Abstracts tagged "Systemic sclerosis"

Abstract Number: 827 • 2015 ACR/ARHP Annual Meeting
Reliability of the Quantitative Assessment of Peripheral Blood Perfusion By Laser Speckle Contrast Analysis in a Systemic Sclerosis Cohort
Valérie Lambrecht¹, Maurizio Cutolo², Filip De Keyser³, Saskia Decuman⁴, Barbara Ruaro², Alberto Sulli⁵, Ellen Deschepper⁶ and Vanessa Smith⁷, ¹Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ²Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, ³Rheumatology, Ghent University Hospital, Ghent, Belgium, ⁴Department of Rheumatology, UGent, Ghent, Belgium, ⁵Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, Genova, Italy, ⁶Biostatistics Unit, Biostatistics Unit, Ghent University, Ghent, Belgium, ⁷Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium
Background/Purpose: Laser speckle contrast analysis (LASCA) is an innovative technique to quantify peripheral blood perfusion (PBP) over a given area. Quantification of blood flow might…
Abstract Number: 1875 • 2015 ACR/ARHP Annual Meeting
Deep Vein Thrombosis and Pulmonary Embolism in Systemic Sclerois
Nabil Hakami^1,2 and Sindhu R. Johnson³, ¹Rheumatology, Toronto Scleroderma Program,Toronto Western Hospital, Mount Sinai Hospital,, Toronto, ON, Canada, ²King Fahad Central Hospital, Riyad, Saudi Arabia, ³Toronto Scleroderma Program, Toronto Western Hospital, Mount Sinai Hospital, University of Toronto, University Health Network Pulmonary Hypertension Programme, Toronto, ON, Canada
Background/Purpose: In systemic sclerosis (SSc) vasculopathy causes frequent episodes of reperfusion injury and free radical mediated endothelial dysfunction, which may influence the onset of local…
Abstract Number: 1876 • 2015 ACR/ARHP Annual Meeting
Caveolin 1 Gene Variants May Effect Disease Progression in Systemic Sclerosis Related Interstitial Lung Disease
Sule Yavuz¹, Elena Lopez-Isac², Ahmet Mesut Onat³, Neslihan Yilmaz⁴, Levent Kilic⁵, Ali Akdogan⁵ and Javier Martín⁶, ¹Rheumatology, Istanbul Bilim University, Faculty of Medicine,Department of Rheumatology, Istanbul, Turkey, ²Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, Granada, Spain, ³Rheumatology, Gaziantep University School of Medicine, Gaziantep, Turkey, ⁴Istanbul Bilim University, Faculty of Medicine, Rheumatology Department, Istanbul, Turkey, ⁵Hacettepe University Vasculitis Center (HUVAC), Ankara, Turkey, ⁶Instituto de Parasitología y Biomedicina López- Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain
Background/Purpose: To determine possible association of Cav-1 genetic variants: rs926198, rs959173 and rs9920 with SSc and/or SSc-related ILD progression. Methods: Three Cav-1 single nucleotide polymorphisms…
Abstract Number: 1878 • 2015 ACR/ARHP Annual Meeting
Diagnostic Performance of the 2013 ACR/EULAR Classification Criteria for Systemic Sclerosis: Results from a Brazilian Validation Cohort
Farley Carvalho¹, Cintia Camargo², Bruna Fernandez¹ and Cristiane Kayser², ¹Universidade Federal de São Paulo, São Paulo, Brazil, ²Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil
Background/Purpose: New classification criteria for systemic sclerosis (SSc) were proposed by the ACR/EULAR in 2013, due to the low sensitivity of the 1980 ACR classification…
Abstract Number: 1724 • 2014 ACR/ARHP Annual Meeting
Loss of IRF5 Ameliorates Tissue Fibrosis in a Murine Model of Systemic Sclerosis
Ryosuke Saigusa¹, Yoshihide Asano¹, Takashi Taniguchi¹, Yohei Ichimura¹, Takehiro Takahashi¹, Tetsuo Toyama¹, Ayumi Yoshizaki¹, Tadatsugu Taniguchi² and Shinichi Sato¹, ¹Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²Molecular Immunology, Institute of Industrial Science, University of Tokyo, Tokyo, Japan
Background/Purpose Systemic sclerosis (SSc) is a multisystem autoimmune disorder with clinical manifestations that result from fibrosis development, immune activation and vascular injuries. A genome-wide association…
Abstract Number: 1715 • 2014 ACR/ARHP Annual Meeting
Serum Levels of CD163/Tweak Predict Risk of Digital Ulcers in Patients with Systemic Sclerosis
Otylia M. Kowal-Bielecka¹, Marek Bielecki², Beata Trzcinska-Butkiewicz³, Malgorzata Michalska-Jakubus⁴, Marek Brzosko³, Dorota Krasowska⁴ and Krzysztof Kowal⁵, ¹Department of Rheumatology and Internal Medicine, Medical University in Bialystok, Bialystok, Poland, ²Department of Orthopedics and Traumatology, Medical University of Bialystok, Bialystok, Poland, ³Department of Rheumatology and Internal Diseases, Pomeranian Medical University, Szczecin, Poland, ⁴Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland, ⁵Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
