Abstracts tagged "Systemic lupus erythematosus (SLE)"

Abstract Number: 1684 • ACR Convergence 2023
The Impact of Pregnancy Timing on Outcomes in SLE
Catherine Sims¹, Amanda Eudy², Ceshae Harding¹, Cuoghi Edens³, Mehret Birru Talabi⁴, Rosalind Ramsey-Goldman⁵, Laura Neil¹ and Megan Clowse⁶, ¹Duke University, Durham, NC, ²Duke University, Raleigh, NC, ³University of Chicago, Chicago, IL, ⁴University of Pittsburgh, Pittsburgh, PA, ⁵Northwestern University, Chicago, IL, ⁶Duke University, Chapel Hill, NC
Background/Purpose: To minimize risk of poor pregnancy outcomes, the ACR Reproductive Health Guideline recommends women conceive when SLE is well controlled and treated with pregnancy-compatible…
Abstract Number: 1899 • ACR Convergence 2023
Healthy People with Lupus 2030: Goals to Improve the Quality of Care and Health of All People with Lupus in the United States
Jinoos Yazdany¹, April Jorge², Claire Barber³, April Barnado⁴, Bonnie Bermas⁵, Ali Duarte-Garcia⁶, Amy Bennett⁷, Candace Feldman⁸, Shivani Garg⁹, Leah Haseley¹⁰, Shraddha Jatwani¹¹, Tracy Johansson¹², Alex Limanni¹³, Wambui Machua¹⁴, Wendy Rodgers¹⁵, Brad Rovin¹⁶, Yesenia Santiago-Casas¹⁷, Lisa Suter¹⁸, JoAnn Zell¹⁹, Patti Katz²⁰ and Christie M. Bartels²¹, ¹University of California, General Department of Medicine, Division of Rheumatology, San Francisco, CA, ²Massachusetts General Hospital, Boston, MA, ³University of Calgary, Calgary, AB, Canada, ⁴Vanderbilt University Medical Center, Nashville, TN, ⁵UT Southwestern, Dallas, TX, ⁶Mayo Clinic, Rochester, MN, ⁷ACR, Atlanta, GA, ⁸Brigham and Women's Hospital, Boston, MA, ⁹Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, ¹⁰University of Washington, Seattle, WA, ¹¹Dignity Health-MMG Rheumatology, East Norriton, PA, ¹²American College of Rheumatology, Atlanta, GA, ¹³Self, Dallas, TX, ¹⁴Piedmont Healthcare, Atlanta, GA, ¹⁵Lupus Foundation of America, Los Angeles, CA, ¹⁶Ohio State University, Columbus, OH, ¹⁷Guillermo Valenzuela MD PA, Plantation, FL, ¹⁸Yale School of Medicine, New Haven, CT, ¹⁹University of Colorado Anschutz Medical Campus, Denver, CO, ²⁰University of California San Francisco, San Rafael, CA, ²¹University of Wisconsin, School of Medicine and Public Health, Madison, WI
Background/Purpose: Collaborating with the Centers for Disease Control and Prevention (CDC), the ACR has developed new quality measures for lupus clinical care, including clinical and…
Abstract Number: 2263 • ACR Convergence 2023
Disease Activity Progression in Systemic Lupus Erythematosus: An Analysis of the SLE Prospective Observational Cohort Study (SPOCS)
Eric Morand¹, Richard Furie², Christine Peschken³, Martin Aringer⁴, Laurent Arnaud⁵, Barnabas Desta⁶, Tina Grünfeld Eén⁷, Alessandro Sorrentino⁸, Stephanie Chen⁹ and Bo Ding⁷, ¹Monash University, Centre for Inflammatory Diseases, Melbourne, Australia, ²Northwell Health, Manhasset, NY, ³University of Manitoba, Winnipeg, MB, Canada, ⁴Carl Gustav Carus, Dresden, Germany, ⁵University Hospitals of Strasbourg, Strasbourg, France, ⁶BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, ⁷BioPharmaceuticals Medical, AstraZeneca, Gothenburg, Sweden, ⁸Medical Affairs, AstraZeneca, Cambridge, United Kingdom, ⁹BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, MD
