Abstracts tagged "T cells"

Abstract Number: 881 • 2014 ACR/ARHP Annual Meeting
DNA Methylation Analysis of the Temporal Artery Microenvironment Reveals a Robust T Cell Signature and Suggests a Role for TNF-α in Giant Cell Arteritis
Patrick S. Coit¹, Lindsey B. De Lott², Bin Nan³, Victor M. Elner⁴ and Amr H. Sawalha¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, ³Department of Biostatistics, University of Michigan, Ann Arbor, MI, ⁴Department of Ophthalmology and Visual Sciences & Department of Pathology, University of Michigan, Ann Arbor, MI
Background/Purpose: Giant cell arteritis (GCA) is a systemic large vessel vasculitis of unknown etiology. A hallmark of GCA is the presence of granulomatous inflammation of…
Abstract Number: 2736 • 2014 ACR/ARHP Annual Meeting
Female Specific Increase in T Cell Glycosylation in Lupus
Gabriela Gorelik¹ and Bruce Richardson², ¹Internal Medicine, University of Michigan, Ann Arbor, MI, ²Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Systemic Lupus Erythematosus (SLE) is an autoimmune inflammatory disease characterized by altered T cell signaling. SLE is characterized by epigenetic mechanisms that cause hypomethylation…
Abstract Number: 2352 • 2014 ACR/ARHP Annual Meeting
RORγt Expressing Foxp3⁺ Regulatory T Cells Regulates the Development of Autoimmune Arthritis in Mice
Yuya Kondo¹, Masahiro Tahara¹, Mana Iizuka¹, Masahiro Yokosawa¹, Shunta Kaneko¹, Hiroto Tsuboi¹, Satoru Takahashi², Isao Matsumoto³ and Takayuki Sumida¹, ¹Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Japan, ³Department of Interenal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Background/Purpose: To determine the effect of RORγt overexpression in T cells on the development of collagen induced arthritis (CIA). Methods: Arthritis was induced with chicken…
Abstract Number: 1734 • 2014 ACR/ARHP Annual Meeting
IL-22 Plays a Significant Role in the Initiation and Augmentation of Th17-Dependent Experimental Arthritis
Debbie M. Roeleveld¹, Renoud Marijnissen², Rebecca Rogier³, Birgitte Walgreen¹, Monique M. Helsen³, Liduine van den Bersselaar³, Shahla Abdollahi-Roodsaz⁴, Wim B. van den Berg³ and Marije I. Koenders³, ¹Experimentel Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, ³Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁴Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease that leads to progressive destruction of cartilage and bone. IL-22 and IL-22-producing T helper cells…
Abstract Number: 860 • 2014 ACR/ARHP Annual Meeting
Inhibition of G Protein βγ Signaling Inhibits Nephritis in Lupus Prone Mice
Teresa Owen¹, Javier Rangel-Moreno², Jesi To³, Bruce Goldman⁴, Alan Smrcka³ and Jennifer H. Anolik⁵, ¹Rheumatology, University of Rochester, Rochester, NY, ²Medicine- Allergy, Immunology, and Rheumatology, University of Rochester, Rochester, NY, ³Pharmacology & Physiology, University of Rochester, Rochester, NY, ⁴Pathology, University of Rochester, Rochester, NY, ⁵Medicine- Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY
Background/Purpose G protein-coupled receptors (GPCRs), including chemokine receptors on leukocytes, signal through G protein Gβγ subunits. An important target of Gβγ is phosphoinositide 3 kinase γ…
Abstract Number: 2735 • 2014 ACR/ARHP Annual Meeting
Association of a-Kinase Anchoring Protein-79 (AKAP79) to PKC Mediates Inhibition of IL2 Transcription and Erk Activation in T Cells
Gabriel Criado¹, María J. Pérez-Lorenzo¹, María Galindo², Jose L. Pablos² and Abel Suarez-Fueyo¹, ¹Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ²Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain
Background/Purpose A-Kinase anchoring Protein AKAP79 associates to and regulates the activity of PKA, PKC and calcineurin, key regulators of T cell activation. We have previously…
Abstract Number: 2174 • 2014 ACR/ARHP Annual Meeting
MicroRNA-146a in Salivary Gland Epithelial Cells Inhibits Co-Stimulatory Molecule CD80 Expression and Increases Autoreactive T Cell Activation in Sjögren’s Syndrome
Adrienne Gauna¹, Jun-O Jin^2,3, Qing Yu², Carol Stewart¹ and Seunghee Cha¹, ¹Oral and Maxillofacial Diagnostic Sciences, University of Florida, Gainesville, FL, ²Department of Immunology and Infectious Diseases, The Forsyth Institute, Cambridge, MA, ³Shanghai Public Health Clinical Center, Fudan University Shanghai Medical College, Shanghai, China
Background/Purpose: Sjögren’s syndrome (SS) causes severe dry mouth and eyes. The presence of immune cell infiltration in the salivary (SG) and lacrimal glands suggests a…
Abstract Number: 1733 • 2014 ACR/ARHP Annual Meeting
Immunomodulatory Effects of Dietary Non-Digestible Oligosaccharides in T Cell-Mediated Autoimmune Arthritis
Rebecca Rogier¹, Tom Ederveen², Anita Hartog³, Birgitte Walgreen⁴, Liduine van den Bersselaar¹, Monique M. Helsen¹, Paul Vos³, Johan Garssen^3,5, Linette Willemsen⁵, Wim B. van den Berg¹, Marije I. Koenders¹ and Shahla Abdollahi-Roodsaz⁶, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Centre for Molecular Bioinformatics Nijmegen (CMBI), Radboud university medical center, Nijmegen, Netherlands, ³Danone Nutricia Research, Utrecht, Netherlands, ⁴Experimentel Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁵Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, Netherlands, ⁶Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Accumulating evidence indicates the relevance of intestinal microbiota in shaping the immune response and supports its contribution to the development of autoimmune diseases. Prebiotic…
Abstract Number: 859 • 2014 ACR/ARHP Annual Meeting
TGF-β3-Producing CD4⁺CD25^–LAG3⁺ Regulatory T Cells Control B Cell Responses
Tomohisa Okamura¹, Kaoru Morita¹, Mariko Inoue¹, Toshihiko Komai¹, Yukiko Iwasaki¹, Shuji Sumitomo¹, Shinichiro Nakachi¹, Hirofumi Shoda², Keishi Fujio² and Kazuhiko Yamamoto¹, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan, ²Department of Allergy and Rheumatology, The University of Tokyo, Tokyo, Japan
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production and associated with a wide range of clinical manifestations. Recent case-control association…
Abstract Number: 2734 • 2014 ACR/ARHP Annual Meeting
B55β Regulates T Cell Survival through the Modulation of AKT during Cytokine Deprivation
José C. Crispin¹, Sokratis A. Apostolidis², Noe Rodriguez Rodriguez¹, Tran Nguyen² and George C. Tsokos³, ¹Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose . The abundance of cytokines controls the length of immune responses through poorly defined mechanisms. B55β is a molecule that triggers apoptosis in activated…
Abstract Number: 2164 • 2014 ACR/ARHP Annual Meeting
Self-Phospholipids Regulate Inflammation Via Activation of CD1d-Restricted T-cells and Induction of ‘anti-inflammatory’ Myeloid-Derived Suppressor Cells (MDSC)
Ram Raj Singh^1,2,3,4, Cynthia Tran¹, Priti Prasad¹, Jing Wang⁵, Dirk Zajonc⁵ and Ramesh Halder¹, ¹Autoimmunity and Tolerance Laboratory, Department of Medicine/Rheumatology, UCLA, Los Angeles, CA, ²Interdepartmental Program in Molecular Toxicology, UCLA, Los Angeles, CA, ³Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, ⁴Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, ⁵La Jolla Institute of Allergy and Immunology, La Jolla, CA
