Abstracts tagged "T cells"

Abstract Number: 2932 • 2016 ACR/ARHP Annual Meeting
HLA-DR3 Restricted Response to Lupus-Related Auto-Antigen Smd: Autoreactive T Cells Are Inherent in Normal Immune Repertoires
Zhenhuan Zhao¹, Jiling Ren¹, Chao Dai², Carol Kannapell¹, Qian Wang³, Felicia Gaskin⁴ and Shu Man Fu⁵, ¹Medicine/CIIR/Rheumatology, University of Virginia, Charlottesville, VA, ²Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, VA, ³University of Virginia, Charlottesville, VA, ⁴Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, ⁵Department of Medicine, University of Virginia, Charlottesville, VA
Background/Purpose: HLA class II is the major susceptibility region for systemic lupus erythematosus (SLE) and other autoimmune disorders such as rheumatoid arthritis, multiple sclerosis and…
Abstract Number: 1449 • 2016 ACR/ARHP Annual Meeting
The Efficiency of the Regulation of Ca2+ Entry through Calcium Release-Activated Calcium Channel in the Treatment of Rheumatoid Arthritis
Shuang Liu¹, Hitoshi Hasegawa², Takeshi Kiyoi³, Tatsuya Sawasaki⁴ and Kazutaka Maeyama⁵, ¹Dept. Pharmacology,, Ehime University Graduate School of Medicine, Toon-shi, Japan, ²Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Toon, Japan, ³Bioscience, Integrated Center for Sciences, Ehime University, Ehime, Japan, ⁴Division of Cell-Free Sciences, Proteo-Science Center, Ehime University, Matsuyama, Japan, ⁵Department of Pharmacology, Informational Biomedicine, Ehime University Graduate School of Medicine, Toon-shi, Ehime, Japan
Background/Purpose: The regulation of Ca2+ entry by targeting a store-operated calcium release-activated channel (CRAC), known as ORAI, has shown benefits in the treatment of rheumatoid…
Abstract Number: 1913 • 2016 ACR/ARHP Annual Meeting
B Cell Depletion Therapy Impact CD8 T Cells in ANCA-Associated Vasculitis
Antoine Néel^1,2, Marie Bucchia³, Aurelie Caristan¹, Mélanie Néel², Marie Rimbert⁴, Christian Agard¹, Maryvonne Hourmant⁵, Gaelle Tilly², Michelle Yap², François Perrin¹, Pascal Godmer⁶, Julie Graveleau¹, Sophie Brouard², Celine Bressollette⁷, Fadi Fakhouri⁸, Mohamed Hamidou⁹ and Nicolas Degauque², ¹Internal Medicine Department, Nantes University Hospital, Nantes, France, ²INSERM U1064, Nantes, France, ³Pediatrics, Nantes University Hospital, Nantes, France, ⁴Immunology Laboratory, Nantes University Hospital, Nantes, France, ⁵Nephrology, Nantes University Hospital, Nantes, France, ⁶CH Vannes, Vannes, France, ⁷Virology Laboratory, Nantes University Hospital, Nantes, France, ⁸Nephrology Department, Nantes University Hospital, Nantes, France, ⁹Internal Medicine Department, Internal Medicine Department, Nantes University Hospital, Nantes, France
Background/Purpose: In anti-neutrophil cytoplasmic antibodies associated vasculitis (AAV), several clues suggest that the efficacy of B cell depletion therapy lies beyond the suppression of ANCA-producing…
Abstract Number: 2262 • 2016 ACR/ARHP Annual Meeting
CR6086 a New Potent EP4 Receptor Antagonist with Immunomodulatory Activities
Tiziana Piepoli¹, Daniele Maggioni², Silvia Zerbi¹, Anna Stucchi¹, Laura Mennuni¹, Marco Lanza¹, Gianfranco Caselli¹ and Lucio Claudio Rovati¹, ¹Rottapharm Biotech, Monza, Italy, ²School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy
Background/Purpose: In the early phase of rheumatoid arthritis (RA), PGE2 recruits different immune cells from the blood stream into target tissues. Via the EP4 receptor,…
Abstract Number: 2933 • 2016 ACR/ARHP Annual Meeting
HLA-DR3 Restricted T Cell Response to Smd and Ro60 Reveals Multiple Cross-Reactive Intra- and Inter-Molecular T Cell Epitopes: Unique Antigenic Structures of Lupus-Related Auto-Antigens and the Basis for B Cell Epitope Spreading
Zhenhuan Zhao¹, Jiling Ren¹, Chao Dai², Carol Kannapell¹, Qian Wang³, Felicia Gaskin⁴ and Shu Man Fu⁵, ¹Medicine/CIIR/Rheumatology, University of Virginia, Charlottesville, VA, ²Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, VA, ³University of Virginia, Charlottesville, VA, ⁴Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, ⁵Department of Medicine, University of Virginia, Charlottesville, VA
Background/Purpose: Complex auto-Abs targeting nuclear proteins is a hallmark of systemic lupus erythematosus (SLE). It is documented that this complexity is the result of “B cell…
Abstract Number: 1461 • 2016 ACR/ARHP Annual Meeting
Modification of Proteins with Malondialdehyde-Acetaldehyde and Citrulline Elicit Antibody Responses in DBA/1J Mice
