Abstracts tagged "T Cell"

Abstract Number: 0074 • ACR Convergence 2023
Distinct PD-1 Receptor Engagement Leads to Different Pharmacodynamic Effects
Yevgeniya Orlovsky, Melissa Swiecki, Kimberly Colby, Changbao Liu, Josephine Wixted, Olesya Chornoguz, Navin Rao, Edith Janssen and Ling-Yang Hao, Janssen Research & Development, LLC, Spring House, PA
Background/Purpose: T cells play an important role in the development and progression of many autoimmune diseases. Inhibition of T cells and their effector mechanisms has…
Abstract Number: 0095 • ACR Convergence 2023
Kynurenine Is a Proinflammatory Metabolite That Activates a Positive Feedback Loop of Rab4A-dependent CD98 Expression and mTORC1 and mTORC2 Activation in SLE
Thomas Winans¹, Nick Huang¹, Joshua Lewis¹, Xiaojing Wang¹, Tamas Faludi¹, Daniel Krakko², Laurence Morel³ and Andras Perl⁴, ¹SUNY Upstate Medical University, Syracuse, NY, ²North Carolina State University, Raleigh, NC, ³University of Texas health San Antonio, San Antonio, TX, ⁴SUNY, Syracuse, NY
Background/Purpose: The kynurenine (KYN) pathway has been linked to disease pathogenesis in patients with systemic lupus erythematosus (SLE) (https://pubmed.ncbi.nlm.nih.gov/26366134/). Genetically enforced overexpression of Rab4A activates…
Abstract Number: 0886 • ACR Convergence 2023
Neonatal Roseolovirus Infection Predisposes to Development of Lupus-like Disease After TLR7 Stimulation
Tarin Bigley¹, Eden Xue¹, Lifei Zhu¹, Li-ping Yang¹ and wayne Yokoyama², ¹Washington University in St. Louis, St. Louis, MO, ²Washington University School of Medicine, St. Louis, MO
Background/Purpose: Viral infections have been implicated as major factors in autoimmune disease but demonstrating causality is often challenging. We found that neonatal infection with a…
Abstract Number: 1580 • ACR Convergence 2023
CXCL13+ T Cell Differentiation in Systemic Lupus Erythematosus Is Controlled by Opposing Effects of Aryl Hydrocarbon Receptor and Type I Interferon
Calvin Law¹, Vanessa Wacleche², Ye Cao³, Arundhati Pillai¹, Alice Horisberger⁴, Sabrina Bracero³, Viktoriya Skidanova³, Zhihan Li³, Ifeoluwakiisi Adejoorin², Isaac Benque³, Diana Pena Nunez³, Daimon Simmons², Joshua Keegan⁴, Lin Chen³, John Sowerby³, Accelerating Medicines Partnership (AMP): RA/SLE², Elena Massarotti², Karen Costenbader⁴, Michael Brenner⁴, James Lederer⁴, Judd Hultquist¹, Jaehyuk Choi¹ and Deepak Rao², ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Brigham and Women's Hospital, Boston, MA, ³Brigham and Women's Hospital, Boston, MA, ⁴Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Expansion of B cell-helper T cells including T follicular helper (Tfh) and T peripheral helper (Tph) cells is a prominent feature of systemic lupus…
Abstract Number: 0076 • ACR Convergence 2023
Characterizing GMCSF Producing T-cells in Rheumatoid Arthritis and Effect of Methotrexate on Them
AASTHA KHULLAR¹, Varun Dhir², Leishangthem Bidyalaxmi¹, Chandra Bhushan Prasad³, Sankar Jayaprakash¹, Siddharth Jain⁴, Biman Saikia¹, Aman Sharma⁵, Shefali Sharma⁶, Ashok Kumar Yadav¹, Shankar Naidu¹ and Sanjay Jain⁷, ¹PGIMER, Chandigarh, India, ²PGIMER, CHD, INDIA, Chandigarh, India, ³Healthway Hospital, Goa, Zuarinagar, India, ⁴AIIMS, Delhi, India, ⁵PGIMER, Chandigarh, India, Chandigarh, India, ⁶PGIMER< Chandigarh, Chandigarh, India, ⁷Post Graduate Institute of Medical Education and Research, Chandigarh, India
