ACR Meeting Abstracts

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Abstracts tagged "T cells"

  • Abstract Number: 2819 • 2019 ACR/ARP Annual Meeting

    The Transcription Factor MAF Controls the Ability of T Peripheral Helper (Tph) Cells to Help B Cells

    Alexandra Bocharnikov1, Vanessa Wacleche 1, Ye Cao 1 and Deepak Rao 2, 1Brigham and Women's Hospital, Boston, 2Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Pathologic T cell-B cell interactions are hallmark features of many autoimmune diseases. PD-1hi CXCR5- T peripheral helper (Tph) cells are B cell-helper T cells…
  • Abstract Number: 500 • 2019 ACR/ARP Annual Meeting

    The Dysregulation of NK Cells and Non-Conventional NK-T and γδ-T Cells in Individuals at Risk of Developing Rheumatoid Arthritis

    Klára Prajzlerová1, Olga Kryštůfková 2, Petra Hánová 3, Hana Hulejová 3, Monika Gregová 1, Nora Petrovská 1, Herman Mann 4, Karel Pavelka 4, Jiří Vencovský 4, Ladislav Senolt 4 and Mária Filková 1, 1Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 2Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague, Czech Republic, 3Institute of Rheumatology, Prague, Czech Republic, 4Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague 2, Czech Republic

    Background/Purpose: The positivity of antibodies against citrullinated proteins (ACPA) precedes the clinical manifestation and significantly increases the risk of rheumatoid arthritis (RA). EULAR characterised individuals…
  • Abstract Number: 2897 • 2019 ACR/ARP Annual Meeting

    Increased CD69+ Tissue-resident Memory T (TRM) Cells and STAT3 Expression in Cutaneous Lupus Erythematosus Patients Recalcitrant to Antimalarials

    Majid Zeidi 1, Kristen Chen 1, Krisha Desai 1, Hee Joo Kim 2, Srita Chakka 3, Rachel Lim 4 and Victoria Werth1, 1Corporal Michael J. Crescenz VAMC, Philadelphia, PA, USA and Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA, Philadelphia, PA, 2Corporal Michael J. Crescenz VAMC, Philadelphia, PA, USA andDepartment of Dermatology, University of Pennsylvania, Philadelphia, PA, USA and Department of Dermatology, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea, Republic of (South), Philadelphia, 3Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA, Philadelphia, 4Corporal Michael J. Crescenz VAMC, Philadelphia, PA, USA, Philadelphia

    Background/Purpose: Cutaneous lupus erythematosus (CLE) is an autoimmune disease with various subsets and clinical manifestations. T lymphocytes are the predominant cell type found in lesional…
  • Abstract Number: 588 • 2019 ACR/ARP Annual Meeting

    The Gut Enthesis Axis Coming into Focus with the Description of Enriched Entheseal Resident Mucosal Associated Invariant T-cells (MAITs) Capable of IL17A and TNF Production

    Richard Cuthbert 1, Qiao Zhou 2, Abdulla Watad 3, Robert Dunsmuir 4, Peter Loughenbury 4, Almas Khan 4, Peter Milner 4, Charles Bridgewood 5 and Dennis McGonagle2, 1University of Leeds, Leeds, 2University of Leeds, Leeds, United Kingdom, 3Department of Medicine “B”, Zabludowicz Center for Autoimmune Diseases Sheba Medical Center, Ramat-Gan, Israel, 4Leeds Teaching Hospitals NHS Trust, Leeds, 5Leeds Institute of Rheumatic and Muscoskeletal Medicine(LIRMM), University of Leeds, Leeds, United Kingdom

    Background/Purpose: Mucosal associated invariant T-cells (MAITs) are innate-like T lymphocytes that express a semi-invariant TCR repertoire that are activated by microbial ligands or cytokines including…
  • Abstract Number: 2918 • 2019 ACR/ARP Annual Meeting

    Metabolic Signatures of Pathogenic T Cells in Medium and Large Vessel Vasculitis

    Mitsuhiro Akiyama 1, Hui Zhang 1, Ryu Watanabe 1, Toshihisa Maeda 2, Gerald Berry 1, Jorg Goronzy 1 and Cornelia Weyand1, 1Stanford University, Stanford, CA, 2Matsubara Mayflower Hospital, Kobe, Japan

