Abstracts tagged "Systemic sclerosis"

Abstract Number: 1726 • 2018 ACR/ARHP Annual Meeting
Sexual Dysfunction in Systemic Sclerosis Female Patients
Barbora Hermankova^1,2, Maja Spiritovic^1,2, Hana Smucrova², Sabina Oreska^2,3, Hana Storkanova^2,3, Karel Pavelka^3,4, Jiri Vencovsky^2,5, Ladislav Šenolt^2,3, Radim Becvar^2,3 and Michal Tomcik^2,3, ¹Department of Physiotherapy, Faculty of Physical Education and Sports, Charles University, Prague, Czech Republic, Prague, Czech Republic, ²Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, ³Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ⁴Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ⁵Department Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Systemic sclerosis (SSc) is a chronic autoimmune disease leading to various physical and psychological impairments including sexual dysfunction. The aim of this study was…
Abstract Number: 1738 • 2018 ACR/ARHP Annual Meeting
Detect Outperforms Echocardiography Based Screening Guidelines for Early Detection of Systemic Sclerosis Associated Pulmonary Arterial Hypertension
Amber Young¹, Victor M. Moles^2,3, Vivek Nagaraja¹, Dharshan Vummidi⁴, Scott H. Visovatti³, Vallerie McLaughlin³ and Dinesh Khanna¹, ¹Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, ²Hospital Jose Maria Cullen, Santa Fe, Argentina, ³Division of Cardiology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ⁴Department of Radiology, University of Michigan, Ann Arbor, MI
Background/Purpose: Pulmonary arterial hypertension (PAH) is a leading cause of mortality in patients with systemic sclerosis (SSc). Active screening can detect SSc-PAH earlier and may…
Abstract Number: 1900 • 2018 ACR/ARHP Annual Meeting
FGFR3/ FGF9 Regulates the Activity of Profibrotic Cytokine and Growth Factor Pathways to Drive Fibroblast Activation and Tissue Fibrosis in Systemic Sclerosis
Debomita Chakraborty¹, Lena Summa², Thuong Trinh-Minh³, Chih-Wei Chen³, Alina Soare², Andreas Ramming⁴, Oliver Distler⁵, Georg Schett² and Jörg Distler³, ¹Department of Internal Medicine 3- Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ²Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ³Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ⁴Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ⁵Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Fibroblast growth factor receptor3 (FGFR3) is a member of the family of 4 different receptors (FGFR1-4) with more than 23 identified ligands FGF1-23. Each…
Abstract Number: 2688 • 2018 ACR/ARHP Annual Meeting
Increased Serum Uric Acid Levels Are Associated with a Higher Risk of Digital Ulcers in Patients with Systemic Sclerosis
Han-Na Lee¹, Seung-Geun Lee¹, Eunsung Kim¹, JungHee Koh¹, Yun-Kyung Kim², Ho-Jae Kim² and Geun-Tae Kim³, ¹Division of Rheumatology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea, Republic of (South), ³Kosin University College of Medicine, Busan, Korea, Republic of (South)
Background/Purpose: Endothelial cell dysfunction and/or injury are considered critical early events in the pathogenesis of vasculopathy in patients with systemic sclerosis (SSc). Hyperuricemia is known…
Abstract Number: 2695 • 2018 ACR/ARHP Annual Meeting
Progressive Skin Fibrosis, Internal Organ Involvement and All-Cause Mortality in an Early Diffuse Cutaneous Systemic Sclerosis United States Multicenter Registry
Kate Homer¹, Benjamin Brennan², Shervin Assassi³, Elana J. Bernstein⁴, Flavia V. Castelino⁵, Robyn T. Domsic⁶, Jessica K. Gordon⁷, Faye N. Hant⁸, Monique Hinchcliff⁹, Ami A. Shah¹⁰, Victoria Shanmugam¹¹, Virginia D. Steen¹², Veronica J. Berrocal¹³, Melanie Hemmrich¹⁴, Tracy M. Frech¹⁵ and Dinesh Khanna¹⁶, ¹Department of Internal Medicine, Rheumatology Division, Scleroderma Program, University of Michigan, Ann Arbor, MI, ²School of Public Health, University of Michigan, Ann Arbor, MI, ³University of Texas McGovern Medical School, Houston, TX, ⁴Rheumatology, Columbia University, New York, NY, ⁵Rheumatology, Harvard Medical School, Boston, MA, ⁶Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁷Rheumatology, Hospital for Special Surgery, New York, NY, ⁸Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ⁹Rheumatology, Northwestern University, Chicago, IL, ¹⁰Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ¹¹Rheumatology, The George Washington University, Washington, DC, ¹²Rheumatology, MedStar Georgetown University Hospital, Washington, DC, ¹³Div of Rheumatology, University of Michigan, Ann Arbor, MI, ¹⁴Bayer AG, Wuppertal, Germany, ¹⁵Division of Rheumatology, University of Utah, Salt Lake City, UT, ¹⁶Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI
Background/Purpose: Early diffuse cutaneous systemic sclerosis (dcSSc) carries a high morbidity and mortality, predominantly due to internal organ involvement. The purpose of this study was…
Abstract Number: 2705 • 2018 ACR/ARHP Annual Meeting
Optimized Protocol for Extracorporeal Shock Wave Therapy on Digital Ulcers in Systemic Sclerosis
Tomonori Ishii¹, Yasushi Kawaguchi², Osamu Ishikawa³, Hiromitsu Takemori⁴, Naruhiko Takasawa⁵, Hitoshi Kobayashi⁶, Yuichi Takahashi⁷, Hidekata Yasuoka⁸, Takao Kodera⁹, Osamu Takai¹⁰, Izaya Nakaya¹¹, Tomomasa Izumiyama¹², Hiroshi Fujii¹³, Yukiko Kamogawa¹³, Yuko Shirota¹³, Tsuyoshi Shirai¹³, Yoko Fujita¹⁴, shinichiro saito¹⁵, Hiroaki Shimokawa¹⁶ and Hideo Harigae¹³, ¹Clinical Research, Innovation and Education Center, Tohoku University Hospital, Sendai, Japan, ²Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ³Department of Dermatology, Gunma University Graduate School of Medicine, gunma, Japan, ⁴Aomori Prefectural Central Hospital, Aomori, Japan, ⁵Department of Internal Medicine, Tohoku Medical and Pharmaceutical University Wakabayashi Hospital, Sendai, Japan, ⁶Iwate Medical University Hospital, Morioka, Japan, ⁷Ｙｕ　Ｆａｍｉｌｙ　Ｃlinic, Sendai, Japan, ⁸Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, tokyo, Japan, ⁹Division of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University, Sendai, Japan, ¹⁰Osaki Citizen Hospital, Sendai, Japan, ¹¹Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Morioka, Japan, ¹²Higashisendai Rheumatic Disease Clinic, Sendai, Japan, ¹³Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan, ¹⁴Department of Hematolgy and Rheumatolgy, Tohoku University Graduate School of Medicine, Sendai, Japan, ¹⁵IMS Meirikai Sendai General Hospital, Sendai, Japan, ¹⁶Department of Cardiovascular medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
Background/Purpose: Extracorporeal shock wave therapy (ESWT) at low energy has been shown to be effective for digital ulcers in systemic sclerosis (SSc) in our study…
Abstract Number: 2709 • 2018 ACR/ARHP Annual Meeting
Conversion of Normal Mean Pulmonary Arterial Pressure to Pulmonary Hypertension in Systemic Sclerosis – a Longitudinal Observational Study
Amber Young¹, Scott H. Visovatti², Tom Cascino², Nektarios Vasilottos³, Vallerie McLaughlin² and Dinesh Khanna¹, ¹Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, ²Division of Cardiology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ³Department of Internal Medicine, University of Michigan, Ann Arbor, MI
Background/Purpose: Pulmonary hypertension (PH) is one of the leading causes of mortality in patients with systemic sclerosis (SSc). Active screening detects PH earlier and may…
Abstract Number: 2938 • 2018 ACR/ARHP Annual Meeting
Evaluation of American College of Rheumatology Provisional Composite Response Index in Systemic Sclerosis (ACR CRISS) in a Phase 3 Randomized Controlled Trial
Dinesh Khanna¹, Celia J. F. Lin², Helen Spotswood³, Jeffrey Siegel², Angelika Jahreis², Christopher P. Denton⁴ and Daniel E. Furst⁵, ¹Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, ²Genentech, Inc., South San Francisco, CA, ³Roche Products Ltd., Welwyn Garden City, United Kingdom, ⁴University College London, London, United Kingdom, ⁵University of California Los Angeles, Los Angeles, CA
Background/Purpose: Treatment with the IL-6 receptor inhibitor tocilizumab (TCZ) in early progressive systemic sclerosis (SSc; focuSSced trial; NCT02453256) resulted in numeric improvements in skin sclerosis…
Abstract Number: 744 • 2017 ACR/ARHP Annual Meeting
Prediction of All-Cause Mortality and Pulmonary Arterial Hypertension (PAH) Progression in Systemic Sclerosis (SSc), an Echocardiography Study
Anders Heiervang Tennøe¹, Anna-Maria Hoffmann-Vold¹, Øyvind Molberg¹, Håvard Fretheim¹, Torhild Garen¹, Einar Gude¹, Arne K Andreassen¹, Klaus Murbræch², Svend Aakhus³, Johanna Andreassen² and Oyvind Midtvedt¹, ¹Oslo University Hospital, Oslo, Norway, ²Cardiology, Oslo University Hospital, Oslo, Norway, ³Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
Background/Purpose: Pulmonary arterial hypertension (PAH) is one of the leading causes of death in systemic sclerosis (SSc). Annual echocardiograms (echo) are recommended to detect PAH…
Abstract Number: 746 • 2017 ACR/ARHP Annual Meeting
Comparison of Disease Characteristics in Patients with Juvenile-Onset and Adult-Onset Progressive Systemic Sclerosis
