Abstracts tagged "systemic sclerosis and ulcers"

Abstract Number: 2701 • 2018 ACR/ARHP Annual Meeting
Botulinum Toxin in the Management of Raynaud’s Phenomenon
Daniel Ennis^1,2, Zareen Ahmad³, Keshini Devakandan¹, Melanie A Anderson⁴ and Sindhu Johnson¹, ¹Toronto Scleroderma Program, Mount Sinai Hospital, Toronto Western Hospital, Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, ON, Canada, ²Rheumatology, University of British Columbia, Vancouver, BC, Canada, ³Toronto Scleroderma Program, Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁴University Health Network Library Services, Toronto General Hospital, Toronto, ON, Canada
Background/Purpose: The objectives of this study were to evaluate the effectiveness and safety of botulinum toxin injection in Raynaud’s phenomenon. Methods: Medline and Embase databases…
Abstract Number: 2716 • 2018 ACR/ARHP Annual Meeting
A New Score to Predict Digital Ulcers Combining Clinical Data, Imaging and Patient History in Systemic Sclerosis
Stefanie Friedrich^1,2, Susanne Lueders³, Gerd R. Burmester⁴, Gabriela Riemekasten⁵ and Sarah Ohrndorf⁴, ¹Department of of Rheumatology and Clinical Immunology, Charité University Hospital, Berlin; Germany, Berlin, Germany, ²Department of Radiology, Charité University Hospital, Berlin; Germany, Berlin, Germany, ³Department of Gastroenterology and Rheumatology, Charité Universitätsmedizin Berlin, Berlin, Germany, ⁴Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Berlin, Germany, ⁵Rheumatology, University Hospital Schleswig-Holstein - Campus Lübeck, Lübeck, Germany
Background/Purpose: Ischemic complications such as digital ulcers (DU) are a common complication in systemic sclerosis (SSc) patients. The aim of this study was to combine…
Abstract Number: 256 • 2017 ACR/ARHP Annual Meeting
Tracking Digital Ulcers in Systemic Sclerosis: Feasibility Study Assessing Lesion Area from Patient-Recorded Smartphone Photographs
Graham Dinsdale¹, Tonia Moore², Joanne Manning², Andrea Murray¹, Ross Atkinson³, Karen Ousey⁴, Mark Dickinson⁵, Christopher Taylor⁶ and Ariane L. Herrick^1,7, ¹Division of Musculoskeletal & Dermatological Sciences, University of Manchester, Salford Royal Hospital NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK, Manchester, United Kingdom, ²Salford Royal Hospital NHS Foundation Trust, Salford, UK, Salford, United Kingdom, ³School of Health Sciences, Division of Nursing, Midwifery & Social Work, University of Manchester, Manchester, UK, Manchester, United Kingdom, ⁴Division of Podiatry and Clinical Sciences, University of Huddersfield, Huddersfield, UK, Huddersfield, United Kingdom, ⁵Photon Science Institute, School of Physics and Astronomy, University of Manchester, Manchester, UK, Manchester, United Kingdom, ⁶Centre for Imaging Sciences, Division of Informatics, Imaging & Data Sciences, University of Manchester, Manchester, UK, Manchester, United Kingdom, ⁷NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK, Manchester, United Kingdom
Background/Purpose: Approximately 50% of patients with systemic sclerosis (SSc) will develop painful digital (finger) ulcers (DUs) at some point during their disease course. These lesions…
Abstract Number: 750 • 2017 ACR/ARHP Annual Meeting
Diltiazem Gel As a New Local Treatment for Scleroderma Digital Ulcers
Mohammad Ali Nazarinia¹, Elmira Esmaeilzadeh² and Saeedeh Shenavandeh², ¹Shiraz Geriatric Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, Shiraz, Iran (Islamic Republic of), ²Department of Internal Medicine, Division of Rheumatology, Shiraz University of Medical Sciences, Shiraz, Iran., Shiraz, Iran (Islamic Republic of)
Background/Purpose: Assessing the effect of Diltiazem gel on healing process of scleroderma digital ulcers and comparing its effect with Nitroglycerin ointment and placebo. Methods: Ninety…
Abstract Number: 2007 • 2017 ACR/ARHP Annual Meeting
Disturbances of the Acral Perfusion Detected By Fluorescence Optical Imaging Are Associated with the Development of Ischemic Complications in Patients with Systemic Sclerosis
