Abstracts tagged "T cells"

Abstract Number: 1025 • 2019 ACR/ARP Annual Meeting
Dynamic Changes During SLE Flare Implicate Age-Associated B Cells and Altered T Follicular and Peripheral Helper Cell Responses in Disease Activity
Kieran Manion¹, Zahi Touma ², Dennisse Bonilla ², Dafna Gladman ³, Murray Urowitz ² and Joan Wither ⁴, ¹Krembil Research Institute, Toronto, ON, Canada, ²University Health Network, University of Toronto, Toronto, ON, Canada, ³Krembil Research Institute, U of Toronto, Toronto, ON, Canada, ⁴University Health Network, Krembil Research Institute, Toronto, ON, Canada
Background/Purpose: SLE is a chronic autoimmune disorder in which periods of relative disease inactivity are punctuated by flares that present with increased inflammation and tissue…
Abstract Number: 1031 • 2019 ACR/ARP Annual Meeting
Expanded Circulating Peripheral Helper T Cells Are Associated with B Cell Differentiation in Systemic Lupus Erythematosus
Ayako Makiyama¹, Asako Chiba ², Daisuke Noto ¹, Goh Murayama ³, Tomohiro Mizuno ⁴, Taiga Kuga ⁵, Ken Yamaji ⁵, Naoto Tamura ⁵ and Sachiko Miyake ², ¹Juntendo University School of Medicine, Tokyo, Japan, ²Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan, ³Department of Internal Medicine and Rhumatology, Juntendo University School of Medicine, Tokyo, Japan, ⁴Department of Immunlogy, Juntendo University School of Medicine, Tokyo, Japan, ⁵Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Autoreactive T-B cell interactions in lymphoid tissue have been thought to play a crucial role in the autoantibody production in systemic lupus erythematosus (SLE).…
Abstract Number: 25 • 2019 ACR/ARP Annual Meeting
Altered Distribution and Enhanced Osteoclastogenesis of Mucosal-associated Invariant T Cells in Gouty Arthritis
Yong-Wook Park¹, Young-Nan Cho ¹, Hae-Seong Jeong ¹, Hye-Mi Jin ¹ and Seung-Jung Kee ¹, ¹Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are subsets of innate invariant T cells and rapidly produce Th1/Th17 cytokines including interferon (IFN)-γ, tumor necrosis factor (TNF)-α,…
Abstract Number: 1069 • 2019 ACR/ARP Annual Meeting
CD4+ T Helper Cell Populations with High PD-1 Expression Are Expanded in Systemic Sclerosis
Alisa Mueller¹, Andrea Fava ², Deepak Rao ¹ and Francesco Boin ³, ¹Brigham and Women's Hospital, Boston, MA, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³UCSF, San Francisco, CA
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by tissue fibrosis, vascular injury, and autoantibody production. CXCR5+ PD-1+ T follicular helper (Tfh) cells, which…
Abstract Number: 66 • 2019 ACR/ARP Annual Meeting
Amelioration of Immune Complex-Mediated Glomerulonephritis by CD6 Modulation
Samantha Chalmers¹, Sayra Garcia ¹, Jeanette Ampudia ², Cherie Ng ², Stephen Connelly ² and Chaim Putterman ³, ¹Albert Einstein College of Medicine, Bronx, NY, ²Equillium, Inc, San Diego, CA, ³Albert Einstein College of Medicine, New York, NY
Background/Purpose: CD6 is a co-stimulatory receptor on T cells, that binds to activated leukocyte cell adhesion molecule (ALCAM), a ligand expressed on antigen presentation cells…
Abstract Number: 1455 • 2019 ACR/ARP Annual Meeting
B and T Cell Immunologic Features Associated with Higher Disease Activity Score and Focus Score in Primary Sjögren Syndrome
Alice Mai¹, Yuriy Baglaenko ², Dario Ferri ³, Kieran Manion ⁴, Dennisse Bonilla ⁵, Arthur Bookman ⁶ and Joan Wither ⁷, ¹University of British Columbia Department of Rheumatology, Vancouver, Canada, ²Brigham Woman's Hospital, Boston, ³University Health Network, Toronto, ON, Canada, ⁴Krembil Research Institute, Toronto, ON, Canada, ⁵University Health Network, University of Toronto, Toronto, ON, Canada, ⁶University Health Network, Toronto, Canada, ⁷University Health Network, Krembil Research Institute, Toronto, ON, Canada