Guzin Karatemiz¹, Amra Adrovic², Sinem Nihal Esatoglu¹, Sezgin Sahin², Kenan Barut², Gulen Hatemi¹, Vedat Hamuryudan¹, Ozgur Kasapcopur² and Emire Seyahi¹, ¹Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, ²Pediatric Rheumatology, Istanbul University, Cerrahpasa Medical School, Department of Pediatric Rheumatology, Istanbul, Turkey
Background/Purpose: Progressive systemic sclerosis (PSSc) has been known to affect mainly adults of 30-50 years of age. Juvenile –onset has been reported to be rare…
Abstract Number: 751 • 2017 ACR/ARHP Annual Meeting
Effect of Probiotics on the Gastrointestinal Symptoms and Immune Parameters in Patients with Systemic Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Thais Marighela¹, Maria Izabel Arismendi¹, Milena Brunialti² and Cristiane Kayser¹, ¹Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil, ²Division of Infectious Diseases, Universidade Federal de São Paulo, São Paulo, Brazil
Background/Purpose: Abnormalities in the intestinal microbiota have been associated with several autoimmune diseases, including systemic sclerosis (SSc). Recent studies have demonstrated the potential of probiotics…
Abstract Number: 982 • 2017 ACR/ARHP Annual Meeting
Epidemiology and Mortality in Systemic Sclerosis in South Korea: A Nationwide Population-Based Study
Kyong-Hee Jung¹, Seong-Ryul Kwon¹, Joo-Hyun Lee², Hyeong Sik Ahn³, Hyun Jung Kim³ and Gil Won Kang⁴, ¹Rheumatology, Inha University, Incheon, Korea, Republic of (South), ²Rheumatology, Inje University Ilsan Paik Hospital, Goyang, Korea, Republic of (South), ³Korea University, Seoul, Korea, Republic of (South), ⁴Chungbuk University, Cheongju, Korea, Republic of (South)
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by small vessel vasculopathy, autoantibody production, and excessive collagen deposition in the skin and…
Abstract Number: 1678 • 2017 ACR/ARHP Annual Meeting
Pathogenic Mechanisms of Esophageal Peristaltic Dysfunction By High Resolution Manometry in Patients with Systemic Sclerosis
Hyun-Sook Kim¹, Yunseok Kim², Jung Ran Choi³ and Joon Seong Lee², ¹Soonchenhyang university school of medicine, Seoul, Korea, Republic of (South), ²Internal medicine, Soonchunhyang university Seoul hospital, Seoul, Korea, Republic of (South), ³Department of Internal Medicine, Pohang St. Mary Hospital, Pohang, Korea, Republic of (South)
Background/Purpose: Pathogenic mechanisms of esophageal involvement in systemic sclerosis (SSc) were suggested as neural dysfunction due to impairment of microcirculation to intramural neuron in early…
Abstract Number: 1691 • 2017 ACR/ARHP Annual Meeting
Risk of Development of Definite Disease in Patients with Early Systemic Sclerosis
Cintia Zumstein Camargo, Maria Izabel Arismendi and Cristiane Kayser, Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil
Background/Purpose: The diagnosis of systemic sclerosis (SSc) in the early stages of the disease is frequently a challenge. In 2001, LeRoy and Medsger proposed criteria…
Abstract Number: 1704 • 2017 ACR/ARHP Annual Meeting
Non-Randomized Controlled Trial to Evaluate the Effect of Extracorporeal Shock Wave Therapy on Digital Ulcers in Systemic Sclerosis
Tomonori Ishii¹, Yasushi Kawaguchi², osamu ishikawa³, naruhiko takasaawa⁴, takao kodera⁵, hidekata yasuoka⁶, yuichi takahashi⁷, osamu takai⁸, Izaya Nakaya⁹, Hiroshi Fujii¹⁰, Yukiko Kamogawa¹⁰, Yuko Shirota¹⁰, Tsuyoshi Shirai¹⁰, Yoko Fujita¹¹, shinichiro saito¹², Hiroaki Shimokawa¹³ and Hideo Harigae¹⁰, ¹Clinical Research, Innovation and Education Center, Tohoku University Hospital, Sendai, Japan, ²Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ³Department of Dermatology, Gunma University Graduate School of Medicine, gunma, Japan, ⁴Department of Internal Medicine, Tohoku Medical and Pharmaceutical University Wakabayashi Hospital, Sendai, Japan, ⁵Division of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University, Sendai, Japan, ⁶Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, tokyo, Japan, ⁷Ｙｕ　Ｆａｍｉｌｙ　Ｃlinic, Sendai, Japan, ⁸Osaki Citizen Hospital, Sendai, Japan, ⁹Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Morioka, Japan, ¹⁰Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan, ¹¹Department of Hematolgy and Rheumatolgy, Tohoku University Graduate School of Medicine, Sendai, Japan, ¹²IMS Meirikai Sendai General Hospital, Sendai, Japan, ¹³Department of Cardiovascular medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
Background/Purpose: Patients with systemic sclerosis (SSc) often display Raynaud’s phenomenon, which causes digital skin ulcers. Since these ulcers are not associated with autoimmune factors, conventional…

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