ACR Meeting Abstracts

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Abstracts tagged "T cells"

  • Abstract Number: 1025 • 2019 ACR/ARP Annual Meeting

    Dynamic Changes During SLE Flare Implicate Age-Associated B Cells and Altered T Follicular and Peripheral Helper Cell Responses in Disease Activity

    Kieran Manion1, Zahi Touma 2, Dennisse Bonilla 2, Dafna Gladman 3, Murray Urowitz 2 and Joan Wither 4, 1Krembil Research Institute, Toronto, ON, Canada, 2University Health Network, University of Toronto, Toronto, ON, Canada, 3Krembil Research Institute, U of Toronto, Toronto, ON, Canada, 4University Health Network, Krembil Research Institute, Toronto, ON, Canada

    Background/Purpose: SLE is a chronic autoimmune disorder in which periods of relative disease inactivity are punctuated by flares that present with increased inflammation and tissue…
  • Abstract Number: 1031 • 2019 ACR/ARP Annual Meeting

    Expanded Circulating Peripheral Helper T Cells Are Associated with B Cell Differentiation in Systemic Lupus Erythematosus

    Ayako Makiyama1, Asako Chiba 2, Daisuke Noto 1, Goh Murayama 3, Tomohiro Mizuno 4, Taiga Kuga 5, Ken Yamaji 5, Naoto Tamura 5 and Sachiko Miyake 2, 1Juntendo University School of Medicine, Tokyo, Japan, 2Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan, 3Department of Internal Medicine and Rhumatology, Juntendo University School of Medicine, Tokyo, Japan, 4Department of Immunlogy, Juntendo University School of Medicine, Tokyo, Japan, 5Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

    Background/Purpose: Autoreactive T-B cell interactions in lymphoid tissue have been thought to play a crucial role in the autoantibody production in systemic lupus erythematosus (SLE).…
  • Abstract Number: 25 • 2019 ACR/ARP Annual Meeting

    Altered Distribution and Enhanced Osteoclastogenesis of Mucosal-associated Invariant T Cells in Gouty Arthritis

    Yong-Wook Park1, Young-Nan Cho 1, Hae-Seong Jeong 1, Hye-Mi Jin 1 and Seung-Jung Kee 1, 1Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea

    Background/Purpose: Mucosal-associated invariant T (MAIT) cells are subsets of innate invariant T cells and rapidly produce Th1/Th17 cytokines including interferon (IFN)-γ, tumor necrosis factor (TNF)-α,…
  • Abstract Number: 1069 • 2019 ACR/ARP Annual Meeting

    CD4+ T Helper Cell Populations with High PD-1 Expression Are Expanded in Systemic Sclerosis

    Alisa Mueller1, Andrea Fava 2, Deepak Rao 1 and Francesco Boin 3, 1Brigham and Women's Hospital, Boston, MA, 2Johns Hopkins University School of Medicine, Baltimore, MD, 3UCSF, San Francisco, CA

    Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by tissue fibrosis, vascular injury, and autoantibody production. CXCR5+ PD-1+ T follicular helper (Tfh) cells, which…
  • Abstract Number: 66 • 2019 ACR/ARP Annual Meeting

    Amelioration of Immune Complex-Mediated Glomerulonephritis by CD6 Modulation

    Samantha Chalmers1, Sayra Garcia 1, Jeanette Ampudia 2, Cherie Ng 2, Stephen Connelly 2 and Chaim Putterman 3, 1Albert Einstein College of Medicine, Bronx, NY, 2Equillium, Inc, San Diego, CA, 3Albert Einstein College of Medicine, New York, NY

    Background/Purpose: CD6 is a co-stimulatory receptor on T cells, that binds to activated leukocyte cell adhesion molecule (ALCAM), a ligand expressed on antigen presentation cells…
  • Abstract Number: 1455 • 2019 ACR/ARP Annual Meeting

    B and T Cell Immunologic Features Associated with Higher Disease Activity Score and Focus Score in Primary Sjögren Syndrome

    Alice Mai1, Yuriy Baglaenko 2, Dario Ferri 3, Kieran Manion 4, Dennisse Bonilla 5, Arthur Bookman 6 and Joan Wither 7, 1University of British Columbia Department of Rheumatology, Vancouver, Canada, 2Brigham Woman's Hospital, Boston, 3University Health Network, Toronto, ON, Canada, 4Krembil Research Institute, Toronto, ON, Canada, 5University Health Network, University of Toronto, Toronto, ON, Canada, 6University Health Network, Toronto, Canada, 7University Health Network, Krembil Research Institute, Toronto, ON, Canada

