ACR Meeting Abstracts

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Abstracts tagged "T Cell"

  • Abstract Number: 0642 • ACR Convergence 2022

    SLAMF6-SAP Signaling Unit Is Increased in SLE T Follicular Helper Cells

    Yevgeniya Gartshteyn1, Leila Khalili2, Adam Mor3 and Anca Askanase2, 1Columbia University Medical Center, Glen Rock, NJ, 2Columbia University Medical Center, New York, NY, 3Columbia University, New York, NY

    Background/Purpose: SLE is a multiorgan disease in which immune cells lack self-tolerance resulting in autoimmunity. SLE T cells infiltrate organs, provide help to autoreactive B…
  • Abstract Number: 1570 • ACR Convergence 2022

    Memory CD4+T Cell Signature Is Associated with Unfavorable Prognosis in IgG4-related Disease: Risk Stratification by Machine-learning

    Yuxue Nie1, zheng liu1, Wei Cao2, Taisheng Li2 and Wen Zhang3, 1Department of Rheumatology, Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, 2Department of Infectious Diseases, Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, 3Peking Union Medical College Hospital, Beijing, China

    Background/Purpose: IgG4-related disease (IgG4-RD) is a chronic immune-mediated disease with significant heterogeneity. A better understanding of the variance in the immune signature of IgG4-RD will…
  • Abstract Number: 1740 • ACR Convergence 2022

    Chronic Inflammation in Patients with Rheumatoid Arthritis or Spondyloarthritis Alters Regulatory T Cells Identity

    Tessnime Abaab1, Lyna Mebrek1, Marie-Christophe Boissier2, Luca Semerano3, Jerome Biton1 and Natacha Bessis1, 1INSERM UMR 1125, Sorbonne Paris Nord University, Bobigny, France, 2INSERM UMR 1125, Sorbonne Paris Nord University,Rheumatology Dpt, APHP, GHUPSSD, Avicenne Hosp, Bobigny, France, 3Hopital Avicenne - AP-HP, Sorbonne Paris Nord University, INSERM UMR1125, Bobigny Cedex, France

    Background/Purpose: Rheumatoid arthritis (RA) and spondyloarthritis (SpA) are inflammatory autoimmune diseases associated with impaired regulatory T cell (Tregs) function. Tregs identity varies according to their…
  • Abstract Number: 2186 • ACR Convergence 2022

    Cellular and Humoral Responses Following SARS-CoV-2 mRNA Vaccination in Patients on PD-1 Immunotherapy with irAEs

    Sokratis Apostolidis1, Paulina Coutifaris2, Mark Painter3, Ajinkya Pattekar2, Rishi Goel1, divij mathew2, Wenzhao Meng2, Kevin Wang2, Bria Fulmer2, Angela Corrigan2, Kendall Lundgreen2, Elizabeth Drapeau2, Derek Oldridge2, Josephine Giles2, Amy Baxter2, Sasikanth Manne2, Michelle Mckeague2, Ahron Flowers2, Oliva Kuthuru2, Sherea Long2, Jeanette Dougherty2, Sigrid Gouma2, Justine Williams2, Maura McLaughlin2, Sharon Adamski2, Alba Grifoni4, Daniela Weiskopf4, Alessandro Sette4, Scott Hensley2, Paul Bates2, Eline Luning Prak1, Laura Vella2, Giorgos Karakousis2, Ravi Amaravadi2, Suzanne McGettigan2, Kristin Kreider2, Tara Mitchell2, Allison Greenplate2, Lynn Schuchter2, Alexander Huang2 and E. John Wherry1, 1University of Pennsylvania, Philadelphia, PA, 2UPenn, Philadelphia, 3UPenn, Philadelphia, PA, 4LJI, La Jolla

    Background/Purpose: Patients with cancer exhibit increased mortality from SARS-CoV-2 infection compared to the general population. SARS-CoV-2 mRNA vaccination in healthy individuals generates effective and long-lasting…
  • Abstract Number: 0646 • ACR Convergence 2022