Stefanie Friedrich^1,2, Susanne Lueders³, Stephanie Werner^3,4, Anne-Marie Glimm⁵, Gabriela Schmittat⁵, Gerd R. Burmester⁶, Gabriela Riemekasten⁷, Marina Backhaus⁸ and Sarah Ohrndorf⁹, ¹Department of of Rheumatology and Clinical Immunology, Department of Rheumatology and Clinical Immunology, Charité University Hospital, Berlin; Germany, Berlin, Germany, ²Department of Radiology, Department of Radiology, Charité University Hospital, Berlin; Germany, Berlin, Germany, ³Department of Rheumatology and Clinical Immunology, Department of Rheumatology and Clinical Immunology, Charité University Hospital, Berlin; Germany, Berlin, Germany, ⁴Department of Rheumatology, Helios St. Johannes Clinic, Duisburg, Germany, ⁵Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany, ⁶Department of Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Free University and Humboldt University Berlin, Berlin, Germany, ⁷Department of Rheumatology, Universitatsklinikum Schleswig-Holstein, Lubeck, Germany, ⁸Rheumatology, Park-Klinik Weissensee, Berlin, Germany, ⁹Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Berlin, Germany
Background/Purpose: Systemic sclerosis (SSc) is a condition causing impaired microcirculation with the risk of ischemic complications such as digital ulcers and pitting scars (DU/PS). Fluorescence…
Abstract Number: 2666 • 2017 ACR/ARHP Annual Meeting
The Clinical Utility of Flow-Mediated Dilation in Systemic Sclerosis Digital Ulcer Assessment
Tracy M. Frech¹, Daniel Machin², Maureen Murtaugh³ and Anthony Donato², ¹Division of Rheumatology, University of Utah, Salt Lake City, UT, ²University of Utah and Salt Lake Veterans Affair Medical Center, Salt Lake City, UT, ³University of Utah, Salt Lake, UT
Background/Purpose: Systemic sclerosis (SSc, scleroderma) patients can have the end-stage vasculopathy manifestation of a digital ulcer (DU). Brachial artery flow mediated dilation (FMD) is an…
Abstract Number: 2922 • 2016 ACR/ARHP Annual Meeting
Disability, Fatigue, and Their Associates in Early Diffuse Cutaneous Systemic Sclerosis
Ariane L. Herrick¹, Sébastien Peytrignet², Xiaoyan Pan³, Roger Hesselstrand⁴, Luc Mouthon⁵, László Czirják⁶, Madelon C. Vonk⁷, Oliver Distler⁸, Joerg H.W Distler⁹, Edith Brown³, Kim Fligelstone³, Rachel Ochiel¹⁰, William Gregory¹¹, Alan Silman¹², Mark Lunt¹³ and Christopher Denton¹⁴, ¹Centre for Musculoskeletal Research, University of Manchester, MAHSC, Salford Royal Hospital, Manchester, United Kingdom, ²Manchester Academic Health Sciences Centre, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, ³Manchester Academic Health Science Centre, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, ⁴Department of Rheumatology, Lund University, Lund, Sweden, ⁵Internal Medicine, Hopital Cochin, Paris, France, ⁶Department of Rheumatology and Immunology, University of Pécs, Faculty of Medicine, Pécs, Hungary, ⁷Department of the Rheumatic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁸Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁹Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany, ¹⁰Royal Free London NHS Foundation Trust, London, United Kingdom, ¹¹Rehabilitation Services, Salford Royal NHS Foundation Trust, Salford, United Kingdom, ¹²Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ¹³Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, ¹⁴Centre for Rheumatology, Royal Free Hospital, London, Great Britain
Background/Purpose: ESOS (European Scleroderma Observational Study) was a prospective observational study of 326 patients with early diffuse cutaneous systemic sclerosis (dcSSc) from 50 centres. Here…
Abstract Number: 854 • 2016 ACR/ARHP Annual Meeting
The Ducas: Proposal for a Digital Ulcer Assessment Score in Scleroderma
Cosimo Bruni¹, Tanaka Ngcozana², Francesca Braschi³, Guya Piemonte⁴, Laura Benelli⁴, Serena Guiducci⁵, Silvia Bellando-Randone³, Jonathan Grotts⁶, Christopher Denton⁷, Daniel E. Furst⁸ and Marco Matucci-Cerinic⁵, ¹Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Firenze, Italy, ²Rheumatology Department, Lower, Royal Free hospital, London, United Kingdom, ³Department of Clinical and Experimental Medicine, Division of Rheumatology, University of Florence, Firenze, Italy, ⁴University of Florence, Florence, Italy, ⁵Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Florence, Italy, ⁶Biostatistics, University of California Los Angeles, Los Angeles, CA, ⁷Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ⁸Division of Rheumatology, Department of Internal Medicine, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: No objective measure is presently available to assess digital ulcer (DU) in SSc patients apart from “healed/non healed” and experience-based clinical judgment. The aim…