    Background/Purpose: Giant cell arteritis (GCA) is an autoimmune vasculitis that causes aortic arch syndrome, blindnesss, and stroke. Embedded in granulomatous infiltrates, CD4 T cells persist…
  • Abstract Number: 596 • 2019 ACR/ARP Annual Meeting

    Prostaglandin Receptor EP4 Drives Pathogenic Th17 Cell Development in Ankylosing Spondylitis and Is a New Marker of Disease Activity

    Anja Meyer1, Charlotte Klasen 1, Pauline Wittekind 1, Iris Waqué 1, Schafiq Nabhani 1 and David Kofler 1, 1University of Cologne, Cologne, Germany

    Background/Purpose: Th17 cells are involved in the pathogenesis of ankylosing spondylitis (AS). However, the mechanism underlying enhanced Th17 cell accumulation in AS remains unknown. The…
  • Abstract Number: 812 • 2019 ACR/ARP Annual Meeting

    Sex Differences in Autoimmunity and Cardiovascular Risk Could Be Associated with Altered Treg Phenotype and Lipoprotein Metabolism

    George Robinson1, Kirsty Waddington 1, Anna Radziszewska 1, Hannah Peckham 1, David A Isenberg 2, Yiannis Ioannou 1, Coziana Ciurtin 3, Ines Pineda-Torra 1 and Elizabeth Jury 1, 1University College London, London, United Kingdom, 2Centre for Rheumatology, London, United Kingdom, 3Centre for Adolescent Rheumatology, University College London London, UK, Londond, United Kingdom

    Background/Purpose: Males and females have altered immune responses resulting in variation in autoimmune risk. Sex differences exist in the frequency and activity of immune-cell subsets…
  • Abstract Number: 1004 • 2019 ACR/ARP Annual Meeting

    Genetic Ablation of γδTCR Inhibits IL-23-induced Neutrophilia and Attenuates Epidermal Hyperplasia, Synovitis, Onycholysis and Enthesitis Associated with Psoriatic Arthritis

    Cuong Nguyen1, Trevor Chan 2, Ilias Tagkopoulos 2, Matthias Eberl 3 and Iannis Adamopoulos 1, 1Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Sacramento, CA, 2University of California, Davis, Department of Computer Science, California, USA, Davis, CA, 3Division of Infection and Immunity, School of Medicine and Systems Immunity Research Institute, Cardiff University, Cardiff CF14 4XN, United Kingdom, Cardiff, United Kingdom

    Background/Purpose: γδ T cells are non-conventional lymphocytes that straddle between innate and adaptive immunity. Although γδ T cells have been implicated in psoriatic arthritis, the…
  • Abstract Number: 1025 • 2019 ACR/ARP Annual Meeting

    Dynamic Changes During SLE Flare Implicate Age-Associated B Cells and Altered T Follicular and Peripheral Helper Cell Responses in Disease Activity

    Kieran Manion1, Zahi Touma 2, Dennisse Bonilla 2, Dafna Gladman 3, Murray Urowitz 2 and Joan Wither 4, 1Krembil Research Institute, Toronto, ON, Canada, 2University Health Network, University of Toronto, Toronto, ON, Canada, 3Krembil Research Institute, U of Toronto, Toronto, ON, Canada, 4University Health Network, Krembil Research Institute, Toronto, ON, Canada

    Background/Purpose: SLE is a chronic autoimmune disorder in which periods of relative disease inactivity are punctuated by flares that present with increased inflammation and tissue…
  • Abstract Number: 1031 • 2019 ACR/ARP Annual Meeting

    Expanded Circulating Peripheral Helper T Cells Are Associated with B Cell Differentiation in Systemic Lupus Erythematosus

    Ayako Makiyama1, Asako Chiba 2, Daisuke Noto 1, Goh Murayama 3, Tomohiro Mizuno 4, Taiga Kuga 5, Ken Yamaji 5, Naoto Tamura 5 and Sachiko Miyake 2, 1Juntendo University School of Medicine, Tokyo, Japan, 2Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan, 3Department of Internal Medicine and Rhumatology, Juntendo University School of Medicine, Tokyo, Japan, 4Department of Immunlogy, Juntendo University School of Medicine, Tokyo, Japan, 5Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

