systemic sclerosis and transcription factor Archives

Abstract Number: 1118 • ACR/ARHP Annual Meeting 2018
Identification of Transcriptional Regulatory Networks in Systemic Sclerosis
Yue Wang¹, Jennifer Franks² and Michael L. Whitfield³, ¹Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Geisel School of Medicine at Dartmouth, Hanover, NH, ³Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: Systemic sclerosis (SSc) is a heterogeneous autoimmune disorder with poor outcomes and no FDA-approved therapies. Prior work has shown gene expression patterns associated with…
Abstract Number: 2072 • ACR/ARHP Annual Meeting 2016
Fli1-Haploinsufficient Dermal Fibroblasts Promote Skin-Localized Transdifferentiation of Th2- and Th17-like Regulatory T Cells
Ryosuke Saigusa¹, Yoshihide Asano², Takuya Miyagawa², Megumi Hirabayashi², Kouki Nakamura¹, Shunsuke Miura³, Takashi Yamashita², Yohei Ichimura¹, Takehiro Takahashi¹, Tetsuo Toyama², Takashi Taniguchi¹, Ayumi Yoshizaki², Maria Trojanowska⁴ and Shinichi Sato¹, ¹Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ³University of Tokyo Graduate School of Medicine, Tokyo, Japan, ⁴Arthritis Center, Boston University, Arthritis Center, Boston, MA
Background/Purpose: Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by autoimmunity/inflammation, vasculopathy, and tissue fibrosis. Fli1 is a member of Ets family transcription…
Abstract Number: 2704 • ACR/ARHP Annual Meeting 2013
Twist1 Regulates Transforming Growth Factor Beta Dependent Activation Of Fibroblasts In Fibrosis
Katrin Palumbo-Zerr¹, Andrea Liebl¹, Pawel Zerr¹, Michal Tomcik², Alfiya Distler¹, Christian Beyer¹, Oliver Distler³, Georg Schett⁴ and Joerg H. W. Distler¹, ¹Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ³Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Twist1 is a member of the tissue-restricted class B of basic-helix-loop-helix (bHLH) transcription factors acting as master regulators on different tissues. Twist1 is controlled…
Abstract Number: 2706 • ACR/ARHP Annual Meeting 2013
Fli1 Haploinsufficiency Exacerbates Dermal Fibrosis Via Activation Of Fibroblasts, Endothelial Cells and Macrophages In Bleomycin-Treated Mice
Takashi Taniguchi¹, Yoshihide Asano¹, Kaname Akamata¹, Shinji Noda¹, Takehiro Takahashi¹, Yohei Ichimura¹, Tetsuo Toyama¹, Maria Trojanowska² and Shinichi Sato¹, ¹Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²Arthritis Center, Boston University, Boston, MA
Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disorder with clinical manifestations resulting from immune activation, vascular injuries and fibrosis development. Previous reports suggest that…
Abstract Number: 2707 • ACR/ARHP Annual Meeting 2013
Downregulation Of KLF5 and Fli1 Cooperatively Contribute To Distinct Manifestations Of Systemic Sclerosis In Vitro and In Vivo
Shinji Noda¹, Yoshihide Asano¹, Katsuhito Fujiu², Ichiro Manabe², Ryozo Nagai², Kaname Akamata¹, Takashi Taniguchi¹, Takehiro Takahashi¹, Yohei Ichimura¹, Tetsuo Toyama¹, Daisuke Tsuruta³, Maria Trojanowska⁴ and Shinichi Sato¹, ¹Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ³Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan, ⁴Arthritis Center, Boston University, Boston, MA
Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by initial vascular injuries and resultant fibrosis of skin and certain internal organs. Although the…
Abstract Number: 665 • ACR/ARHP Annual Meeting 2013
DNA hypermethylation of Forkhead box protein 3 (FOXP3) locus leads to quantitative defects of regulatory T cells in systemic sclerosis
Yaoyao Wang¹, Ye Shu², Qing Wang¹, Ming Zhao¹, Gongping Liang¹, Qianjin Lu¹ and Rong Xiao¹, ¹Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China, ²Department of Dermatology, Hunan Children's Hospital, Changsha, China

Background/Purpose: Systemic sclerosis (SSc) is a systemic autoimmune disease of which the etiology and pathogenesis remains complex and poorly understood. Attention has recently been directed…

Abstracts tagged "systemic sclerosis and transcription factor"

Identification of Transcriptional Regulatory Networks in Systemic Sclerosis

Fli1-Haploinsufficient Dermal Fibroblasts Promote Skin-Localized Transdifferentiation of Th2- and Th17-like Regulatory T Cells

Twist1 Regulates Transforming Growth Factor Beta Dependent Activation Of Fibroblasts In Fibrosis

Fli1 Haploinsufficiency Exacerbates Dermal Fibrosis Via Activation Of Fibroblasts, Endothelial Cells and Macrophages In Bleomycin-Treated Mice

Downregulation Of KLF5 and Fli1 Cooperatively Contribute To Distinct Manifestations Of Systemic Sclerosis In Vitro and In Vivo

DNA hypermethylation of Forkhead box protein 3 (FOXP3) locus leads to quantitative defects of regulatory T cells in systemic sclerosis