Peter M. Maloley¹, Michael J. Duryee², Carlos D. Hunter², James R. O'Dell³, Daniel R. Anderson¹, Ted R Mikuls⁴, Geoffrey M. Thiele¹ and Lynell W. Klassen³, ¹University of Nebraska Medical Center, Omaha, NE, ²Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ³Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁴Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Previous studies have shown that proteins modified with malondialdehyde-acetaldehyde (MAA) and/or citrulline (CIT) co-localize in rheumatoid arthritis (RA) synovial tissues, are pro-inflammatory, and promote…
Abstract Number: 1914 • 2016 ACR/ARHP Annual Meeting
Immune Recognition of a Novel Citrullinated Epitope of Cartilage Proteoglycan Aggrecan in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid Arthritis
Adrienn Markovics¹, Timea Ocsko¹, Robert S. Katz², Edit I Buzas³, Tibor T. Glant¹ and Katalin Mikecz¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Rush University Medical Center, Chicago, IL, ³Semmelweis University, Budapest, Hungary
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease leading to the inflammatory destruction of synovial joints. Anti-citrullinated protein antibodies (ACPA) are frequently detected in the…
Abstract Number: 2411 • 2016 ACR/ARHP Annual Meeting
Multiple Genetic Susceptibility Loci in Juvenile Idiopathic Arthritis Are Bound By a Set of Transcription Factors
Leah C. Kottyan¹, Halima Moncrieffe², Xiaoting Chen³, Mario Pujato⁴, John B. Harley⁵, Matthew Weirauch⁶ and Susan D. Thompson⁷, ¹3333 Burnet Ave., Cincinnati, Cincinnati, OH, ²Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Cincinnati Childrens Hospital, Cincinnati, OH, ⁴1Center of Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center; University of Cincinnati, Cincinnati, OH, ⁵Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Childrens Hospital, Cincinnati, OH, ⁶Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ⁷Center for Autoimmune Disease Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Genome wide association studies (GWASs) and dense genotyping of immune-related disease regions have identified 17 loci associated with juvenile idiopathic arthritis (JIA) (p<5×10-8), 11…
Abstract Number: 2934 • 2016 ACR/ARHP Annual Meeting
Clinical Assessment of the Monoclonal Anitbody, PRX003, a Potential Novel Treatment for Th17-Mediated Inflammatory Disease
Gene G. Kinney¹, Kenneth Flanagan¹, Michael Skov¹, Ronald Goldblum², Sue Griffith³, Robin M. Barbour¹, Wagner Zago¹, Ted Yednock¹, Martin Koller¹ and Dan Ness¹, ¹Prothena Biosciences Inc, South San Francisco, CA, ²Carlsbad Pharmaceutical Consulting, Inc., Carlsbad, CA, ³ClinPharma Services, Inc, San Diego, CA
Background/Purpose: Melanoma cell adhesion molecule (MCAM; CD146) is expressed on the surface of Th17 cells, which have the capacity to produce IL-17 and a multitude…
Abstract Number: 1557 • 2016 ACR/ARHP Annual Meeting
3-D Explant Method Facilitates the Study of Lymphocytes in Synovium and Reveals a Population of Resident Memory-like T Cells in Rheumatoid Arthritis
Lauren Henderson¹, Deepak Rao², Nikola Teslovich^3,4, Sandra King⁵, Fumitaka Mizoguchi⁶, Sarah Ameri⁶, Allyn Morris⁷, Christopher Elco⁸, James Lederer⁹, Scott Martin¹⁰, Barry Simmons¹⁰, John Wright¹⁰, Michael Brenner², Soumya Raychaudhuri^{11,12,13,14,15}, Peter Nigrovic^1,16 and Robert Fuhlbrigge^17,18, ¹Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Divisions of Genetics and Rheumatology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, ⁴Brigham and Women's Hospital and Harvard Medical School, Cambridge, MA, ⁵Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁶Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁷Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, ⁸Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ⁹Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹⁰Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ¹¹Divisions of Genetics and Rheumatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ¹²Program in Medical and Population Genetics, Broad Institute of Massachusetts Technical Institute, Harvard University, Cambridge, MA, ¹³Partners Center for Personalized Genetic Medicine, Boston, MA, ¹⁴Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden, ¹⁵Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, ¹⁶Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, ¹⁷Immunology, Boston Children's Hospital, Boston, MA, ¹⁸Dermatology, Brigham and Women’s Hospital, Boston, MA
Background/Purpose: Tissue resident memory T (TRM) cells survive indefinitely in barrier tissues and mediate swift immunologic memory responses at sites of microbe entry. TRM cells…
Abstract Number: 1915 • 2016 ACR/ARHP Annual Meeting
Partial Elimination of Intestinal Microbiota Dampens T Helper 17 Cell Differentiation and Established Collagen-Induced Arthritis in Mice