Background/Purpose: Background: GMCSF producing T-cells may be implicated in the pathogenesis of autoimmune diseases like rheumatoid arthritis (RA), multiple sclerosis (MS) and psoriatic arthritis. Few…
Abstract Number: 0114 • ACR Convergence 2023
Platelets Are Highly Activated and Could Participate in Immune Abnormality of APS
Yu Shi¹, Xiaofan Luo², Quan Chen³, Jiuliang zhao⁴, Mengtao Li⁴ and xiaofeng Zeng⁵, ¹Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, ²Nankai University, Tianjin, China, ³Nankai University, Beijing, China, ⁴Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, ⁵Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
Background/Purpose: Platelets play a pivotal role in the process of coagulation and other biological process. Studies have shown multiple evidences that platelets are highly activated…
Abstract Number: 0909 • ACR Convergence 2023
Rab4A Controls the Depletion of IL-2 in CD4+ T Cells via Enhanced CD38 Expression: Potential Involvement in Proinflammatory Lineage Development in Systemic Lupus Erythematosus
Joy Park¹, Xiaojing Wang², Aparna Godavarthy¹, Akshay Patel², Krakko Daniel¹, Jessica Nolan¹, Joanne Chilton¹, Bryan Blaker¹ and Andras Perl³, ¹Upstate Medical University, Syracuse, NY, ²SUNY Upstate Medical University, Syracuse, NY, ³SUNY, Syracuse, NY
Background/Purpose: HRES-1/Rab4 (Rab4A) is a small GTPase that is overexpressed in SLE patient T cells1,2, mediates the enhanced recycling of CD3 and CD4 cell surface…
Abstract Number: 1689 • ACR Convergence 2023
Deep Cellular Immune Profiling in Psoriatic Arthritis Correlates with Imaging Phenotypes and Response to Targeted Advanced Therapy
Lihi Eder¹, Xianwei Li², Sydney Thib³, Darshini Ganatra⁴, Liqun Diao² and Vinod Chandran⁵, ¹Women’s College Research Institute, Division of Rheumatology, University of Toronto, Toronto, ON, Canada, ²Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ³Women’s College Research Institute, Toronto, ON, Canada, ⁴Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁵Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, ON, Canada
Background/Purpose: To characterize the relationships between peripheral blood immune cell profiles in patients with psoriatic arthritis (PsA) and (1) baseline clinical and imaging disease features;…
Abstract Number: 0077 • ACR Convergence 2023
Circulating CD4+CXCR5-PD-1hiICOS+ Cells Are Elevated in Patients with Newly Diagnosed Giant Cell Arteritis and Associate with the Clinical Outcome
Maria-Eugenia Miranda-Carus¹, Beatriz Nieto-Carvalhal¹, Irene Monjo², Mariela Uyaguari-Morocho¹, Irene Casado-Juárez³, Alejandro Balsa⁴ and Eugenio De Miguel⁴, ¹Hospital Universitario La Paz - IdiPAZ, Madrid, Spain, ²University Hospital La Paz, Madrid, Spain, ³Hospital La Paz - IdiPAZ, Madrid, Spain, ⁴Hospital Universitario La Paz, Madrid, Spain
Background/Purpose: Giant cell arteritis (GCA) is a large-vessel granulomatous vasculitis. It is characterized by the presence at the inflamed arterial walls, of activated PD-1+ CD4…
Abstract Number: 0196 • ACR Convergence 2023
Limited Regulatory T Cell Response in Post-Chikungunya Viral Arthritis: A Therapeutic Opportunity?
