Abstracts tagged "Systemic sclerosis"

Abstract Number: 2988 • 2015 ACR/ARHP Annual Meeting
Novel Use of Musculoskeletal Ultrasound (MSUS) to Measure Ulcers in the Skin of Systemic Sclerosis (SSc) Patients.
Yossra Suliman^1,2, Veena K. Ranganath², Suzanne Kafaja³ and Daniel E. Furst⁴, ¹Rheumatology and Rehabilitation department, Assiut university, Faculty of Medicine,, Assiut, Egypt, ²Medicine, Division of Rheumatology, David Geffen School of Medicine, Los Angeles, CA, ³Medicine/Rheumatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁴Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: 1) To describe the role of MSUS, using both grey scale (GS) and Power Doppler (PD), to detect skin ulcers in SSc patients. 2)…
Abstract Number: 3011 • 2015 ACR/ARHP Annual Meeting
The Homeoprotein Engrailed-1 Regulates Canonical TGF Beta Signaling in Experimental Systemic Sclerosis
Tatjana Mallano¹, Katrin Palumbo-Zerr¹, Christian Beyer^1,2, Clara Dees¹, Jingang Huang¹, Thomas Wohlfahrt¹, Oliver Distler³, Georg Schett¹ and Jeorg HW Distler^1,2, ¹Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ³Department of Rheumatology, Center of Experimental Rheumatology and Zurich Center of Integrative Human Physiology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Systemic sclerosis (SSc) is a chronic fibrotic connective disease of unknown etiology that affects the skin and internal organs. Transforming growth factor-β (TGFβ) has…
Abstract Number: 3130 • 2015 ACR/ARHP Annual Meeting
Epstein-Barr Virus Induces Activation of Infammatory Markers Via the TLR8 Transduction Pathway in Infected Scleroderma Monocytes
Antonella Farina¹, Giovanna Peruzzi^2,3, Valentina Lacconi⁴, Edoardo Rosato⁵, Silvia Quarta⁶, Stefania Morrone¹, Alberto Faggioni¹, Maria Trojanowska⁴ and Giuseppina Alessandra Farina⁴, ¹Department of Experimental Medicine, Sapienza University, Department of Experimental Medicine, Rome, Italy, ²Istituto Italiano di Tecnologia (IIT), CLNS@Sapienza, Rome, Italy, ³Istituto Italiano di Tecnologia (IIT), CLNS@Sapienza, Viale Regina Elena 291, 00161, Rome, Italy, Rome, Italy, ⁴Arthritis Center, Boston University, Arthritis Center, Boston, MA, ⁵Department of Clinical Medicine, Clinical Immunology Unit,, Sapienza University,Department of Clinical Medicine, Rome, Italy, ⁶Department of Clinical Medicine, Clinical Immunology Unit., Sapienza University,Department of Clinical Medicine, Rome, Italy
Background/Purpose: Monocytes from patients with systemic sclerosis (Scleroderma, SSc), are characterized by the increased expression of IFN-regulatory genes, implicating dysregulation of the innate immune response…
Abstract Number: 3135 • 2015 ACR/ARHP Annual Meeting
Incidences and Predictors of Organ Manifestations in the Early Course of Systemic Sclerosis: A Longitudinal Study
Veronika K. Jaeger¹, Elina G. Wirz^2,3, Yannick Allanore⁴, Gabriela Riemekasten⁵, Eric Hachulla⁶, Oliver Distler⁷, Paolo Airo⁸, Patricia E. Carreira⁹, Alexandra Balbir-Gurman¹⁰, Mohammed Tikly¹¹, Serena Vettori¹², Nemanja Damjanov¹³, Ulf Müller-Ladner¹⁴, Jorg HW. Distler¹⁵, Mangtao Li¹⁶, Ulrich A. Walker¹⁷ and EUSTAR collaborators, ¹Department of Rheumatology, University Hospital Basel, Basel, Switzerland, ²Department of Rheumatology, University Hospital Basel, Basel, Switzerland, Basel, Switzerland, ³Department of Dermatology, University Hospital Basel, Basel, Switzerland, ⁴Department of Rheumatology A, Paris Descartes University, Cochin Hospital, Paris, France, ⁵Clinic of Rheumatology, University of Luebeck, Lübeck, Germany, ⁶Service de Médecine Interne, Hôpital