Abstracts tagged "Systemic sclerosis"

Abstract Number: 2938 • 2018 ACR/ARHP Annual Meeting
Evaluation of American College of Rheumatology Provisional Composite Response Index in Systemic Sclerosis (ACR CRISS) in a Phase 3 Randomized Controlled Trial
Dinesh Khanna¹, Celia J. F. Lin², Helen Spotswood³, Jeffrey Siegel², Angelika Jahreis², Christopher P. Denton⁴ and Daniel E. Furst⁵, ¹Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, ²Genentech, Inc., South San Francisco, CA, ³Roche Products Ltd., Welwyn Garden City, United Kingdom, ⁴University College London, London, United Kingdom, ⁵University of California Los Angeles, Los Angeles, CA
Background/Purpose: Treatment with the IL-6 receptor inhibitor tocilizumab (TCZ) in early progressive systemic sclerosis (SSc; focuSSced trial; NCT02453256) resulted in numeric improvements in skin sclerosis…
Abstract Number: 810 • 2018 ACR/ARHP Annual Meeting
Sexual Dysfunction in Women with Systemic Sclerosis
Marina Soledad Dalpiaz¹, Juan Argüello², Maria Florencia Rodriguez³, Marta Mamani⁴, Anastasia Secco⁵, Natalia Tamborenea², Eduardo Kerzberg⁶, Sandra Fabiana Montoya⁶, Carolina Aimo⁶, Fernando Manuel Villalobos⁶, Eliana Rebeca Serrano⁷, Maria Elena Crespo Espindola⁸ and Ana Lía Gervilla Galan⁹, ¹Hospital Bernardino Rivadavia, Ciudad Autónoma de Buenos Aires, Argentina, ²Hospital Bernardino Rivadavia, Buenos Aires, Argentina, ³Reumatologia, Hospital Bernardino Rivadavia, Ciudad Autónoma de Buenos Aires, Argentina, ⁴Rheumatology Department, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, ⁵Rheumatology Section, Hospital Bernardino Rivadavia, CABA, Argentina, ⁶Hospital General de Agudos José María Ramos Mejía, BUENOS AIRES, Argentina, ⁷Rheumatology Section, Hospital General de Agudos Dr. Enrique Tornú, Buenos Aires, Argentina, ⁸Reumatologia, Hospital Señor del Milagro, Salta, Argentina, ⁹Hospital San Roque, San Salvador de Jujuy, Argentina
Background/Purpose: Impaired sexual function is common among women with chronic illnesses, including Systemic Sclerosis (SSc). Studies of sexual functioning among women with SSc have concluded…
Abstract Number: 898 • 2018 ACR/ARHP Annual Meeting
Efficacy and Safety of Tocilizumab for the Treatment of Systemic Sclerosis: Results from a Phase 3 Randomized Controlled Trial
Dinesh Khanna¹, Celia J. F. Lin², Masataka Kuwana³, Yannick Allanore⁴, Anastas Batalov⁵, Irena Butrimiene⁶, Patricia Carreira⁷, Marco Matucci Cerinic⁸, Oliver Distler⁹, Dusanka Martinović Kaliterna¹⁰, Carina Mihai¹¹, Mette Mogensen¹², Marzena Olesinska¹³, Janet E. Pope¹⁴, Gabriela Riemekasten¹⁵, Tatiana S. Rodriguez-Reyna¹⁶, Maria José Santos¹⁷, Jacob van Laar¹⁸, Helen Spotswood¹⁹, Jeffrey Siegel², Angelika Jahreis², Daniel E. Furst²⁰ and Christopher P. Denton²¹, ¹University of Michigan, Ann Arbor, MI, ²Genentech, Inc., South San Francisco, CA, ³Nippon Medical School, Tokyo, Japan, ⁴Cochin Hospital, Paris Descartes University, Paris, France, Paris, France, ⁵Medical University of Plovdiv, Plovdiv, Bulgaria, ⁶Rheumatology Clinic, Medical Faculty, Vilnius University, Vilnius, Lithuania, ⁷Servicio de Reumatología, Hospital Universitario, Madrid, Spain, ⁸University of Florence, Florence, Italy, ⁹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ¹⁰University of Split, Split, Croatia, ¹¹Cantacuzino Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, ¹²Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark, ¹³National Institute of Geriatrics, Rheumatology and Rehabilitation,, Warsaw, Poland, ¹⁴Department of Medicine, University of Western Ontario, London, ON, Canada, ¹⁵Rheumatology, University Hospital Schleswig-Holstein - Campus Lübeck, Lübeck, Germany, ¹⁶Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ¹⁷Serviço de Reumatologia do Hospital Garcia de Orta, Almada, Portugal, Almada, Portugal, ¹⁸University Medical Center Utrecht, Utrecht, Netherlands, ¹⁹Roche Products Ltd., Welwyn Garden City, United Kingdom, ²⁰University of California Los Angeles, Los Angeles, CA, ²¹University College London, London, United Kingdom
