Abstracts tagged "systemic vasculitides"

Abstract Number: 163 • 2020 Pediatric Rheumatology Symposium
Anti-Dense Fine Speckled (DFS) Autoantibodies in Autoinflammatory Vasculopathies
Asa Laestadius¹, May Choi ¹, Marvin Fritzler ¹, Aurore Fifi-Mah ², Susanne Benseler ³ and Joao Dantas ¹, ¹University of Calgary, Calgary, Canada, ²Calgary, Canada, ³Univeristy of Calgary, Calagry, Canada
Background/Purpose: Autoantibodies to dense fine speckles 70 (DFS70) is now recognized to be more common among apparently healthy individuals compared to patients with ANA-related rheumatic…
Abstract Number: 013 • 2020 Pediatric Rheumatology Symposium
A Preliminary Data-driven Anatomic Classification for Childhood Takayasu Arteritis (cTA)
Ellen Go¹, Simon Eng ², David Cabral ³ and Rae Yeung ¹, ¹The Hospital for Sick Children, Toronto, Canada, ²Toronto, Canada, ³BC Children's Hospital and University of British Columbia, Vancouver, British Columbia, Canada
Background/Purpose: The pattern of arterial involvement and disease severity varies in those affected with cTA. Distinct imaging patterns that have some congruence with clinical phenotype…
Abstract Number: 885 • 2019 ACR/ARP Annual Meeting
TLR9 Signaling in HCV-Associated Atypical Memory B Cells Triggers Th1 and Rheumatoid Factor Autoantibody Responses
Chloé COMARMOND¹, Valerie Lorin ², Cindy Marques ¹, Anna Maciejewski-Duval ¹, Nizar Joher ², Cyril Planchais ², Maxime Touzot ³, Thierry Hieu ², Valentin Quiniou ¹, Anne Desbois ⁴, Michelle Rosenzwajg ¹, David Klatzmann ¹, Patrice Cacoub ⁵, Hugo Mouquet ² and David Saadoun ⁵, ¹Assistance Publique des Hopitaux de Paris, PARIS, France, ²Institut Pasteur, PARIS, France, ³Institut Curie, Paris, France, ⁴GHPS, Paris, France, ⁵AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, F-75013, Paris, France, Paris, France
Background/Purpose: Hepatitis C virus (HCV) infection contributes to the development of autoimmune disorders such as cryoglobulinemia vasculitis (CV). However, it remains unclear why only some…
Abstract Number: 1665 • 2019 ACR/ARP Annual Meeting
Glucocorticoids in Incident ANCA-Associated Vasculitis (AAV) Patients – A Study of Routine Clinical Practice in the EU Demonstrates Prolonged Use and Temporal Relationship to Adverse Events and Infections
Dieter Goette¹ and Peter Rutherford ¹, ¹Vifor Pharma, Zurich, Zurich, Switzerland
Background/Purpose: AAV is a severe systemic vasculitis and rapid induction of remission is essential and high dose glucocorticoids (GC) are part of standard of care.…
Abstract Number: 1684 • 2019 ACR/ARP Annual Meeting
Remission and Low Disease Activity State in Patients with Granulomatosis with Polyangiitis and Microscopic Polyangiitis: Prevalence and Impact on Damage Accrual
Paolo Delvino ¹, Federica Sardanelli ², Pascal Cohen ³, Xavier Puéchal for the French Vasculitis Study Group ³, Luc Mouthon ³, Loic Guillevin ³ and Benjamin Terrier³, ¹Rheumatology Department, IRCCS Policlinico S. Matteo Foundation, University of Pavia, Vercelli, Italy, ²Department of Internal Medicine , Clinical Immunology Unit of Genoa and Policlinico San Martino, Genova, Italy, ³National Referral Center for Rare Systemic Autoimmune Diseases Paris Cochin, Paris, France
Background/Purpose: Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) require glucocorticoids (GCs) and immunosuppressants (IS) to induce and maintain remission. At the era of highly…
Abstract Number: 1686 • 2019 ACR/ARP Annual Meeting
Risk of Vasculitis Associated with Inflammatory Bowel Diseases: Evidence for a Role of TNF-α Blockers
Benjamin Terrier¹, Laurent Beaugerie ², Philippe Seksik ², Harry Sokol ² and Julien Kirchgesner ², ¹National Referral Center for Rare Systemic Autoimmune Diseases Paris Cochin, Paris, France, ²Saint-Antoine Hospital, Paris, France
Background/Purpose: An increased risk of side effects, especially infections, has been reported among patients receiving tumor necrosis factor (TNF)-α blockers. Some leukocytoclastic cutaneous vasculitides reportedly occurred…