Abstract Number: 2889 • 2016 ACR/ARHP Annual Meeting
Therapeutic Plasma Exchange for the Treatment of Raynaud’s and Digital Ulcers in Systemic Sclerosis: A Systematic Review
Edward S Harris¹, Herbert J Meiselman², Patrick M Moriarty³ and Allan Metzger⁴, ¹Scleroderma Education Project Ltd, Madison, WI, ²Keck School of Medicine, University of Southern California, Los Angeles, CA, ³Clinical Pharmacology, University of Kansas Medical Center, Kansas City, KS, ⁴RDL Reference Laboratory Inc, Los Angeles, CA
Background/Purpose: Raynaud's phenomenon (RP) is an early marker of microvascular damage in systemic sclerosis (SSc) and digital ulcers (DU) are a serious complication of vascular…
Abstract Number: 2896 • 2016 ACR/ARHP Annual Meeting
Safety and Effectiveness of Hyperbaric Oxygen Therapy for Systemic Sclerosis Ulcers
Susan Armstrong¹, A. Wayne Evans², Zareen Ahmad³ and Sindhu R. Johnson⁴, ¹Toronto Scleroderma Program, Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ²Hyperbaric Medicine Unit, Department of Anaesthesia, Faculty of Medicine, University of Toronto, Toronto, ON, Canada, ³Division of Rheumatology, Toronto Scleroderma Program, Division of Rheumatology, Mount Sinai Hospital, Department of Medicine, University of Toronto, Toronto, ON, Canada, ⁴Division of Rheumatology, Toronto Western Hospital, Mount Sinai Hospital, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada
Background/Purpose: Vascular complications of systemic sclerosis (SSc, scleroderma) can result in ulcers in the distal extremities, which limit function and are often refractory to conventional…
Abstract Number: 2905 • 2016 ACR/ARHP Annual Meeting
Predictors of Poor Hand Function in Systemic Sclerosis
Ashraf Raslan¹ and Vivien Hsu², ¹Medicine, Rutgers-RWJ Medical School, Jersey City, NJ, ²Rheumatology, RWJ Med Schl Scleroderma Prog, New Brunswick, NJ
Background/Purpose: Systemic Sclerosis (SSc) is a progressive systemic disease that can lead to variable degrees of morbidity and disability. Hand dysfunction in SSc patients [1]…
Abstract Number: 830 • 2015 ACR/ARHP Annual Meeting
Calcinosis Is Associated with Digital Ulcers and Osteoporosis in Patients with Systemic Sclerosis
Antonia Valenzuela¹, Murray Baron², Ariane L. Herrick³, Susana Proudman⁴, Wendy Stevens⁵, Tatiana Sofia Rodriguez-Reyna⁶, Alessandra Vacca⁷, Thomas A. Medsger Jr.⁸, Monique Hinchcliff⁹, Vivien Hsu¹⁰, David Fiorentino¹¹, Lorinda Chung¹² and the Canadian Scleroderma Research Group, and the ASIG rubric, ¹Stanford University School of Medicine, Stanford, CA, ²Rheumatology, McGill University, Jewish General Hospital, Montreal, QC, Canada, ³Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁴Rheumatology Unit, Royal Adelaide Hospital North Terrace, Adelaide, Australia, ⁵Department of Rheumatology, St. Vincent’s Hospital Melbourne, Melbourne, Australia, ⁶Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ⁷University Hospital of Cagliari, Rheumatology Unit, Monserrato, Italy, ⁸Department of Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁹Rheumatology, Northwestern University, Chicago, IL, ¹⁰Rheumatology, RWJ Med Schl Scleroderma Prog, New Brunswick, NJ, ¹¹Department of Dermatology, Stanford University School of Medicine, Palo Alto, CA, ¹²Stanford University, Palo Alto, CA
Background/Purpose: Calcinosis is a debilitating complication of systemic sclerosis (SSc). We sought to determine the clinical factors associated with calcinosis in an international multi-center collaborative…
Abstract Number: 851 • 2015 ACR/ARHP Annual Meeting
Does the Clinical Context Improve the Reliability of Rheumatologists Grading Digital Ulcers in Systemic Sclerosis?