    Background/Purpose: Autoreactive T-B cell interactions in lymphoid tissue have been thought to play a crucial role in the autoantibody production in systemic lupus erythematosus (SLE).…
  • Abstract Number: 25 • 2019 ACR/ARP Annual Meeting

    Altered Distribution and Enhanced Osteoclastogenesis of Mucosal-associated Invariant T Cells in Gouty Arthritis

    Yong-Wook Park1, Young-Nan Cho 1, Hae-Seong Jeong 1, Hye-Mi Jin 1 and Seung-Jung Kee 1, 1Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea

    Background/Purpose: Mucosal-associated invariant T (MAIT) cells are subsets of innate invariant T cells and rapidly produce Th1/Th17 cytokines including interferon (IFN)-γ, tumor necrosis factor (TNF)-α,…
  • Abstract Number: 1069 • 2019 ACR/ARP Annual Meeting

    CD4+ T Helper Cell Populations with High PD-1 Expression Are Expanded in Systemic Sclerosis

    Alisa Mueller1, Andrea Fava 2, Deepak Rao 1 and Francesco Boin 3, 1Brigham and Women's Hospital, Boston, MA, 2Johns Hopkins University School of Medicine, Baltimore, MD, 3UCSF, San Francisco, CA

    Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by tissue fibrosis, vascular injury, and autoantibody production. CXCR5+ PD-1+ T follicular helper (Tfh) cells, which…
  • Abstract Number: 66 • 2019 ACR/ARP Annual Meeting

    Amelioration of Immune Complex-Mediated Glomerulonephritis by CD6 Modulation

    Samantha Chalmers1, Sayra Garcia 1, Jeanette Ampudia 2, Cherie Ng 2, Stephen Connelly 2 and Chaim Putterman 3, 1Albert Einstein College of Medicine, Bronx, NY, 2Equillium, Inc, San Diego, CA, 3Albert Einstein College of Medicine, New York, NY

    Background/Purpose: CD6 is a co-stimulatory receptor on T cells, that binds to activated leukocyte cell adhesion molecule (ALCAM), a ligand expressed on antigen presentation cells…
  • Abstract Number: 1455 • 2019 ACR/ARP Annual Meeting

    B and T Cell Immunologic Features Associated with Higher Disease Activity Score and Focus Score in Primary Sjögren Syndrome

    Alice Mai1, Yuriy Baglaenko 2, Dario Ferri 3, Kieran Manion 4, Dennisse Bonilla 5, Arthur Bookman 6 and Joan Wither 7, 1University of British Columbia Department of Rheumatology, Vancouver, Canada, 2Brigham Woman's Hospital, Boston, 3University Health Network, Toronto, ON, Canada, 4Krembil Research Institute, Toronto, ON, Canada, 5University Health Network, University of Toronto, Toronto, ON, Canada, 6University Health Network, Toronto, Canada, 7University Health Network, Krembil Research Institute, Toronto, ON, Canada

    Background/Purpose: Primary Sjögren syndrome (pSS) is a systemic autoimmune disease with an incompletely understood pathogenesis and heterogenous disease manifestations. Identifying cellular immune changes that may…
  • Abstract Number: 94 • 2019 ACR/ARP Annual Meeting

    Tumor Necrosis Factor Receptor 2 Signaling Potentiates Proliferation and Suppressive Activities of Follicular Regulatory T Cells

    Shotaro kawano1, Hiroki Mitoma 2, Shoichiro Inokuchi 3, Masahiro Ayano 2, Yasutaka Kimoto 4, Mitsuteru Akahoshi 2, Yojiro Arinobu 2, Koichi Akashi 2, Takahiko Horiuchi 5 and Hiroaki Niiro 6, 1Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 2Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Fukuoka, Japan, Fukuoka, Japan, 3Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Fukuoka, Japan, Fukuoka, Fukuoka, Japan, 4Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, 5Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, Beppu, Japan, 6Clinical Education Centre, Kyushu University Hospital, Fukuoka, Japan, Fukuoka, Japan

    Background/Purpose: Tumor Necrosis Factor (TNF) α is a multifunctional cytokine with pro-inflammatory and anti-inflammatory characteristics. Regulatory T cells (Treg) express a remarkably high level of…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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