Abstracts tagged "T Cell"

Abstract Number: 0921 • ACR Convergence 2023
SAPhigh T Peripheral Helper Cells Are a Novel Subset Associated with Lupus Nephritis
Yevgeniya Gartshteyn¹, Leila Khalili², Laura Geraldino-Pardilla², Adam Mor³ and Anca Askanase⁴, ¹Columbia University Medical Center, New York, NJ, ²Division of Rheumatology, Columbia University Irving Medical Center, New York, NY, ³Columbia University, New York, NY, ⁴Columbia University Medical Center, New York, NY
Background/Purpose: Better understanding of the abnormal immune responses in lupus nephritis (LN) is fundamental to identifying new therapies. We previously reported that the adaptor protein…
Abstract Number: 1732 • ACR Convergence 2023
Immunopathogenesis and Preclinical Trials in a Humanized Mouse Model of Rheumatoid Arthritis(RA)
Huiyi Wang¹, Kangkang Luo¹, Shuxin Xu¹, Jiayin Zhou¹, Santi Chen², Jun wang², Wenzhao Li², Jing Zhao¹ and Cunxiang Ju¹, ¹GemPharmatech CO., Ltd., Nanjing, China, ²GemPharmatech LLC, La Jolla, CA
Background/Purpose: The differences between human and mouse immune systems make it challenging to accurately reflect the immunopathogenesis of autoimmune diseases in patients. Therefore, translational research…
Abstract Number: 020 • 2023 Pediatric Rheumatology Symposium
Generation of Human Resident Memory T Cells in 3D Synovial Organoid Model
Margaret Chang¹, Maryrose Hahn¹, Brian Wauford¹, Rachel Blaustein², Kevin Wei² and Peter Nigrovic¹, ¹Boston Children's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, MA
Background/Purpose: Most rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) patients experience episodic arthritis flares and require life-long medications to control their disease. We observed…
Abstract Number: 129 • 2023 Pediatric Rheumatology Symposium
Interrogation of STAT3 Activation in Patients with Polyarticular Juvenile Arthritis (polyJIA)
Stephanie Wood¹, Justin Branch¹, Priscilla vasquez¹, Marietta De Guzman¹, Amanda Brown², A. Carmela Sagcal-Gironella³, Saimun Singla⁴, Andrea Ramirez⁵ and Tiphanie Vogel⁵, ¹Baylor College of Medicine, Texas Children's Hospital, Houston, TX, ²University of Arkansas for Medical Sciences, Little Rock, AR, ³Hackensack University Medical Center, Hackensack, NJ, ⁴Self, Houston, TX, ⁵Baylor College of Medicine, Houston, TX
Background/Purpose: A better understanding of the pathogenesis of polyJIA is necessary to guide more effective clinical care, such as the development of data-driven approaches to…
Abstract Number: L03 • ACR Convergence 2022
A Phase 2 Trial of Peresolimab for Adults with Rheumatoid Arthritis
Jay Tuttle¹, Edit Drescher², Jesus Abraham Simón-Campos³, Paul Emery⁴, Maria Greenwald⁵, Alan Kivitz⁶, Hyungmin Rha¹, Pia Yachi¹, Christina Kiley¹ and Ajay Nirula⁷, ¹Eli Lilly and Company, Indianapolis, IN, ²Csolnoky Ferenc Hospital, Veszprém, Hungary, ³Köhler & Milstein Research/Hospital Agustín O'Horán, Merida, Yucatan, Mexico, ⁴University of Leeds, Leeds, United Kingdom, ⁵Desert Medical Advances, Palm Desert, CA, ⁶Altoona Center for Clinical Research, Duncansville, PA, ⁷Eli Lilly, San Diego, CA
Background/Purpose: Peresolimab is a humanized immunoglobulin G1 monoclonal antibody that stimulates human programmed cell death protein 1 (PD-1). We hypothesized that peresolimab binding to PD-1,…
