Abstracts tagged "T cells and systemic lupus erythematosus (SLE)"

Abstract Number: 148 • ACR/ARHP Annual Meeting 2018
High Level of CD38 Expression in SLE CD8 T Cells Dictates Decreased Cytotoxicity
Eri Katsuyama, Abel Suarez-Fueyo, Sean Bradley, Michihito Kono, Lama Mulki, Vasileios C. Kyttaris and George C Tsokos, Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, Boston, MA
Background/Purpose: CD38 is an ectonucleotidase that has the ability to degrade nicotinamide adenine dinucleotide (NAD). The percentage of CD38 expressing CD8 T cells are increased…
Abstract Number: 972 • ACR/ARHP Annual Meeting 2018
An Anti-CD28 Domain Antibody, Lulizumab, in Systemic Lupus Erythematosus: Results of a Phase II Study
Joan T. Merrill¹, Diane E. Shevell², Dominique Duchesne², Miroslawa Nowak², Sudeep Kundu², Ihab G. Girgis², Yanhua Sarah Hu², Steven G. Nadler³, Subhashis Banerjee² and John Throup², ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Bristol-Myers Squibb, Princeton, NJ, ³Immunosciences Translational Research, Bristol-Myers Squibb, Princeton, NJ
Background/Purpose: The T cell costimulatory molecule, CD28, is critical for the activation of pathogenic T cells in autoimmune diseases.1,2 An anti-CD28 domain antagonist antibody, lulizumab…
Abstract Number: 973 • ACR/ARHP Annual Meeting 2018
Low-Dose IL-2 Combined with Rapamycin Efficiently Promoted Disease Remission and Recovered the Balance of Th17/Regulatory T Cells in Patients with Refractory Systemic Lupus Erythematosus
Xiaona Jing¹, Chong Gao², Liran Hao¹, Meihua Hao¹, Zhaoyun Liang¹, Xiao-Feng Li³ and Junwei Chen¹, ¹The Second Hospital of Shanxi Medical University, Taiyuan, China, ²Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, Cambridge, MA, ³Rheumatology, the Second Hospital of Shanxi Medical University, Taiyuan, China
Background/Purpose:To observe the clinical effect of low-dose IL-2 combined with rapamycin on the balance of Th17/Treg cells and on remission of patients with refractory SLE.…
Abstract Number: 2947 • ACR/ARHP Annual Meeting 2018
Peripheral Helper T Cells in Systemic Lupus Erythematosus
Ayako Makiyama^1,2, Asako Chiba¹, Goh Murayama³, Ken Yamaji³, Naoto Tamura³ and Sachiko Miyake¹, ¹Immunology, Juntendo University School of Medicine, Tokyo, Japan, ²Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ³Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Autoreactive T-B cell interactions in lymphoid tissue have been thought to play a crucial role in the autoantibody production in systemic lupus erythematosus (SLE).…
Abstract Number: 2883 • ACR/ARHP Annual Meeting 2016
The CD4+CD52low T Cell Contributes to the Development of Systemic Lupus Erythematosus through the CCR8/TARC Pathway
Tomohito Sato¹, Masataka Umeda¹, Tomohiro Koga², Takashi Igawa¹, Syota Kurushima¹, Ayuko Takatani¹, Toshimasa Shimizu¹, Shoichi Fukui¹, Ayako Nishino¹, Yoshiro Horai¹, Shinya Kawashiri¹, Naoki Iwamoto¹, Yasuko Hirai¹, Mami Tamai¹, Hideki Nakamura¹, Tomoki Origuchi³ and Atsushi Kawakami⁴, ¹Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, ²Department of Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, ³Department of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁴Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki City, Japan
Background/Purpose: CD52 is a cell-surface glycoprotein that is widely expressed in lymphocytes, monocytes and eosinophils. CD4+CD52high T cells inhibit the activation of CD4+CD52low T cells…
Abstract Number: 3019 • ACR/ARHP Annual Meeting 2015
The CD4+CD52low T Cell Contributes to Disease Activity and Autoantybody Production in Systemic Lupus Erythematosus