Huriez, Université de Lille, Lille, France, ⁷Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁸UO Reumatologia ed Immunologia Clinica, Spedali Civili, Brescia, Italy, ⁹Servicio de Reumatologia, Hospital Universitario 12 de Octubre, Madrid, Spain, ¹⁰B. Shine Rheumatology Unit, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion - Institute of Technology, Haifa, Israel, ¹¹Division of Rheumatology, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, ¹²Department of Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ¹³Institute of Rheumatology, University of Belgrade Medical School, Belgrade, Serbia, ¹⁴Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ¹⁵Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ¹⁶Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China, ¹⁷Rheumatology, University Hospital, Basel, Basel, Switzerland
Background/Purpose: Systemic sclerosis (SSc) is a rare and clinically heterogeneous autoimmune disorder characterised by fibrosis and microvascular obliteration of the skin and internal organs, particularly…
Abstract Number: 2708 • 2014 ACR/ARHP Annual Meeting
Post-Occlusive Reactive Hyperemia (PORH) Test Mirrors Vascular Changes in Systemic Sclerosis (SSc):a Laser Speckle Contrast (LASCA) Study
Alessandra Della Rossa¹, Anna d'Ascanio², Massimo Cagnoni¹, Chiara Stagnaro³, Alice Parma⁴, Marta Mosca⁵ and Stefano Bombardieri⁶, ¹malattie muscoloscheletriche e cutanee, Rheumatology Unit, Pisa, Italy, ²Malattie muscolo-scheletriche e cutanee, Rheumatology Unit, Pisa, Italy, ³Malattie scheletriche e muscolocutanee, Rheumatology Unit, Pisa, Italy, ⁴University of Pisa, Rheumatology Unit, Pisa, Italy, ⁵Rheumatology Unit, University of Pisa, Pisa, Italy, ⁶Rheumatology Unit, Pisa, Italy
Background/Purpose Vascular involvement is a key feature of Systemic sclerosis (SSc) and involves both the micro and macrovasculature. Vascular changes are central in the disease’s…
Abstract Number: 2706 • 2014 ACR/ARHP Annual Meeting
Ulnar and Radial Stenosis in Systemic Sclerosis
María Eugenia Lara¹, Mariano Rivero¹, Julia Romero¹, Guadalupe Palacios², Ignacio Carrillo³, Claudia L. Giraldo⁴, Amalia Schiel⁵, Hugo Armando Laborde¹, Marina Khoury⁶, Saez Diego⁷, Gustavo Citera⁸, Oscar L. Rillo⁹ and Juan C. Barreira¹, ¹Rheumatology, British Hospital, Buenos Aires, Argentina, ²British Hospital, Buenos Aires, Argentina, ³Rheumatology section, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ⁴Rheumatology, Hospital Gral. de Agudos Dr. E. Tornú, Buenos Aires, Argentina, ⁵Central Laboratory, British Hospital, Buenos Aires, Argentina, ⁶Teaching and Research, British Hospital, Buenos Aires, Argentina, ⁷Imaging, British Hospital, Buenos Aires, Argentina, ⁸Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ⁹Rheumatology Unit, Hospital General de Agudos Dr. E. Tornú, Buenos Aires, Argentina
Background/Purpose: Systemic sclerosis (SSc) is a chronic, autoimmune disease. Endothelial damage has been recognized as the initial pathogenic factor. The involvement of the microvasculature is…
Abstract Number: 1724 • 2014 ACR/ARHP Annual Meeting
Loss of IRF5 Ameliorates Tissue Fibrosis in a Murine Model of Systemic Sclerosis
Ryosuke Saigusa¹, Yoshihide Asano¹, Takashi Taniguchi¹, Yohei Ichimura¹, Takehiro Takahashi¹, Tetsuo Toyama¹, Ayumi Yoshizaki¹, Tadatsugu Taniguchi² and Shinichi Sato¹, ¹Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²Molecular Immunology, Institute of Industrial Science, University of Tokyo, Tokyo, Japan
