ACR Meeting Abstracts

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Abstracts tagged "T cells"

  • Abstract Number: 2932 • 2016 ACR/ARHP Annual Meeting

    HLA-DR3 Restricted Response to Lupus-Related Auto-Antigen Smd: Autoreactive T Cells Are Inherent in Normal Immune Repertoires

    Zhenhuan Zhao1, Jiling Ren1, Chao Dai2, Carol Kannapell1, Qian Wang3, Felicia Gaskin4 and Shu Man Fu5, 1Medicine/CIIR/Rheumatology, University of Virginia, Charlottesville, VA, 2Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, VA, 3University of Virginia, Charlottesville, VA, 4Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, 5Department of Medicine, University of Virginia, Charlottesville, VA

    Background/Purpose: HLA class II is the major susceptibility region for systemic lupus erythematosus (SLE) and other autoimmune disorders such as rheumatoid arthritis, multiple sclerosis and…
  • Abstract Number: 1449 • 2016 ACR/ARHP Annual Meeting

    The Efficiency of the Regulation of Ca2+ Entry through Calcium Release-Activated Calcium Channel in the Treatment of Rheumatoid Arthritis

    Shuang Liu1, Hitoshi Hasegawa2, Takeshi Kiyoi3, Tatsuya Sawasaki4 and Kazutaka Maeyama5, 1Dept. Pharmacology,, Ehime University Graduate School of Medicine, Toon-shi, Japan, 2Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Toon, Japan, 3Bioscience, Integrated Center for Sciences, Ehime University, Ehime, Japan, 4Division of Cell-Free Sciences, Proteo-Science Center, Ehime University, Matsuyama, Japan, 5Department of Pharmacology, Informational Biomedicine, Ehime University Graduate School of Medicine, Toon-shi, Ehime, Japan

    Background/Purpose:  The regulation of Ca2+ entry by targeting a store-operated calcium release-activated channel (CRAC), known as ORAI, has shown benefits in the treatment of rheumatoid…
  • Abstract Number: 1913 • 2016 ACR/ARHP Annual Meeting

    B Cell Depletion Therapy Impact CD8 T Cells in ANCA-Associated Vasculitis

    Antoine Néel1,2, Marie Bucchia3, Aurelie Caristan1, Mélanie Néel2, Marie Rimbert4, Christian Agard1, Maryvonne Hourmant5, Gaelle Tilly2, Michelle Yap2, François Perrin1, Pascal Godmer6, Julie Graveleau1, Sophie Brouard2, Celine Bressollette7, Fadi Fakhouri8, Mohamed Hamidou9 and Nicolas Degauque2, 1Internal Medicine Department, Nantes University Hospital, Nantes, France, 2INSERM U1064, Nantes, France, 3Pediatrics, Nantes University Hospital, Nantes, France, 4Immunology Laboratory, Nantes University Hospital, Nantes, France, 5Nephrology, Nantes University Hospital, Nantes, France, 6CH Vannes, Vannes, France, 7Virology Laboratory, Nantes University Hospital, Nantes, France, 8Nephrology Department, Nantes University Hospital, Nantes, France, 9Internal Medicine Department, Internal Medicine Department, Nantes University Hospital, Nantes, France

    Background/Purpose: In anti-neutrophil cytoplasmic antibodies associated vasculitis (AAV), several clues suggest that the efficacy of B cell depletion therapy lies beyond the suppression of ANCA-producing…
  • Abstract Number: 2262 • 2016 ACR/ARHP Annual Meeting

    CR6086 a New Potent EP4 Receptor Antagonist with Immunomodulatory Activities

    Tiziana Piepoli1, Daniele Maggioni2, Silvia Zerbi1, Anna Stucchi1, Laura Mennuni1, Marco Lanza1, Gianfranco Caselli1 and Lucio Claudio Rovati1, 1Rottapharm Biotech, Monza, Italy, 2School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy

    Background/Purpose: In the early phase of rheumatoid arthritis (RA), PGE2 recruits different immune cells from the blood stream into target tissues. Via the EP4 receptor,…
  • Abstract Number: 2933 • 2016 ACR/ARHP Annual Meeting

    HLA-DR3 Restricted T Cell Response to Smd and Ro60 Reveals Multiple Cross-Reactive Intra- and Inter-Molecular T Cell Epitopes: Unique Antigenic Structures of Lupus-Related Auto-Antigens and the Basis for B Cell Epitope Spreading

    Zhenhuan Zhao1, Jiling Ren1, Chao Dai2, Carol Kannapell1, Qian Wang3, Felicia Gaskin4 and Shu Man Fu5, 1Medicine/CIIR/Rheumatology, University of Virginia, Charlottesville, VA, 2Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, VA, 3University of Virginia, Charlottesville, VA, 4Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, 5Department of Medicine, University of Virginia, Charlottesville, VA

