ACR Meeting Abstracts

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Abstracts tagged "T Cell"

  • Abstract Number: 1836 • ACR Convergence 2024

    Transcriptional Changes in the Formation of Tissue Resident Memory T Cells in the Joint

    Yang Yang1, Yusuke Miyashita1, Vitor Aguiar1, Maria Gutierrez-Arcelus1, Kellen Winden2, Peter Nigrovic3 and Margaret Chang1, 1Boston Children's Hospital, Boston, MA, 2Boston Children's Hospital, Boston, MA, 3Boston Children's Hospital, Brookline, MA

    Background/Purpose: Rheumatoid arthritis is a chronic autoimmune disease characterized by joint-specific memory, the phenomenon in which arthritis repeatedly flares in the same joints. We previously…
  • Abstract Number: 1855 • ACR Convergence 2024

    ­Identification of Autoreactive Cytotoxic T Cells in ANCA-Associated Vasculitis

    Laura van Dam1, Shady Younis2, Jae-Seung Moon3, Mengrui Zhang4, Shima Parfasar4, Audra Horomanski3, orr Sharpe3, Jolijn van Leeuwen5, Tobias Lanz4, Cees van Kooten6, Onno Teng7 and William Robinson8, 1Stanford, Palo Alto, CA, 2Stanford University, Stanford, CA, 3Department of Immunology and Rheumatology, Stanford University, Stanford, CA, 4Department of Immunology and Rheumatology, Stanford University, Stanford, 5Department of Nephrology, Leiden University Medical Center, Leiden, Netherlands, 6Department of Nephrology, Leiden University Medical Center, Leiden, 7Leiden University Medical Center, Leiderdorp, Netherlands, 8Division of Immunology and Rheumatology, Stanford University, and VA Palo Alto Health Care System, Stanford, CA

    Background/Purpose: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare and severe autoimmune disease, characterized by a pauci-immune necrotizing vasculitis leading to inflammation and damage…
  • Abstract Number: 2290 • ACR Convergence 2024

    Umbilical Cord-derived Mesenchymal Stem Cells Suppress Sjogren’s Syndrome Pathology

    Yukitomo Hagiwara1, Goh Murayama2, Taiga Kuga2, Yujin Nishioka2, Takumi Saito2, Yu Yamaji2, Tomoko Miyashita2, Makio Kusaoi3, Ken Yamaji2 and Naoto Tamura2, 1Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan, 2Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, 3Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Bunkyo, Tokyo, Japan

    Background/Purpose: Primary Sjögren's syndrome (pSS) is characterized by lymphocytic infiltration of the salivary and lacrimal glands, leading to functional loss and gradually causing dry mouth…
  • Abstract Number: 0038 • ACR Convergence 2024

    The Role of Dual Specificity Phosphatase 22 (DUSP22) in Rheumatoid Arthritis: Mechanism and Genetic Investigations

    Wei-Ting Hung1, Yi-Ming Chen2, Wen-Nan Huang3, Tsai-Hung Yen4, Tse-Hua Tan5 and Huai-Chia Chuang6, 1Taichung Veteran General Hospital, Taichung City, Taiwan (Republic of China), 2Taichung Veterans General Hospital, Taiwan, Taichung, Taiwan (Republic of China), 3Taichung Veterans General Hospital, Taichung, Taiwan, Taichung, Taiwan (Republic of China), 4Taichung Veterans General Hospital, Xitun District, Taichung City, Taiwan (Republic of China), 5National Health Research Institutes, Mao-Li, Taiwan (Republic of China), 6National Health Research Institutes, Zhunan, Taiwan (Republic of China)

    Background/Purpose: Rheumatoid arthritis (RA) is a debilitating autoimmune disorder characterized by chronic inflammation and joint damage. This study investigates the role of Dual Specificity Phosphatase…
  • Abstract Number: 0869 • ACR Convergence 2024

    Deciphering Pathogenic Phenotypes by Multi-modal Deep Single-cell Blood Immunophenotyping in Individuals At-risk for Rheumatoid Arthritis