Background/Purpose Self-lipids play an increasingly appreciated role in immunity and inflammation. Lipid antigens are presented by CD1d and CD1a-d molecules in mouse and human, respectively,…
Abstract Number: 1648 • 2014 ACR/ARHP Annual Meeting
Urinary T Cells and Macrophages Strongly Reflect the Disease Activity, Kidney Function, and the Histopathologic Classification in Patients with Lupus Nephritis
Yoko Wada¹, Minoru Sakatsume², Masaaki Nakano³ and Ichiei Narita¹, ¹Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, ²Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, ³School of Health Sciences, Faculty of Medicine, Niigata University, Niigata, Japan
Background/Purpose: Lupus nephritis (LN) is one of the common manifestations of systemic lupus erythematosus (SLE), and the occurrence of LN is considered to be a…
Abstract Number: 858 • 2014 ACR/ARHP Annual Meeting
ABT-199, a Potent and Selective BCL-2 Inhibitor, Prevents Lupus Nephritis in the Spontaneous NZB/W F1 Mouse Model By Depleting Selective Lymphocyte Populations While Sparing Platelets
Li Chun Wang¹, Stuart Perper¹, Annette Schwartz², Christian Goess³, Liz O'connor⁴, Dawna Hartman², Candace Graff², Andrew Souers⁵, Joel Leverson⁵, Steven Elmore⁵ and Lisa Olson², ¹Immunology, AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, ²AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, ³Pharmacology, AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, ⁴Toxicology, AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, ⁵AbbVie Inc, North Chicago, IL
Background/Purpose Proteins in the BCL-2 family are key regulators of apoptosis, or programmed cell death. Navitoclax, a selective inhibitor of both BCL-2 and BCL-X(L) demonstrated…
Abstract Number: 2738 • 2014 ACR/ARHP Annual Meeting
Shk-186, a Kv1.3 channel inhibitor That Targets Effector Memory T Cells: Safety and Tolerability in Humans and Its Evaluation in a Model of Rapidly Progressive Glomerulonephritis
Ernesto J. Muñoz-Elías¹, Kayla Norton¹, John B. Grigg¹, Liz Bromley¹, David W. Peckham¹, Eric J. Tarcha¹, Jared Odegard², James Qin², Megan Yuasa³, Anne Stevens⁴, Wayel H. Abdulahad⁵, Galina Schmunk⁶, K. George Chandy⁶ and Shawn P. Iadonato¹, ¹Kineta Inc., Seattle, WA, ²Benaroya Research Institute at Virginia Mason, Seattle, WA, ³Seattle Children's Res Institute, Seattle Children's Research Institute, Seattle, WA, ⁴Seattle Children's Res Inst, Seattle Children's Hospital, Seattle, WA, ⁵Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ⁶Department of Physiology, Biophysics, and Surgery, UC Irvine, Irvine, CA
Background/Purpose: The voltage-gated potassium channel Kv1.3 is a novel target for the treatment of autoimmune disorders including psoriatic and rheumatic diseases. ShK-186 is an exquisitely specific,…
Abstract Number: 1899 • 2014 ACR/ARHP Annual Meeting
Blockade of Interleukin-33 Signaling Prevents Death in a Mouse Model of Familial Hemophagocytic Lymphohistiocytosis
Julia Rood¹, Portia Kreiger², Erietta Stelekati¹, E. John Wherry¹ and Edward M. Behrens³, ¹Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ²Pathology, Alfred I. duPont Hospital for Children, Wilmington, DE, ³Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose Cytokine storm syndromes, such as macrophage activation syndrome and familial hemophagocytic lymphohistiocytosis (FHL), represent important causes of mortality in pediatric rheumatology. Studies of a…

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