ACR Meeting Abstracts

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Abstracts tagged "T cells and rheumatoid arthritis"

  • Abstract Number: 994 • 2019 ACR/ARP Annual Meeting

    Increased Antibody and T-cell Responses Following Treatment of Collagen-Induced Arthritis in C57Bl/6 Mice with Organic Dust Inhalants

    Michael Duryee1, Jill Poole 1, Amy Nelson 1, Katherine Janike 1, Kathryn Rentfro 1, Lynell Klassen 1, James O'Dell 2, Bryant England 3, Geoffrey Thiele 2 and Ted Mikuls 2, 1University of Nebraska Medical Center, Omaha, NE, 2VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, NE, 3VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha

    Background/Purpose: Increasing evidence suggests that inhalant exposures, such as tobacco smoke or silica, are implicated in the initiation of autoimmunity leading to rheumatoid arthritis (RA).…
  • Abstract Number: 54 • 2018 ACR/ARHP Annual Meeting

    In a Macaque Model of RA By Immunization with Citrullinated Peptides, the Valine in the 11 Position of the DRB1 Molecule Has Greater Impacts on T-Cell Response to Citrullinated Peptides Than the 70-74 Position in the Shared Epitope

    Samuel Bitoun1, Pierre Roques2, Roger Le Grand3 and Xavier Mariette4, 1INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, Le Kremlin Bicêtre, France, 2Immunology of viral infections and autoimmune diseases, IDMIT Infrastructure CEA - Université Paris Sud - INSERM U1184, Fontenay-Aux-Roses,, France, 3Immunology of viral infections and autoimmune diseases, IDMIT Infrastructure CEA - Université Paris Sud - INSERM U1184, Fontenay-Aux-Roses, France, 4Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France

    Background/Purpose: Among genetic risk factors of RA, HLA class II molecules confers the highest risk of ACPA positive RA. The shared epitope (SE) hypothesis that…
  • Abstract Number: 2050 • 2018 ACR/ARHP Annual Meeting

    B and T Cell Phenotypes of First Degree Relatives of RA Patients in an Indigenous North American Cohort

    Stacy Tanner1, Christine Zhang2, Irene Smolik3, Aaron Marshall2 and Hani El-Gabalawy4, 1Rheumatology, University of Manitoba, Winnipeg, MB, Canada, 2Immunology, University of Manitoba, Winnipeg, MB, Canada, 3Arthritis Center, University of Manitoba, Winnipeg, MB, Canada, 4University of Manitoba, Winnipeg, MB, Canada

    Background/Purpose: First degree relatives (FDR) of patients with RA are known to have approximately 4 times increased risk of developing RA and prevalence of RA…
  • Abstract Number: 407 • 2017 ACR/ARHP Annual Meeting

    Selective Inhibition of Tfh Cells By a Small Molecule Inhibitor Abrogates Progression of Experimental Inflammatory Arthritis

    Frank Migliore1, Sedrick Bradley1, Linh Hellmers1, Quretul Quresh2, Jerald M. Zakem3, William E. Davis3, Tamika Webb-Detiege1, Zongbing You4, Robert Quinet2 and Xin Zhang5, 1Ochsner Clinic Foundation, New Orleans, LA, 2Rheumatology, Ochsner Medical Center, New Orleans, LA, 3University of Queensland School of Medicine, Brisbane, Australia, 4Tulane University Health Science Center, New Orleans, LA, 5Laboratory of Cellular Immunology, Institution of Translational Research, Ochsner Medical Center, New Orleans, LA

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease characterized by progressive infiltration of the joints by T cells and other leukocytes, production of…
  • Abstract Number: 457 • 2016 ACR/ARHP Annual Meeting

    Novel Mechanism Mediated By the IL-23/Th17 Axis Contributing to Auto-Immune Arthritis

    René Pfeifle1, Tobias Rothe1, Natacha Ipseiz1, Stephan Culemann1, Ulrike Harre2, Gerhard Krönke3 and Georg Schett4, 1Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, 3Universitätsklinikum Erlangen, Erlangen, Austria, 4Department of Internal Medicine III, Institute for Clinical Immunology,, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany

    Background/Purpose: Checkpoints and mechanisms regulating the onset of rheumatoid arthritis (RA) remain largely elusive. Apart from B cells and auto-antibodies, Th17 cells were shown to…
  • Abstract Number: 2449 • 2014 ACR/ARHP Annual Meeting

    Microrna-346 Regulation of Follicular Helper T Cells Is Involved in the Pathogenesis of rheumatoid Arthritis Disease

    Xinyi Tang1, Jie Ma2 and Shengjun Wang3, 1Department of Laboratory Medicine, Jiangsu University Affi�liated People’s Hospital, Zhenjiang, China, 2Department of Laboratory Medicine, Jiangsu University Affiliated People’s Hospital, Zhenjiang, China, 3Department of Laboratory Medicine, Jiangsu University Affiliated People’s Hospital, Zhenjiang, China

    Background/Purpose Follicular helper T (Tfh) cells have been identified as a new subset of effector helper T cells that are essential in regulating the development…
  • Abstract Number: 1740 • 2014 ACR/ARHP Annual Meeting

    Predicting the Evolution of Inflammatory Arthritis in ACPA-Positive Individuals: Can T-Cell Subsets Model Help?

    Laura Hunt1, Agata Burska2, Elizabeth M.A. Hensor1, Jackie L. Nam1, Frederique Ponchel1 and Paul Emery1, 1NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds., Leeds, United Kingdom

    Background/Purpose: ACPA+ individuals with non-specific musculoskeletal symptoms are at high risk of developing rheumatoid arthritis (RA). We previously demonstrated dys-regulation of T-cell subsets with loss…
  • Abstract Number: 406 • 2012 ACR/ARHP Annual Meeting

    βig-h3 Regulates the Inflammatory Arthritis by Mediating Selective Recruitment of Effector/Memory T Cells

    Keum Hee Sa1, Jin Hee Kang1, Mahmudul Md Alam1, Kyung Hwa Lee1, Churl Hyun Im1, Eon Jeong Nam1, In San Kim2 and Young Mo Kang3, 1Internal Medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea, 2Biochemistry & Cell Biology, Cell and Matrix Research Institute, Kyungpook National University School of Medicine, Daegu, South Korea, 3Department of Internal Medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea

    Background/Purpose: Transforming growth factor-beta inducible gene-h3 (βig-h3) is abundantly expressed in synovial tissues of rheumatoid arthritis (RA) and has a regulatory role in growth, differentiation,…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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