Abstract Number: 1737 • 2019 ACR/ARP Annual Meeting
Systemic Vascular Involvement in Kawasaki Disease: A Single Center Cohort
Monica Bray¹, Andrea Ramirez ¹, Eyal Muscal ¹ and Marietta De Guzman ², ¹Baylor College of Medicine, Houston, TX, ²Baylor College of Medicine/Texas Children's Hospital, Houston, TX
Background/Purpose: Kawasaki disease is classically thought to be a monophasic disease that primarily targets the coronary arteries. The American Heart Association Kawasaki guidelines note that…
Abstract Number: 2640 • 2019 ACR/ARP Annual Meeting
Performance of Berden’s Classification and ANCA Renal Risk Score for the Prediction of End-Stage Renal Disease in ANCA-associated Vasculitis
Onay Gercik¹, Emre Bilgin ², Dilek Solmaz ¹, Fulya Cakalagaoglu ³, Arzu Saglam ⁴, Ozge Aybi ⁵, Riza Kardas ⁵, Zeki Soypacaci ⁶, Gokhan Kabadayi ⁷, Tolga Yildirim ⁸, İdil Kurut Aysin ⁹, Omer Karadag ¹⁰ and Servet Akar ¹¹, ¹Izmir Katip Celebi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, İzmir, Turkey, ²Hacettepe University Vasculitis Centre, Ankara, Turkey, Ankara, Turkey, ³Izmir Katip Celebi University, Faculty of Medicine, Department of Pathology, Izmir, Turkey, ⁴Hacettepe University, Faculty of Medicine, Department of Pathology, Ankara, Turkey, ⁵Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Ankara, Turkey, ⁶Izmir Katip Celebi University Faculty of Medicine, Department of Internal Medicine, Division of Nephrology, Izmir, Turkey, ⁷Izmir Katip Celebi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, İzmir, Turkey, ⁸Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Nephrology, Ankara, Turkey, ⁹Izmir Katip Celebi University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, İzmir, Turkey, ¹⁰Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, ¹¹Izmir Katip Celebi University, Faculty of Medicine, Division of Rheumatology, İzmir, Turkey
Background/Purpose: Renal involvement in ANCA-associated vasculitides (AAVs) is an important factor for morbidity and mortality. Berden’s histopathologic classification for ANCA-associated glomerulonephritis has been proven to…
Abstract Number: 2786 • 2019 ACR/ARP Annual Meeting
Renal Histopathological Classifications Predict the Renal Outcomes of Plasma Exchange-Treated ANCA-Associated Vasculitides with Renal Failure
Dorian Nezam ¹, Pauline Morel ¹, Stanislas Faguer ², Alexandre Karras ³, Julien Aniort ⁴, Dimitri Titeca-Beauport ⁵, Justine Solignac ⁶, Didier Ducloux ⁷, Rafik Mesbah ⁸, Pierre-Louis Carron ⁹, Cédric Rafat ¹⁰, Pierre Gobert ¹¹, Vincent Audard ¹², Séverine Beaudreuil ¹³, François Maurier ¹⁴, Nihal Martis ¹⁵, Aurélien Tiple ⁴, Stéphane Bally ¹⁶, Aurélie Hummel ¹⁷, Claire de Moreuil ¹⁸, Tiphaine Goulenok ¹⁷, Dominique Nochy ¹⁹, Noémie Jourde-Chiche ²⁰, Alexis Régent ²¹, Loic Guillevin ²¹ and Benjamin Terrier²¹, ¹Cochin Hospital, Paris, France, ²CHU Toulouse, Toulouse, France, ³Paris HEGP, Paris, France, ⁴CHU, Clermont-Ferrand, France, ⁵CHU, Amiens, France, ⁶CHU, Marseille, France, ⁷CHU, Besancon, France, ⁸CH, Boulogne sur Mer, France, ⁹Grenoble, Grenoble, France, ¹⁰Tenon Hospital, Paris, France, ¹¹Clinique Rhone Durance, Avignon, France, ¹²Henri Mondor Hospital, Créteil, France, ¹³Bicetre Hospital, Le Kremlin Bicetre, France, ¹⁴Service de Médecine Interne, Hôpital Belle Isle, Metz, Metz, France, ¹⁵CHU, Nice, France, ¹⁶CH, Chambery, France, ¹⁷APHP, Paris, France, ¹⁸CHU Brest, Brest, France, ¹⁹HEGP Hospital, Paris, France, ²⁰APHM, Marseille, Marseille, France, ²¹National Referral Center for Rare Systemic Autoimmune Diseases Paris Cochin, Paris, France
Background/Purpose: ANCA-associated vasculitides (AAVs) are the most frequent cause of rapidly progressive glomerulonephritis (RPGN), for which the major prognostic issue is the risk of developing…

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