ACR Meeting Abstracts

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Abstracts tagged "T cells"

  • Abstract Number: 1774 • 2019 ACR/ARP Annual Meeting

    Potential Involvement of OX40 Expressing Tfh Cells on Regulation of Autoantibody Sialylation in Experimental and Rheumatoid Arthritis

    Izumi Kurata1, Isao Matsumoto 1, Natsuko Mikami 1, Ayako Ohyama 1, Atsumu Osada 1, Yuya Kondo 1, Hiroto Tsuboi 1 and Takayuki Sumida 1, 1Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

    Background/Purpose: Recently, IL-23-Th17 cells axis and hyposialylation of antibodies were proved to be linked to experimental and rheumatoid arthritis. However it remains uncertain how Tfh,…
  • Abstract Number: 97 • 2019 ACR/ARP Annual Meeting

    Low Frequency of Circulating T Follicular Helper 1 Cells Is Associated to Adequate Response to Adalimumab Therapy in Rheumatoid Arthritis

    Charlotte Lucas1, Roussine Codo 2, Jean-David Albert 3, Rachel Jean 2, Stéphane Rodriguez 4, Patricia Amé-Thomas 5 and Aleth Perdriger 6, 1Rheumatology department, Rennes University Hospital, France, Rennes, Bretagne, France, 2SITI Laboratory, Rennes University Hospital, EFS, INSERM1236, France, Rennes, Bretagne, France, 3Rheumatology department, Rennes University Hospital and Institut NUMECAN, INSERM U 1241, Rennes, Bretagne, France, 4PhD, SITI Laboratory, Rennes University Hospital, EFS, INSERM1236, France, Rennes, Bretagne, France, 5SITI Laboratory, Univ Rennes, Rennes University Hospital, EFS, INSERM1236, France, Rennes, Bretagne, France, 6Rheumatology department, Rennes University Hospital, France, Rennes, France

    Background/Purpose: T follicular helper cells (Tfh) constitute a distinct CD4+ helper T-cell subset, promoting B-cell maturation and activation. Circulating Tfh (cTfh) seem to play a…
  • Abstract Number: 2035 • 2019 ACR/ARP Annual Meeting

    Systemic Lupus Erythematosus (SLE) Is Caused by Expanded DOCK8-Positive Autoantibody-Inducing CD4 T (aiCD4 T) Cell

    Shunichi Shiozawa1, Ken Tsumiyama 1, Yumi Miyazaki 2, Keiichi Sakurai 3, Takahiko Horiuchi 4, Motohiro Oribe 5, Takashi Yamane 6, Hidetoshi Kagawa 7 and Kazuko Shiozawa 8, 1Institute for Rheumatic Diseases, Ashiya, Japan, 2Kyushu University Beppu Hospital, Tokyo, Japan, 3Rheumatology and Allergology, St. Marianna University School of Medicine, Tokyo, Japan, 4Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, Beppu, Japan, 5Oribe Rheumatology Clinic, Oita, Japan, 6Department of Rheumatology, Kakogawa Central City Hospital, Kakogawa, Japan, 7Rheumatology, Red Cross Society Himeji Hospital, Himeji, Japan, 8Rheumatic Diseases Center, Hyogo Prefectural Kakogawa Medical Center, Ashiya, Japan

    Background/Purpose: We previously found in reproducible experiments in which the mice not prone to autoimmune disease were immunized repeatedly with antigen that overstimulation of CD4…
  • Abstract Number: 102 • 2019 ACR/ARP Annual Meeting

    Serine Arginine-Rich Splicing Factor 1 (SRSF1) Restrains IFN-γ and IL-17 Inflammatory Cytokine Production and Its Selective Deficiency in T Cells Exacerbates Experimental Autoimmune Encephalomyelitis (EAE) and Nephrotoxic Nephritis (NTN)

    Takayuki Katsuyama1, Kotaro Otomo 1, Hao Li 2, Michihito Kono 3, Nobuya Yoshida 1, George Tsokos 1 and Vaishali R. Moulton 1, 1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 2Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, 3Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan

    Background/Purpose: CD4 T helper 1 (Th1) and Th17 cells producing IFN-γ and IL-17 are aberrantly increased and contribute to inflammatory responses in autoimmune diseases including…
  • Abstract Number: 2420 • 2019 ACR/ARP Annual Meeting

    Role of T Follicular Helper Cells and T Peripheral Helper Cells in the Activation of B Cells in Sjögren Syndrome

