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Abstracts tagged "T Cell"

  • Abstract Number: 1005 • ACR Convergence 2025

    CD49a Contributes to Binding and Survival of Synovial Resident Memory T cells

    Yusuke Miyashita1, Yang Yang2, Madison Mangin3, Maryrose Hahn2 and Margaret Chang2, 1Boston Children's Hospital, Brookline, MA, 2Boston Children's Hospital, Boston, MA, 3Boston Children's Hospital, St Simons Island, GA

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease featured with recurrent inflammation in the same joints, a characteristic termed joint-specific memory. We previously demonstrated…
  • Abstract Number: 0980 • ACR Convergence 2025

    Expansion of Viral-Reactive CD8+ T cell Repertoire Stratified by Pathotype in New-onset ACPA+ Rheumatoid Arthritis

    Carl Coyle1, Wittaya Suwakulsiri2, Lukas Andriessen3, Megan Soon4, Pascale Wehr5, Sumera Qureshi6, Christopher Altmann7, Annabelle Small8, Vincent Wong9, Andrew Cope6, Kevin Wei10, Hendrik Nel5, Mihir Wechalekar11 and Ranjeny Thomas2, 1Kings College London, London, United Kingdom, 2Frazer Institute, University of Queensland, Brisbane, Queensland, Australia, 3Frazer Institute, University of Queensland, Woolloongabba, Queensland, Australia, 4Frazer Institute, The University of Queensland, Brisbane, Australia, 5University of Queensland, Woolloongabba, Queensland, Australia, 6King's College London, London, United Kingdom, 7Flinders University, Adelaide, Australia, 8Flinders University, Bedford Park, South Australia, Australia, 9College of Medicine and Public Health, Bedford Park, South Australia, Australia, 10Brigham and Women's Hospital at Harvard Medical School, Boston, MA, 11Flinders Medical Centre, Adelaide, Australia

    Background/Purpose: Development of Rheumatoid Arthritis (RA) is strongly associated with specific HLA-DRB1 genotypes and the HLA-DR antigen binding groove, the shared epitope. HLA-B*08 also increases…
  • Abstract Number: 0471 • ACR Convergence 2025

    An Open-label, Randomized, Controlled Phase 1/2 Study to Assess the Safety and Efficacy of KYV-101 Anti-CD19 CAR-T Cell Therapy in Active and Difficult-to-treat ACPA positive Rheumatoid Arthritis: Preliminary Results of the COMPARE Trial

    Fredrik Albach1, Ioanna Minopoulou1, Artur Wilhelm2, Robert Biesen1, Arnd Kleyer1, Norman Drzeniek3, Edgar Wiebe4, Anja Fleischmann3, Dominic Borie5, Vincent Casteleyn3, Tobias Alexander3, Christian Furth6, Jan Zernicke3, Burkhard Muche7, Sandra Hermann4, Pfeil Alexander8, Veronika Scholz3, Elpida Phithak3, Olaf Penack9, Kamran Movassaghi9, Eva Vanessa Schrezenmeier10, Udo Schneider3, Antonia Busse11, Georg Schett12, Ulrich Keller11, Lars Bullinger9, Gerhard Krönke13, Marie Luise Hütter-Krönke14 and David Simon15, 1Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, Berlin, Germany, 2Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany, Berlin, 3Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, Berlin, 4Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, Berlin, Berlin, Germany, 5Kyverna Therapeutics, Emeryville, CA, 6Department of Nuclear Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany, Berlin, 7Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, 8Department of Internal Medicine III, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany, 9Department of Hematology, Oncology and Tumor Immunology, Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany, Berlin, 10Department of Nephrology, Charité - Universitätsmedizin Berlin, Berlin, Germany, Berlin, 11Department of Hematology, Oncology and Cancer Immunology, Charité - Universitätsmedizin Berlin, Campus Steglitz, Berlin, Germany; Max-Delbrück-Center for Molecular Medicine, Berlin, Germany; German Cancer Consortium (DKTK) partner site Charité Berlin and German Cancer Research Center (DKFZ), Heidelberg, Germany, Berlin, 12Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany, Erlangen, Germany, 13Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany, Berlin, Berlin, Germany, 14Department of Hematology, Oncology and Cancer Immunology, Charité - Universitätsmedizin Berlin, Campus Steglitz, Berlin, Germany, Berlin, 15Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany, Berlin, Germany

    Background/Purpose: Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by autoreactive B cells that produce anti-citrullinated protein antibodies (ACPA), contributing to sustained synovial inflammation…
  • Abstract Number: 2303 • ACR Convergence 2025

    Metabolic impact of low dose IL‐2 therapy for primary Sjögren’s Disease in a double‐blind, randomized clinical trial