Abstract Number: 0628 • ACR Convergence 2022
A Positive-feedback Model for the Contribution of Virus-Specific T Cells to the Development of Rheumatoid Arthritis
Hendrik Nel¹, Pascale Wehr², Christopher Andoniou³, Iona Schuster³, Stephanie Gras⁴, Helen McGuire⁵, Helen Weedon⁶, Annabelle Small⁷, Katie Lowe⁷, Mariapia Degli-Esposti³, Mihir Wechalekar⁸ and Ranjeny Thomas⁹, ¹University of Queensland, Brisbane, Australia, Woolloongabba, Australia, ²University of Queensland Diamantina Institute, Brisbane, Australia, ³Infection and Immunity Program and Department of Microbiology, Biomedicine Discovery Institute, Monash, Australia, ⁴Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia, ⁵The University of Sydney, Charles Perkins Centre, Camperdown, Australia, ⁶Flinders University of South Australia, Bedford Park, Australia, ⁷Flinders University, Adelaide, Australia, ⁸Flinders Medical Centre, Bedford Park, Australia, ⁹University of Queensland, Brisbane, Australia
Background/Purpose: Rheumatoid Arthritis (RA) is associated with specific HLA-DR genotypes with an emphasis on the role of CD4+ effector-memory T cells (Tem) in disease pathogenesis.…
Abstract Number: 1478 • ACR Convergence 2022
Urine ALCAM Is a Strong Predictor of Lupus Nephritis
Dalena Chu¹, Noa Schwartz², Jeanette Ampudia¹, Joel Guthridge³, Judith James³, Jill Buyon⁴, Stephen Connelly¹, Maple Fung¹, Cherie Ng¹, AMP SLE/RA consortium⁵, Michelle Petri⁶, Chandra Mohan⁷ and Chaim Putterman⁸, ¹Equillium, Inc., La Jolla, CA, ²Albert Einstein College of Medicine/Montefiore Medical Center, New York, NY, ³Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴NYU Grossman School of Medicine, New York, NY, ⁵Accelerating Medicines Partnership, Los Angeles, CA, ⁶Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD, ⁷University of Houston, Houston, TX, ⁸Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: T cells play a critical role in the pathogenicity of SLE and lupus nephritis (LN). Hence, identifying T cell co-stimulatory pathways and mediators that…
Abstract Number: 1739 • ACR Convergence 2022
Single-Cell Characterization of the TCR Repertoire Across Tissue and Blood in Rheumatoid Arthritis
Garrett Dunlap¹, Aaron Wagner², Nida Meednu³, Anna Jonsson⁴, Fan Zhang⁵, Kevin Wei⁶, Paul Utz⁷, William Robinson⁷, Holden Maecker⁷, Judith James⁸, Joel Guthridge⁸, S. Louis Bridges, Jr.⁹, Laura Donlin⁹, Susan Goodman⁹, Edward DiCarlo⁹, Vivian Bykerk⁹, Christopher Ritchlin¹⁰, Darren Tabechian¹¹, James Lederer⁴, Ellen Gravallese¹², Mandy McGeachy¹³, Gary S. Firestein¹⁴, Peter Gregersen¹⁵, Diane Horowitz¹⁶, David Boyle¹⁷, Laura Geraldino-Pardilla¹⁸, Harris Perlman¹⁹, Arthur Mandelin²⁰, Joan Bathon¹⁸, Laura Hughes²¹, V. Michael Holers²², Kevin D Deane²³, Larry Moreland²², Andrew Filer²⁴, Costantino Pitzalis²⁵, Lindsy Forbess²⁶, Ami Ben-artzi²⁷, Karen Salomon-Escoto²⁸, Soumya Raychaudhuri⁴, Michael Brenner¹², Accelerating Medicines Partership (AMP) RA/SLE Network²⁹, Andrew McDavid², Jennifer Anolik³ and Deepak Rao⁴, ¹Harvard University, Boston, MA, ²University of Rochester, Rochester, NY, ³University of Rochester Medical center, Rochester, NY, ⁴Brigham and Women's Hospital, Boston, MA, ⁵University of Colorado, Aurora, CO, ⁶Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁷Stanford University School of Medicine, Palo Alto, CA, ⁸Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁹Hospital for Special Surgery, New York, NY, ¹⁰Allergy, Immunology and Rheumatology Division, University of Rochester Medical School, Canandaigua, NY, ¹¹URMC, Rochester, NY, ¹²Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ¹³University of Pittsburgh, Pittsburgh, PA, ¹⁴University of California, San Diego, San Diego, CA, ¹⁵The Feinstein Inst for Med Research, Larchmont, NY, ¹⁶Northwell Health, Jericho, NY, ¹⁷UCSD, La Jolla, CA, ¹⁸Columbia University, New York, NY, ¹⁹Northwestern University, Chicago, IL, ²⁰Northwestern University Feinberg School of Medicine, Chicago, IL, ²¹University of Alabama at Birmingham, Birmingham, AL, ²²University of Colorado, Denver, CO, ²³University of Colorado Denver Anschutz Medical Campus, Denver, CO, ²⁴University of Birmingham, Birmingham, United Kingdom, ²⁵Queen Mary University of London, London, United Kingdom, ²⁶Cedars-Sinai Medical Center, Los Angeles, CA, ²⁷Ami Ben-Artzi, MD Inc., Beverly Hills, CA, ²⁸University of Massachusetts Medical School, Worcester, MA, ²⁹National Institutes of Health, Washington, DC
Background/Purpose: In rheumatoid arthritis (RA), T cells represent a large proportion of the immune population present in inflamed joint synovium, and subsets of both CD4+…
Abstract Number: 2184 • ACR Convergence 2022
CaMK4 Controls the Humoral Response via the T Follicular Helper Compartment and Regulates Autoimmunity
Marc Scherlinger¹, Hao Li², Wenliang Pan², Maria Tsokos¹ and George Tsokos², ¹BIDMC Harvard University, Boston, MA, ²Division of Rheumatology and Clinical Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by a dysregulated T cell compartment and production of autoantibodies leading to organ damage. We previously identified that…
Abstract Number: 0642 • ACR Convergence 2022
SLAMF6-SAP Signaling Unit Is Increased in SLE T Follicular Helper Cells
Yevgeniya Gartshteyn¹, Leila Khalili², Adam Mor³ and Anca Askanase², ¹Columbia University Medical Center, Glen Rock, NJ, ²Columbia University Medical Center, New York, NY, ³Columbia University, New York, NY
Background/Purpose: SLE is a multiorgan disease in which immune cells lack self-tolerance resulting in autoimmunity. SLE T cells infiltrate organs, provide help to autoreactive B…
Abstract Number: 1570 • ACR Convergence 2022
Memory CD4+T Cell Signature Is Associated with Unfavorable Prognosis in IgG4-related Disease: Risk Stratification by Machine-learning
Yuxue Nie¹, zheng liu¹, Wei Cao², Taisheng Li² and Wen Zhang³, ¹Department of Rheumatology, Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, ²Department of Infectious Diseases, Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, ³Peking Union Medical College Hospital, Beijing, China
Background/Purpose: IgG4-related disease (IgG4-RD) is a chronic immune-mediated disease with significant heterogeneity. A better understanding of the variance in the immune signature of IgG4-RD will…
Abstract Number: 1740 • ACR Convergence 2022
Chronic Inflammation in Patients with Rheumatoid Arthritis or Spondyloarthritis Alters Regulatory T Cells Identity
