Abstracts tagged "T cells"

Abstract Number: 936 • 2015 ACR/ARHP Annual Meeting
IL-1 Receptor Antagonist Maintains Intestinal Microbial Homeostasis to Prevent Overt Toll-like Receptor 4-Dependent Intestinal Th17 Differentiation and Autoimmune Arthritis
Rebecca Rogier¹, Tom Ederveen¹, Jos Boekhorst², Harm Wopereis³, Johan Garssen⁴, Peter van der Kraan⁵, Sacha van Hijum², Marije Koenders⁶, Wim van den Berg⁶ and Shahla Abdollahi-Roodsaz^7,8, ¹Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, ²Centre for Molecular Bioinformatics Nijmegen (CMBI), Radboud university medical center, Nijmegen, Netherlands, ³Danone Research, Wageningen, Netherlands, ⁴Danone Nutricia Research, Utrecht, Netherlands, ⁵Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁶Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁷Medicine, NYU School of Medicine, New York, NY, ⁸Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Interleukin-1 (IL-1) plays a pivotal role in inflammation and immunity. Activation of IL-1 receptor is physiologically inhibited by the IL-1 receptor antagonist (IL-1Ra). Mice…
Abstract Number: 1750 • 2015 ACR/ARHP Annual Meeting
Identification of Autoantibody-Inducing CD4 T Cell (aiCD4 T cell) That Causes Systemic Lupus Erythematosus (SLE) As DOCK8+ CD4 T Cell: Proof of Concept of Self-Organized Criticality Theory
Shunichi Shiozawa¹, Yumi Miyazaki², Kazuko Shiozawa³ and Ken Tsumiyama², ¹Department of Medicine, Rheumatic Diseases Unit, Kyushu University Beppu Hospital, Beppu, Japan, ²Medicine, Rheumatic Diseases Unit, Kyushu University Beppu Hospital, Beppu, Japan, ³Rheumatic Diseases Center, Konan Kakogawa Hospital, Kakogawa, Japan
Background/Purpose: We have shown that repeated immunization with antigen causes systemic autoimmunity in mice otherwise not prone to spontaneous autoimmune diseases. Overstimulation of CD4 T…
Abstract Number: 2016 • 2015 ACR/ARHP Annual Meeting
Functional Tertiary Lymphoid Structures within the Kidneys of Lupus Prone Mice Resembles Lymph Nodes in Gene Expression Profiling Analysis and Are Detected By in Vivo Imaging
Premasany Kanapathippillai, Sayed Esmaeil Dorraji and Kristin A Fenton, RNA and Molecular Pathology, UIT, The Artic University of Norway, Tromso, Norway
Background/Purpose: The formation of tertiary lymphoid structures (TLS) are known to occur during the development of several diseases, including systemic lupus erythematosus (SLE), but in…
Abstract Number: 3027 • 2015 ACR/ARHP Annual Meeting
Hyperactivated State of Mucosal Associated Invariant T Cells Due to Activation Potency of Monocytes in Systemic Lupus Erythematous
Goh Murayama¹, Asako Chiba², Ken Yamaji³, Naoto Tamura³, Yoshinari Takasaki³ and Sachiko Miyake², ¹Department of Internal Medicine and Rheumatology,, Juntendo University School of Medicine, Tokyo, Japan., Tokyo, Japan, ²Division of Immunology/NCNP, Natl Institute of Neuroscience, Kodaira Tokyo, Japan, ³Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that express a semi-invariant TCRα chain: Vα7.2-Jα33 in humans and Vα19-Jα33 in mice. MAIT cells are…
Abstract Number: 2727 • 2014 ACR/ARHP Annual Meeting
T Cells Trigger Interstitial Pneumonia in Polymyositis
Akira Takeda^1,2, Yasutsugu Fukushima³, Takaji Matsutani⁴, Yoichiro Haji¹, Chisun Min¹, Ryo Rokutanda¹, Yasuhiro Suyama¹, Mitsumasa Kishimoto⁵, Ken-ichi Yamaguchi¹ and Masato Okada⁶, ¹Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, ²Division of Clinical Immunology & Rheumatology, International University of Health and Welfare Hospital, Nasu-shiobara, Japan, ³Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine, Mibu, Japan, ⁴Laboratory of Immune Regulation, Wakayama Medical University, Ibaraki, Japan, ⁵St. Luke's International Hospital, Tokyo, Japan, ⁶Immuno-Rheumatology Center, St. Luke's International Hospital, tokyo, Japan
Background/Purpose: The lung is frequently affected in connective tissue diseases (CTDs). Polymyositis (PM) is a major CTD characterized by idiopathic inflammatory lesions of muscle and…
Abstract Number: 1751 • 2014 ACR/ARHP Annual Meeting