    Ruiling Feng, Bo Huang and Yuebo Jin, Peking University People’s Hospital, Beijing, China (People's Republic)

    Background/Purpose: Low-dose interleukin 2 (Ld-IL2) is increasingly being explored as an immune-modulating treatment for autoimmune diseases which mainly affect T cell subsets. This study investigates…
  • Abstract Number: 1004 • ACR Convergence 2025

    Single-Cell Analysis Reveals Tissue Resident Memory T Cells Heterogeneity in the Joint

    Yang Yang1, Yusuke Miyashita2, Madison Mangin3, Kellen Winden1, Peter Nigrovic2 and Margaret Chang1, 1Boston Children's Hospital, Boston, MA, 2Boston Children's Hospital, Brookline, MA, 3Boston Children's Hospital, St Simons Island, GA

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint-specific memory, the phenomenon in which arthritis repeatedly flares in the same joints. We…
  • Abstract Number: 0979 • ACR Convergence 2025

    IL-23 upregulates IFN-γ secretion in Th17.1, but not in Th17 or classical Th1 cells

    Bennie van Heeswijk1, Wida Razawy2, Anne-Marie Mus-Otten3, Patrick Asmawidjaja2, Pieter Leenen2 and Erik Lubberts4, 1Erasmus MC, University Medical Center Rotterdam, Hoofddorp, Netherlands, 2Erasmus University Medical Center, Rotterdam, the Netherlands, Rotterdam, Netherlands, 3Erasmus medical center, Rotterdam, Netherlands, 4Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands

    Background/Purpose: Interleukin-23 (IL-23) is a key cytokine in the pathogenesis of psoriatic diseases, as demonstrated by the clinical success of IL-23-targeted therapies. Monocytes are a…
  • Abstract Number: 0273 • ACR Convergence 2025

    Effector CD8+ T cells and PD-1hi CXCL13hi CD4+ T cells contribute to recurrent immune checkpoint inhibitor mediated inflammatory arthritis

    Synat Keam1, Yuanteng Li2, Yanshuo Chu1, Jean Tayar3, Huifang Lu4, Michael Wu5, Sandeep Agarwal6, Nitin Jain7, Pavlos Msaouel1, Adi Diab2, Cara Haymaker1, Linghua Wang1, Roza Nurieva8 and Sang Kim9, 1The University of Texas MD Anderson Cancer Center, houston, 2MD Anderson Cancer Center, Houston, TX, 3The University of Texas, MD Anderson Cancer Center, Houston, TX, 4UT MD Anderson Cancer Center, Houston, TX, 5Baylor College of Medicine, Houston, 6Baylor College of Medicine, Houston, TX, 7The Universty of Texas MD Anderson Cancer Center, Houston, 8University of Texas MD Anderson, Houston, TX, 9Yale University, Branford, CT

    Background/Purpose: Immune checkpoint inhibitor (ICI) therapy is associated with life- and/or organ-threatening immune-related adverse events, including inflammatory arthritis (ICI-IA). However, the mechanisms behind ICI-IA, especially…
  • Abstract Number: 2293 • ACR Convergence 2025

    CLN-978, a CD19 x CD3-Directed T Cell Engager, Leads to Rapid and Deep B Cell Depletion In Vitro and In Vivo, Supporting Clinical Development Across Multiple Autoimmune Diseases

    Ella Ioffe, Karsten Sauer, Todd Shearer, Jennifer Michaelson, Jeffrey Jones, Yue Zhang, Stephen Wax and Antoine Sreih, Cullinan Therapeutics Inc, Cambridge, MA

    Background/Purpose: Treatments depleting CD19-expressing B cells have shown benefit in a range of autoimmune diseases. T cell engagers (TCE) offer off-the-shelf convenience, the predictable pharmacokinetic/pharmacodynamic…
  • Abstract Number: 1001 • ACR Convergence 2025

    LBL-057, a Novel ADCC Enhanced PD-1 Agonist VHH-Fc Antibody

    Hongyan Shang1, Xiao Huang2, Duqing Jiang1, Jianming Sun2, Yurong Qin2, Guojin Wu2, Chengze Ni1, Jing Guan2, Jordan Zhu3, Xiaoqiang Kang2 and Hong Ling2, 1Nanjing Leads Biolabs Co., Ltd., nanjing, China (People's Republic), 2Nanjing Leads Biolabs Co., Ltd., Nan Jing, China (People's Republic), 3Nanjing Leads Biolabs Co., Ltd., Nan Jing

    Background/Purpose: Programmed cell death protein 1 (PD-1) is expressed on activated T cells and serves as a key co-inhibitory checkpoint molecule in immune regulation. Aberrant…
  • Abstract Number: 0950 • ACR Convergence 2025