    Anastasia Dupré1, Juliette Pascaud 1, Elodie Rivière 2, Michael Mingueneau 3, Gaetane Nocturne 4 and Xavier Mariette 5, 1IMVA - IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre, Paris, France, 2IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre ; Arthritis R&D, France, Paris, France, 3Biomarker Discovery Platform UTechS CB, Hub de Bioinformatique et biostatistique, C3IB, Institut Pasteur, Paris, France, 4Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France., Paris, France, 5Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France

    Background/Purpose: Primary Sjögren's Syndrome (pSS) is a rare systemic autoimmune disease characterized by a dysregulation of cellular and humoral immunity, leading to a hyper-activation of…
  • Abstract Number: 109 • 2019 ACR/ARP Annual Meeting

    Targeting CD6 Expression Attenuates T Cell Activity in Murine Collagen Induced Arthritis

    Yan Li 1, Jeffrey H. Ruth 2, Stephanie Rasmussen 3, Kalana S. Athukorala 2, Daniel P. Weber 2, M. Asif Amin 2, Phillip Campbell 3, Nora Singer 4, David Fox5 and Feng Lin 1, 1Cleveland Clinic, Cleveland, OH, 2University of Michigan, Ann Arbor, MI, 3Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 4The MetroHealth System -Case Western Reserve University School of Medicine, Cleveland, OH, 5Division of Rheumatology, Department of Internal Medicine, Autoimmunity Center of Excellence,University of Michigan, Ann Arbor, MI

    Background/Purpose: CD6, an important regulator of T cell function, interacts with the ligands CD166 and CD318. We previously examined CD318 expression on synovial tissues (STs)…
  • Abstract Number: 2421 • 2019 ACR/ARP Annual Meeting

    Circulating CCR7loPD-1hi Follicular Helper T Cells Indicate Disease Activity and Glandular Inflammation in Patients with Primary Sjögren’s Syndrome

    Ji-Won Kim1, Jaeseon Lee 2, Ui Hong Jung 1, Sung-Hoon Park 1, Jennifer Lee 3, Seung-Ki Kwok 3 and Sung-Hwan Park 3, 1Catholic University of Daegu School of Medicine, Daegu, Republic of Korea, 2Catholic University of Korea, College of Medicine, Seoul, Republic of Korea, 3Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

    Background/Purpose: Since primary Sjögren’s syndrome (pSS) is an autoummune disease of B cell hyperactivity and pathologic autoantibody response, follicular helper T (Tfh) cells and follicular…
  • Abstract Number: 110 • 2019 ACR/ARP Annual Meeting

    Bioinformatics Analysis of Transcriptomics Data Reveals That SRSF1 Is a Novel Molecular Brake for the T Cell Activation Program and Controls Key Cytokine Signaling Genes Implicated in Systemic Lupus Erythematosus

    Rhea Bhargava1, Michelle S. Lee 2, Takayuki Katsuyama 3 and Vaishali R. Moulton 3, 1Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, 2Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, 3Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

    Background/Purpose: T cells from systemic lupus erythematosus (SLE) patients exhibit a hyperactive phenotype with defects in homeostasis, signaling and cytokine production. By discovery approaches, we…
  • Abstract Number: 2816 • 2019 ACR/ARP Annual Meeting

    An Expanded Granzyme K+ CD8 T Cell Population Induces Inflammatory Responses in Rheumatoid Arthritis Synovium

    Anna Helena Jonsson1, Fan Zhang 2, Gerald Watts 2, Kevin Wei 1, Deepak Rao 2, Soumya Raychaudhuri 2 and Michael Brenner 3, 1Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2Brigham and Women's Hospital, Boston, MA, 3Brigham and Women’s Hospital:, Boston

    Background/Purpose: CD8 T cells represent nearly half of T cells in inflamed synovium from patients with rheumatoid arthritis (RA). Research to date has focused on…
  • Abstract Number: 111 • 2019 ACR/ARP Annual Meeting

    The Transcription Factor STAT3 Regulates Pathogenic Th17 Responses in Autoimmune Disease via Noncanonical Roles

    Catherine Poholek1, Itay Raphael 2 and Mandy McGeachy 2, 1UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, 2University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: The Th17 lineage of CD4 T cells drives autoimmune diseases such as RA, SLE, IBD, and MS. The JAK2/STAT3 signaling pathway is required for…
  • Abstract Number: 2818 • 2019 ACR/ARP Annual Meeting