Background/Purpose Systemic sclerosis (SSc) is a multisystem autoimmune disorder with clinical manifestations that result from fibrosis development, immune activation and vascular injuries. A genome-wide association…
Abstract Number: 1715 • 2014 ACR/ARHP Annual Meeting
Serum Levels of CD163/Tweak Predict Risk of Digital Ulcers in Patients with Systemic Sclerosis
Otylia M. Kowal-Bielecka¹, Marek Bielecki², Beata Trzcinska-Butkiewicz³, Malgorzata Michalska-Jakubus⁴, Marek Brzosko³, Dorota Krasowska⁴ and Krzysztof Kowal⁵, ¹Department of Rheumatology and Internal Medicine, Medical University in Bialystok, Bialystok, Poland, ²Department of Orthopedics and Traumatology, Medical University of Bialystok, Bialystok, Poland, ³Department of Rheumatology and Internal Diseases, Pomeranian Medical University, Szczecin, Poland, ⁴Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland, ⁵Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
Background/Purpose: TNF-like weak inducer of apoptosis (TWEAK) regulates inflammation, angiogenesis and tissue remodeling. CD163 molecule, a scavenger receptor and marker of alternatively activated macrophages, modulates…
Abstract Number: 766 • 2014 ACR/ARHP Annual Meeting
Endothelial Fli1 Deficiency Delays Wound Healing Due to Impaired Anastomosis of Newly Formed Vessels – a Possible Mechanism of Refractory Skin Ulcers in Systemic Sclerosis
Yoshihide Asano¹ and Maria Trojanowska², ¹Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²Arthritis Center, Boston University, Boston, MA
Background/Purpose Systemic sclerosis (SSc) is a multisystem inflammatory and vascular disease resulting in fibrosis of the skin and certain internal organs. Although the pathogenesis of…
Abstract Number: 740 • 2014 ACR/ARHP Annual Meeting
Right Ventricular Diastolic Impairment Is Common in Systemic Sclerosis and Is a Marker of Several Organ-Target Damage of the Disease
Christophe Meune¹, Dinesh Khanna², Jamil Aboulhosn³, Jerome Avouac⁴, Andre Kahan⁵, Daniel E. Furst⁶ and Yannick Allanore⁴, ¹Paris 13 University, University Hospital of Paris-Seine-Saint-Denis, Cardiology Department, Bobigny, France, ²University of Michigan Health System, Ann Arbor, MI, ³Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁴Paris Descartes University, Rheumatology A Department and INSERM U1016, Cochin Hospital, Paris, France, ⁵Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ⁶University of California, Los Angeles, Department of Medicine, Los Angeles, CA
Background/Purpose Heart failure and cardiac dysfunctions both of intrinsic or secondary origin and targeting LV (left ventricule) and/or RV (right ventricule) are critical complications promoting…
Abstract Number: 748 • 2014 ACR/ARHP Annual Meeting
Increased Expression of Chemerin in Endothelial Cells Due to Fli1 Deficiency May Contribute to the Development of Digital Ulcers in Systemic Sclerosis
Kaname Akamata, Yoshihide Asano, Takashi Taniguchi, Hayakazu Sumida, Naohiko Aozasa, Shinji Noda, Tetsuo Toyama, Takehiro Takahashi, Yohei Ichimura, Ayumi Yoshizaki and Shinichi Sato, Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disorder characterized by vascular injuries and fibrosis development. In SSc lesional skin, transcription factor Friend leukemia virus…
Abstract Number: 721 • 2014 ACR/ARHP Annual Meeting
Muscle Disease in Systemic Sclerosis Is Associated with an Increased Risk for Cardiac Involvement
Jison Hong¹, Antonia Valenzuela², David Fiorentino³ and Lorinda Chung⁴, ¹Medicine- Immunology & Rheumatology, Stanford University School of Medicine, Palo Alto, CA, ²Division of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, ³Dermatology, Stanford University, Redwood City, CA, ⁴Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA
Background/Purpose Patients with systemic sclerosis (SSc) and muscle involvement (myopathy/myositis) have more severe disease and worse outcomes. We sought to determine the prevalence of muscle…
Abstract Number: 739 • 2014 ACR/ARHP Annual Meeting
Lack of Association Between Esophageal Symptoms and Abnormal Findings in High-Resolution Manometry in a Mexican Mestizo Cohort with Systemic Sclerosis (SSc)
Ana Arana-Guajardo¹, Miguel Villarreal-Alarcón², Gustavo Torres-Barrera³, David Vega-Morales⁴, Hector Maldonado-Garza³ and Mario Garza-Elizondo², ¹Departamento de Medicina Interna del Hospital Universitario, Servicio de Reumatología, Departamento de Medicina Interna del Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, Mexico, ²Departamento de Medicina Interna del Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Servicio de Reumatología, Departamento de Medicina Interna del Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, Mexico, ³Departamento de Medicina Interna del Hospital Universitario, Servicio de Gastroenterología, Departamento de Medicina Interna del Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, Mexico, ⁴Rheumatology, Hospital Universitario UANL, Monterrey, Mexico
Background/Purpose . Esophageal involvement is present in 50-70% of SSc patients and it is the most common visceral organ complication. The impact of the esophageal…
Abstract Number: 733 • 2014 ACR/ARHP Annual Meeting
Impact of Geographic Variation on the Risk of Digital Ulcers Development in Systemic Sclerosis: A Brazilian Multicenter Registry
Eduardo José do Rosário e Souza¹, Carolina de Souza Muller², Andrea Tavares Dantas³, Henrique A. Mariz³, Alex Magno Coelho Horimoto⁴, Renato Alvarenga Rezende¹, Isabela Guimarães², Izaias Pereira da Costa⁴, Glauce Rejane Leonardi Bertazzi⁵, Luiza Paiola⁵, Eutília Andrade Medeiros Freire⁶, Roberta Ismael⁶, Ana Paula Toledo Del-Rio⁷, Juliana Sekiyama⁷, Carolina Barros Kahwage⁸ and Cristiane Kayser⁹, ¹Serviço de Reumatologia, Hospital Santa Casa, Minas Gerais, Belo Horizonte, Brazil, ²Universidade Federal do Paraná, Curitiba, Brazil, ³Disciplina de Reumatologia, Hospital das Clínicas - Universidade Federal de Pernambuco, Recife, Brazil, ⁴Universidade Federal do Mato Grosso do Sul, Campo Grande, Brazil, ⁵Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, Brazil, ⁶Universidade Federal da Paraíba, João Pessoa, Brazil, ⁷Universidade Estadual de Campinas, Campinas, Brazil, ⁸Universidade Federal de São Paulo, São Paulo, Brazil, ⁹Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil
Background/Purpose: Digital ulcers (DU) and Raynaud’s phenomenon (RP) are a frequent complication in patients with Systemic Sclerosis (SSc). The present study aimed to evaluate the…
Abstract Number: 825 • 2013 ACR/ARHP Annual Meeting
Activating Transcription Factor 3 Regulates Canonical Transforming Growth Factor Beta Signaling In Experimental Fibrosis
Tatjana Mallano¹, Katrin Palumbo-Zerr¹, Christian Beyer¹, Clara Dees¹, Jingang Huang¹, Tsonwin Hai², Georg A. Schett³ and Joerg H. W. Distler¹, ¹Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²The Ohio State Biochemistry Program, The Ohio State University, Columbus, USA, Colombus, OH, ³Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Activating transcription factor 3 (ATF3), a member of the activating transcription factor/cAMP-responsive element binding protein (ATF/CREB) family of transcription factors is induced by various…

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