ACR Meeting Abstracts

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Abstracts tagged "T cells and kinase"

  • Abstract Number: 2109 • 2016 ACR/ARHP Annual Meeting

    Immunoprofiling of Bruton’s Tyrosine Kinase (Btk)/Tec Family Kinase Inhibitors Indicate Activities Beyond Btk in Immunocyte Function

    Jolanta Kosek1, Lori Capone2, Mary Adams1, Eun Mi Hur1, Peter H. Schafer3 and Garth Ringheim1, 1Inflammation and Immunology Translational Development, Celgene Corporation, Summit, NJ, 2Celgene Corporation, Summit, NJ, 3Department of Translational Development, Celgene Corporation, Summit, NJ

    Background/Purpose:  CC-292, CC-90008, and ibrutinib are covalent Btk/Tec family kinase inhibitors that block Btk activity by binding with high affinity to the adenosine triphosphate (ATP)…
  • Abstract Number: 2785 • 2016 ACR/ARHP Annual Meeting

    Translatable in Vitro Immunocyte Functional Measures of CC-292 and CC-90008 Inhibitors of the Bruton’s Tyrosine Kinase (Btk)/Tec Family and the Pathology Observed in the MLR/Lpr Mouse Model of Systemic Lupus Erythematosus (SLE)

    Garth Ringheim1, Jolanta Kosek2, Lori Capone3, Mary Adams4,5, Eun Mi Hur4 and Peter H. Schafer5, 186 Morris Avenue, Celgene Corporation, Summit, NJ, 2Translational Development, Celgene Corporation, Summit, NJ, 3Celgene Corporation, Summit, NJ, 4Inflammation and Immunology Translational Development, Celgene Corporation, Summit, NJ, 5Department of Translational Development, Celgene Corporation, Summit, NJ

    Background/Purpose:  CC-292 and CC-90008 are covalent Btk/Tec family kinase inhibitors that block Btk activity by binding with high affinity to the adenosine triphosphate (ATP) binding…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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