    Jun Inamo1, Joshua Keegan2, Alec Griffith2, Tusharkanti Ghosh1, Alice Horisberger2, Kaitlyn Howard2, John Pulford2, Ekaterina Murzin2, Brandon Hancock2, Thomas Eisenhaure3, Salina Dominguez4, Miranda Gurra5, Siddarth Gurajala3, Anna Helena Jonsson1, Jennifer Seifert6, Marie Feser7, Jill Norris8, Ye Cao2, William Apruzzese9, S. Louis Bridges10, Vivian Bykerk11, Susan Goodman12, Laura Donlin11, Gary S. Firestein13, Joan Bathon14, Laura B. Hughes15, Darren Tabechian16, Andrew Filer17, Costantino Pitzalis18, Jennifer Anolik19, Larry Moreland20, Nir Hacohen21, Joel Guthridge22, Judith James22, Carla Cuda5, Harris Perlman5, Michael B. Brenner2, Soumya Raychaudhuri23, Jeffrey Sparks24, Michael Holers7, Kevin Deane25, James A. Lederer26, Deepak Rao26 and Fan Zhang27, and the Accelerating Medicines Partnership RA/SLE Network, 1University of Colorado School of Medicine, Aurora, CO, 2Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 3Broad Institute of MIT and Harvard, Cambridge, 4Northwestern University, Chicago, 5Northwestern University, Chicago, IL, 6University of Colorado and Oklahoma Medical Research Foundation, Aurora, CO, 7Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 8Colorado School of Public Health, Denver, CO, 9Accelerating Medicines Partnership® Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP® RA/SLE) Network, Boston, MA, 10Division of Rheumatology, Weill Cornell Medical College, New York, NY, 11Hospital For Special Surgery, New York, NY, 12Hospital for Special Surgery, New York 10025, NY, 13University of California, San Diego, La Jolla, 14Columbia University, New York, NY, 15University of Alabama at Birmingham Medicine, Birmingham, AL, 16University of Rochester Medical Center, Rochester, 17Rheumatology Research Group, Institute for Inflammation and Ageing, NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Birmingham, United Kingdom, 18QMUL, Bromley Kent, United Kingdom, 19University of Rochester Medical Center, Rochester, NY, 20University of Colorado, Denver, CO, 21Broad Institute of MIT and Harvard, Boston, MA, 22Oklahoma Medical Research Foundation, Oklahoma City, OK, 23Brigham and Women's Hospital, Boston, MA, 24Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Boston, MA, 25University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 26Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 27University of Colorado, Aurora, CO

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease with currently no effective prevention strategies. Single-cell technologies have been recently used to investigate established RA…
  • Abstract Number: 1657 • ACR Convergence 2024

    Immunological Profiling of Pain in Knee Osteoarthritis: Treg Cells as Potential New Key Players in Symptomatic Knee Osteoarthritis

    Marie Binvignat1, Maria Marco-Salvador1, Johanna Dubois1, Paul Stys1, Alice Courties2, Fabien Pitoiset1, Alexandra Roux3, Michele Barbier4, Roberta Lorenzon2, Signe Hassler3, Claire Ribet1, helene Vantomme1, Leslie Adda1, Vanessa Mhanna1, Nicolas Coatnoan2, Gwladys Fourcade1, Vimala Didelot1, PIerre Barennes1, Lise Minssen2, Caroline Aheng1, Sanchita Bhattacharya5, Yannick Marie6, Atul J. butte5, Adrien Six1, Nicolas Tchitcheck1, Michelle Rosenzwajg1, Francis Berenbaum1, David Klatzmann1, Encarnita Mariotti-Ferrandiz1 and Jérémie Sellam7, 1Sorbonne University, Paris, France, 2AP-HP, Paris, France, 3Sorbonne University, Paris, 4AP-HP, Paris, 5UCSF, San Francisco, 6ICM, Paris, France, 7Saint-Antoine Hospital - AP-HP, Paris, Ile-de-France, France

    Background/Purpose: Pain is the main osteoarthritis (OA) symptom and remains poorly understood. While significant attention has been given to the potential role of innate immunity,…
  • Abstract Number: 1837 • ACR Convergence 2024

    Baseline Multiome Sequencing of CD45RO+CD45RA-CD4+ T Cell Reveals Distinct Immune Profiles Associated with Subsequent Response to Secukinumab Treatment

    Addison Pacheco1, Zoya Qaiyum2, Fataneh Tavasolian3, Melissa Lim4, Michael Tang1 and Robert Inman1, 1University Health Network, Toronto, ON, Canada, 2Krembil Research Institute, Toronto, ON, Canada, 3Krembil Research Institute - the University Health Network, Toronto, ON, Canada, 4University of Toronto, Toronto, ON, Canada

