Abstracts tagged "Systemic sclerosis"

Abstract Number: 2292 • 2012 ACR/ARHP Annual Meeting
Increased Synthesis of Leukotrienes by Peripheral Blood Mononuclear Cells Is Associated with More Severe Disease and Worse Prognosis in Patients with Systemic Sclerosis
Otylia M. Kowal-Bielecka¹, Anna Lapinska², Marek Bielecki³, Oliver Distler⁴, Izabela Domyslawska¹, Lech Chyczewski², Stanislaw Sierakowski⁵, Steffen Gay⁶ and Krzysztof Kowal⁷, ¹Department of Rheumatology and Internal Medicine, Medical University in Bialystok, Bialystok, Poland, ²Department of Medical Pathomorphology, Medical University in Bialystok, Bialystok, Poland, ³Department of Orthopedics and Traumatology, Medical University in Bialystok, Bialystok, Poland, ⁴Department of Rheumatology and Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁵Department of Rheumatology and Internal Diseases, Medical University in Bialystok, Bialystok, Poland, ⁶Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Switzerland, Zurich, Switzerland, ⁷Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
Background/Purpose: Eicosanoids are a group of arachidonic acid-derived lipid mediators which play a key role in the regulation of inflammatory response and connective tissue remodeling.…
Abstract Number: 2298 • 2012 ACR/ARHP Annual Meeting
The Arachidonate 5-Lipoxygenase Activating Protein (ALOX5AP) Polymorphism Is Associated with Risk of Scleroderma-Related Interstitial Lung Disease: A Multicenter Study From the EULAR Scleroderma Trial and Research Group
Otylia M. Kowal-Bielecka¹, Sylwia Chwiesko-Minarowska², Pawel Bernatowicz², Yannick Allanore³, Timothy RD Radstake⁴, Jasper Broen⁵, Marco Matucci-Cerinic⁶, Roger Hesselstrand⁷, Dorota Krasowska⁸, Gabriela Riemekasten⁹, Madelon C. Vonk¹⁰, Oksana Kowalczuk², Marek Bielecki¹¹, Robert Milewski¹², Lech Chyczewski¹³, Jacek Niklinski² and Krzysztof Kowal¹⁴, ¹Department of Rheumatology and Internal Medicine, Medical University in Bialystok, Bialystok, Poland, ²Department of Clinical Molecular Biology, Medical University of Bialystok, Bialystok, Poland, ³Rheumatology, Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ⁴Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁵Department of Rheumatology & Clinical Immunology, University Medical Center, Utrecht, Netherlands, ⁶Department of Biomedicine & Division of Rheumatology AOUC, University of Florence, Florence, Italy, ⁷Rheumatology, Lund University, Lund, Sweden, ⁸Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland, ⁹Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, ¹⁰Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ¹¹Department of Orthopedics and Traumatology, Medical University of Bialystok, Bialystok, Poland, ¹²Department of Statistics and Medical Informatics, Medical University of Bialystok, Bialystok, Poland, ¹³Department of Medical Pathomorphology, Medical University in Bialystok, Bialystok, Poland, ¹⁴Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
Background/Purpose: Systemic sclerosis (SSc, scleroderma) is an autoimmune disease characterized by chronic inflammation, vascular injury and profound fibrosis of the skin and internal organ. Leukotrienes…

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