    Background/Purpose: Primary Sjögren syndrome (pSS) is a systemic autoimmune disease with an incompletely understood pathogenesis and heterogenous disease manifestations. Identifying cellular immune changes that may…
  • Abstract Number: 94 • 2019 ACR/ARP Annual Meeting

    Tumor Necrosis Factor Receptor 2 Signaling Potentiates Proliferation and Suppressive Activities of Follicular Regulatory T Cells

    Shotaro kawano1, Hiroki Mitoma 2, Shoichiro Inokuchi 3, Masahiro Ayano 2, Yasutaka Kimoto 4, Mitsuteru Akahoshi 2, Yojiro Arinobu 2, Koichi Akashi 2, Takahiko Horiuchi 5 and Hiroaki Niiro 6, 1Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 2Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Fukuoka, Japan, Fukuoka, Japan, 3Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Fukuoka, Japan, Fukuoka, Fukuoka, Japan, 4Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, 5Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, Beppu, Japan, 6Clinical Education Centre, Kyushu University Hospital, Fukuoka, Japan, Fukuoka, Japan

    Background/Purpose: Tumor Necrosis Factor (TNF) α is a multifunctional cytokine with pro-inflammatory and anti-inflammatory characteristics. Regulatory T cells (Treg) express a remarkably high level of…
  • Abstract Number: 1774 • 2019 ACR/ARP Annual Meeting

    Potential Involvement of OX40 Expressing Tfh Cells on Regulation of Autoantibody Sialylation in Experimental and Rheumatoid Arthritis

    Izumi Kurata1, Isao Matsumoto 1, Natsuko Mikami 1, Ayako Ohyama 1, Atsumu Osada 1, Yuya Kondo 1, Hiroto Tsuboi 1 and Takayuki Sumida 1, 1Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

    Background/Purpose: Recently, IL-23-Th17 cells axis and hyposialylation of antibodies were proved to be linked to experimental and rheumatoid arthritis. However it remains uncertain how Tfh,…
  • Abstract Number: 97 • 2019 ACR/ARP Annual Meeting

    Low Frequency of Circulating T Follicular Helper 1 Cells Is Associated to Adequate Response to Adalimumab Therapy in Rheumatoid Arthritis

    Charlotte Lucas1, Roussine Codo 2, Jean-David Albert 3, Rachel Jean 2, Stéphane Rodriguez 4, Patricia Amé-Thomas 5 and Aleth Perdriger 6, 1Rheumatology department, Rennes University Hospital, France, Rennes, Bretagne, France, 2SITI Laboratory, Rennes University Hospital, EFS, INSERM1236, France, Rennes, Bretagne, France, 3Rheumatology department, Rennes University Hospital and Institut NUMECAN, INSERM U 1241, Rennes, Bretagne, France, 4PhD, SITI Laboratory, Rennes University Hospital, EFS, INSERM1236, France, Rennes, Bretagne, France, 5SITI Laboratory, Univ Rennes, Rennes University Hospital, EFS, INSERM1236, France, Rennes, Bretagne, France, 6Rheumatology department, Rennes University Hospital, France, Rennes, France

    Background/Purpose: T follicular helper cells (Tfh) constitute a distinct CD4+ helper T-cell subset, promoting B-cell maturation and activation. Circulating Tfh (cTfh) seem to play a…
  • Abstract Number: 2035 • 2019 ACR/ARP Annual Meeting

    Systemic Lupus Erythematosus (SLE) Is Caused by Expanded DOCK8-Positive Autoantibody-Inducing CD4 T (aiCD4 T) Cell

    Shunichi Shiozawa1, Ken Tsumiyama 1, Yumi Miyazaki 2, Keiichi Sakurai 3, Takahiko Horiuchi 4, Motohiro Oribe 5, Takashi Yamane 6, Hidetoshi Kagawa 7 and Kazuko Shiozawa 8, 1Institute for Rheumatic Diseases, Ashiya, Japan, 2Kyushu University Beppu Hospital, Tokyo, Japan, 3Rheumatology and Allergology, St. Marianna University School of Medicine, Tokyo, Japan, 4Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, Beppu, Japan, 5Oribe Rheumatology Clinic, Oita, Japan, 6Department of Rheumatology, Kakogawa Central City Hospital, Kakogawa, Japan, 7Rheumatology, Red Cross Society Himeji Hospital, Himeji, Japan, 8Rheumatic Diseases Center, Hyogo Prefectural Kakogawa Medical Center, Ashiya, Japan

