Noamani², Dennisse Bonilla³, Nan-Hua Chang⁴, Larissa Lisnevskaia⁵, Sindhu R. Johnson⁶, Earl Silverman⁷, Arthur A. M. Bookman⁸, Joan E. Wither⁹ and Carolina Landolt-Marticorena³, ¹Medicine, University of Toronto, Toronto, ON, Canada, ²Genetics and developmental biology, Toronto Western Research Institute, Toronto, ON, Canada, ³Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, ⁴Genetics and Development, Toronto Western Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ⁵Rheumatology, Lakeridge Health Center, Toronto, ON, Canada, ⁶Medicine, Toronto Scleroderma Program, Toronto Western Hospital, Toronto General Hospital, Mount Sinai Hospital, and University of Toronto, Toronto, ON, Canada, ⁷Division of Rheumatology, Hosp for Sick Children, Toronto, ON, Canada, ⁸Division of Rheumatology, Toronto Western Hospital (UHN), Toronto, ON, Canada, ⁹Toronto Western Research Institute, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: The systemic autoimmune rheumatic diseases (SARD; Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA), Sjogren’s Disease (SjD), Systemic Sclerosis (SSc)) are proposed to have a…
Abstract Number: 2221 • 2013 ACR/ARHP Annual Meeting
The Histamine H₄ Receptor Drives Inflammation In Preclinical Models Of Arthritis
Paul J. Dunford¹, Jeffery Cowden², Fuqu Yu², Homayon Banie², Mandana Farahani², Ping Ling², Steven Nguyen², Jason Riley², Mai Zhang², Jian Zhu² and Robin L. Thurmond², ¹Immunology, Janssen R&D, LLC, San Diego, CA, ²Janssen R&D, LLC, San Diego, CA
Background/Purpose: The histamine H4 receptor (H4R) has been shown to drive inflammatory responses in models of asthma, colitis and dermatitis and in these models it…

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