ACR Meeting Abstracts

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Abstracts tagged "T Cell"

  • Abstract Number: L03 • ACR Convergence 2024

    CD9 Expressing T Follicular Helper Cells Are a Highly Functional Subset Expanded in Systemic Lupus Erythematosus

    Kyleigh Brimmer1, Olivia Antao1, Daniel Mayer1, Gina Sanchez1, Rebecca Francis1, Htay Htay Kyi2, Mary Salim2, Boyan Xia2, Eugenio Capitle2 and Jason Weinstein1, 1Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ, 2Division of Allergy, Immunology and Rheumatology, University Hospital, Newark, NJ

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is characterized by the generation of autoantibodies that promote tissue injury. The development of pathogenic autoantibody-secreting B cells in lupus…
  • Abstract Number: L16 • ACR Convergence 2024

    Dapirolizumab Pegol Demonstrated Significant Improvement in Systemic Lupus Erythematosus Disease Activity: Efficacy and Safety Results of a Phase 3 Trial

    Megan Clowse1, David Isenberg2, Joan Merrill3, Thomas Dörner4, Michelle Petri5, Edward Vital6, Eric Morand7, Teri Jimenez8, Stephen Brookes9, Janine Gaiha-Rohrbach10, Christophe Martin11, Annette Nelde12 and Christian Stach13, 1Division of Rheumatology and Immunology, Duke University, Durham, NC, 2Department of Ageing, Rheumatology and Regenerative Medicine, Division of Medicine, University College London, London, United Kingdom, 3Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Department of Medicine/Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany, 5Johns Hopkins University School of Medicine, Baltimore, MD, 6Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 7Centre for Inflammatory Diseases, Monash University, Melbourne, Australia, 8UCB, Raleigh, NC, 9Biogen, Maidenhead, United Kingdom, 10Biogen, Cambridge, MA, 11UCB, Slough, United Kingdom, 12Biogen, Baar, Switzerland, 13UCB, Monheim am Rhein, Germany

    Background/Purpose: Dapirolizumab pegol (DZP) is a novel, polyethylene glycol (PEG)-conjugated antigen-binding (Fab') fragment, lacking an Fc domain, that inhibits CD40L signaling. By binding to CD40L,…
  • Abstract Number: 0080 • ACR Convergence 2024

    Enhanced Cytotoxicity of Aging Associated NKG2C+ CD8+ T Cells in Ankylosing Spondylitis via HLA-B27

    Kunhai Tang, Xiaobei Ma, Jian Gao, Feng Qian, Qi Zhu, Jiucun Wang and Jing Liu, Fudan University, Shanghai, China (People's Republic)

    Background/Purpose: Ankylosing spondylitis (AS) is an immune-related chronic inflammatory disease characterized by inflammatory pain in the lower back and spinal ankylosing, accompanied by immune system disorders, such…
  • Abstract Number: 0876 • ACR Convergence 2024

    C-CAR168 as a Novel Anti-CD20/BCMA Bispecific Autologous CAR-T Therapy for the Treatment of Autoimmune Diseases

    jiaqi Huang1, Xin Yao1, Xiaobing Luo1, Xiaoteng Lv2, Yutian Wei2, Michael Patrick1, Fei Wang2, Yi Hong2 and Yihong Yao1, 1AbelZeta Inc., Rockville, MD, 2AbelZeta Inc., Shanghai, China (People's Republic)

    Background/Purpose: B cells are pivotal in autoimmune disease pathogenesis as they produce autoantibodies and undergo aberrant maturation processes, and B-cell dysregulation and the production of…
  • Abstract Number: 1707 • ACR Convergence 2024

    TRBV9-Targeted Bispecific T Cell-Engaging Antibodies to Reset the Autoreactive T Cell Compartment in Spondyloarthritis and HLA-DQ8 Celiac Disease

    Stephanie Glavaris, Alexander Pearlman, Jin Liu, Jiaxin Ge, Yuanxuan Xia, Kyle J. Kaeo, Tolulope Awosika, Colin Gliech, Tushar Nichakawade, Nikita Marcou, Chetan Bettegowda, Drew Pardoll, Kenneth W. Kinzler, Shibin Zhou, Bert Vogelstein, Suman Paul and Maximilian F. Konig, The Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Therapies that indiscriminately deplete all T cells carry a high risk of opportunistic infection, precluding their widespread use in T cell-mediated autoimmune diseases. Targeting…
  • Abstract Number: 1841 • ACR Convergence 2024

    Preclinical Evaluation of ALLO-329: Allogeneic CD19 CAR T Cells Expressing an Anti-Rejection CD70 CAR for the Treatment of Autoimmune Diseases

    Kristen Zhang, Joanne Li, Duy Nguyen, Nguyen Tan, Hsin-Yuan Cheng, David Huang, Suhasni Gopalakrishnan, Zachary Roberts, Cesar Sommer and Elvin Lauron, Allogene Therapeutics, South San Francisco, CA