    Background/Purpose: We previously found in reproducible experiments in which the mice not prone to autoimmune disease were immunized repeatedly with antigen that overstimulation of CD4…
  • Abstract Number: 102 • 2019 ACR/ARP Annual Meeting

    Serine Arginine-Rich Splicing Factor 1 (SRSF1) Restrains IFN-γ and IL-17 Inflammatory Cytokine Production and Its Selective Deficiency in T Cells Exacerbates Experimental Autoimmune Encephalomyelitis (EAE) and Nephrotoxic Nephritis (NTN)

    Takayuki Katsuyama1, Kotaro Otomo 1, Hao Li 2, Michihito Kono 3, Nobuya Yoshida 1, George Tsokos 1 and Vaishali R. Moulton 1, 1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 2Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, 3Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan

    Background/Purpose: CD4 T helper 1 (Th1) and Th17 cells producing IFN-γ and IL-17 are aberrantly increased and contribute to inflammatory responses in autoimmune diseases including…
  • Abstract Number: 2420 • 2019 ACR/ARP Annual Meeting

    Role of T Follicular Helper Cells and T Peripheral Helper Cells in the Activation of B Cells in Sjögren Syndrome

    Anastasia Dupré1, Juliette Pascaud 1, Elodie Rivière 2, Michael Mingueneau 3, Gaetane Nocturne 4 and Xavier Mariette 5, 1IMVA - IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre, Paris, France, 2IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre ; Arthritis R&D, France, Paris, France, 3Biomarker Discovery Platform UTechS CB, Hub de Bioinformatique et biostatistique, C3IB, Institut Pasteur, Paris, France, 4Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France., Paris, France, 5Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France

    Background/Purpose: Primary Sjögren's Syndrome (pSS) is a rare systemic autoimmune disease characterized by a dysregulation of cellular and humoral immunity, leading to a hyper-activation of…
  • Abstract Number: 109 • 2019 ACR/ARP Annual Meeting

    Targeting CD6 Expression Attenuates T Cell Activity in Murine Collagen Induced Arthritis

    Yan Li 1, Jeffrey H. Ruth 2, Stephanie Rasmussen 3, Kalana S. Athukorala 2, Daniel P. Weber 2, M. Asif Amin 2, Phillip Campbell 3, Nora Singer 4, David Fox5 and Feng Lin 1, 1Cleveland Clinic, Cleveland, OH, 2University of Michigan, Ann Arbor, MI, 3Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 4The MetroHealth System -Case Western Reserve University School of Medicine, Cleveland, OH, 5Division of Rheumatology, Department of Internal Medicine, Autoimmunity Center of Excellence,University of Michigan, Ann Arbor, MI

    Background/Purpose: CD6, an important regulator of T cell function, interacts with the ligands CD166 and CD318. We previously examined CD318 expression on synovial tissues (STs)…
  • Abstract Number: 2421 • 2019 ACR/ARP Annual Meeting

    Circulating CCR7loPD-1hi Follicular Helper T Cells Indicate Disease Activity and Glandular Inflammation in Patients with Primary Sjögren’s Syndrome

    Ji-Won Kim1, Jaeseon Lee 2, Ui Hong Jung 1, Sung-Hoon Park 1, Jennifer Lee 3, Seung-Ki Kwok 3 and Sung-Hwan Park 3, 1Catholic University of Daegu School of Medicine, Daegu, Republic of Korea, 2Catholic University of Korea, College of Medicine, Seoul, Republic of Korea, 3Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

    Background/Purpose: Since primary Sjögren’s syndrome (pSS) is an autoummune disease of B cell hyperactivity and pathologic autoantibody response, follicular helper T (Tfh) cells and follicular…
  • Abstract Number: 110 • 2019 ACR/ARP Annual Meeting

    Bioinformatics Analysis of Transcriptomics Data Reveals That SRSF1 Is a Novel Molecular Brake for the T Cell Activation Program and Controls Key Cytokine Signaling Genes Implicated in Systemic Lupus Erythematosus

    Rhea Bhargava1, Michelle S. Lee 2, Takayuki Katsuyama 3 and Vaishali R. Moulton 3, 1Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, 2Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, 3Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

    Background/Purpose: T cells from systemic lupus erythematosus (SLE) patients exhibit a hyperactive phenotype with defects in homeostasis, signaling and cytokine production. By discovery approaches, we…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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