Abstracts tagged "T cells"

Abstract Number: 268 • 2016 ACR/ARHP Annual Meeting
Effect of Abatacept Treatment on T Cells in Muscle Tissue and Peripheral Blood in Polymyositis and Dermatomyositis Patients
Quan Tang¹, Daniel Ramsköld², Olga Krystufkova³, Herman F Mann⁴, Cecilia Wick⁵, Maryam Dastmalchi⁶, Peter Brodin⁷, Vivianne Malmström⁸, Jiri Vencovsky⁹ and Ingrid E. Lundberg⁶, ¹Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ²Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Stockholm, Sweden, ³Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ⁴1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, ⁵Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, ⁶Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁷Science for Life Laboratory, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ⁸Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ⁹Pediatria II, Reumatologia, PRINTO, Istituto Giannina Gaslini, Genoa, Italy
Background/Purpose: Abatacept (CTLA4-Ig), a blocking agent for T cell co-stimulation, has been proven beneficial in several autoimmune diseases. The aim of the study was to…
Abstract Number: 1749 • 2016 ACR/ARHP Annual Meeting
The Role of Mucosal-Associated Invariant T (MAIT) Cells in Lupus Dermatitis
Goh Murayama¹, Asako Chiba², Hirofumi Amano³, Ken Yamaji¹, Naoto Tamura¹ and Sachiko Miyake⁴, ¹Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ²Juntendo Univ Sch of Med, Juntendo University School of Medicine, Tokyo, Japan, ³Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan, ⁴Immunology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate T cells that are restricted by MHC-related molecule-1 (MR1) and express a semi-invariant TCRa chain: Va7.2-Ja33 in…
Abstract Number: 1920 • 2016 ACR/ARHP Annual Meeting
Vitamin D Induces a Type 1 Regulatory T Cell (Tr1)-like Phenotype in Human C-C Chemokine Receptor Type 6 (Ccr6)+ th Cells and Promotes Their Migration to an Inflammatory Environment
Wendy Dankers¹, Jan Piet van Hamburg¹, Nadine Davelaar¹, Patrick Asmawidjaja¹, Hoyan Wen¹, Johannes van Leeuwen², Edgar Colin³ and Erik Lubberts¹, ¹Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ²Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ³Rheumatology, ZGT, Almelo, Netherlands
Background/Purpose: The active vitamin D metabolite 1,25(OH)2D3 suppresses various experimental autoimmune diseases. In addition, serum vitamin D levels, vitamin D intake and polymorphisms in the…
Abstract Number: 2710 • 2016 ACR/ARHP Annual Meeting
Bacterial Dysbiosis Associates with Functional Intraepithelial Lymphocyte Changes in Inflammatory Bowel Disease and Spondyloarthritis
Neha Ohri^1,2,3, Mark Gerich^3,4, Blair Fennimore^3,5, Diana Ir⁶, Charles Robertson⁶, Daniel Frank⁶, Liron Caplan⁷, Brandie Wagner⁸ and Kristine Kuhn^9,10, ¹Division of Rheumatology, Mount Sinai West, New York City, NY, ²Division of Rheumatology, University of Colorado, Aurora, CO, ³Mucosal Inflammation Program, University of Colorado, Aurora, CO, ⁴Division of Gastroenterology, University of Colorado, Aurora, CO, ⁵Department of Gastroenterology, University of Colorado, Aurora, CO, ⁶Division of Infectious Disease, University of Colorado, Aurora, CO, ⁷Denver Veterans Affairs Medical Center and UC Denver SOM, Denver, CO, ⁸Department of Biostatistics and Informatics, University of Colorado, Aurora, CO, ⁹Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ¹⁰Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: The microbiome is hypothesized to influence human health and disease. Changes in resident bacteria, termed dysbiosis, occur in spondyloarthritis (SpA) and inflammatory bowel disease…
Abstract Number: 3040 • 2016 ACR/ARHP Annual Meeting
Th17 Migration into the Synovial Fluid of Patients with Active Psoriatic Arthritis Is Enhanced By Regulatory T Cells
Helen Baldwin¹, Amara Ezeonyeji², Mohammed Rohan Butt² and Michael R. Ehrenstein³, ¹Rheumatology, University College London, London, United Kingdom, ²Rheumatology, Medicine, University College London, London, United Kingdom, ³Medicine, University College London, London, United Kingdom