Background/Purpose: TNF-like weak inducer of apoptosis (TWEAK) regulates inflammation, angiogenesis and tissue remodeling. CD163 molecule, a scavenger receptor and marker of alternatively activated macrophages, modulates…
Abstract Number: 766 • 2014 ACR/ARHP Annual Meeting
Endothelial Fli1 Deficiency Delays Wound Healing Due to Impaired Anastomosis of Newly Formed Vessels – a Possible Mechanism of Refractory Skin Ulcers in Systemic Sclerosis
Yoshihide Asano¹ and Maria Trojanowska², ¹Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²Arthritis Center, Boston University, Boston, MA
Background/Purpose Systemic sclerosis (SSc) is a multisystem inflammatory and vascular disease resulting in fibrosis of the skin and certain internal organs. Although the pathogenesis of…
Abstract Number: 740 • 2014 ACR/ARHP Annual Meeting
Right Ventricular Diastolic Impairment Is Common in Systemic Sclerosis and Is a Marker of Several Organ-Target Damage of the Disease
Christophe Meune¹, Dinesh Khanna², Jamil Aboulhosn³, Jerome Avouac⁴, Andre Kahan⁵, Daniel E. Furst⁶ and Yannick Allanore⁴, ¹Paris 13 University, University Hospital of Paris-Seine-Saint-Denis, Cardiology Department, Bobigny, France, ²University of Michigan Health System, Ann Arbor, MI, ³Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁴Paris Descartes University, Rheumatology A Department and INSERM U1016, Cochin Hospital, Paris, France, ⁵Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ⁶University of California, Los Angeles, Department of Medicine, Los Angeles, CA
Background/Purpose Heart failure and cardiac dysfunctions both of intrinsic or secondary origin and targeting LV (left ventricule) and/or RV (right ventricule) are critical complications promoting…
Abstract Number: 748 • 2014 ACR/ARHP Annual Meeting
Increased Expression of Chemerin in Endothelial Cells Due to Fli1 Deficiency May Contribute to the Development of Digital Ulcers in Systemic Sclerosis
Kaname Akamata, Yoshihide Asano, Takashi Taniguchi, Hayakazu Sumida, Naohiko Aozasa, Shinji Noda, Tetsuo Toyama, Takehiro Takahashi, Yohei Ichimura, Ayumi Yoshizaki and Shinichi Sato, Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disorder characterized by vascular injuries and fibrosis development. In SSc lesional skin, transcription factor Friend leukemia virus…
Abstract Number: 721 • 2014 ACR/ARHP Annual Meeting
Muscle Disease in Systemic Sclerosis Is Associated with an Increased Risk for Cardiac Involvement
Jison Hong¹, Antonia Valenzuela², David Fiorentino³ and Lorinda Chung⁴, ¹Medicine- Immunology & Rheumatology, Stanford University School of Medicine, Palo Alto, CA, ²Division of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, ³Dermatology, Stanford University, Redwood City, CA, ⁴Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA
Background/Purpose Patients with systemic sclerosis (SSc) and muscle involvement (myopathy/myositis) have more severe disease and worse outcomes. We sought to determine the prevalence of muscle…
Abstract Number: 739 • 2014 ACR/ARHP Annual Meeting
Lack of Association Between Esophageal Symptoms and Abnormal Findings in High-Resolution Manometry in a Mexican Mestizo Cohort with Systemic Sclerosis (SSc)
Ana Arana-Guajardo¹, Miguel Villarreal-Alarcón², Gustavo Torres-Barrera³, David Vega-Morales⁴, Hector Maldonado-Garza³ and Mario Garza-Elizondo², ¹Departamento de Medicina Interna del Hospital Universitario, Servicio de Reumatología, Departamento de Medicina Interna del Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, Mexico, ²Departamento de Medicina Interna del Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Servicio de Reumatología, Departamento de Medicina Interna del Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, Mexico, ³Departamento de Medicina Interna del Hospital Universitario, Servicio de Gastroenterología, Departamento de Medicina Interna del Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, Mexico, ⁴Rheumatology, Hospital Universitario UANL, Monterrey, Mexico
Background/Purpose . Esophageal involvement is present in 50-70% of SSc patients and it is the most common visceral organ complication. The impact of the esophageal…