Masataka Umeda¹, Tomohiro Koga¹, Kunihiro Ichinose², Toru Michitsuji¹, Toshimasa Shimizu², Shoichi Fukui³, Ayako Nishino³, Yoshikazu Nakashima⁴, Yoshiro Horai¹, Takahisa Suzuki¹, Shin-ya Kawashiri³, Naoki Iwamoto¹, Toshiyuki Aramaki⁵, Mami Tamai¹, Yasuko Hirai¹, Hideki Nakamura¹, Kazuo Yamamoto⁶, Tomoki Origuchi^7,8, Yukitaka Ueki⁹ and Atsushi Kawakami¹, ¹Department of Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, ²Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Department of Immunology and Rheumatology, Nagasaki University, Nagasaki, Japan, ⁴Department of Rheumatology, Nagasaki University, Nagasaki, Japan, ⁵Department of Rheumatology, Sasebo Chuo Hospital, Sasebo, Japan, ⁶Biomedical Research Support Center, Nagasaki University School of Medicine, Nagasaki, Japan, ⁷Department of Rehabilitation Sciences, Nagasaki University, Nagasaki, Japan, ⁸Department of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁹Kyushu multicenter rheumatoid arthritis ultrasound prospective observational cohort study group, Nagasaki, Japan
Background/Purpose: CD52 is a cell-surface glycoprotein that is widely expressed in lymphocytes, monocytes and eosinophils. The anti-CD52 antibody has been used to treat multiple autoimmune…
Abstract Number: 813 • ACR/ARHP Annual Meeting 2015
Expression of Inducible Costimulator Ligand (ICOSL) on CD4+ T Cells in Patients with Systemic Lupus Erythematosus
Minyoung Her¹, Dongyook Kim¹, JeongHa Park² and Donghoon Han³, ¹Department of Internal medicine, Division of Rheumatology, Inje university, Busan Paik hospital, Busan, South Korea, ²Wallas Memorial Baptist Hospital, Busan, South Korea, ³Inje university, Busan Paik hospital, Busan, South Korea
Background/Purpose: Inducible costimulator (ICOS) is an immunostimulatory receptor that belongs to the CD28/CTLA4 family. ICOSL (ICOS ligand), which belongs to the B7 family, is the…
Abstract Number: 1935 • ACR/ARHP Annual Meeting 2015
Regulation of T Follicular Helper Cells in Systemic Lupus Erythematosus By E3 Ubiquitin Ligase Cbl-b
William Willis¹, Yun Xiao², Nicholas A. Young¹, Wael N. Jarjour¹ and Jian Zhang², ¹Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Activation of polyclonal CD4+ T cells and B cells is a hallmark of human and murine lupus, which suggests a global defect in the…
Abstract Number: 2680 • ACR/ARHP Annual Meeting 2014
DNA Hydroxymethylation Changes in CD4+T Cells from Patients with Systemic Lupus Erythematosus
Ming Zhao, Wei Liao, Bochen Zhu, Ruifang Wu and Qianjin Lu, Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China
Background/Purpose Recent studies have uncovered 5-hydroxymethylcytosine (5hmC) as the sixth base of the genome, and that the Ten-eleven translocation (TET) family proteins is responsible for…
Abstract Number: 1743 • ACR/ARHP Annual Meeting 2013
Administration Of AMG 557, a Human Anti-B7RP-1 (ICOSL) Antibody, Leads To The Selective Inhibition Of Anti-KLH IgG Responses In Subjects With SLE: Results Of a Phase 1 Randomized, Double-Blind, Placebo-Controlled, Sequential, Rising, Multiple-Dose Study
Barbara Sullivan¹, Wayne H. Tsuji², Vishala L. Chindalore³, Thomas D. Geppert⁴, Alla Rudinskaya⁵, Patricia Pardo⁶, Alan Kivitz⁷, C. Michael Neuwelt⁸, Meggan Mackay⁹, R. John Looney¹⁰, J. Carter Thorne¹¹, Marilee Andrew¹², Greg Arnold¹³, Michael Boedigheimer¹, Kit Chiu¹, Cherie Green¹, Arunan Kaliyaperumal¹, Christine Wang¹⁴, Andrew Welcher¹ and James Chung¹, ¹Amgen, Thousand Oaks, CA, ²Clinical Research/Inflammation, Amgen, Seattle, WA, ³Anniston Medical Clinic PC, Anniston, AL, ⁴Metroplex Clinical Research Center, LLC, Dallas, TX, ⁵Danbury Hospital, Danbury, CT, ⁶MRA Clinical Research, Miami, FL, ⁷Altoona Center for Clinical Research, Duncansville, PA, ⁸East Bay Rheumatology Research Institute, San Leandro, CA, ⁹Autoimmune & Musculoskeletal Disease, Feinstein Institute for Medical Research, Manhasset, NY, ¹⁰Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ¹¹Southlake Regional Health Centre, Newmarket, ON, Canada, ¹²Amgen, Seattle, WA, ¹³Medical Sciences, Amgen, Thousand Oaks, CA, ¹⁴Biostatistics, Amgen, Thousand Oaks, CA
