Abstracts tagged "T cells"

Abstract Number: 820 • 2015 ACR/ARHP Annual Meeting
Peripheral Blood and Disease Features Associated with Complement Components C3 and C4 in SLE
Mikhail Olferiev, David Fernandez, Leila Khalili, Dina Greenman, Mary K. Crow and Kyriakos A. Kirou, Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, New York, NY
Background/Purpose: Decreases in peripheral blood levels of complement components of C3 and C4 are associated with SLE and often indicate a lupus flare. The aim…
Abstract Number: 1623 • 2015 ACR/ARHP Annual Meeting
Genome-Wide Association Study of DNA Methylation in Th1 and Th17 Cells in Rheumatoid Arthritis
Katharina Stutzer¹, Fausto Pirronello¹, Simone Wahl², Hendrik Schulze-Koops¹, Alla Skapenko¹ and Jan Leipe³, ¹Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany, ²Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Munich, Germany, ³Division of Rheumatology and Clinical Immunology, Med. Klinik und Poliklinik IV, University of Munich, Munich, Germany
Background/Purpose: Rheumatoid arthritis (RA) is a common autoimmune disease characterized by systemic inflammation. Although the understanding of the pathogenesis is incomplete, there is substantial evidence…
Abstract Number: 1944 • 2015 ACR/ARHP Annual Meeting
Dalazatide Modulates CD4+ Effector Memory T-Cell Activity of Patients with Granulomatosis with Polyangiitis in Vitro
Lucas L. Lintermans¹, Ernesto J. Muñoz-Elías², Minke G. Huitema¹, Elisabeth Brouwer¹, Abraham Rutgers¹, Coen A. Stegeman³, Peter Heeringa⁴ and Wayel H. Abdulahad¹, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ²Translational Immunology & Preclinical Development, Kineta, Inc., Seattle, WA, ³Nephrology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ⁴Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
Background/Purpose: There is substantial evidence that CD4+ effector memory T (TEM) cells play a crucial role in the pathogenesis of Granulomatosis with polyangiitis (GPA). The…
Abstract Number: 3023 • 2015 ACR/ARHP Annual Meeting
Decreased Intracellular Calcium Flux in Follicular Helper T Cells after T Cell Receptor Stimulation
Abhinav Seth¹, Edward I. Herman², Jason S. Weinstein¹, Jin Young Choi³ and Joseph E. Craft⁴, ¹Department of Internal Medicine (Rheumatology), Yale University School of Medicine, New Haven, CT, ²Department of Immunobiology, Yale University School of Medicine, New Haven, CT, ³Internal Medicine, Section of Rheumatology, Yale University School of Medicine, New Haven, CT, ⁴Dept of Internal Med/Rheum, Yale University School of Medicine, New Haven, CT
Background/Purpose: Follicular helper T (Tfh) cells are a specialized subset of CD4+ helper T cells that are required for B cell maturation in germinal centers…
Abstract Number: 821 • 2015 ACR/ARHP Annual Meeting
Elevated Serum Levels of Soluble CD146 in Patients with Systemic Sclerosis
Kazunori Kato¹, Tomoko Ito², Naoto Tamura², Sayuri Okuda¹, Masakazu Matsushita², Kurisu Tada², Ken Yamaji² and Yoshinari Takasaki², ¹Department of Biomedical Engineering, Toyo University, Saitama, Japan, ²Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: CD146 is a transmembrane glycoprotein belonging to Ig-superfamily. Human endothelial cells, activated fibroblasts and Th17 cells express CD146 that involved in angiogenesis, fibrosis and…
Abstract Number: 1656 • 2015 ACR/ARHP Annual Meeting
Repeated CD4+ T-Cell Depletion in Patients with Rheumatoid Arthritis over Multiple Cycles of Rituximab Treatment
Matthieu Lavielle¹, Denis Mulleman¹, Hsueh Cheng Sung², Clément Bahuaud², Philippe Goupille¹, Hervé Watier³ and Gilles Thibault³, ¹Service de Rhumatologie, CHRU de Tours, Université François-Rabelais de Tours, CNRS 7292, Tours, France, ²Université François-Rabelais de Tours, CNRS 7292, Tours, France, ³Laboratoire d'Immunologie, CHRU de Tours, Université François-Rabelais de Tours, CNRS 7292, Tours, France