Background/Purpose: The international, multicenter SLE Prospective Observational Cohort Study (SPOCS) collected data on patients with SLE in relation to their type 1 interferon gene signature…
Abstract Number: 2280 • ACR Convergence 2023
The LFA-REAL Clinician Reported Outcome Predicts Damage in Patients with Systemic Lupus Erythematosus (SLE). Data from a Prevalent Latin American Lupus Cohort
Manuel Ugarte-Gil¹, Rocío Gamboa-Cárdenas², Victor Pimentel-Quiroz², Cristina Reategui-Sokolova³, Claudia Elera-Fitzcarrald⁴, Erika Noriega⁵, Cesar Pastor-Asurza⁶, Zoila Rodriguez-Bellido⁶, Risto Perich-Campos⁶ and Graciela S Alarcón⁷, ¹Universidad Cientifica del Sur, Lima, Peru, ²Universidad Cientifica del Sur/Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Peru, ³Hospital Guillermo Almenara Irigoyen, EsSalud/Universidad San Ignacio de Loyola, Lima, Peru, ⁴Hospital Guillermo Almenara Irigoyen, EsSalud/Universidad Privada San Juan Bautista, Lima, Peru, ⁵Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Peru, ⁶Hospital Guillermo Almenara Irigoyen, EsSalud/Universidad Nacional Mayor de San Marcos, Lima, Peru, ⁷Heersink School of Medicine. The University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: The Lupus Foundation of America Rapid Evaluation of Activity in Lupus (LFA-REAL) clinican-reported outcome (ClinRO) correlates well with other disease activity indices such us…
Abstract Number: 2297 • ACR Convergence 2023
Interferon-α as a Biomarker to Predict Flares in Lupus Nephritis
Laura Patricia Whittall Garcia¹, Dafna Gladman², Murray Urowitz³, Zahi Touma⁴ and Joan Wither¹, ¹University Health Network, Toronto, ON, Canada, ²Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Department of Medicine, University of Toronto, Toronto, ON, Canada, ³Schroeder Arthritis Institute, Krembil Research Institute; University of Toronto Lupus Clinic; Division of Rheumatology, Toronto, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada
Background/Purpose: Type I Interferons (IFN-I) play a role in SLE and Lupus Nephritis (LN) pathogenesis. We have recently shown that IFN-I gene expression predicts the…
Abstract Number: 2313 • ACR Convergence 2023
Utilization of Palliative Care in Hospitalized Patients with Systemic Lupus Erythematosus: A Nationwide Cohort Analysis
Saman Tanveer¹, Hema Pinnam², Fatima Tanveer³ and Daksh Ahluwalia¹, ¹John H. Stroger Jr. Hospital of Cook County, Chicago, IL, ²J.S.S. Medical College, Mysore, India, ³CMH Lahore Medical College, Lahore, Pakistan
Background/Purpose: We aimed to investigate trends in utilization of hospital palliative care services among hospitalized patients with systemic lupus erythematosus (SLE) and analyze its impact…
Abstract Number: 2330 • ACR Convergence 2023
Disease-Related Outcomes of Cognitive Behavioral Therapy in Randomized Control Trial for Youth with Childhood-onset SLE: A Secondary Analysis