Tessnime Abaab¹, Lyna Mebrek¹, Marie-Christophe Boissier², Luca Semerano³, Jerome Biton¹ and Natacha Bessis¹, ¹INSERM UMR 1125, Sorbonne Paris Nord University, Bobigny, France, ²INSERM UMR 1125, Sorbonne Paris Nord University,Rheumatology Dpt, APHP, GHUPSSD, Avicenne Hosp, Bobigny, France, ³Hopital Avicenne - AP-HP, Sorbonne Paris Nord University, INSERM UMR1125, Bobigny Cedex, France
Background/Purpose: Rheumatoid arthritis (RA) and spondyloarthritis (SpA) are inflammatory autoimmune diseases associated with impaired regulatory T cell (Tregs) function. Tregs identity varies according to their…
Abstract Number: 2186 • ACR Convergence 2022
Cellular and Humoral Responses Following SARS-CoV-2 mRNA Vaccination in Patients on PD-1 Immunotherapy with irAEs
Sokratis Apostolidis¹, Paulina Coutifaris², Mark Painter³, Ajinkya Pattekar², Rishi Goel¹, divij mathew², Wenzhao Meng², Kevin Wang², Bria Fulmer², Angela Corrigan², Kendall Lundgreen², Elizabeth Drapeau², Derek Oldridge², Josephine Giles², Amy Baxter², Sasikanth Manne², Michelle Mckeague², Ahron Flowers², Oliva Kuthuru², Sherea Long², Jeanette Dougherty², Sigrid Gouma², Justine Williams², Maura McLaughlin², Sharon Adamski², Alba Grifoni⁴, Daniela Weiskopf⁴, Alessandro Sette⁴, Scott Hensley², Paul Bates², Eline Luning Prak¹, Laura Vella², Giorgos Karakousis², Ravi Amaravadi², Suzanne McGettigan², Kristin Kreider², Tara Mitchell², Allison Greenplate², Lynn Schuchter², Alexander Huang² and E. John Wherry¹, ¹University of Pennsylvania, Philadelphia, PA, ²UPenn, Philadelphia, ³UPenn, Philadelphia, PA, ⁴LJI, La Jolla
Background/Purpose: Patients with cancer exhibit increased mortality from SARS-CoV-2 infection compared to the general population. SARS-CoV-2 mRNA vaccination in healthy individuals generates effective and long-lasting…
Abstract Number: 0646 • ACR Convergence 2022
Modulation of Type I IFN Production and Regulatory T Cells by the PKGI/ROCK Signaling Pathway
Ruth Fernandez Ruiz¹, Ilona Nln², Jacqueline Paredes² and Timothy Niewold², ¹Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ²Hospital for Special Surgery, New York, NY
Background/Purpose: IFNα is a pathogenic factor in SLE. The PRKG1 rs7897633 variant has been previously identified as the top hit in European ancestry patients with…
Abstract Number: 1625 • ACR Convergence 2022
Single Cell and Spatial Transcriptomics Identifies Pathogenic Drivers of Sjogren’s Disease in Humans
Blake Warner¹, Thomas Pranzatelli², Paola Perez², Daniel Martin², Shyh-Ing Jang², Kalie Dominick², Eiko Yamada², Kevin Byrd³, Quinn Easter⁴, A. Darise Farris⁵, Christopher Lessard⁵, Amanda Oliver⁶, Raquel Bartolome-Casado⁶, Zohreh Khavandgar¹, Sarthak Gupta⁷, Sarah Teichmann⁶, Alan Baer⁸ and John Chiorini², ¹National Institutes of Health, Bethesda, MD, ²NIDCR, Bethesda, MD, ³American Dental Association, Scientific Research Institute, Gaithersburg, MD, ⁴American Dental Association, Gaithersburg, MD, ⁵Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Wellcome Sanger Institute, Cambridgeshire, United Kingdom, ⁷National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, ⁸Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Sjogren's Disease(SjD) is a systemic autoimmune disease characterized by exocrine dysfunction. The pathogenesis is incompletely understood, but involves gene-environment interactions leading to infiltration of…

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