    Background/Purpose:  Complex auto-Abs targeting nuclear proteins is a hallmark of systemic lupus erythematosus (SLE). It is documented that this complexity is the result of “B cell…
  • Abstract Number: 1461 • 2016 ACR/ARHP Annual Meeting

    Modification of Proteins with Malondialdehyde-Acetaldehyde and Citrulline Elicit Antibody Responses in DBA/1J Mice

    Peter M. Maloley1, Michael J. Duryee2, Carlos D. Hunter2, James R. O'Dell3, Daniel R. Anderson1, Ted R Mikuls4, Geoffrey M. Thiele1 and Lynell W. Klassen3, 1University of Nebraska Medical Center, Omaha, NE, 2Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 3Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 4Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Previous studies have shown that proteins modified with malondialdehyde-acetaldehyde (MAA) and/or citrulline (CIT) co-localize in rheumatoid arthritis (RA) synovial tissues, are pro-inflammatory, and promote…
  • Abstract Number: 1914 • 2016 ACR/ARHP Annual Meeting

    Immune Recognition of a Novel Citrullinated Epitope of Cartilage Proteoglycan Aggrecan in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid Arthritis

    Adrienn Markovics1, Timea Ocsko1, Robert S. Katz2, Edit I Buzas3, Tibor T. Glant1 and Katalin Mikecz1, 1Orthopedic Surgery, Rush University Medical Center, Chicago, IL, 2Rush University Medical Center, Chicago, IL, 3Semmelweis University, Budapest, Hungary

    Background/Purpose:  Rheumatoid arthritis (RA) is an autoimmune disease leading to the inflammatory destruction of synovial joints. Anti-citrullinated protein antibodies (ACPA) are frequently detected in the…
  • Abstract Number: 2411 • 2016 ACR/ARHP Annual Meeting

    Multiple Genetic Susceptibility Loci in Juvenile Idiopathic Arthritis Are Bound By a Set of Transcription Factors

    Leah C. Kottyan1, Halima Moncrieffe2, Xiaoting Chen3, Mario Pujato4, John B. Harley5, Matthew Weirauch6 and Susan D. Thompson7, 13333 Burnet Ave., Cincinnati, Cincinnati, OH, 2Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3Cincinnati Childrens Hospital, Cincinnati, OH, 41Center of Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center; University of Cincinnati, Cincinnati, OH, 5Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Childrens Hospital, Cincinnati, OH, 6Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 7Center for Autoimmune Disease Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

    Background/Purpose: Genome wide association studies (GWASs) and dense genotyping of immune-related disease regions have identified 17 loci associated with juvenile idiopathic arthritis (JIA) (p<5×10-8), 11…
  • Abstract Number: 2934 • 2016 ACR/ARHP Annual Meeting

    Clinical Assessment of the Monoclonal Anitbody, PRX003, a Potential Novel Treatment for Th17-Mediated Inflammatory Disease

    Gene G. Kinney1, Kenneth Flanagan1, Michael Skov1, Ronald Goldblum2, Sue Griffith3, Robin M. Barbour1, Wagner Zago1, Ted Yednock1, Martin Koller1 and Dan Ness1, 1Prothena Biosciences Inc, South San Francisco, CA, 2Carlsbad Pharmaceutical Consulting, Inc., Carlsbad, CA, 3ClinPharma Services, Inc, San Diego, CA

    Background/Purpose: Melanoma cell adhesion molecule (MCAM; CD146) is expressed on the surface of Th17 cells, which have the capacity to produce IL-17 and a multitude…
  • Abstract Number: 1557 • 2016 ACR/ARHP Annual Meeting

    3-D Explant Method Facilitates the Study of Lymphocytes in Synovium and Reveals a Population of Resident Memory-like T Cells in Rheumatoid Arthritis

    Lauren Henderson1, Deepak Rao2, Nikola Teslovich3,4, Sandra King5, Fumitaka Mizoguchi6, Sarah Ameri6, Allyn Morris7, Christopher Elco8, James Lederer9, Scott Martin10, Barry Simmons10, John Wright10, Michael Brenner2, Soumya Raychaudhuri11,12,13,14,15, Peter Nigrovic1,16 and Robert Fuhlbrigge17,18, 1Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 2Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 3Divisions of Genetics and Rheumatology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 4Brigham and Women's Hospital and Harvard Medical School, Cambridge, MA, 5Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 6Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 7Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, 8Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 9Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 10Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 11Divisions of Genetics and Rheumatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 12Program in Medical and Population Genetics, Broad Institute of Massachusetts Technical Institute, Harvard University, Cambridge, MA, 13Partners Center for Personalized Genetic Medicine, Boston, MA, 14Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden, 15Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, 16Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, 17Immunology, Boston Children's Hospital, Boston, MA, 18Dermatology, Brigham and Women’s Hospital, Boston, MA

    Background/Purpose: Tissue resident memory T (TRM) cells survive indefinitely in barrier tissues and mediate swift immunologic memory responses at sites of microbe entry. TRM cells…
  • Abstract Number: 1915 • 2016 ACR/ARHP Annual Meeting