Background/Purpose: Uncontrolled migration of Th17 cells into the skin and joints is a major driver in the pathogenesis of psoriatic arthritis (PsA). Modulation of T…
Abstract Number: 481 • 2016 ACR/ARHP Annual Meeting
Dual Effect of 3-Bromopyruvate on Both Th17 and Treg Cell Differentiation and Dendritic Cell Activation Ameliorates Autoimmune Arthritis in Mice
Takaichi Okano¹, Jun Saegusa², Keisuke Nishimura³, Yo Ueda⁴, Sho Sendo², Soshi Takahashi⁵, Kengo Akashi³, Akira Onishi⁶ and Akio Morinobu², ¹Rheumatology and Clinical immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ²Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ³Department of Rheumatology, Kobe University Hospital, Kobe, Japan, ⁴Kobe University Graduate School of Medicine, Kobe, Japan, ⁵Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ⁶Department for Rheumatology, Kobe University Hospital, Kobe, Japan
Background/Purpose: Recent studies have shown that cellular metabolism plays an important role in regulating immune cell function. In the process of cell differentiation, both interleukin-17-producing…
Abstract Number: 1754 • 2016 ACR/ARHP Annual Meeting
Double-Negative T (DNT) Cell over-Expressing PD-1 and Helios Is Responsible for Lupus Tissue Injury in Systemic Lupus Erythematosus (SLE): Direct Proof That Increased Interferon Alpha (IFNα) Expression Is Sufficient to Induce SLE in Ifnα-Transgenic Mice
Ken Tsumiyama¹, Chieri Akiyama², Yumi Miyazaki¹, Yasushi Miura², Akira Hashiramoto² and Shunichi Shiozawa¹, ¹Department of Medicine, Rheumatic Diseases Unit, Kyushu University Beppu Hospital, Beppu, Japan, ²Department of Biophysics, Kobe University Graduate School of Health Science, Kobe, Japan
Background/Purpose: Previous studies strongly suggest that interferon α (IFNα) may be the principal driver of SLE, where increased IFNα and IFNα-regulated gene transcripts explain many of the immune…
Abstract Number: 1921 • 2016 ACR/ARHP Annual Meeting
Evidence for Prevotella Copri As an Immune-Relevant Bacterium in Rheumatoid Arthritis
Annalisa Pianta¹, Sheila Arvikar¹, Klemen Strle¹, Elise E. Drouin², Qi Wang³, Catherine E. Costello³ and Allen C. Steere⁴, ¹Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, MA, ⁴Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Prevotella copri Methods: HLA-DR-presented peptides were identified directly from RA patients' synovial tissue or peripheral blood mononuclear cells (PBMC) by tandem mass spectrometry. P.…
Abstract Number: 2711 • 2016 ACR/ARHP Annual Meeting
Tissue-Resident IL-23 Responsive Innate T Cells in Mice Comprise Tcrαβ+ and TCRγδ+ Subsets with Overlapping Function
Katia Urso, Imtiyaz Hossain and Joerg Ermann, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Multiple lines of evidence suggest a critical role for the IL-23/IL-17A axis in spondyloarthritis. In susceptible inbred strains, hydrodynamic injection of IL-23 minicircles into…
Abstract Number: 3107 • 2016 ACR/ARHP Annual Meeting
Switching from Anabolic to Catabolic Metabolism – a Novel Immunomodulatory Therapy in RA
Zhen Yang¹, Yi Shen¹, Eric L. Matteson², Ebru Hosgur¹, Jison Hong³, Jorg Goronzy⁴ and Cornelia M. Weyand¹, ¹Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ²Rheumatology, Mayo Clinic, Rochester, MN, ³Medicine/Immunology & Rheumatology, Stanford University, Palo Alto, CA, ⁴Medicine/Division of Immunology & Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Inflammatory activity in RA relies on numerous anabolic processes; including cellular proliferation, cell trafficking, secretion of proinflammatory cytokines and release of antibodies. Lasting reversal…
Abstract Number: 582 • 2016 ACR/ARHP Annual Meeting
ACPA Induce Pathogenic Cytokines Expression in PBMC of ACPA+-RA Patients and Inhibition of Its Effect By Cit-ME a Synthetic Citrullinated Peptide