    Background/Purpose: Autologous CD19 chimeric antigen receptor (CAR) T cell therapies have recently shown to be well tolerated and highly effective in patients with autoimmune diseases…
  • Abstract Number: 1859 • ACR Convergence 2024

    Clonal Relationships Between Tph and Tfh Cells in Patients with SLE and in Murine Lupus

    Takanori Sasaki1, John Sowerby2, Yinan Xiao2, Runci Wang2, Pui Lee3, Yujie Qu4, Marc Sze4, Stephen Alves4, Marc Levesque4, Karen Costenbader5 and Deepak Rao6, 1Brigham and Women's Hospital and Harvard Medical School, Brookline, MA, 2Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 3Boston Children's Hospital, Newton, MA, 4Merck & Co., Inc., Boston, MA, 5Brigham and Women's Hospital/ Harvard Medical School, Boston, MA, 6Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: T helper cells, including T peripheral helper (Tph) cells and T follicular helper (Tfh) cells, play pivotal roles in promoting B cell activation and…
  • Abstract Number: 2430 • ACR Convergence 2024

    Dapirolizumab Pegol Impacts Important Immunologic Pathways in Systemic Lupus Erythematosus: Pharmacodynamic Analysis of T Cell and Antigen Presenting Cell Pathways from a Phase 2b Trial

    Alex S. Powlesland1, Ioana Cutcutache1, Andrew Skelton1, Anthony Shock1, Matthew Page1, Eris Bame2, Janine Gaiha-Rohrbach2, George Stojan3, Ania Skowera1, Christian Stach4 and Thomas Dörner5, 1UCB Pharma, Slough, United Kingdom, 2Biogen Inc., Cambridge, MA, 3UCB Pharma, Atlanta, GA, 4UCB Pharma, Monheim am Rheim, Germany, 5Department of Medicine, Rheumatology and Clinical Immunology,Charite Universitätsmedizin Berlin, Germany and DRFZ, Berlin, Berlin, Germany

    Background/Purpose: CD40-CD40L interactions play a pivotal role in systemic lupus erythematosus (SLE) pathogenesis by orchestrating a range of immune and inflammatory responses involving B cells,…
  • Abstract Number: 0087 • ACR Convergence 2024

    SYNCAR: An Engineered IL-2/IL-2R-system That Selectively Enhances CD19 CAR T Cells to Deplete B Cells and Provide Therapeutic Benefit in SLE and RA Mouse Models Without Lymphodepletion

    Ethan Jung1, Marie semana1, Ivan Cheng1, Helena Silva1, Sandro Vivona1, Somya Singh1, Michele Bauer1, Mohammed Ali1, Henry Rosas1, Woei Chang1, Deepti Rokkam1, Patrick Lupardus1, Martin Oft1 and Paul-Joseph Aspuria2, 1Synthekine, Menlo Park, 2Sythekine, Menlo Park, CA

    Background/Purpose: CD19 CAR-T therapy has demonstrated efficacy in autoimmune (AI) diseases like systemic lupus erythematosus (SLE) and lupus nephritis (LN), showing its potential beyond oncology.…
  • Abstract Number: 0885 • ACR Convergence 2024

    Reproducible Single Cell Annotation of Programs Underlying T-cell Subsets, Activation States, and Functions

    Dylan Kotliar1, Michelle Curtis1, Ryan Agnew1, Kathryn Weinand1, Aparna Nathan2, Yuriy Baglaenko1, Yu Zhao1, Pardis Sabeti3, Deepak Rao4 and Soumya Raychaudhuri1, 1Brigham and Women's Hospital, Boston, MA, 2Harvard Medical School, Boston, MA, 3Broad Institute, Boston, MA, 4Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: T-cells play a key role in the pathogenesis of autoimmune disease and in protection against cancer and infection. Consequently, there is widespread interest in…
  • Abstract Number: 1751 • ACR Convergence 2024

    Precision Targeting of Autoreactive 9G4 B Cells in Systemic Lupus Erythematosus Using Engineered Chimeric Antigen Receptor (CAR)- and Chimeric T Cell Receptor (cTCR)-T Cells

    Jin Liu1, Brian Mog1, Yuanxuan Xia1, Elana Shaw1, Alexander Pearlman1, Dylan Ferris1, Kyle J. Kaeo1, Colin Gliech1, Tolulope Awosika1, Brock Moritz1, Tushar Nichakawade1, Yang Li1, Stephanie Glavaris1, Sarah DiNapoli1, Nikita Marcou1, Taha Ahmedna1, Victoria Duarte Alvarado1, Denis Wirtz1, Regina Bugrovsky2, Scott A. Jenks2, Iñaki Sanz3, Daniel Goldman4, Michelle Petri4, Chetan Bettegowda1, Suman Paul1, Kenneth W. Kinzler1, Shibin Zhou1, Felipe Andrade5, Bert Vogelstein1 and Maximilian F. Konig1, 1The Johns Hopkins University School of Medicine, Baltimore, MD, 2Emory University School of Medicine, Atlanta, GA, 3Emory University School of Medicine, Atlanta, 4Johns Hopkins University School of Medicine, Timonium, MD, 5The Johns Hopkins University School of Medicine, Timonium, MD