Background/Purpose: The anti–interleukin-6 (IL-6) receptor-alpha antibody tocilizumab (TCZ) demonstrated numeric improvement in skin thickening (modified Rodnan skin score [mRSS]) and clinically meaningful lung function preservation…
Abstract Number: 1212 • 2018 ACR/ARHP Annual Meeting
Superiority of Musculoskeletal Ultrasound (MSUS) over Clinical Examination Regarding Detection of Arthritis in Patients with Systemic Sclerosis
Daria Feldmann¹, Reinhard Voll², Florian Kollert³ and Stephanie Finzel¹, ¹Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, ²Clinic for Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, ³Department of Rheumatology, Immunology, and Allergology, Inselspital, University Hospital Bern, Bern, Switzerland
Background/Purpose: Arthralgia is frequent in patients with systemic sclerosis (SSc). However, correct clinical assessment of arthritis remains a challenge especially in patients with severe soft…
Abstract Number: 1726 • 2018 ACR/ARHP Annual Meeting
Sexual Dysfunction in Systemic Sclerosis Female Patients
Barbora Hermankova^1,2, Maja Spiritovic^1,2, Hana Smucrova², Sabina Oreska^2,3, Hana Storkanova^2,3, Karel Pavelka^3,4, Jiri Vencovsky^2,5, Ladislav Šenolt^2,3, Radim Becvar^2,3 and Michal Tomcik^2,3, ¹Department of Physiotherapy, Faculty of Physical Education and Sports, Charles University, Prague, Czech Republic, Prague, Czech Republic, ²Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, ³Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ⁴Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ⁵Department Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Systemic sclerosis (SSc) is a chronic autoimmune disease leading to various physical and psychological impairments including sexual dysfunction. The aim of this study was…
Abstract Number: 744 • 2017 ACR/ARHP Annual Meeting
Prediction of All-Cause Mortality and Pulmonary Arterial Hypertension (PAH) Progression in Systemic Sclerosis (SSc), an Echocardiography Study
Anders Heiervang Tennøe¹, Anna-Maria Hoffmann-Vold¹, Øyvind Molberg¹, Håvard Fretheim¹, Torhild Garen¹, Einar Gude¹, Arne K Andreassen¹, Klaus Murbræch², Svend Aakhus³, Johanna Andreassen² and Oyvind Midtvedt¹, ¹Oslo University Hospital, Oslo, Norway, ²Cardiology, Oslo University Hospital, Oslo, Norway, ³Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
Background/Purpose: Pulmonary arterial hypertension (PAH) is one of the leading causes of death in systemic sclerosis (SSc). Annual echocardiograms (echo) are recommended to detect PAH…
Abstract Number: 746 • 2017 ACR/ARHP Annual Meeting
Comparison of Disease Characteristics in Patients with Juvenile-Onset and Adult-Onset Progressive Systemic Sclerosis
Guzin Karatemiz¹, Amra Adrovic², Sinem Nihal Esatoglu¹, Sezgin Sahin², Kenan Barut², Gulen Hatemi¹, Vedat Hamuryudan¹, Ozgur Kasapcopur² and Emire Seyahi¹, ¹Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, ²Pediatric Rheumatology, Istanbul University, Cerrahpasa Medical School, Department of Pediatric Rheumatology, Istanbul, Turkey
Background/Purpose: Progressive systemic sclerosis (PSSc) has been known to affect mainly adults of 30-50 years of age. Juvenile –onset has been reported to be rare…
Abstract Number: 751 • 2017 ACR/ARHP Annual Meeting