Background/Purpose: Primary Sjögren syndrome (pSS) is a systemic autoimmune disease with an incompletely understood pathogenesis and heterogenous disease manifestations. Identifying cellular immune changes that may…
Abstract Number: 94 • 2019 ACR/ARP Annual Meeting
Tumor Necrosis Factor Receptor 2 Signaling Potentiates Proliferation and Suppressive Activities of Follicular Regulatory T Cells
Shotaro kawano¹, Hiroki Mitoma ², Shoichiro Inokuchi ³, Masahiro Ayano ², Yasutaka Kimoto ⁴, Mitsuteru Akahoshi ², Yojiro Arinobu ², Koichi Akashi ², Takahiko Horiuchi ⁵ and Hiroaki Niiro ⁶, ¹Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ²Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Fukuoka, Japan, Fukuoka, Japan, ³Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Fukuoka, Japan, Fukuoka, Fukuoka, Japan, ⁴Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, ⁵Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, Beppu, Japan, ⁶Clinical Education Centre, Kyushu University Hospital, Fukuoka, Japan, Fukuoka, Japan
Background/Purpose: Tumor Necrosis Factor (TNF) α is a multifunctional cytokine with pro-inflammatory and anti-inflammatory characteristics. Regulatory T cells (Treg) express a remarkably high level of…
Abstract Number: 1774 • 2019 ACR/ARP Annual Meeting
Potential Involvement of OX40 Expressing Tfh Cells on Regulation of Autoantibody Sialylation in Experimental and Rheumatoid Arthritis
Izumi Kurata¹, Isao Matsumoto ¹, Natsuko Mikami ¹, Ayako Ohyama ¹, Atsumu Osada ¹, Yuya Kondo ¹, Hiroto Tsuboi ¹ and Takayuki Sumida ¹, ¹Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Background/Purpose: Recently, IL-23-Th17 cells axis and hyposialylation of antibodies were proved to be linked to experimental and rheumatoid arthritis. However it remains uncertain how Tfh,…
Abstract Number: 97 • 2019 ACR/ARP Annual Meeting
Low Frequency of Circulating T Follicular Helper 1 Cells Is Associated to Adequate Response to Adalimumab Therapy in Rheumatoid Arthritis
Charlotte Lucas¹, Roussine Codo ², Jean-David Albert ³, Rachel Jean ², Stéphane Rodriguez ⁴, Patricia Amé-Thomas ⁵ and Aleth Perdriger ⁶, ¹Rheumatology department, Rennes University Hospital, France, Rennes, Bretagne, France, ²SITI Laboratory, Rennes University Hospital, EFS, INSERM1236, France, Rennes, Bretagne, France, ³Rheumatology department, Rennes University Hospital and Institut NUMECAN, INSERM U 1241, Rennes, Bretagne, France, ⁴PhD, SITI Laboratory, Rennes University Hospital, EFS, INSERM1236, France, Rennes, Bretagne, France, ⁵SITI Laboratory, Univ Rennes, Rennes University Hospital, EFS, INSERM1236, France, Rennes, Bretagne, France, ⁶Rheumatology department, Rennes University Hospital, France, Rennes, France
Background/Purpose: T follicular helper cells (Tfh) constitute a distinct CD4+ helper T-cell subset, promoting B-cell maturation and activation. Circulating Tfh (cTfh) seem to play a…
Abstract Number: 2035 • 2019 ACR/ARP Annual Meeting
Systemic Lupus Erythematosus (SLE) Is Caused by Expanded DOCK8-Positive Autoantibody-Inducing CD4 T (aiCD4 T) Cell
Shunichi Shiozawa¹, Ken Tsumiyama ¹, Yumi Miyazaki ², Keiichi Sakurai ³, Takahiko Horiuchi ⁴, Motohiro Oribe ⁵, Takashi Yamane ⁶, Hidetoshi Kagawa ⁷ and Kazuko Shiozawa ⁸, ¹Institute for Rheumatic Diseases, Ashiya, Japan, ²Kyushu University Beppu Hospital, Tokyo, Japan, ³Rheumatology and Allergology, St. Marianna University School of Medicine, Tokyo, Japan, ⁴Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, Beppu, Japan, ⁵Oribe Rheumatology Clinic, Oita, Japan, ⁶Department of Rheumatology, Kakogawa Central City Hospital, Kakogawa, Japan, ⁷Rheumatology, Red Cross Society Himeji Hospital, Himeji, Japan, ⁸Rheumatic Diseases Center, Hyogo Prefectural Kakogawa Medical Center, Ashiya, Japan
Background/Purpose: We previously found in reproducible experiments in which the mice not prone to autoimmune disease were immunized repeatedly with antigen that overstimulation of CD4…
Abstract Number: 102 • 2019 ACR/ARP Annual Meeting
