Abstracts tagged "T cells and systemic lupus erythematosus (SLE)"

Abstract Number: 1452 • 2012 ACR/ARHP Annual Meeting
Inherent Strain-Based Differences in Qualitative CD4 T Cell Responses Determine Lupus Severity
Kateryna Soloviova¹, Maksym Puliaiev¹ and Charles S. Via², ¹Pathology Department, Uniformed Services University of Health Sciences, Bethesda, MD, ²Pathology Rm B3-100, Uniformed Services University of Health Sciences, Bethesda, MD
Background/Purpose: A lupus-like disease can be induced in B6D2F1 mice by the transfer of parental DBA/2 splenocytes (DBA->F1). Transfer of splenocytes from the other parent…
Abstract Number: 847 • 2012 ACR/ARHP Annual Meeting
Enhanced ROCK Activation in Patients with Systemic Lupus Erythematosus
Josephine Isgro¹, Sanjay Gupta², Tanya M. Pavri², Roland Duculan², Kyriakos A. Kirou³, Jane E. Salmon⁴ and Alessandra B. Pernis², ¹Pediatric Rheumatology, Morgan Stanley Children's Hospital of New-York Presbyterian, Columbia University Medical Center, New York, NY, ²Autoimmunity & Inflammation Research Program, Hospital for Special Surgery, New York, NY, ³Hospital for Special Surgery, New York, NY, ⁴Rheumatology, Hospital for Special Surgery, New York, NY
Background/Purpose: The Rho GTPases, Rac and RhoA, play a key role in immune responses by regulating both cytoskeletal reorganization and gene expression. RhoA exerts many…
Abstract Number: 687 • 2012 ACR/ARHP Annual Meeting
Gammadelta T Cells and Their Intracellular Cytokine Profile in Peripheral Blood of Patients with Systemic Lupus Erythematosus
Lingyun Sun, Xia Li and Zhimin Lu, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: Gammadelta T cells represent a minor population of human peripheral blood T lymphocytes. As very rapid cytokine-producing cells, gammadelta T cells can regulate other…

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