Rebecca Rogier¹, Heather Evans-Marin², Birgitte Walgreen¹, Monique M. Helsen¹, Liduine van den Bersselaar¹, Peter M. van der Kraan¹, Fons A.J. van de Loo³, Peter L. van Lent¹, Jose U. Scher⁴, Wim B. van den Berg¹, Marije I. Koenders¹ and Shahla Abdolahi-Roodsaz¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Division of Rheumatology, New York University School of Medicine, New York, NY, ³Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁴New York University School of Medicine, New York, NY
Background/Purpose: High-throughput sequencing of intestinal microbiota recently revealed that the composition of intestinal microbiota is perturbed in patients with new onset untreated rheumatoid arthritis (RA).…
Abstract Number: 2582 • 2016 ACR/ARHP Annual Meeting
N-Acetylcysteine Regulates Osteoclastogenesis and Th17 Cell Differentiation in Rheumatoid Arthritis
Kyung-Ann Lee¹, Hae-Rim Kim², Sang Heon Lee³, Bomi Kim⁴ and Kyoung-Woon Kim⁵, ¹Department of Nuclear medicine, Konkuk University Medical center, seoul, Korea, The Republic of, ²Division of Rheumatology, Department of Internal Medicine, Konkuk University Medical Center, Seoul, Korea, The Republic of, ³Department of Internal Medicine,Division of Rheumatology., Division of Rheumatology, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea, The Republic of, ⁴Convergent Research Consortium for Immunologic disease, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, The Republic of, ⁵Dept of Internal Medicine, Konkuk University Hospital, Seoul, South Korea
Background/Purpose: This study aimed to determine the regulatory role of N-Acetyl-L-cysteine (NAC), an antioxidant, in T cell and osteoclast differentiation in rheumatoid arthritis (RA). Methods:…
Abstract Number: 2935 • 2016 ACR/ARHP Annual Meeting
Activation Status of Mucosal-Associated Invariant T Cells Sensitively Reflects Disease Activity of Systemic Lupus Erythematosus
Asako Chiba¹, Goh Murayama², Mie Kitagaichi³, Naoto Tamura⁴, Ken Yamaji², Yoshinari Takasaki⁴ and Sachiko Miyake¹, ¹Immunology, Juntendo University School of Medicine, Tokyo, Japan, ²Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ³Department of Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ⁴Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that express a semi-invariant TCRα chain: Vα7.2-Jα33 in humans and Vα19-Jα33 in mice. MAIT cells are…
Abstract Number: 1567 • 2016 ACR/ARHP Annual Meeting
A Functional Genomic Screen of Rheumatoid Arthritis Risk Genes in Primary Human T Cells Reveals DDX6 As a Negative Modulator of Cytokine Expression
Rumey Ishizawar¹, Chantel Lester², Jing Cui³, John Doench⁴, Robert Plenge⁵ and Michael Brenner⁶, ¹Division of Rheumatology, Allergy, and Immunology and Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ³Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Broad Institute of MIT and Harvard, Cambridge, MA, ⁵Genetics & Pharmacogenomics, Merck Research Laboratories, Merck & Co., Boston, MA, ⁶Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: In rheumatoid arthritis (RA), genome-wide association studies have identified over 100 risk alleles. A major challenge is identifying causal genes in RA risk loci. As…
Abstract Number: 1916 • 2016 ACR/ARHP Annual Meeting
Heightened MAIT Cell Sensitivity to MR1 Ligands Could Impact Control of Dysbiosis in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis
Diahann Jansen¹, Elizabeth Klinken¹, Hendrik Nel², Soi Cheng Law², Helen Benham^3,4,5, Lisa Cummins⁶, Matthew Brown⁷, Tony Kenna², Ligong Liu⁸, David Fairlie⁸, Jamie Rossjohn^9,10,11, Mark Morrison³, Ranjeny Thomas³, Paraic O Cuiv¹, James McCluskey¹² and Alexandra Corbett¹², ¹The University of Queensland Diamantina Institute, Translational Research Institute, Woolloongabba, Australia, ²The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia, ³Translational Research Institute, The University of Queensland Diamantina Institute, Woolloongabba, Australia, ⁴University of Queensland School of Medicine, Brisbane, Australia, ⁵Rheumatology, Princess Alexandra Hospital, Woolloongabba, Australia, ⁶Princess Alexandra Hospital, Woolloongabba, Australia, ⁷Queensland University of Technology, Brisbane, Australia, ⁸Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia, ⁹Infection and Immunity Program, Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia, ¹⁰Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom, ¹¹Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Australia, ¹²Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Australia
Background/Purpose: Mucosal associated invariant T (MAIT) cells are an innate-like lymphocyte population predominant at mucosal sites, which express a semi-invariant T cell receptor restricted to…

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