Smadar Gertel¹, Gidi Karmon², Eszter Szarka³, , Esther Houri-Levi⁴, Edna mozes⁵, Yehuda Shoenfeld⁴ and Howard Amital^6,7, ¹Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, ²Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel, ³Department of Immunology,, Eötvös Loránd University, Budapest,, Budapest, Hungary, ⁴Zabludowicz Center For Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel, Ramat-Gan, Israel, ⁵Department of Immunology,, The Weizmann Institute of Science, Rehovot, Israel., Rehovot, Israel, ⁶Department of Medicine B, Center for Autoimmune Diseases, Sheba Medical Center, Tel-hashomer, Israel, ⁷Department of Internal Medicine 'D', Sackler Faculty of Medicine, Tel-Aviv University, Kfar-Saba, Israel
ACPA induce pathogenic cytokines expression in PBMC of ACPA+-RA patients and inhibition of its effect by Cit-ME a synthetic citrullinated peptide.Smadar Gertel1, Gidi Karmon1, Eszter…
Abstract Number: 1822 • 2016 ACR/ARHP Annual Meeting
CD4+ T Cell Lymphopenia Is Associated with Deficient Ubiquitination of the Cell Cycle Inhibibitor p27kip1 By the E3 Ligase Casitas B-Lineage Lymphoma-b in Patients with Systemic Lupus Erythematosus
Diana Gómez-Martín, Jorge Romo-Tena, Javier Merayo-Chalico and Jorge Alcocer-Varela, Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: Lymphopenia has been associated with the development of autoimmune diseases. Particularly, in patients with Systemic Lupus Erythematosus (SLE) is a common clinical feature. However,…
Abstract Number: 1933 • 2016 ACR/ARHP Annual Meeting
M2 Macrophage Is the Predominant Phenotype in Airways Inflammatory Lesions in Patients with Granulomatosis with Polyangiitis
Alexandre W.S. Souza¹, Mirjan van Timmeren², Jan-Stephan Sanders³, Coen A. Stegeman⁴, Peter Heeringa⁵, Cees G.M. Kallenberg⁶ and Johanna Westra⁶, ¹Universidade Federal de São Paulo, São Paulo, Brazil, ²University of Groningen, Groningen, Netherlands, ³University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁴Nephrology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁵Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁶Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Macrophages may present two main phenotypes indicated as M1 and M2 under different stimuli. M1- and M2-macrophages have divergent functions that range from enhancement…
Abstract Number: 2839 • 2016 ACR/ARHP Annual Meeting
Circulating CD4+CD28null T-Cells Predict the Occurrence of New Lung Damage in Systemic Lupus Erythematosus (SLE) Patients
Manuel Ugarte-Gil^1,2, César Sánchez-Zúñiga³, Rocio V. Gamboa-Cardenas¹, Madeley Aliaga-Zamudio⁴, Francisco Zevallos¹, Ana Mosqueira-Riveros⁴, Mariela Medina¹, Giannina Tineo-Pozo⁴, Claudia Elera-Fitzcarrald¹, Victor Pimentel-Quiroz¹, Omar Sarmiento-Velasquez¹, Jorge M. Cucho-Venegas¹, Jose Alfaro-Lozano¹, Zoila Rodriguez-Bellido^1,5, Cesar A. Pastor-Asurza^1,5, Graciela S. Alarcón⁶ and Risto Perich-Campos^1,5, ¹Rheumatology, Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, ²Universidad Cientifica del Sur, Lima, Peru, ³Diagnostic Support, Hospital Grau. EsSalud, Lima, Peru, ⁴Molecular Biology, Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, ⁵Universidad Nacional Mayor de San Marcos, Lima, Peru, ⁶Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Peripheral CD4+CD28null T-cells constitute a subset of long-lived cytotoxic CD4+ T-cell with pro-inflammatory functions. This T-cell subpopulation has been reported to be associated with…
Abstract Number: 3109 • 2016 ACR/ARHP Annual Meeting
Regulatory T Cells Deficient in Protein Phosphatase 2A Lose Suppressive Function and Convert to an Effector Phenotype
Isaac R. Kasper¹, Hao Li¹, Sokratis Apostolidis², Maria G. Tsokos³ and George C. Tsokos⁴, ¹Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, ²Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, ³Beth Israel Deaconess Medical Center, Boston, MA, ⁴Medicine/Rheumatology, Harvard Medical School Beth Israel, Boston, MA
Background/Purpose: Regulatory T cells (Tregs) represent the fundamental T-cell capable of promoting self-tolerance and balancing excessive inflammation. Quantitative and qualitative Treg deficiencies have been characterized…

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