    Ep300-Catalyzed Rad50 Lactylation Compromises Genomic Stability and Drives CD4+T cells Cell Senescence in SLE

    mingyang zhang1, huanzi dai2, cun lan3 and mingyang sun3, 1Daping Hospital, Army Medical University, chongqing, Chongqing, China (People's Republic), 2Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing, PR China., Chongqing, China (People's Republic), 3Daping Hospital, Army Medical University, chongqing, China (People's Republic)

    Background/Purpose: Senescent CD4+ T cells are increasingly implicated in systemic lupus erythematosus (SLE) pathogenesis. While metabolic reprogramming in lupus T cells enhances glycolysis and lactate…
  • Abstract Number: 0110 • ACR Convergence 2025

    SKG Mice Develop CD4⁺ T Cell–Driven Psoriasis and Enable Study of Endogenous Antigen-Specific Responses

    Yuka Nakao1, Astha Patel1, Bahram Razani2, Steven yu1, Steven Lazarevsky2, Marlys Fassett2 and Judith Ashouri1, 1University of California, San Francisco, San Francisco, CA, 2UCSF Department of Dermatology, San Francisco, CA

    Background/Purpose: Psoriasis (Pso) and psoriatic arthritis (PsA) are chronic immune-mediated diseases affecting millions, yet early immunologic triggers remain poorly defined. Therapies targeting TNFα, IL-17, and…
  • Abstract Number: 2277 • ACR Convergence 2025

    Immunophenotyping of peripheral blood mononuclear cells reveals potential cellular biomarkers of disease in rheumatoid arthritis

    John Bui1, Jason Dubovsky2, Jennifer Abrams3, Sara Charmsaz4, Michelle Blake1, Joshua Beilke4, Anne-Renee van der Vuurst de Vries1, Joseph Arron5, Jonathan Graf6 and Jeffrey Bluestone7, 1Sonoma Biotherapeutics, Seattle, WA, 2Sonoma Biotherapeutics, South San Francisco, 3Sonomabio, San Francisco, CA, 4Sonoma Biotherapeutics, Seattle, 5Sonoma Biotherapeutics, San Francisco, CA, 6UCSF, San Francisco, CA, 7Sonoma Biotherapeutics, South San Francisco, CA

    Background/Purpose: Emerging cell-based therapies for rheumatoid arthritis (RA) target the underlying immunologic activity of disease. Objective biomarkers to-date are downstream sequelae of RA immunologic drivers.…
  • Abstract Number: 1000 • ACR Convergence 2025

    A Deep-Learning Based Approach Uncovers Novel Mediators of Micro-RNA Restraint of Type-2 Immunity

    Shaan Sekhon1, Robin Kageyama2, Neil Sprenkle3, Hannah Happ2, Eric Wigton2, Heather Pua3 and Mark Ansel2, 1University of California, San Francisco, Berkeley, 2University of California, San Francisco, San Francisco, 3Vanderbilt University, Nashville

    Background/Purpose: MicroRNAs, such as miR-24 and miR-27, co-expressed within the Mirc11 and Mirc22 clusters, orchestrate a regulatory network critical to Th2 cell differentiation and cytokine…
  • Abstract Number: 0948 • ACR Convergence 2025

    Presentation of Apoptotic Cell-Derived Autoantigens in Systemic Autoimmune Disease

    Lance Peterson1, Hannah KL De Cleene2, Cheryl Lichti2, David Bending3 and Kodi Ravichandran2, 1Rheumatology and Immunology, Pediatrics, Washington University School of Medicine, St. Louis, MO, 2Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 3Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, England, United Kingdom

    Background/Purpose: Systemic lupus erythematosus is a chronic, multisystem autoimmune disease characterized by the dysregulated clearance of dying cells, which results in the release of damage-associated…
  • Abstract Number: 0101 • ACR Convergence 2025

    Enrichment of putative bacteria-reactive gut-derived IL-17+ tissue resident memory helper T cells in arthritic ankles in the SKG mouse model of spondyloarthritis

    Benjamin Cai1, Megan Soon2, Zewen Kelvin Tuong2, Mark Morrison2, Anne-Sophie Bergot3 and Ranjeny Thomas4, 1Frazer Institute, The University of Queensland, Brisbane, Queensland, Australia, 2Frazer Institute, The University of Queensland, Brisbane, Australia, 3Frazer Institute, The University of Queensland, Woolloongabba, Queensland, Australia, 4Frazer Institute, University of Queensland, Brisbane, Queensland, Australia

    Background/Purpose: In spondyloarthropathy (SpA), arthritis is often associated with gut inflammation. The strong genetic association with HLA-B27 implicates involvement of T cells, but how gut…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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