Natoshia Cunningham¹, Michelle Adler¹, Ashley Danguecan², Mallet Reid¹, Samantha Ely³, Mathew Reeves⁴, Lawrence Ng², Paris Moaf², Tala El Tal⁵, Sarah Mossad², Luana Flores Pereira², Deborah Levy², Linda Hiraki², Jennifer Stinson², Sara Ahola Kohut², khalid abulaban⁶, Elizabeth Kessler⁷, Stacy Allen⁸, Tamar Rubinstein⁹, Evin Rothschild¹⁰, Natalie Rosenwasser¹¹, Kabita Nanda¹², Susan Canny¹³, Emily Smitherman¹⁴, Livie Huie¹⁵, James Birmingham¹⁶, Ekemini Ogbu¹⁷, Hermine Brunner¹⁸, Dhriti Sharma¹⁹, Allison Thompson²⁰, Janel Thompson²¹, Miranda Moyer²⁰, Emily Nguyen²⁰, Angela Chapson²⁰ and Andrea Knight², ¹Michigan State University, Grand Rapids, MI, ²The Hospital for Sick Children, Toronto, ON, Canada, ³Michigan State University, Wayne State University, Grand Rapids, MI, ⁴Michigan State University, East Lansing, MI, ⁵Children's Hospital of Eastern Ontario (CHEO), Ottawa, ON, Canada, ⁶Helen DeVos Children's Hospital, Ada, MI, ⁷Spectrum Health, Grand Rapids, MI, ⁸Helen DeVos Children's Hospital, Caledonia, MI, ⁹Albert Einstein College of Medicine, Children's Hospital at Montefiore, White Plains, NY, ¹⁰Albert Einstein Medical Center, Children's Hospital at Montefiore, Bronx, NY, ¹¹Seattle Children's Hospital, Seattle, WA, ¹²Seattle Children's Hospital/University of Washington, Seattle, WA, ¹³Seattle Children's Hospital/University of Washington, Seattle, WA, ¹⁴University of Alabama at Birmingham, Birmingham, AL, ¹⁵University of Alabama at Birmingham, Gardendale, AL, ¹⁶Self, Ada, MI, ¹⁷Cincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine, Johns Hopkins University, Cincinnati, OH, ¹⁸Cincinnati Children's Hospital Medical Center, Division of Rheumatology, Cincinnati, OH, ¹⁹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²⁰Patient Co-Investigative Team, n/a, ²¹Patient Co-Investigative Team, Revere, PA
Background/Purpose: Childhood-onset systemic lupus erythematosus (cSLE) is associated with symptoms such as fatigue, pain, and depressive symptoms that contribute to poor health-related quality of life.…
Abstract Number: 2349 • ACR Convergence 2023
Selection of the Dose for Subcutaneous Administration to Non-Japanese Subjects and Intravenous Administration to Japanese Subjects in the First-in-Human Study of DS-7011a, an Anti-TLR7 Monoclonal Antibody for the Treatment of Systemic Lupus Erythematosus
Li Zhang¹, Jun Tanaka², Michael Dodds³, Mirjam Trame³, Sophia Xu¹, Masafumi Kumazaki⁴, Yoshiaki Tomimori⁵, Samarth Patel¹, Aparna Mohan¹, Giorgio Senaldi¹ and Tarek Leil¹, ¹Daiichi Sankyo, Basking Ridge, NJ, ²Daiichi Sankyo, Inc., Basking Ridge, NJ, ³Certara Strategic Consulting, Princeton, NJ, ⁴Daiichi Sankyo, Tokyo, Japan, ⁵Daiichi Sankyo Co., Ltd., Shinagawa-ku, Japan
Background/Purpose: Toll-like receptor (TLR)7 is a pattern recognition receptor whose ligands include nucleic acids and whose gain-of-function mutations have been reported to result insystemic lupus…
Abstract Number: 2486 • ACR Convergence 2023
Should SLE Patients Entering Clinical Trials Be Required to Have at Least One BILAG a And/or Two BILAG B Scores?