Background/Purpose: The interaction of inducible costimulator (ICOS) with its ligand, B7-related protein-1 (B7RP-1 or ICOSL), plays a role in T cell differentiation, cytokine production, and…
Abstract Number: L8 • ACR/ARHP Annual Meeting 2013
Overexpression of Set1 at the Promoter Contributes to cAMP Response Element Modulator Alpha Overexpression in Systemic Lupus Erythematosus
Qing Zhang¹, Huilin Zhang², Hai Long¹, Jieyue Liao³, Ming Zhao¹, Xiangning Qiu¹ and Qianjin Lu¹, ¹Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China, ²Nursing Department, Second Xiangya Hospital, Central South University, Changsha, China, ³Department of Dermatology, Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China
Background/Purpose: In recent years, accumulating evidence has demonstrated that increased cAMP response element modulator α (CREMα) which contributes to IL-2 reduction and IL-17A overproduction in…
Abstract Number: 2497 • ACR/ARHP Annual Meeting 2012
Altered Circulating Follicular Helper T Cell Phenotype and Subset Composition Are Associated with Disease Activity in Patients with Systemic Lupus Erythematosus
Hsi-en Ho¹, Jin Young Choi², Viviane M. Bunin², Sandra G. Pasoto³, Solange Carrasco⁴, Eduardo F. Borba⁵, Celio R. Goncalves⁶, Priscila R. Costa⁷, Esper G. Kallas⁷, Eloisa Bonfa⁶ and Joseph E. Craft², ¹Internal Medicine, Section of Rheumatology, Yale University School of Medicine, New Haven, CT, ²Yale University School of Medicine, Internal Medicine, Section of Rheumatology, New Haven, CT, ³Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ⁴University of São Paulo, São Paulo, Brazil, ⁵Rheumatology Division; University of São Paulo, São Paulo, Brazil, ⁶Universidade de São Paulo, Division of Rheumatology, Faculdade de Medicina, Sao Paulo, Brazil, ⁷Universidade de São Paulo, Division of Immunology, Faculdade de Medicina, Sao Paulo, Brazil
Background/Purpose: Autoreactive B cells in SLE undergo autoantigen selection, suggesting a requirement for germinal center follicular helper T (Tfh) cells in their maturation. However, evidence…
Abstract Number: 2499 • ACR/ARHP Annual Meeting 2012
The Peroxisome-Proliferator Activated Receptor-γ Agonist Pioglitazone Modulates Aberrant T-Cell Responses in Systemic Lupus Erythematosus
Wenpu Zhao¹, Celine C. Berthier², Matthias Kretzler³ and Mariana J. Kaplan⁴, ¹University of Michigan Rheumatology, Ann Arbor, MI, ²Nephrology, University of Michigan, Ann Arbor, MI, ³Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI, ⁴Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD
Background/Purpose: Previous studies indicate that PPAR-γ agonists, including pioglitazone (PIO), down-regulate autoimmune responses and renal inflammation in murine SLE. However, the mechanisms implicated in this process…
Abstract Number: 2337 • ACR/ARHP Annual Meeting 2012
Therapeutic Promotion of CD8 CTL by CpG Oligodeoxynucleotides (ODN) in an Induced Model of Lupus
Maksym Puliaiev¹, Kateryna Soloviova¹ and Charles S. Via², ¹Pathology Department, Uniformed Services University of Health Sciences, Bethesda, MD, ²Pathology Rm B3-100, Uniformed Services University of Health Sciences, Bethesda, MD
Background/Purpose: In addition to TcR signaling and costimulation, CD8 T cells require a third signal to mature into effector cytotoxic T lymphocytes (CTL). In pathogen…
Abstract Number: 2316 • ACR/ARHP Annual Meeting 2012
Generation of CD4⁺ Follicular Helper Tcells by Complement and Immune Complexes
Anil K. Chauhan¹, Richard DiPaolo² and Terry L. Moore³, ¹Rheumatology, Saint Louis University, St. Louis, MO, ²Molecular Microbiology and Immunology, Saint Louis, MO, ³Internal Medicine/Rheumatology, Saint Louis University, Saint Louis, MO
Background/Purpose: Complement opsonized immune complexes (ICs) are key players of disease pathology. We showed in systemic lupus erythematosus (SLE), ICs and complement (C’) drive activation…