Serine Arginine-Rich Splicing Factor 1 (SRSF1) Restrains IFN-γ and IL-17 Inflammatory Cytokine Production and Its Selective Deficiency in T Cells Exacerbates Experimental Autoimmune Encephalomyelitis (EAE) and Nephrotoxic Nephritis (NTN)
Takayuki Katsuyama¹, Kotaro Otomo ¹, Hao Li ², Michihito Kono ³, Nobuya Yoshida ¹, George Tsokos ¹ and Vaishali R. Moulton ¹, ¹Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, ³Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
Background/Purpose: CD4 T helper 1 (Th1) and Th17 cells producing IFN-γ and IL-17 are aberrantly increased and contribute to inflammatory responses in autoimmune diseases including…
Abstract Number: 2420 • 2019 ACR/ARP Annual Meeting
Role of T Follicular Helper Cells and T Peripheral Helper Cells in the Activation of B Cells in Sjögren Syndrome
Anastasia Dupré¹, Juliette Pascaud ¹, Elodie Rivière ², Michael Mingueneau ³, Gaetane Nocturne ⁴ and Xavier Mariette ⁵, ¹IMVA - IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre, Paris, France, ²IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre ; Arthritis R&D, France, Paris, France, ³Biomarker Discovery Platform UTechS CB, Hub de Bioinformatique et biostatistique, C3IB, Institut Pasteur, Paris, France, ⁴Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France., Paris, France, ⁵Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France
Background/Purpose: Primary Sjögren's Syndrome (pSS) is a rare systemic autoimmune disease characterized by a dysregulation of cellular and humoral immunity, leading to a hyper-activation of…
Abstract Number: 109 • 2019 ACR/ARP Annual Meeting
Targeting CD6 Expression Attenuates T Cell Activity in Murine Collagen Induced Arthritis
Yan Li ¹, Jeffrey H. Ruth ², Stephanie Rasmussen ³, Kalana S. Athukorala ², Daniel P. Weber ², M. Asif Amin ², Phillip Campbell ³, Nora Singer ⁴, David Fox⁵ and Feng Lin ¹, ¹Cleveland Clinic, Cleveland, OH, ²University of Michigan, Ann Arbor, MI, ³Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ⁴The MetroHealth System -Case Western Reserve University School of Medicine, Cleveland, OH, ⁵Division of Rheumatology, Department of Internal Medicine, Autoimmunity Center of Excellence,University of Michigan, Ann Arbor, MI
Background/Purpose: CD6, an important regulator of T cell function, interacts with the ligands CD166 and CD318. We previously examined CD318 expression on synovial tissues (STs)…
Abstract Number: 2421 • 2019 ACR/ARP Annual Meeting
Circulating CCR7loPD-1hi Follicular Helper T Cells Indicate Disease Activity and Glandular Inflammation in Patients with Primary Sjögren’s Syndrome
Ji-Won Kim¹, Jaeseon Lee ², Ui Hong Jung ¹, Sung-Hoon Park ¹, Jennifer Lee ³, Seung-Ki Kwok ³ and Sung-Hwan Park ³, ¹Catholic University of Daegu School of Medicine, Daegu, Republic of Korea, ²Catholic University of Korea, College of Medicine, Seoul, Republic of Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
Background/Purpose: Since primary Sjögren’s syndrome (pSS) is an autoummune disease of B cell hyperactivity and pathologic autoantibody response, follicular helper T (Tfh) cells and follicular…
Abstract Number: 110 • 2019 ACR/ARP Annual Meeting
Bioinformatics Analysis of Transcriptomics Data Reveals That SRSF1 Is a Novel Molecular Brake for the T Cell Activation Program and Controls Key Cytokine Signaling Genes Implicated in Systemic Lupus Erythematosus
Rhea Bhargava¹, Michelle S. Lee ², Takayuki Katsuyama ³ and Vaishali R. Moulton ³, ¹Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, ²Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, ³Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: T cells from systemic lupus erythematosus (SLE) patients exhibit a hyperactive phenotype with defects in homeostasis, signaling and cytokine production. By discovery approaches, we…

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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