Background/Purpose: CD4+ T-cell depletion after a first cycle of rituximab (RTX) in patients with rheumatoid arthritis (RA) was previously reported by our group (Mélet J…
Abstract Number: 1946 • 2015 ACR/ARHP Annual Meeting
A Novel HLA-DRB1*10:01 Restricted T Cell Epitope from Citrullinated Type II Collagen Relevant for Rheumatoid Arthritis
Karine Chemin¹, Sabrina Pollastro², Eddie James³, Changrong Ge⁴, Inka Albrecht⁵, Jessica Herrath⁶, Christina Gerstner⁷, Thais Rizzi², Karolina Tandre⁸, Lars Rönnblom⁸, Anca I Catrina⁹, Rikard Holmdahl¹⁰, L. Klareskog¹¹, Niek De Vries¹² and Vivianne Malmström¹¹, ¹Medicine, Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, ²Department of Clinical Immunology and Rheumatology, Amsterdam, Netherlands, ³Benaroya Research Institute at Virginia Mason, Seattle, WA, ⁴Department of Medical Biochemistry and Biophysics, Medical Inflammation Research, Karolinska Institute, Stockholm, Sweden, ⁵Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, ⁶Department of Medicine,, Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, ⁷Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Stockholm, Sweden, ⁸Section of Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ⁹Unit of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ¹⁰Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, ¹¹Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ¹²Dept. of Clinical Immunology & Rheumatology, Amsterdam Rheumatology and immunology Center, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Antibodies against citrullinated collagen type II (Cit-CII) are common in sera and synovial fluids of Rheumatoid Arthritis (RA) patients, whereas the known CII T-cell…
Abstract Number: 3024 • 2015 ACR/ARHP Annual Meeting
FcÎ³riiia Mediated Signal Cause Epigenetic Changes in Human Naive CD4+ T-Cells
Ye Bi¹, Chen Chen², Terry Moore³ and Anil K. Chauhan⁴, ¹Internal Medicine, Saint Louis University, St. Louis, MO, ²Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Division of Rheumatology and Pediatric Rheumatology, Saint Louis University School of Medicine, St Louis, MO, ⁴Internal Medicine-Rheumatology, Saint Louis University, St Louis, MO
Background/Purpose: Signals that trigger epigenetic changes in CD4+ T-cells are unknown. To examine a role for FcγRIIIa mediated co-signal in causing epigenetic changes in human…
Abstract Number: 900 • 2015 ACR/ARHP Annual Meeting
A Multidimensional Immunomics Approach Annotates an Immunome Shaped By the Interplay Between the Periphery and the Skin Microenvironment in Systemic Sclerosis
Hari Balaji Venkatanarayanan^1,2, Andrea Low³, Raymond Ong Jr.⁴, Liyun Lai^1,2, Juntao Li^2,5, Chie Hwee Ang^1,2, Suzan Saidin^1,2, Camillus Chua^1,2, Jing Yao Leong^1,2, Agnieszka Maliszewska^1,2, Lakshmi Ramakrishna^1,2, Julian Thumboo⁶ and Salvatore Albani^1,2, ¹SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, ²Duke-National University of Singapore Graduate Medical School, Singapore, Singapore, ³Division of Rheumatology, Singapore General Hospital, Singapore, Singapore, ⁴Singhealth Translational Immunology and Inflammation Centre (STIIC), Singapore Health Services Pte Ltd, Singapore, Singapore, ⁵SingHealth Translational Immunology and Inflammation Centre (STIIC), Singapore Health Services Pte Ltd, Singapore, Singapore, ⁶Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore
Background/Purpose: Systemic sclerosis (SSc), is a chronic autoimmune disorder of the connective tissue. There is an unmet need to define precise immune correlates involved in…
Abstract Number: 1674 • 2015 ACR/ARHP Annual Meeting
Predictive Factors of Persistence in Therapy with Abatacept in Patients with Rheumatoid Arthritis
Silvia Piantoni¹, Enrico Colombo¹, Angela Tincani¹, Paolo Airò² and Mirko Scarsi³, ¹Rheumatology and Clinical Immunology Unit, Spedali Civili and University of Brescia, Brescia, Italy, ²Rheumatology and Clinical immunology Unit, Spedali Civili of Brescia, Brescia, Italy, ³Internal Medicine Unit, Esine Vallecamonica Hospital, ASL Vallecamonica-Sebino, Esine, Italy