    Background/Purpose: Our study aims to discriminate immune profiles between secukinumab responders (SEC-R) and nonresponders (SEC-NR) in axial spondyloarthritis (axSpA) patients before biologic treatment.Methods: CD45RO+CD45RA-CD4+ T…
  • Abstract Number: 1856 • ACR Convergence 2024

    Distinct Proliferative and Special Properties of Peripheral Helper T Cells in RA Synovium

    Yuki Masuo1, Akinori Murakami1, Rinko Akamine1, Osamu Iri1, Koichi Murata1, Kohei Nishitani1, Hiromu Ito1, Takayuki Fujii1, Ryu Watanabe2, Takeshi Iwasaki1, Shinichiro Nakamura1, Shinichi Kuriyama1, Yugo Morita1, Yasuhiro Murakawa1, Chikashi Terao3, Yukinori Okada4, Motomu Hashimoto2, Shuichi Matsuda5, Hideki Ueno1 and Hiroyuki Yoshitomi1, 1Kyoto University, Kyoto, Japan, 2Osaka Metropolitan University, Osaka, Japan, 3RIKEN, Tokyo, Japan, 4The University of Tokyo / Osaka University / RIKEN, Tokyo, Japan, 5Department of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan

    Background/Purpose: Tertiary lymphoid structures (TLSs) are organized aggregates of immune cells that are frequently observed in the target tissues of chronic diseases. In patients with…
  • Abstract Number: 2300 • ACR Convergence 2024

    Activation of Tissue-Resident T Cells in Sjögren’s Disease with Human Salivary Organoids

    Brandon Law1, Rahmatullah Rahmati2 and Andrew Luster3, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts Eye & Ear, Boston, MA, 3Massachusetts General Hospital, Charlestown, MA

    Background/Purpose: Sjögren's disease (SjD) is a chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands, particularly the salivary glands. These focal lymphocytic infiltrates are…
  • Abstract Number: 0071 • ACR Convergence 2024

    Stage-Specific Roles of Interleukin-23/Interleukin-17 Axis and Type 1 Regulatory T Cells Dynamics in Axial Spondyloarthritis

    Jina Yeo1, Min-Gang Kim2, Hee Sung Kwon3, Mi Ryoung Seo1, Hyo-Jin Choi1, YunJae Jung4, Eun Young Lee5 and Han Joo Baek6, 1Division of Rheumatology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea, 2Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea, 3Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea, 4Department of Microbiology, College of Medicine, Gachon University, Incheon, Republic of Korea, 53Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea, 6Division of Rheumatology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Inchon, South Africa

    Background/Purpose: The interleukin (IL)-23/IL-17 pathway is central to axial spondyloarthritis (axSpA) pathogenesis, yet treatments targeting IL-23 show inconsistent effectiveness across spondyloarthritis subtypes. We hypothesized that…
  • Abstract Number: 0873 • ACR Convergence 2024

    Epigenetic Control of Pathogenic CD4 T Cell Polarization During Progression to Rheumatoid Arthritis (RA)

    Ziyuan He1, Pravina Venkatesan1, Adam Savage1, Marla Glass1, Lauren Okada2, Upaasana Krishnan2, Christy Bennett1, Nhung Tran2, Yudong He2, Samir Rachid Zaim1, Padmapriyadarshini Ravisankar2, Jessica Garber2, Palak Genge2, Kevin Lee2, Regina Mettey2, Cole Phalen2, Sugandhika Khosa2, Marie Feser3, Fan Zhang4, David Boyle5, Kristine Kuhn4, Kristen Demoruelle6, Cate Speake7, Jane Buckner8, Ananda Goldrath1, Thomas Bumol9, V. Michael Holers10, Peter Skene1, Gary Firestein11, Xiaojun Li1, Kevin Deane12, Troy Torgerson13 and Mark Gillespie1, 1Allen Institute for Immunology, Seattle, WA, 2Allen Institute for Immunology, Seattle, 3Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 4University of Colorado, Aurora, CO, 5UCSD, La Jolla, CA, 6University of Colorado Anschutz Medical Campus, Golden, CO, 7Benaroya Research Institute at Virginia Mason, Seattle, 8Benaroya Research Institute, Seattle, WA, 9Allen Institute for Immunology, San Diego, CA, 10University of Colorado, Denver, CO, 11University of California, San Diego, San Diego, CA, 12University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 13Allen Institute for Immunology, Enumclaw, WA