    Background/Purpose: The autoreactive B cell compartment in systemic lupus erythematosus (SLE) is characterized by expansion of B cells expressing immunoglobulin heavy variable gene 4-34 (IGHV4-34)…
  • Abstract Number: 1842 • ACR Convergence 2024

    Development of Next Generation CAR T Cell Therapy for the Off-the-shelf Treatment of Autoimmune Diseases Without Conditioning Chemotherapy

    John Goulding1, John Reiser2, Alison O'Connor1, Bryan Hancock1, Jonatan Tuncel1, Brian Groff1, Rina Mbofung1, Daniel Morales-Mantilla1, Allan Williams1, Dan Lu1, Bi-Huei Yang1, Eigen Peralta1, Alma Gutierrez1, Miguel Meza1, Betsy Rezner1, Amanda Sims1, Alec Witty1, Yijia Pan1, Mark Jelcic1, Shohreh Sikaroodi1, Matthew Denholtz1, Tom Lee1, Anil Bagri1, Lilly Wong1, Jode Goodridge1 and Bahram Valamehr1, 1Fate Therapeutics Inc., San Diego, CA, 2Fate Therapeutics Inc, San Diego, CA

    Background/Purpose: Developed initially as a novel strategy to treat B cell malignancies, chimeric antigen receptor (CAR) T cells have now been used to treat multiple…
  • Abstract Number: 1860 • ACR Convergence 2024

    Targeting Th1 Effector Cytokines, TNF-α and IFN-γ, Attenuates Experimental Autoimmune Myeloperoxidase ANCA Associated Vasculitis

    Kei Nagai1, Daniel Koo Yuk Cheong2, Anh Cao-Le2, Joshua Ooi3 and Poh Yi Gan2, 1Department of Nephrology, University of Tsukuba, Tsukuba, Ibaraki, Japan, 2Department of Medicine, Monash University, Melbourne, Victoria, Australia, 3Monash University-T Cell Therapies Research Group, Clayton, Victoria, Australia

    Background/Purpose: Anti-cytokine monoclonal antibody (mAb) therapies have shown efficacy in numerous autoimmune diseases but have yet to succeed in myeloperoxidase anti-neutrophil cytoplasmic antibody associated vasculitis…
  • Abstract Number: 2530 • ACR Convergence 2024

    Single-cell Multi-omics Analysis of Reactive Lymph Nodes, Affected Tissues, and Blood Reveals a Naive-like CD4+TRAIL+ T Cell Population That Differentially Directs Effector Anti-nuclear Antigen Reactive Responses in Patients with Sjogren’s Syndrome and Systemic Sclerosis

    Theodoros Ioannis Papadimitriou1, Prashant Singh2, Arjan van Caam3, Madelon Vonk4, Irene E. van der Horst-Bruinsma5, Peter van der kraan3, Erik Aarntzen6, Martijn Huijnen7, Hans Koenen8 and Rogier Thurlings1, 1Radboudumc, Department of Rheumatology, Nijmegen, Gelderland, Netherlands, 2Radboudumc, Department of Medical BioSciences, Nijmegen, Netherlands, 3Radboudumc, Department of Rheumatology, Nijmegen, Netherlands, 4Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 5Department of Rheumatology, Radboud University Medical Centre, Nijmegen, Netherlands, 6Radboudumc, Department of Medical Imaging, Nijmegen, Netherlands, 7Radboudumc, Department of Medical BioSciences, Nijmegen, Gelderland, Netherlands, 8Radboudumc, Department of Medical Immunology, Nijmegen, Gelderland, Netherlands

    Background/Purpose: Recognition of self-peptides by autoreactive CD4+ T-cells is central to the disruption of immune tolerance. Although systemic autoimmune diseases such as Sjogren’s syndrome (SjS)…
  • Abstract Number: 0093 • ACR Convergence 2024

    Overexpression of Epidermal Ifnk Promotes Systemic CD8+ T Cell Maturation After UV-exposure

    Benjamin Klein1, Kelsey E. McNeely2, Debbie Colesa2, Yiqing Gao2, Nguyen Thi Kim Nguyen2, Johann Gudjonsson1 and J. Michelle Kahlenberg1, 1University of Michigan, Ann Arbor, MI, 2University of Michigan Michigan Medicine, Ann Arbor, MI

    Background/Purpose: Skin involvement is the most common organ manifestation in systemic lupus erythematosus (SLE), and exacerbation of cutaneous lupus (CLE) can precede systemic disease flares.…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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