Background/Purpose: The prediction of a stable treatment for rheumatoid arthritis (RA) is one of the targets of clinical research in rheumatology. However, only few biomarkers…
Abstract Number: 1965 • 2015 ACR/ARHP Annual Meeting
T Cell Activation, Proliferation and Differentiation Markers Lack Diagnostic Accuracy for Detecting Active GCA and PMR
Kornelis S.M. van der Geest¹, Wayel H. Abdulahad², Qi Wang², Mirjam Roffel², Gerda Horst², Abraham Rutgers², Annemieke M.H. Boots² and Elisabeth Brouwer², ¹Dept. of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
Background/Purpose: The most important biomarker in GCA and PMR patients is increased erythrocytes sedimentation rate (ESR) and/ or increased serum level of C-reactive protein (CRP).…
Abstract Number: 3025 • 2015 ACR/ARHP Annual Meeting
FcγRIIIa-Psyk Signaling up-Regulates TLR3 and TLR5 in Human Naïve CD4+ T-Cells
Chen Chen¹, Ye Bi², Terry Moore³ and Anil K. Chauhan⁴, ¹Rheumatology/Internal Medicine, Saint Louis University, St. Louis, MO, ²Internal Medicine, Saint Louis University, St. Louis, MO, ³Division of Rheumatology and Pediatric Rheumatology, Saint Louis University School of Medicine, St Louis, MO, ⁴Internal Medicine-Rheumatology, Saint Louis University, St Louis, MO
Background/Purpose: To delineate mechanism of FcγRIIIa-pSyk signal in TH17 and IFN-γhigh subset development. To examine whether Toll-like receptor signaling play a role in CD4+ T-cell…
Abstract Number: 901 • 2015 ACR/ARHP Annual Meeting
Novel B Cell-Derived Peptide Regulation of Homeostatic T-Cell Trafficking Is Subverted in Rheumatoid Arthritis
Helen McGettrick¹, Myriam Chimen², Ashley Martin³, Francesca Barone⁴, Andrew Filer⁵, Karim Raza⁶, Christopher Buckley⁴, Parth Narendran⁷ and G. Ed Rainger², ¹Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, ²Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom, ³School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom, ⁴University of Birmingham, Rheumatology Research Group, Birmingham, United Kingdom, ⁵University of Birmingham, Birmingham, United Kingdom, ⁶University of Birmingham, Rheumatology Research Group, Institute of Inflammation and Ageing, United Kingdom, Birmingham, United Kingdom, ⁷Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom
Background/Purpose: In rheumatoid arthritis (RA), inappropriate recruitment of T-cells into the joint contributes to disease pathogenesis and joint destruction. We examined the ability of adiponectin…
Abstract Number: 1750 • 2015 ACR/ARHP Annual Meeting
Identification of Autoantibody-Inducing CD4 T Cell (aiCD4 T cell) That Causes Systemic Lupus Erythematosus (SLE) As DOCK8+ CD4 T Cell: Proof of Concept of Self-Organized Criticality Theory
Shunichi Shiozawa¹, Yumi Miyazaki², Kazuko Shiozawa³ and Ken Tsumiyama², ¹Department of Medicine, Rheumatic Diseases Unit, Kyushu University Beppu Hospital, Beppu, Japan, ²Medicine, Rheumatic Diseases Unit, Kyushu University Beppu Hospital, Beppu, Japan, ³Rheumatic Diseases Center, Konan Kakogawa Hospital, Kakogawa, Japan
Background/Purpose: We have shown that repeated immunization with antigen causes systemic autoimmunity in mice otherwise not prone to spontaneous autoimmune diseases. Overstimulation of CD4 T…
Abstract Number: 2016 • 2015 ACR/ARHP Annual Meeting
Functional Tertiary Lymphoid Structures within the Kidneys of Lupus Prone Mice Resembles Lymph Nodes in Gene Expression Profiling Analysis and Are Detected By in Vivo Imaging
Premasany Kanapathippillai, Sayed Esmaeil Dorraji and Kristin A Fenton, RNA and Molecular Pathology, UIT, The Artic University of Norway, Tromso, Norway
Background/Purpose: The formation of tertiary lymphoid structures (TLS) are known to occur during the development of several diseases, including systemic lupus erythematosus (SLE), but in…

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