CD4 Aptamer-RORγt shRNA Chimera Inhibits IL-17 Synthesis By Human CD4⁺ T cells
Cong-Qiu Chu¹, Pingfang Song², Yuan K. Chou³, Xiaowei Zhang², Roberto Meza-Romero², Kentaro Yomogida³ and Gil Benedek², ¹Rheumatology, Oregon Health & Science Univ, Portland, OR, ²Oregon Health & Science University, Portland, OR, ³Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR
Background/Purpose RNA interfering (RNAi)-mediated gene silencing holds great promise for manipulating T cells to study basic T cell biology and for developing potential T cell…
Abstract Number: 1495 • 2014 ACR/ARHP Annual Meeting
Preclinical and Clinical Phase I Profile of MK-8457, a Selective Spleen Tyrosine Kinase and Zeta-Chain-Associated Protein Kinase 70 Inhibitor, Developed for the Treatment of Rheumatoid Arthritis
Gene Marcantonio¹, Alan Bass², Gretchen Baltus³, Judith Boice¹, Hongmin Chen⁴, Michael Crackower⁵, Jeroen Elassaiss-Schaap⁶, Michael Ellis⁷, Tomoko Freshwater⁸, Francois Gervais⁹, Jane Guo¹⁰, Sammy Kim⁹, Lily Moy⁵, Alan Northrup⁷, Jie Zhang-Hoover⁴, Mathew Maddess¹¹, Richard Miller¹², Marcella Ruddy⁵, Stella Vincent¹³, Haoling Weng¹ and Hani Houshyar¹⁴, ¹Merck & Co., Whitehouse Station, NJ, ²Safety Assessment, Merck & Co., Boston, MA, ³Immunomodulatory Regulators, Merck & Co., Boston, MA, ⁴Pharmacology, Merck & Co., Boston, MA, ⁵Merck & Co., Boston, MA, ⁶Clinical PK-PD, Merck & Co., Oss, Netherlands, ⁷Medicinal Chemistry, Merck & Co., Boston, MA, ⁸PPDM Early Stage, Merck & Co., Rahway, NJ, ⁹Cell Pathways and Proteins, Merck & Co., Boston, MA, ¹⁰Immunology, Merck & Co., Boston, MA, ¹¹Discovery Process Chemistry, Merck & Co., Boston, MA, ¹²Biochemistry & Biophysics, Merck & Co., Boston, MA, ¹³PPDM Preclinical ADME, Merck & Co., Boston, MA, ¹⁴33 Avenue Louis Pasteur, Merck & Co., Boston, MA
Background/Purpose: Spleen tyrosine kinase (SYK) is a potential target for treatment of several diseases including rheumatoid arthritis. SYK is a member of the Zeta-chain-associated protein…
Abstract Number: 397 • 2014 ACR/ARHP Annual Meeting
Th9 Lymphocytes in Rheumatoid Arthritis
Rossella Talotta¹, Angela Berzi², Fabiola Atzeni¹, Donata Dell'Acqua¹, Piercarlo Sarzi-Puttini¹ and Daria Trabattoni², ¹Rheumatology Unit, L. Sacco University Hospital, Milan, Italy, ²Chair of Immunology, Department of Biomedical and Clinical Sciences “L. Sacco, Milan, Italy
Background/Purpose Th9 cells are IL-9-secreting Th lymphocytes that are involved in the immunological responses underlying parasitic infections and allergic diseases. In the case of autoimmune…
Abstract Number: 2726 • 2014 ACR/ARHP Annual Meeting
CD28null T Cells from Polymyositis Patients Are Cytotoxic to Autologous Muscle Cells in Vitro Via Perforin-Dependent Mechanisms
Jayesh Pandya¹, Paulius Venalis¹, Lubna Al-Khalili², Mohammad Shahadat Hossain¹, Ingrid E. Lundberg¹, Vivianne Malmström¹ and Andreas E. R. Fasth¹, ¹Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ²Division of Industrial Biotechnology, KTH - Royal Institute of Technology, Stockholm, Sweden
Background/Purpose: Inflammatory infiltrates of muscles in polymyositis are dominated by CD4+CD28null and CD8+CD28null T cells. In contrast to conventional CD28+ T cells, these cells…
Abstract Number: 1749 • 2014 ACR/ARHP Annual Meeting
Molecular Mechanisms Underlying 1,25(OH)₂D₃-Mediated Suppression of Th17 Cell Activity
Wendy Dankers^1,2, Jan Piet van Hamburg^2,3, Wida Razawy^1,2, Nadine Davelaar^1,2, Anne-Marie Mus^1,2, Patrick Asmawidjaja^1,2, Johannes van Leeuwen⁴, Edgar Colin⁵ and Erik Lubberts^1,2, ¹Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ²Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ³Rheumatology, Erasmus MC, Rotterdam, Netherlands, ⁴Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁵Rheumatology, ZGT, Almelo, Netherlands
Background/Purpose Vitamin D has suppressive effects on autoimmune diseases, such as rheumatoid arthritis (RA). Within these diseases, Th17 cells play a crucial role in the…
Abstract Number: 1465 • 2014 ACR/ARHP Annual Meeting