    Background/Purpose: Multiple T cell subsets, including Th1, Th17 cells, and Tfh/Tph, contribute to rheumatoid arthritis (RA) pathology. Clinical trials have shown efficacy of T cell…
  • Abstract Number: 1659 • ACR Convergence 2024

    Shared Lung and Joint T Cell Repertoire in Early Rheumatoid Arthritis Driven by Cigarette Smoking

    Koen Venken1, Matthias Jarlborg1, Frederik Stevenaert2, Thomas Malfait3, Carolien Vlieghe1, Yann Abraham2, Teddy Manuello1, Tine Decruy1, Stijn Van Hee1, Hans Wils2, Pieter Peeters2, Philippe Carron4, Filip Van den Bosch3, Viggo Van Tendeloo2, Bart Lambrecht1, Ruth Wittoek5, Peggy Jacques6 and Dirk Elewaut7, 1VIB Center for Inflammation Research - Ghent University, Ghent, Belgium, 2Janssen Research and Development, Beerse, Belgium, 3Ghent University Hospital, Ghent, Belgium, 4UZ Gent, Gent, Belgium, 5Dept. of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium, 6University Hospital of GHent, Gent, Belgium, 7Ghent University and VIB Center for Inflammation Research, Ghent, Belgium

    Background/Purpose: Cigarette smoking has been associated with the production of anti-citrullinated protein antibodies (ACPA) and an increased risk of developing rheumatoid arthritis (RA) in individuals…
  • Abstract Number: 1838 • ACR Convergence 2024

    M5542: A Potent CD80, CD86, and OX40L Antagonist Fusion Molecule for the Treatment of Autoimmune Diseases

    Michelle Downing1, Ling Zhang1, Aditee Desphpande1, Hong Zhang1, Ohad Tarcic2, Mira toister-achituv2, Alec Gross3, Gang Chen3 and Chia Chi Sun1, 1EMD Serono Research and Development Institute, Inc., Billerica, MA, 2Inter-lab Ltd, Merck KGaA, Yavne, Israel, 3EMD Serono Reserch and Development Institute, Inc, Billerica, MA

    Background/Purpose: Overactive adaptive immune responses contribute to many autoimmune diseases such as systemic lupus erythematosus (SLE). Chronically activated autoreactive T-effector cells play a pivotal role…
  • Abstract Number: 1857 • ACR Convergence 2024

    Thymic Mimetic Cells in Humans, Mice and Fish Are Evolutionarily Ancient with Species-specific Adaptations

    Brooke Huisman1, Daniel Michelson1, Sara Rubin1, Katherine Kohlsaat2, Wilson Gomarga2, Yuan Fang1, Ji Myung Lee2, Pedro del Nido2, Meena Nathan2, Christophe Benoist1, Leonard Zon2 and Diane Mathis1, 1Harvard Medical School, Boston, MA, 2Boston Children's Hospital, Boston, MA

    Background/Purpose: Thymic mimetic cells are molecular hybrids between medullary thymic epithelial cells (mTECs) and diverse peripheral cell types. They are involved in eliminating autoreactive T…
  • Abstract Number: 2386 • ACR Convergence 2024

    Landscape of Immune Cells and Autoimmunity in Systemic Lupus Erythematosus Patients with Obesity

    Alexandra Reese1, Chandana Keshavamurthy2, Sneha Centala1, Samantha Ahrens1, Shivani Shah2, Douglas Reeves2, William Davis3, Robert Quinet4, Jerald Zakem1, Qingli Wu1, Kimmy Tran1, Teresa Leeth5, Daniyal Nadeem6, Sarwat Umer7, Samina Hayat5 and Xin Zhang1, 1Ochsner Health, New Orleans, LA, 2Ochsner Clinic Foundation, New Orleans, 3Ochsner Health System, New Orleans, LA, 4Ochsner Health, River Ridge, LA, 5Louisiana State University Shreveport, Shreveport, LA, 6LSU Shreveport, Shreveport, 7LSU HEALTH SHREVEPORT, SHREVEPORT, LA

    Background/Purpose: Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease characterized by autoantibodies and disruption of multiple organs due to immunomodulatory dysfunction. Obesity is a…
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