    Modulation of Type I IFN Production and Regulatory T Cells by the PKGI/ROCK Signaling Pathway

    Ruth Fernandez Ruiz1, Ilona Nln2, Jacqueline Paredes2 and Timothy Niewold2, 1Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, 2Hospital for Special Surgery, New York, NY

    Background/Purpose: IFNα is a pathogenic factor in SLE. The PRKG1 rs7897633 variant has been previously identified as the top hit in European ancestry patients with…
  • Abstract Number: 1625 • ACR Convergence 2022

    Single Cell and Spatial Transcriptomics Identifies Pathogenic Drivers of Sjogren’s Disease in Humans

    Blake Warner1, Thomas Pranzatelli2, Paola Perez2, Daniel Martin2, Shyh-Ing Jang2, Kalie Dominick2, Eiko Yamada2, Kevin Byrd3, Quinn Easter4, A. Darise Farris5, Christopher Lessard5, Amanda Oliver6, Raquel Bartolome-Casado6, Zohreh Khavandgar1, Sarthak Gupta7, Sarah Teichmann6, Alan Baer8 and John Chiorini2, 1National Institutes of Health, Bethesda, MD, 2NIDCR, Bethesda, MD, 3American Dental Association, Scientific Research Institute, Gaithersburg, MD, 4American Dental Association, Gaithersburg, MD, 5Oklahoma Medical Research Foundation, Oklahoma City, OK, 6Wellcome Sanger Institute, Cambridgeshire, United Kingdom, 7National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 8Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Sjogren's Disease(SjD) is a systemic autoimmune disease characterized by exocrine dysfunction. The pathogenesis is incompletely understood, but involves gene-environment interactions leading to infiltration of…
  • Abstract Number: 1741 • ACR Convergence 2022

    Mutated Nod2 Controls T Cell Function and Promotes Uveitis in a Blau Syndrome Mouse Model

    Leah Huey1, Kylie Koney1, Emily Vance1, Chia-Feng Tsai2, Rosalie K. Chu2, Marina A. Gritsenko2, Ellen Lee1, Holly Rosenzweig1 and Ruth Napier1, 1Oregon Health & Science University and VA Portland Health Care System, Portland, OR, 2Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA

    Background/Purpose: Mutations in the microbial signaling molecule NOD2 cause granulomatous uveitis, arthritis, and dermatitis in Blau Syndrome. We previously showed a novel role for Nod2…
  • Abstract Number: 0044 • ACR Convergence 2022

    Follistatin-like Protein 1 Alters T Cell Receptor Signaling Dynamics in Vitro, While Expression in Vivo Correlates with Disease and Deficiency Increases Acute Inflammation in a Mouse Model of Kawasaki Disease

    Mateo Amezcua1, Janice Huang1, Miao Chen1, Renee Escalona2, Edward Dick2 and Mark Gorelik1, 1Columbia University, New York, NY, 2Texas Biomedical Research Institute, San Antonio, TX

    Background/Purpose: Kawasaki disease (KD) is an acute, febrile illness of childhood, associated with cardiac inflammation and vasculitis of coronary arteries and sometimes other medium sized…
  • Abstract Number: 0649 • ACR Convergence 2022

    Phosphofructokinase P Fine-Tunes T Regulatory Cell Metabolism, Function and Stability in Systemic Autoimmunity

    Marc Scherlinger1, Wenliang Pan2, Ryo Hisada1, Milena Vukelic3, Masataka Umeda1, Afroditi Boulougoura2, Maria Tsokos1 and George Tsokos2, 1BIDMC Harvard University, Boston, MA, 2Division of Rheumatology and Clinical Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 3Albert Einstein College of Medicine, New York, NY

    Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by a defective T regulatory (Treg) cell compartment which participate in immune dysregulation. Although the underlying mechanism are…
  • Abstract Number: 1677 • ACR Convergence 2022

    Chimeric Autoantigen-T Cell Receptor (CATCR)-T Cell Therapies to Selectively Target Autoreactive B Cells

