Abstracts tagged "T cells"

Abstract Number: 3147 • 2016 ACR/ARHP Annual Meeting
Remote Inflammation Triggers Autoimmune Arthritis through Th17 Distribution
Nina Chevalier¹, Jian Tan², Linda Mason², Remy Robert², Craig McKenzie², Seth Masters³ and Charles Mackay², ¹University Freiburg Medical Center, Freiburg, Germany, ²Monash University, Melbourne, Australia, ³WEHI, Melbourne, Australia
Background/Purpose: Autoimmune diseases, such as autoimmune inflammatory arthritis, result through breakdown of immune tolerance and development of self-reactive T cells, or autoantibody-producing B cells. Tolerance…
Abstract Number: 660 • 2016 ACR/ARHP Annual Meeting
Expression of the Chemokine Receptor CXCR5 Is Decreased in the Periphery of Patients with Primary Sjogren’s Syndrome
Marie Wahren-Herlenius¹, Lara Adnan Aqrawi¹, Margarita Ivanchenko¹, Albin Björk¹, Jorge Ramírez¹, Marika Kvarnström¹, Janicke Cecilie Liaaen Jensen² and Kathrine Skarstein³, ¹Karolinska Institutet, Stockholm, Sweden, ²University of Oslo, Oslo, Norway, ³University of Bergen, Bergen, Norway
Background/Purpose: CXCR5 is a chemokine receptor expressed on B and T cell subsets, which binds the CXCL13 ligand produced by follicular dendritic cells. It is…
Abstract Number: 1905 • 2016 ACR/ARHP Annual Meeting
Therapeutic Targeting of JAK/STAT Pathway Inhibits Follicular Helper T Cell Maturation and Function
Flora Sagez and Jacques-Eric Gottenberg, Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France
Background/Purpose: T follicular helper (Tfh) cells represent a CD4+T cell subset specialized to provide help to B cells and to induce memory B cell and…
Abstract Number: 1986 • 2016 ACR/ARHP Annual Meeting
Murine Model of Arthritis Flare Identifies Tissue Resident Memory T Cells in Recurrent Synovitis
Margaret H Chang¹, Anais Levescot², Allyn Morris², Robert Fuhlbrigge^1,3 and Peter Nigrovic^1,2, ¹Immunology, Boston Children's Hospital, Boston, MA, ²Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, ³Dermatology, Brigham and Women’s Hospital, Boston, MA
Background/Purpose: There are 75,000 children affected by JIA in the United States. Despite recent therapeutic advances, treatment often requires chronic therapy and is associated with…
Abstract Number: 2923 • 2016 ACR/ARHP Annual Meeting
T-Cell Receptor Signaling Inhibition By CC-90005, a Selective Protein Kinase C Theta Antagonist, Reduces Antigen Mediated T-Cell Activation and Arthritis Pathology in the Mouse CIA Model
Garth Ringheim¹, Jolanta Kosek¹, Lori Capone², Eun Mi Hur¹ and Peter H. Schafer³, ¹Inflammation and Immunology Translational Development, Celgene Corporation, Summit, NJ, ²Celgene Corporation, Summit, NJ, ³Department of Translational Development, Celgene Corporation, Summit, NJ
Background/Purpose: PKC-θ is a member of the Ca2+-independent novel PKC subfamily, most abundantly expressed in T-cells, and mediates early antigen recognition signal transduction and cell…
Abstract Number: 3216 • 2016 ACR/ARHP Annual Meeting
Integrated High-Dimensional Analyses Reveal a Pathologically Expanded ‘Peripheral’ B Cell-Helper T Cell Population in Rheumatoid Arthritis
Deepak Rao¹, Michael Gurish², Kamil Slowikowski³, Chamith Fonseka², Jennifer Marshall⁴, Yanyan Liu⁵, Laura T. Donlin⁶, Lauren Henderson⁷, Fumitaka Mizoguchi⁸, Nikola Teslovich⁹, Michael Weinblatt¹⁰, Elena Massarotti¹⁰, Jonathan Coblyn¹¹, Simon M. Helfgott¹⁰, Yvonne C. Lee¹², Derrick J. Todd¹⁰, Vivian P. Bykerk¹³, Susan M. Goodman¹⁴, Alessandra B. Pernis¹⁵, Lionel Ivashkiv¹⁴, Elizabeth W. Karlson¹⁰, Peter Nigrovic⁹, Andrew Filer¹⁶, Christopher Buckley¹⁷, James Lederer¹⁸, Soumya Raychaudhuri¹⁹ and Michael Brenner¹, ¹Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology, Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Divisions of Rheumatology and Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, ⁵Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁶Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ⁷Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, ⁸Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, ⁹Brigham and Women's Hospital and Harvard Medical School, Cambridge, MA, ¹⁰Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹²Rheumatology Immunology & Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹³Divison of Rheumatology, Hospital for Special Surgery, New York, NY, ¹⁴Medicine, Hospital for Special Surgery, New York, NY, ¹⁵David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ¹⁶University of Birmingham, Birmingham, United Kingdom, ¹⁷Rheumatology, University of Birmingham, Birmingham, United Kingdom, ¹⁸Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹⁹Brigham and Women's Hospital, Boston, MA
Background/Purpose: Determining the pathologic functions of T cells that infiltrate target tissues remains a central challenge in autoimmune diseases. In rheumatoid arthritis (RA), the formation…
Abstract Number: 674 • 2016 ACR/ARHP Annual Meeting
Targeting Glandular IL-21-Production in Primary Sjogren′s Syndrome Patients By Immunomodulatory Treatment
Gwenny M. Verstappen¹, Hendrik L.F. Broekman¹, Erlin A. Haacke², Petra M. Meiners³, Fred K.L. Spijkervet³, Arjan Vissink⁴, Hendrika Bootsma⁵ and Frans G.M. Kroese¹, ¹Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁴Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁵Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, The Netherlands, Groningen, Netherlands
Background/Purpose: Interleukin-21 plays a central role in plasma cell differentiation and germinal center (GC) formation and is likely involved in the pathogenesis of primary Sjögren’s…
Abstract Number: 1908 • 2016 ACR/ARHP Annual Meeting
Identification of a Novel Pro-Inflammatory T Cell Epitope from His-tRNA-Synthetase Associated with Interstitial Lung Disease in Anti-Jo-1 Positive Patients
Angeles Shunashy Galindo-Feria¹, Inka Albrecht², Antonella Notarnicola², Maryam Dastmalchi², Anatoly Dubnovitsky³, Tatiana Sandalova³, Genadiy Kozhukh³, Lars Rönnblom⁴, Adnane Achour⁵, Vivianne Malmström⁶ and Ingrid E. Lundberg², ¹Department of Medicine., Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³Department of Medicine Solna and Department of Infectious Diseases,, Science for Life Laboratory, Karolinska Institutet and Karolinska University Hospital, Solna, Sweden, ⁴Uppsala University, Department of Medical Sciences, Rheumatology and Science for Life Laboratory, Uppsala, Sweden, ⁵Science for Life Laboratory, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ⁶Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Previous studies have demonstrated that CD4+ T cells from peripheral blood of anti-histidyl-tRNA synthetase (anti-His-tRNA) also known as anti-Jo-1 positive patients proliferate in response…
Abstract Number: 2008 • 2016 ACR/ARHP Annual Meeting
Rapamycin Elicits Rapid and Lasting Improvement of Disease Activity through Blocking Pro-Inflammatory T Cell Lineage Specification in Patients with Active SLE
Zhi-Wei Lai¹, Ivan Marchena², Hajra Tily², Ricardo Garcia¹, Julie Yu², Lisa Francis², Maha Dawood², Ryan Kelly², Stephen Faraone², Paul E. Phillips³ and Andras Perl⁴, ¹Medicine, SUNY, Syracuse, NY, ²SUNY, Syracuse, NY, ³Dept of Medicine/Div of Rheum, SUNY-Upstate Medical Univ, Syracuse, NY, ⁴Department of Medicine, Upstate Medical University, Syracuse, NY
Background/Purpose: The rationale for this prospective, biomarker-driven, open-label clinical trial of rapamycin (ClinicalTrials.gov Identifier: NCT00779194) has been based on growing evidence for involvement of the…
Abstract Number: 2926 • 2016 ACR/ARHP Annual Meeting
Rorc Positive Th17, Th17/Th1, and Th17.1 Cells from the Blood of Treatment NaïVe RA Patients Differ in IL-17A but Are All Pathogenic When Co-Cultured with RA Synovial Fibroblasts