Ewa Olech¹ and Joan Merrill², ¹IQVIA, Rheumatology Consultants, PLLC, Las Vegas, NV, ²Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: High placebo response rates have challenged interpretation of clinical trial results in SLE and may have contributed to failure of some effective treatments. One…
Abstract Number: 2555 • ACR Convergence 2023
Cluster Analysis Reveals Subgroups in Patients with Serologically Active Clinically Quiescent Systemic Lupus Erythematosus: Implication for Long-term Prognosis Prediction
YuFang Ding¹, Qian Wang¹, Xinping Tian², Mengtao Li², xiaofeng Zeng¹ and Jiuliang zhao², ¹Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, ²Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
Background/Purpose: Serologically active clinically quiescent (SACQ) is a clinical state of systemic lupus erythematosus (SLE) characterized by high levels of serologic markers without clinical activity.…
Abstract Number: 0121 • ACR Convergence 2023
High Prevalence of Mental Health Disorders Among Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus
Jeong Yee¹, Candace Feldman¹, Emily G. Oakes¹, Elizabeth Karlson¹, Jack Ellrodt¹, Laura Kubzansky², Karestan Koenen² and Karen Costenbader³, ¹Brigham and Women's Hospital, Boston, MA, ²Harvard T.H. Chan School of Public Health, Boston, MA, ³Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are complex autoimmune diseases associated with pain and decreased quality of life. Mental health conditions related…
Abstract Number: 0186 • ACR Convergence 2023
Retention in Rheumatology Care and on Hydroxychloroquine and SLE Outcomes by Neighborhood Disadvantage: A Medicare Cohort Study of Acute Care and Kidney Failure
Christie M. Bartels¹, Ang Yu², Felix Elwert², Andrea Gilmore-Bykovskyi³, W. Ryan Powell⁴, Shivani Garg⁵ and Amy J. Kind⁴, ¹University of Wisconsin, School of Medicine and Public Health, Madison, WI, ²Department of Sociology, University of Wisconsin, Madison, WI, ³Berbee Walsh Department of Emergency Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, ⁴Center for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, ⁵Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI
Background/Purpose: Gaps in systemic lupus (SLE) care are believed to contribute to higher kidney failure (ESKD), acute care use, mortality, and disease damage in US…
Abstract Number: 0469 • ACR Convergence 2023
Hydroxychloroquine and Preeclampsia Risk in Lupus Pregnancy: Results from a Large Regional Integrated Health Network
Julia Simard¹, Emily Liu², Amadeia Rector³, Miranda Cantu⁴, Daniel Kuo⁵, Eliza Chakravarty⁶, Maurice Druzin⁷, Gary Shaw⁷, Michael Weisman⁸ and Monique Hedderson², ¹Department of Epidemiology & Population Health, Stanford University School of Medicine, Stanford, CA, ²Kaiser Permanente Division of Research, Oakland, CA, ³Stanford University, San Francisco, CA, ⁴Global Lupus Support Group, Portage, MI, ⁵Kaiser Permanente, Redwood City, CA, ⁶Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁷Stanford University, Stanford, CA, ⁸Stanford, Los Angeles, CA
Background/Purpose: Pregnancies in patients with systemic lupus erythematosus (SLE) are at greater risk of preeclampsia. Hydroxychloroquine (HCQ) is recommended during SLE pregnancy to control disease…
Abstract Number: 0557 • ACR Convergence 2023
Longitudinal Evaluation of Cell-bound Complement Activation Products in Patients with SLE
Jennifer Rogers¹, Amanda Eudy², Daniel Wojdyla³, Tyler O'Malley⁴, David Pisetsky⁵, Roberta Alexander⁴, Kai Sun¹, Lisa Criscione-Schreiber⁶, Jayanth Doss¹, Rebecca Sadun¹, Mithu Maheswaranathan⁶ and Megan Clowse⁷, ¹Duke University, Durham, NC, ²Duke University, Raleigh, NC, ³Duke Clinical Research Institute, Durham, NC, ⁴Exagen, Vista, CA, ⁵Duke University Medical Center, Durham, NC, ⁶Duke University School of Medicine, Durham, NC, ⁷Duke University, Chapel Hill, NC
Background/Purpose: Cell-bound complement activation products (CB-CAPs), when part of a multi-analyte assay with algorithm (MAP), are valuable SLE diagnostic biomarkers. Levels of erythrocyte-bound complement activation…
Abstract Number: 0573 • ACR Convergence 2023
Presence of Mediterranean Fever Gene Variants Provides Protection from the Development of Lupus Nephritis in Patients with Systemic Lupus Erythematosus
Yushiro Endo¹, Tomohiro Koga¹ and Atsushi Kawakami², ¹Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University, Nagasaki, Japan, ²Nagasaki University, Nagasaki, Japan
Background/Purpose: Previous studies showed that the prevalence of variants in Mediterranean Fever (MEFV) genes was lower in adult patients with SLE compared to healthy population…

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