    Differences in the Phenotypic Landscape and Antigen Specificity of CD4+ T Cells Are Present in CCP+ Subjects Before the Onset of Rheumatoid Arthritis

    Virginia Muir 1, Cliff Rims 1, Kevin Deane 2, Jeffrey Carlin 3, Sylvia Posso 1, Sunil Nagpal 4, Navin Rao 4, Frédéric Baribaud 5, George Vratsanos 6, William Robinson 7, Gary Firestein 8, V. Michael Holers 9, Peter Linsley 1, Eddie James1 and Jane Buckner 1, 1Benaroya Research Institute, Seattle, WA, 2University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora, CO, 3Virginia Mason Medical Center, Seattle, WA, 4Janssen R&D, Spring House, PA, 5Janssen Research & Development, LLC, Spring House, PA, 6JNJ, Raritan, NJ, 7Stanford University, Palo Alto, CA, 8University of California, San Diego, San Diego, 9University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Denver

    Background/Purpose: The “Targeting Immune Responses for Prevention of RA” (TIP-RA) collaboration studies individuals at high risk for developing rheumatoid arthritis (RA) because of serum anti-citrullinated…
  • Abstract Number: 113 • 2019 ACR/ARP Annual Meeting

    In Vitro Characterization of the Effect of Cenerimod, a Potent and Selective Sphingosine 1-Phosphate Receptor 1 (S1P1) Modulator, on S1P1 Receptor Expression, Receptor Internalization, and Migration of Primary Human T Cells in the Presence or Absence of Glucocorticoids

    Paulina Kulig 1, Mark Murphy 1 and Marcel Keller1, 1Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland

    Background/Purpose: Cenerimod is a potent, selective, and orally active sphingosine 1-phosphate receptor 1 (S1P1) modulator that is currently being evaluated in a Phase 2b study…
  • Abstract Number: 2819 • 2019 ACR/ARP Annual Meeting

    The Transcription Factor MAF Controls the Ability of T Peripheral Helper (Tph) Cells to Help B Cells

    Alexandra Bocharnikov1, Vanessa Wacleche 1, Ye Cao 1 and Deepak Rao 2, 1Brigham and Women's Hospital, Boston, 2Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Pathologic T cell-B cell interactions are hallmark features of many autoimmune diseases. PD-1hi CXCR5- T peripheral helper (Tph) cells are B cell-helper T cells…
  • Abstract Number: 500 • 2019 ACR/ARP Annual Meeting

    The Dysregulation of NK Cells and Non-Conventional NK-T and γδ-T Cells in Individuals at Risk of Developing Rheumatoid Arthritis

    Klára Prajzlerová1, Olga Kryštůfková 2, Petra Hánová 3, Hana Hulejová 3, Monika Gregová 1, Nora Petrovská 1, Herman Mann 4, Karel Pavelka 4, Jiří Vencovský 4, Ladislav Senolt 4 and Mária Filková 1, 1Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 2Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague, Czech Republic, 3Institute of Rheumatology, Prague, Czech Republic, 4Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague 2, Czech Republic

    Background/Purpose: The positivity of antibodies against citrullinated proteins (ACPA) precedes the clinical manifestation and significantly increases the risk of rheumatoid arthritis (RA). EULAR characterised individuals…
  • Abstract Number: 2897 • 2019 ACR/ARP Annual Meeting

    Increased CD69+ Tissue-resident Memory T (TRM) Cells and STAT3 Expression in Cutaneous Lupus Erythematosus Patients Recalcitrant to Antimalarials

    Majid Zeidi 1, Kristen Chen 1, Krisha Desai 1, Hee Joo Kim 2, Srita Chakka 3, Rachel Lim 4 and Victoria Werth1, 1Corporal Michael J. Crescenz VAMC, Philadelphia, PA, USA and Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA, Philadelphia, PA, 2Corporal Michael J. Crescenz VAMC, Philadelphia, PA, USA andDepartment of Dermatology, University of Pennsylvania, Philadelphia, PA, USA and Department of Dermatology, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea, Republic of (South), Philadelphia, 3Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA, Philadelphia, 4Corporal Michael J. Crescenz VAMC, Philadelphia, PA, USA, Philadelphia

    Background/Purpose: Cutaneous lupus erythematosus (CLE) is an autoimmune disease with various subsets and clinical manifestations. T lymphocytes are the predominant cell type found in lesional…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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