Sandra M.J. Paulissen¹, Jan Piet van Hamburg², Nadine Davelaar², Wendy Dankers³, Patrick Asmawidjaja², Anne-Marie Otten-Mus² and Erik Lubberts², ¹Room Nb-84, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, ²Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ³Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands
Background/Purpose: T cells play a central role in the early stages of rheumatoid arthritis (RA). In this context, we have shown increased proportions of memory…
Abstract Number: 918 • 2016 ACR/ARHP Annual Meeting
Anergic B Cells May Preserve Peripheral Tolerance in Lupus-Prone Congenic Mice
Kieran Manion^1,2, Yuriy Baglaenko^1,2, Nan-Hua Chang², Nafiseh Talaei³ and Joan Wither⁴, ¹Immunology, University of Toronto, Toronto, ON, Canada, ²Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ³Genetics and Development, Krembil Research Institute, Toronto, ON, Canada, ⁴Krembil Research Institute, University Health Network, Toronto, ON, Canada
Background/Purpose: Anergic autoreactive B cells are thought to play a critical role in systemic lupus erythematosus (SLE), a chronic autoimmune disease where breach of tolerance…
Abstract Number: 1909 • 2016 ACR/ARHP Annual Meeting
The Transcription Factor Fra2 Is Playing a Key Role in Treg Development and Autoimmunity
Florian Renoux¹, Mara Stellato², Daniela Impellizzieri³, Riyun Huang⁴, Arun Subramaniam⁵, Clara Dees⁶, Jeorg HW Distler⁶, Gabriela Kania², Onur Boyman³ and Oliver Distler², ¹Depertment of Rheumatology, University Hospital Zurich, Schlieren, Switzerland, ²Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Division of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland, ⁴Immune Mediated Diseases, Sanofi-Genzyme, Framingham, MA, ⁵Sanofi-Genzyme, Framingham, MA, ⁶Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Decreased numbers or altered functions of regulatory T cells (Tregs) have been reported in many inflammatory rheumatic diseases, and Tregs are considered promising…
Abstract Number: 2058 • 2016 ACR/ARHP Annual Meeting
Ectonucleotidase-Mediated Protection of Lupus Mice from Exaggerated Immune Responses and Arterial Vasculopathy
Jason S Knight¹, Levi F Mazza¹, Srilakshmi Yalavarthi¹, Yogen Kanthi² and David J Pinsky², ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI
Background/Purpose: CD39 and CD73 are so-called ectonucleotidases, surface enzymes expressed by leukocytes and endothelial cells that jut into the extracellular space. There, they mediate the…
Abstract Number: 2928 • 2016 ACR/ARHP Annual Meeting
Hypomethylation of an Intragenic Alternative Promoter Contributes to Impaired Treg Function in Rheumatoid Arthritis By Transcriptional Interference with Expression of the Treg-Specific Protein, Glycoprotein a Repetitions Predominant (GARP)
Alla Skapenko, Jan Leipe and Hendrik Schulze-Koops, Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany
Background/Purpose: The expression of Treg specific genes, such as the master transcription factor of Tregs, FoxP3 or the Treg specific surface molecule, glycoprotein A repetitions…
Abstract Number: 922 • 2016 ACR/ARHP Annual Meeting
Negative Regulation of IL-17 Receptor Signaling By Regnase-1 Limits Immunopathology in a Mouse Model of Psoriatic Skin Disease
Sarah L. Gaffen¹, Leticia Monin², Nicole Ward³, Johann Gudjonsson⁴, Abhishek Garg⁵, Alicia Mathers² and Pappachan Kolattukudy⁶, ¹Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA, ³Case Western Reserve University, Cleveland, OH, ⁴Dermatology, University of Michigan, Ann Arbor, MI, ⁵Rheumatology/Clinical Immun, University of Pittsburgh, Pittsburgh, PA, ⁶University of Central Florida, Orlando, FL
Background/Purpose: IL-17 cytokines have emerged as drivers of autoimmunity. Indeed, the IL-17A-targeting antibody secukinumab (Cosentyx) was recently approved for treatment of plaque psoriasis, and shows…

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