    Partial Elimination of Intestinal Microbiota Dampens T Helper 17 Cell Differentiation and Established Collagen-Induced Arthritis in Mice

    Rebecca Rogier1, Heather Evans-Marin2, Birgitte Walgreen1, Monique M. Helsen1, Liduine van den Bersselaar1, Peter M. van der Kraan1, Fons A.J. van de Loo3, Peter L. van Lent1, Jose U. Scher4, Wim B. van den Berg1, Marije I. Koenders1 and Shahla Abdolahi-Roodsaz1, 1Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 2Division of Rheumatology, New York University School of Medicine, New York, NY, 3Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 4New York University School of Medicine, New York, NY

    Background/Purpose: High-throughput sequencing of intestinal microbiota recently revealed that the composition of intestinal microbiota is perturbed in patients with new onset untreated rheumatoid arthritis (RA).…
  • Abstract Number: 2582 • 2016 ACR/ARHP Annual Meeting

    N-Acetylcysteine Regulates Osteoclastogenesis and Th17 Cell Differentiation in Rheumatoid Arthritis

    Kyung-Ann Lee1, Hae-Rim Kim2, Sang Heon Lee3, Bomi Kim4 and Kyoung-Woon Kim5, 1Department of Nuclear medicine, Konkuk University Medical center, seoul, Korea, The Republic of, 2Division of Rheumatology, Department of Internal Medicine, Konkuk University Medical Center, Seoul, Korea, The Republic of, 3Department of Internal Medicine,Division of Rheumatology., Division of Rheumatology, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea, The Republic of, 4Convergent Research Consortium for Immunologic disease, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, The Republic of, 5Dept of Internal Medicine, Konkuk University Hospital, Seoul, South Korea

    Background/Purpose:  This study aimed to determine the regulatory role of N-Acetyl-L-cysteine (NAC), an antioxidant, in T cell and osteoclast differentiation in rheumatoid arthritis (RA). Methods:…
  • Abstract Number: 2935 • 2016 ACR/ARHP Annual Meeting

    Activation Status of Mucosal-Associated Invariant T Cells Sensitively Reflects Disease Activity of Systemic Lupus Erythematosus

    Asako Chiba1, Goh Murayama2, Mie Kitagaichi3, Naoto Tamura4, Ken Yamaji2, Yoshinari Takasaki4 and Sachiko Miyake1, 1Immunology, Juntendo University School of Medicine, Tokyo, Japan, 2Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, 3Department of Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, 4Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

    Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that express a semi-invariant TCRα chain: Vα7.2-Jα33 in humans and Vα19-Jα33 in mice. MAIT cells are…
  • Abstract Number: 1567 • 2016 ACR/ARHP Annual Meeting

    A Functional Genomic Screen of Rheumatoid Arthritis Risk Genes in Primary Human T Cells Reveals DDX6 As a Negative Modulator of Cytokine Expression

    Rumey Ishizawar1, Chantel Lester2, Jing Cui3, John Doench4, Robert Plenge5 and Michael Brenner6, 1Division of Rheumatology, Allergy, and Immunology and Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, 2Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 3Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 4Broad Institute of MIT and Harvard, Cambridge, MA, 5Genetics & Pharmacogenomics, Merck Research Laboratories, Merck & Co., Boston, MA, 6Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose:  In rheumatoid arthritis (RA), genome-wide association studies have identified over 100 risk alleles. A major challenge is identifying causal genes in RA risk loci. As…
  • Abstract Number: 1916 • 2016 ACR/ARHP Annual Meeting

    Heightened MAIT Cell Sensitivity to MR1 Ligands Could Impact Control of Dysbiosis in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis

    Diahann Jansen1, Elizabeth Klinken1, Hendrik Nel2, Soi Cheng Law2, Helen Benham3,4,5, Lisa Cummins6, Matthew Brown7, Tony Kenna2, Ligong Liu8, David Fairlie8, Jamie Rossjohn9,10,11, Mark Morrison3, Ranjeny Thomas3, Paraic O Cuiv1, James McCluskey12 and Alexandra Corbett12, 1The University of Queensland Diamantina Institute, Translational Research Institute, Woolloongabba, Australia, 2The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia, 3Translational Research Institute, The University of Queensland Diamantina Institute, Woolloongabba, Australia, 4University of Queensland School of Medicine, Brisbane, Australia, 5Rheumatology, Princess Alexandra Hospital, Woolloongabba, Australia, 6Princess Alexandra Hospital, Woolloongabba, Australia, 7Queensland University of Technology, Brisbane, Australia, 8Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia, 9Infection and Immunity Program, Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia, 10Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom, 11Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Australia, 12Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Australia

    Background/Purpose: Mucosal associated invariant T (MAIT) cells are an innate-like lymphocyte population predominant at mucosal sites, which express a semi-invariant T cell receptor restricted to…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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