Abstract Number: 733 • 2014 ACR/ARHP Annual Meeting
Impact of Geographic Variation on the Risk of Digital Ulcers Development in Systemic Sclerosis: A Brazilian Multicenter Registry
Eduardo José do Rosário e Souza¹, Carolina de Souza Muller², Andrea Tavares Dantas³, Henrique A. Mariz³, Alex Magno Coelho Horimoto⁴, Renato Alvarenga Rezende¹, Isabela Guimarães², Izaias Pereira da Costa⁴, Glauce Rejane Leonardi Bertazzi⁵, Luiza Paiola⁵, Eutília Andrade Medeiros Freire⁶, Roberta Ismael⁶, Ana Paula Toledo Del-Rio⁷, Juliana Sekiyama⁷, Carolina Barros Kahwage⁸ and Cristiane Kayser⁹, ¹Serviço de Reumatologia, Hospital Santa Casa, Minas Gerais, Belo Horizonte, Brazil, ²Universidade Federal do Paraná, Curitiba, Brazil, ³Disciplina de Reumatologia, Hospital das Clínicas - Universidade Federal de Pernambuco, Recife, Brazil, ⁴Universidade Federal do Mato Grosso do Sul, Campo Grande, Brazil, ⁵Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, Brazil, ⁶Universidade Federal da Paraíba, João Pessoa, Brazil, ⁷Universidade Estadual de Campinas, Campinas, Brazil, ⁸Universidade Federal de São Paulo, São Paulo, Brazil, ⁹Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil
Background/Purpose: Digital ulcers (DU) and Raynaud’s phenomenon (RP) are a frequent complication in patients with Systemic Sclerosis (SSc). The present study aimed to evaluate the…
Abstract Number: 2708 • 2014 ACR/ARHP Annual Meeting
Post-Occlusive Reactive Hyperemia (PORH) Test Mirrors Vascular Changes in Systemic Sclerosis (SSc):a Laser Speckle Contrast (LASCA) Study
Alessandra Della Rossa¹, Anna d'Ascanio², Massimo Cagnoni¹, Chiara Stagnaro³, Alice Parma⁴, Marta Mosca⁵ and Stefano Bombardieri⁶, ¹malattie muscoloscheletriche e cutanee, Rheumatology Unit, Pisa, Italy, ²Malattie muscolo-scheletriche e cutanee, Rheumatology Unit, Pisa, Italy, ³Malattie scheletriche e muscolocutanee, Rheumatology Unit, Pisa, Italy, ⁴University of Pisa, Rheumatology Unit, Pisa, Italy, ⁵Rheumatology Unit, University of Pisa, Pisa, Italy, ⁶Rheumatology Unit, Pisa, Italy
Background/Purpose Vascular involvement is a key feature of Systemic sclerosis (SSc) and involves both the micro and macrovasculature. Vascular changes are central in the disease’s…
Abstract Number: 2706 • 2014 ACR/ARHP Annual Meeting
Ulnar and Radial Stenosis in Systemic Sclerosis
María Eugenia Lara¹, Mariano Rivero¹, Julia Romero¹, Guadalupe Palacios², Ignacio Carrillo³, Claudia L. Giraldo⁴, Amalia Schiel⁵, Hugo Armando Laborde¹, Marina Khoury⁶, Saez Diego⁷, Gustavo Citera⁸, Oscar L. Rillo⁹ and Juan C. Barreira¹, ¹Rheumatology, British Hospital, Buenos Aires, Argentina, ²British Hospital, Buenos Aires, Argentina, ³Rheumatology section, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ⁴Rheumatology, Hospital Gral. de Agudos Dr. E. Tornú, Buenos Aires, Argentina, ⁵Central Laboratory, British Hospital, Buenos Aires, Argentina, ⁶Teaching and Research, British Hospital, Buenos Aires, Argentina, ⁷Imaging, British Hospital, Buenos Aires, Argentina, ⁸Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ⁹Rheumatology Unit, Hospital General de Agudos Dr. E. Tornú, Buenos Aires, Argentina
Background/Purpose: Systemic sclerosis (SSc) is a chronic, autoimmune disease. Endothelial damage has been recognized as the initial pathogenic factor. The involvement of the microvasculature is…
Abstract Number: 2594 • 2013 ACR/ARHP Annual Meeting
Stabilisation Of Microcirculation In Early Systemic Sclerosis Patients With Diffuse Skin Involvement Following Rituximab Treatment
Vanessa Smith¹, Carmen Pizzorni², Valeria Riccieri³, Saskia Decuman⁴, Yves P. Piette¹, Ellen Deschepper⁵, Filip De Keyser¹ and Maurizio Cutolo⁶, ¹Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ²Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, ³Department of Internal Medicine and Medical Specialities, University Sapienza, Rome, Italy, ⁴Department of Internal Medicine, Ghent University, Ghent, Belgium, ⁵Biostatistics Unit, Department of Public Health, Ghent University, Ghent, Belgium, ⁶University of Genova, Genova, Italy
Background/Purpose: Microangiopathy in systemic sclerosis is progressive over time [1, 2]. This study assesses microangiopathic evolution by nailfold videocapillarocopic (NVC) analysis after two treatment course…

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