Follicular Helper T Cells Control Autoimmunity through IL-21/IL-21 Receptor Interaction in RA Patients
Shikha Singla¹, Minzi Chen², Jerry Pounds Jr.², Omar Khan², Jerald M. Zakem², Kismet Collins², Tamika Webb-Detiege², William E. Davis², Robert Quinet² and Xin Zhang³, ¹Rheumatology, Ochner Medical Center, New Orleans, LA, ²Rheumatology, Ochsner Medical Center, New Orleans, LA, ³Institute of Translational Research, Ochsner Medical Center, New Orleans, LA
Background/Purpose Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the synovium, causing progressive joint destruction and reduction in quality of life…
Abstract Number: 366 • 2014 ACR/ARHP Annual Meeting
Soluble 4-1BB Is a Marker of Joint Involvement and Disease Activity in Rheumatoid Arthritis
Morten Aagaard Nielsen¹, Thomas Andersen², Kristian Stengaard-Pedersen³, Kim Hoerslev-Petersen⁴, Merete Lund Hetland⁵, Peter Junker⁶, Mikkel Ostergaard⁷, Malene Hvid¹ and Bent Deleuran⁸, ¹Department of Biomedicine, Aarhus University, Aarhus, Denmark, ²Dept. of Biomedicine, Aarhus University, Aarhus, Denmark, ³Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁴Rheumatology, Research Unit at King Christian X Hospital for Rheumatic Diseases, Graasten, Denmark, ⁵DANBIO, Center for Rheumatology and Spine Diseases, Glostrup University Hospital, Glostrup, Denmark, Glostrup, Denmark, ⁶University of Southern Denmark, Odense, Denmark, ⁷Copenhagen University Hospital at Glostrup, Copenhagen, Denmark, ⁸Dept. of Rheumatology, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose 4-1BB is induced on T cells after antigen encounter and promotes clonal expansion and accumulation of high numbers of antigen-specific effector-type T cells primarily…
Abstract Number: 3003 • 2014 ACR/ARHP Annual Meeting
Am80 Ameliorates Bleomycin-Induced Dermal Fibrosis By Suppressing the Pro-Fibrotic Phenotype of Fibroblasts, Endothelial Cells, and Immune Cells
Tetsuo Toyama¹, Yoshihide Asano¹, Takehiro Takahashi¹, Ryosuke Saigusa¹, Yohei Ichimura¹, Takashi Taniguchi¹, Shinji Noda¹, Kaname Akamata¹, Shinichi Sato¹, Takafumi Kadono¹ and Koichi Shudo², ¹Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²Reseach Foundation ITSUU Laboratory, Tokyo, Japan
Background/Purpose: Am80 is a synthetic retinoid serving as an agonist for retinoic acid receptor α/β with chemical and pharmacological advantages over all-trans retinoic acid, such…
Abstract Number: 2724 • 2014 ACR/ARHP Annual Meeting
Deficiency of Ro52/TRIM21 in Different Subsets of Peripheral Blood Mononuclear Cells from Patients with Inflammatory Myopathies
Angeles Shunashy Galindo-Feria¹, Diana Gómez-Martín², Ana Barrera-Vargas², Javier Merayo-Chalico¹ and Jorge Alcocer-Varela², ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: The detection of Ro52/TRIM21 autoantibodies has been considered an independent prognostic marker in different rheumatic conditions. However, the information about the expression of Ro52/TRIM21…
Abstract Number: 1745 • 2014 ACR/ARHP Annual Meeting
Memory Stem T Cells Are Selectively Enriched in Patients with Rheumatoid Arthritis, Contract upon Anti-TNF Treatment, and May Provide a Long-Term Reservoir of Arthritogenic Lymphocytes
Nicoletta Cieri¹, Giacomo Oliveira¹, Raffaella Greco², Mattia Baldini³, Elena Baldissera⁴, Fabio Ciceri² and Chiara Bonini¹, ¹Division of Immunology, Infectious Diseases and Transplants, Experimental Hematology Unit, San Raffaele Scientific Institute, Milan, Italy, ²Division of Regenerative Medicine, Gene Therapy and Stem Cells, Hematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy, ³Division of Immunology, Infectious Diseases and Transplants, Clinical immunopathology and advanced medical therapeutics, San Raffaele Scientific Institute, Milan, Italy, ⁴Clinical immunopathology and advanced medical therapeutics, San Raffaele Scientific Institute, Milan, Italy
Background/Purpose: the T-cell memory compartment is multi-faceted and encompasses multiple subsets with divergent properties. In addition to central memory (TCM) and effector memory (TEM) cells,…

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