Effect of Probiotics on the Gastrointestinal Symptoms and Immune Parameters in Patients with Systemic Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Thais Marighela¹, Maria Izabel Arismendi¹, Milena Brunialti² and Cristiane Kayser¹, ¹Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil, ²Division of Infectious Diseases, Universidade Federal de São Paulo, São Paulo, Brazil
Background/Purpose: Abnormalities in the intestinal microbiota have been associated with several autoimmune diseases, including systemic sclerosis (SSc). Recent studies have demonstrated the potential of probiotics…
Abstract Number: 982 • 2017 ACR/ARHP Annual Meeting
Epidemiology and Mortality in Systemic Sclerosis in South Korea: A Nationwide Population-Based Study
Kyong-Hee Jung¹, Seong-Ryul Kwon¹, Joo-Hyun Lee², Hyeong Sik Ahn³, Hyun Jung Kim³ and Gil Won Kang⁴, ¹Rheumatology, Inha University, Incheon, Korea, Republic of (South), ²Rheumatology, Inje University Ilsan Paik Hospital, Goyang, Korea, Republic of (South), ³Korea University, Seoul, Korea, Republic of (South), ⁴Chungbuk University, Cheongju, Korea, Republic of (South)
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by small vessel vasculopathy, autoantibody production, and excessive collagen deposition in the skin and…
Abstract Number: 1678 • 2017 ACR/ARHP Annual Meeting
Pathogenic Mechanisms of Esophageal Peristaltic Dysfunction By High Resolution Manometry in Patients with Systemic Sclerosis
Hyun-Sook Kim¹, Yunseok Kim², Jung Ran Choi³ and Joon Seong Lee², ¹Soonchenhyang university school of medicine, Seoul, Korea, Republic of (South), ²Internal medicine, Soonchunhyang university Seoul hospital, Seoul, Korea, Republic of (South), ³Department of Internal Medicine, Pohang St. Mary Hospital, Pohang, Korea, Republic of (South)
Background/Purpose: Pathogenic mechanisms of esophageal involvement in systemic sclerosis (SSc) were suggested as neural dysfunction due to impairment of microcirculation to intramural neuron in early…
Abstract Number: 1691 • 2017 ACR/ARHP Annual Meeting
Risk of Development of Definite Disease in Patients with Early Systemic Sclerosis
Cintia Zumstein Camargo, Maria Izabel Arismendi and Cristiane Kayser, Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil
Background/Purpose: The diagnosis of systemic sclerosis (SSc) in the early stages of the disease is frequently a challenge. In 2001, LeRoy and Medsger proposed criteria…
Abstract Number: 1704 • 2017 ACR/ARHP Annual Meeting
Non-Randomized Controlled Trial to Evaluate the Effect of Extracorporeal Shock Wave Therapy on Digital Ulcers in Systemic Sclerosis
Tomonori Ishii¹, Yasushi Kawaguchi², osamu ishikawa³, naruhiko takasaawa⁴, takao kodera⁵, hidekata yasuoka⁶, yuichi takahashi⁷, osamu takai⁸, Izaya Nakaya⁹, Hiroshi Fujii¹⁰, Yukiko Kamogawa¹⁰, Yuko Shirota¹⁰, Tsuyoshi Shirai¹⁰, Yoko Fujita¹¹, shinichiro saito¹², Hiroaki Shimokawa¹³ and Hideo Harigae¹⁰, ¹Clinical Research, Innovation and Education Center, Tohoku University Hospital, Sendai, Japan, ²Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ³Department of Dermatology, Gunma University Graduate School of Medicine, gunma, Japan, ⁴Department of Internal Medicine, Tohoku Medical and Pharmaceutical University Wakabayashi Hospital, Sendai, Japan, ⁵Division of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University, Sendai, Japan, ⁶Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, tokyo, Japan, ⁷Ｙｕ　Ｆａｍｉｌｙ　Ｃlinic, Sendai, Japan, ⁸Osaki Citizen Hospital, Sendai, Japan, ⁹Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Morioka, Japan, ¹⁰Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan, ¹¹Department of Hematolgy and Rheumatolgy, Tohoku University Graduate School of Medicine, Sendai, Japan, ¹²IMS Meirikai Sendai General Hospital, Sendai, Japan, ¹³Department of Cardiovascular medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