    Brian J. Mog1, Elana R. Shaw1, Michael S. Hwang1, Alexander H. Pearlman1, Sarah R. DiNapoli1, Suman Paul1, Chetan Bettegowda1, Nickolas Papadopoulos1, Sandra B. Gabelli1, Michelle Petri2, Antony Rosen1, Shibin Zhou1, Kenneth W. Kinzler1, Bert Vogelstein1 and Maximilian F. Konig1, 1The Johns Hopkins University School of Medicine, Baltimore, MD, 2Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD

    Background/Purpose: Chimeric antigen receptor (CAR)-T cell therapies have revolutionized the treatment of cancer and can be curative. CD19-targeted CAR-T cells hold promise for the treatment…
  • Abstract Number: 1742 • ACR Convergence 2022

    Shared Epitope Allomorphs Directly Influence Antigen-specific T-cell Responses in RA

    Ravi Kumar1, Anatoly Dubnovitsky1, Christina Gerstner1, Niyaz Yoosuf2, Sara Turcinov1, Sanjay Boddul1, Fredrik Wermeling1, Lars Klareskog1, Leonid Padyukov1 and vivianne malmström1, 1Karolinska Institutet, Stockholm, Sweden, 2Bioinvent International AB, Lund, Sweden

    Background/Purpose: The products of rheumatoid arthritis (RA)-associated MHC class II risk alleles HLA-DRB1*04:01 and *04:04 (DR4) differ only by two amino acids in the peptide…
  • Abstract Number: 0053 • ACR Convergence 2022

    Natural Microbial Exposure Increases Susceptibility of C57BL/6 Mice to Collagen-induced Arthritis

    Sahar Lotfi-Emran1 and David Masopust2, 1University of Minnesota, Minneapolis, MN, 2University of Minnesota, Department of Microbiology and Immunology, Minneapolis, MN

    Background/Purpose: Mice exposed to natural microbes (NME) develop an appropriately mature immune system, one that resembles that of a non-neonatal human.1,2 Collagen induced arthritis is…
  • Abstract Number: 0651 • ACR Convergence 2022

    Inflammatory Dendritic Cell Drive Intra-renal T Cells to Double-negative T Cell in Lupus Nephritis

    Latha Prabha Ganesan, Shane Bruckner, Noushin Saljoughian, James Turman, Murugesan Rajaram, Brad Rovin, Wael Jarjour and Samir Parikh, The Ohio State University, Columbus, OH

    Background/Purpose: The pathogenesis of lupus nephritis (LN) is incompletely understood stalling progress and resulting in suboptimal patient outcomes. We previously identified a novel inflammatory dendritic…
  • Abstract Number: 1702 • ACR Convergence 2022

    Targeting CD6-CD318 Axis with UMCD6 (anti-CD6) Enhances in Vivo Killing of Cancer Cells Through Direct Activation of NK Cells

    Mikel Gurrea-Rubio1, Qi Wu1, Eliza Pei-Suen Tsou1, M. Asif Amin1, Phillip Campbell1, Peggy Randon1, Matthew Lind1, Sarah Ory1, Camila Amarista1, Sirapa Vichaikul2, Jeffrey Ruth1, Feng Ling3 and David Fox1, 1University of Michigan, Ann Arbor, MI, 2Michigan Medicine, Howell, MI, 3Cleveland Clinic, Cleveland, OH

    Background/Purpose: Immune checkpoint inhibitors represent a major advance in cancer treatment, but disease prognosis continues to be poor for most patients. Resistance of cancer cells…
  • Abstract Number: 1745 • ACR Convergence 2022

    Effects of Excess IL-18 in Mixed Inflammatory Environments

    Vinh Dang1, Jemy Varghese1, Emily Landy2, Lauren Van Der Kraak2, Leonardo Huang1, Anastasia Frank-Kamenetskii1 and Scott Canna1, 1Children's Hospital of Philadelphia, Philadelphia, PA, 2University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Interleukin 18 (IL-18) is an inflammasome-activated, IL-1 family cytokine that canonically induces interferongamma (IFNg). IL-18 activity is potently inhibited by a soluble, IFNg-inducible antagonist,…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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