Michael Hughes¹, Chris Roberts², Andrew Tracey¹, Graham Dinsdale¹, Andrea Murray¹ and Ariane L. Herrick¹, ¹Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, ²Centre for Biostatistics, Institute of Population Health, University of Manchester, Manchester, United Kingdom
Background/Purpose: Digital ulcers (DUs) are often a primary end point in SSc clinical trials, although the reliability of rheumatologists grading DUs is poor to moderate…
Abstract Number: 2974 • 2015 ACR/ARHP Annual Meeting
Insulin Resistance Is Associated with the Digital Ulcer in Patients with Systemic Sclerosis
Seung-Geun Lee¹, Eun-Kyoung Park², Dong-Wan Koo², Geun-Tae Kim³, Hee-Sang Tag³ and Joung-Wook Lee⁴, ¹Division of Rheumatology, Department of Internal Medicine, Busan National University School of Medicine, Busan, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Pusan National University School of Medicine, Busan, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Kosin University College of Medicine, Busan, South Korea, ⁴Divsion of Rheumatology, Department of Internal Medicine, Busan St. Marys center, Busan, South Korea
Background/Purpose: Growing evidence supports the view that systemic sclerosis (SSc) is a vascular disease mediated by autoimmunity and evolving into progressive tissue fibrosis. Several vascular…
Abstract Number: 1928 • 2014 ACR/ARHP Annual Meeting
A Multicenter, Prospective Cohort Study Using Nailfold Videocapillaroscopy and Other Clinical Characteristics to Determine the Risk of Developing New Digital Ulcers in Patients with Systemic Sclerosis
Vanessa Smith¹, Maurizio Cutolo², Ariane Herrick³, Oliver Distler⁴, Mike Becker⁵, Emma Beltran⁶, Patrick Carpentier⁷, Clodoveo Ferri⁸, Murat Inanc⁹, Panayiotis Vlachoyiannopoulos¹⁰, Harbajan Chadha-Boreham¹¹, Emmanuelle Cottreel¹¹, Thomas Pfister¹¹, Daniel Rosenberg¹¹ and Juan Torres, on behalf of the CAP study investigators¹², ¹Ghent University Hospital, Ghent, Belgium, ²Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, ³Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁴Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ⁵Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany, ⁶Hospital La Fe, Valencia, Spain, ⁷Vascular Medicine, La Tronche Hospital, Grenoble, France, ⁸Rheumatology, University of Modena & Reggio E, Moderna, Italy, ⁹Rheumatology, Division of Rheumatology, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey, ¹⁰Pathophysiology, School of Medicine, National University of Athens, Athens, Greece, ¹¹Actelion Pharmaceuticals Ltd, Allschwil, Switzerland, ¹²Syntax for Science SL, Basel, Switzerland
Background/Purpose Digital ulcers (DU) are painful and disabling and affect almost 50% of systemic sclerosis (SSc) patients. Nailfold videocapillaroscopy (NVC) non-invasively assesses SSc-related micro-angiopathy and…

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