Aileen Chang¹, Sarah Tritsch¹, Carlos Herrera¹, Liliana Encinales², Andres Cadena³, Wendy Rosales⁴, Evelyn Mendoza⁵, Samuel Simmens¹, Richard Amdur⁶, Paige Fierbaugh¹, Abigale Proctor¹, Alfonso Sucerquia¹, Christopher Mores¹, David Boyle⁷, Gary Firestein⁷ and Gary Simon¹, ¹George Washington University, Washington, DC, ²Allied Research Society, Barranquilla, Colombia, ³Clinica de la Costa, Barranquilla, Colombia, ⁴Universidad Libre, Barranquilla, Colombia, ⁵Universidad Libre, Bogotá, Colombia, ⁶Northwell, Washington, DC, ⁷University of California San Diego, San Diego, CA
Background/Purpose: The objective was to define the relationship between chronic chikungunya (CHIKV) post-viral arthritis disease severity, interleukin (IL)-2, and T cell subsets in order to…
Abstract Number: 0921 • ACR Convergence 2023
SAPhigh T Peripheral Helper Cells Are a Novel Subset Associated with Lupus Nephritis
Yevgeniya Gartshteyn¹, Leila Khalili², Laura Geraldino-Pardilla², Adam Mor³ and Anca Askanase⁴, ¹Columbia University Medical Center, New York, NJ, ²Division of Rheumatology, Columbia University Irving Medical Center, New York, NY, ³Columbia University, New York, NY, ⁴Columbia University Medical Center, New York, NY
Background/Purpose: Better understanding of the abnormal immune responses in lupus nephritis (LN) is fundamental to identifying new therapies. We previously reported that the adaptor protein…
Abstract Number: 1732 • ACR Convergence 2023
Immunopathogenesis and Preclinical Trials in a Humanized Mouse Model of Rheumatoid Arthritis(RA)
Huiyi Wang¹, Kangkang Luo¹, Shuxin Xu¹, Jiayin Zhou¹, Santi Chen², Jun wang², Wenzhao Li², Jing Zhao¹ and Cunxiang Ju¹, ¹GemPharmatech CO., Ltd., Nanjing, China, ²GemPharmatech LLC, La Jolla, CA
Background/Purpose: The differences between human and mouse immune systems make it challenging to accurately reflect the immunopathogenesis of autoimmune diseases in patients. Therefore, translational research…
Abstract Number: 0078 • ACR Convergence 2023
Circulating CD4+CXCR5+PD-1hi Follicular Helper T Cells Are Elevated in Patients with Rheumatoid Arthritis and Predict Treatment Response to Abatacept or TNF Blockers
Maria-Eugenia Miranda-Carus¹, Beatriz Nieto-Carvalhal¹, Irene Monjo², Mariela Uyaguari-Morocho¹, Alejandro Villalba³, Laura Nuño¹, Diana Peiteado¹, Elisa Fernández¹, Sara García-Carazo¹ and Alejandro Balsa⁴, ¹Hospital Universitario La Paz - IdiPAZ, Madrid, Spain, ²University Hospital La Paz, Madrid, Spain, ³Rheumatology Department, La Paz University Hospital, Madrid, Spain, ⁴Hospital Universitario La Paz, Madrid, Spain
Background/Purpose: CD4+CXCR5+PD-1hi follicular helper (Tfh) T cells dwell in the germinal centers (GCs), help B cells, and are implicated in Rheumatoid Arthritis (RA) pathogenesis. Circulating…
Abstract Number: 0210 • ACR Convergence 2023
Longitudinal T Cell Responses to a Series of Four SARS-CoV-2 Vaccine Doses or COVID-19 in Patients on TNF Inhibitors
Hilde Ørbo¹, Asia-Sophia Wolf², Kristin Hammersbøen Bjørlykke³, Sarah E. Josefsson², Guri Solum², Ingrid Fadum Kjønstad⁴, Ingrid Jyssum¹, Ingrid Christensen¹, Anne Therese Tveter¹, Joseph Sexton¹, Grete B. Kro⁵, Gunnveig Grødeland⁶, Tore Kvien¹, Jørgen Jahnsen³, John Torgils Vaage⁷, Espen Haavardsholm¹, Sella Provan⁸, Hassen Kared⁹, Ludvig A. Munthe⁷, Kristin Kaasen Jørgensen³, Silje Watterdal Syversen¹, Siri Mjaaland² and Guro Goll¹, ¹Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway, ²Norwegian Institute of Public Health, Oslo, Norway, ³Department of Gastroenterology, Akershus University Hospital, Oslo, Norway, ⁴National Institute of Public Health, Oslo, Norway, ⁵Department of Microbiology, Oslo University Hospital, Oslo, Norway, ⁶Department of Immunology, Oslo University Hospital, Oslo, Norway, ⁷Department of Immunology, Oslo University Hospital, Oslo, Norway, ⁸Diakonhjemmet Hospital, Oslo, Norway, ⁹Department of Immunology, Oslo University Hospital, Oslo, Norway
Background/Purpose: T cells are critical for control of viral infection with SARS-CoV-2, but knowledge is lacking on cellular immune responses following repeated vaccination and breakthrough…
Abstract Number: 0929 • ACR Convergence 2023
Persistent Up- or Down-regulation of SOCS1 Exacerbates the Pathogenesis of Systemic Lupus Erythematosus Through Several Mechanisms
Reiko Takahashi and Yoshitaka Imura, Medical Research Institute KITANO HOSPITAL, PIIF Tazuke-Kofukai, Osaka, Japan
Background/Purpose: SOCS1 (suppressor of cytokine signaling 1) is a suppressor molecule of the JAK/STAT pathway and has been reported to be involved in the pathogenesis…

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