Background/Purpose: Patients with systemic sclerosis (SSc) often display Raynaud’s phenomenon, which causes digital skin ulcers. Since these ulcers are not associated with autoimmune factors, conventional…
Abstract Number: 1720 • 2017 ACR/ARHP Annual Meeting
TGF-ß-Induced Tissue Fibrosis in TBRIcaCol1Cre Transgenic Mice Is Abrogated By the Second Generation Tyrosine Kinase Inhibitor SKI-606 (Bosutinib)
Peter J. Wermuth and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Bosutinib (SKI-606), a second-generation tyrosine kinase inhibitor that blocks the activity of the BCR-ABL kinase responsible for Philadelphia chromosome positive chronic myeloid leukemias, also…
Abstract Number: 2049 • 2017 ACR/ARHP Annual Meeting
Factor Structure and Convergent Validity of the Derriford Appearance Scale-24 Using Standard Scoring Versus Treating “Not Applicable” Responses As Missing Data: A Scleroderma Patient-Centered Intervention Network Cohort Study
Erin L. Merz¹, Linda Kwakkenbos^2,3,4, Marie-Eve Carrier², Shadi Gholizadeh⁵, Sarah D. Mills⁶, Rina S. Fox⁷, Lisa Jewett^2,8, Heidi Williamson⁹, Diana Harcourt⁹, Shervin Assassi¹⁰, Daniel E. Furst¹¹, Karen Gottesman¹², Maureen D Mayes¹³, Tim Moss⁹, Brett D. Thombs^2,3 and Vanessa L. Malcarne^6,14, ¹Department of Psychology, California State University, Dominguez Hills, Carson, CA, ²McGill University, Montreal, QC, Canada, ³Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada, ⁴Radboud University, Nijmegen, Netherlands, ⁵Psychoogy, SDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, ⁶SDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, ⁷Northwestern University Feinberg School of Medicine, Chicago, IL, ⁸Jewish General Hospital, Montreal, QC, Canada, ⁹University of the West of England, Bristol, United Kingdom, ¹⁰University of Texas McGovern Medical School, Houston, TX, ¹¹Department of Internal Medicine and Rheumarology, University of California Los Angeles, David Geffen School of Medicine, Division of Rheumatology; University of Washington, Seattlr, Washington; University of Florence, Florence, Italy, Los Angeles, CA, ¹²Scleroderma Foundation, Los Angeles, CA, ¹³Department of Internal Medicine - Rheumatology, University of Texas-McGovern Medical School, Houston, TX, ¹⁴Psychology, San Diego State University, San Diego, CA
Background/Purpose: Valid measures of appearance concern are needed in systemic sclerosis, a rare, disfiguring rheumatologic disease. The Derriford Appearance Scale-24 (DAS-24) is a self-report measure…
Abstract Number: 2670 • 2017 ACR/ARHP Annual Meeting
Trigeminal Neuralgia in Systemic Sclerosis
Nancy Maltez¹, Marie Hudson², Yves Troyanov³, May Choi⁴, Mianbo Wang⁵, Marvin J. Fritzler⁶, Murray Baron⁷ and Doug Smith⁸, ¹Rheumatology, The Ottawa Hospital, Ottawa, ON, Canada, ²Division of Rheumatology, Jewish General Hospital, Lady David Institute for Medical Research, Montreal, QC, Canada, ³Rheumatology, Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada, ⁴University of Calgary, Calgary, AB, Canada, ⁵Lady Davis Institute for Medical Research, Montreal, QC, Canada, ⁶Medicine, University of Calgary, Calgary, AB, Canada, ⁷Rheumatology, McGill University, Jewish General Hospital, Montreal, QC, Canada, ⁸Division of Rheumatology, Department of Medicine, The Ottawa Hospital - University of Ottawa, Ottawa, ON, Canada
Background/Purpose: Trigeminal neuralgia (TN) is characterized by pain and spasms affecting one or more divisions of the fifth cranial nerve. Of note, TN is one…

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