Abstracts tagged "Systemic lupus erythematosus (SLE)"

Abstract Number: 1806 • ACR Convergence 2024
Bisphenol a Methylation Scores Associate with SLE and ClinicalSubphenotypes
Holme Vestin¹, Nina Oparina², Maija-Leena Eloranta¹, Martina Frodlund³, Iva Gunnarsson⁴, Christopher Sjowall⁵, Elisabet Svenungsson⁶, Lars Rönnblom¹, Ann-Christine Syvänen¹, Johanna Sandling¹, Juliana Imgenberg-Kreuz¹ and Dag Leonard¹, ¹Uppsala university, Uppsala, Sweden, ²UU, Uppsala, Sweden, ³Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection/Rheumatology, Linköping University, Linköping, Sweden, ⁴Karolinska Institute, Stockholm, Sweden, ⁵Linköping University, Linköping, Sweden, ⁶Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Systemic Lupus Erythematosus (SLE) is characterized by production of auto-antibodies, immune complex formation and an activated type I interferon system. Both genetic and environmental…
Abstract Number: 1945 • ACR Convergence 2024
The Bridge to Adult Care from Childhood for Young Adults with Rheumatic Disease (BACC YARD) Program, a Pediatric-to-Adult Rheumatology Transition Program: 2024 Updates
John Bridges¹, Eileen Rife², Randy Cron³, Livie Timmerman⁴, Linda McAllister⁵, Annelle Reed⁶, Carolyn Smith⁷, Emily Smitherman³, Matthew Stoll³, Bethany Walker⁵ and Melissa Mannion³, ¹University of Alabama at Birmingham/Children's of Alabama, Birmingham, AL, ²University of Alabama Birmingham, Vestavia Hills, AL, ³University of Alabama at Birmingham, Birmingham, AL, ⁴University of Alabama at Birmingham, Gardendale, AL, ⁵Children's of Alabama, Trussville, AL, ⁶Children's of Alabama, Tuscaloosa, AL, ⁷Children's of Alabama, Birmingham, AL
Background/Purpose: The transition period from pediatric to adult-oriented rheumatology care is a high-risk time for disease flare and poor outcomes. We previously demonstrated implementation of…
Abstract Number: 2371 • ACR Convergence 2024
The Role of Intracytoplasmic Toll- Like Receptors (TLR) and MyD88 in B Cell Subsets as Renal Response Predictors in Patients with Lupus Nephritis
Fabiola Cassiano-Quezada¹, José Jiram Torres-Ruiz², Jennifer Balderas Miranda³, José Luis Maravillas-Montero⁴, Karina Santana-de Anda², Beatriz Alcalá-Carmona⁵, Nancy R Mejía-Domínguez⁵, Yatzil Reyna-Juárez⁵, María José Ostos-prado⁵, Guillermo Juarez-Vega⁴ and Diana Gomez-martin⁶, ¹Department of Internal Medicine. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Distrito Federal, Mexico, ²Departament of Immunology and Rheumatology. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Distrito Federal, Mexico, ³Universidad Nacional Autónoma de México, Ciudad de México, Mexico, ⁴Red de Apoyo a la Investigación, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán and Universidad Nacional Autónoma de México, Mexico City, Distrito Federal, Mexico, ⁵Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Distrito Federal, Mexico, ⁶INCMNSZ, Mexico City, Federal District, Mexico
Background/Purpose: Recently, a gain of-function mutation within TLR7 was identified to induce SLE in a murine model and increased the survival of activated B lymphocytes,…
Abstract Number: 2388 • ACR Convergence 2024
Racial/Ethnic Variation in Multimorbidity Risk and Accrual and Comorbid Conditions Among Patients with Systemic Lupus Erythematosus
Katrina Williamson¹, Herbert Heien², Maria Stevens², Cynthia Crowson², Rozalina McCoy² and Ali Duarte-Garcia², ¹Mayo Clinic Rochester, Rochester, MN, ²Mayo Clinic, Rochester, MN
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have been shown to have increased burden of multimorbidity. Racial disparities in multimorbidity have also been shown repeatedly.…
Abstract Number: 2408 • ACR Convergence 2024
Impact of Pain and Fatigue on Quality of Life Among Patients with Systemic Lupus Erythematosus
Amanda Eudy¹, Megan Clowse², Meenakshi Jolly³, David Pisetsky⁴, Kai Sun⁵, Rebecca Sadun⁵, Lisa Criscione-Schreiber⁶, Mithu Maheswaranathan⁶, Jayanth Doss⁵ and Jennifer Rogers⁶, ¹Duke University, Raleigh, NC, ²Duke University, Chapel Hill, NC, ³Rush University Medical Center, Chicago, ⁴Duke University Medical Center, Durham, NC, ⁵Duke University, Durham, NC, ⁶Duke University, Durham
Background/Purpose: Our prior qualitative work discovered a subgroup of patients with SLE who experience persistent symptoms of fatigue and widespread pain, even on self-described “good…
Abstract Number: 2424 • ACR Convergence 2024
Anifrolumab Effects on Response to Influenza Vaccine in SLE
Cristina Arriens¹, Anca Askanase², Wambui Machua³, Fotios Koumpouras⁴, Ken Smith¹, Joel Guthridge¹, Judith James¹ and Joan Merrill⁵, ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Columbia University Medical Center, New York, NY, ³Piedmont Hospital Center, Atlanta, GA, ⁴Yale School of Medicine, New Haven, CT, ⁵Oklahoma Medical Research Foundation, Oklahoma City 73104, OK
Background/Purpose: Risk for infections in systemic lupus may arise from immunosuppressant treatments or intrinsic immune defects. Disordered interferon signals are a hallmark of SLE. Anifrolumab, which…
Abstract Number: 2545 • ACR Convergence 2024
Phosphodiesterase 1B Contributes to Neuropsychiatric Manifestations in Lupus-Prone Mice Through Microglial Activation
Shuhei Takeyama¹, Michihito Kono¹, Kohei Karino¹, Yuki Kudo¹, Masatoshi Kanda², Hiroyuki Nakamura², Kenichi Miyamoto¹, Kazuro Kamada³, Maria Tada¹, Ryo Hisada¹, Yuichiro Fujieda¹, Masaru Kato¹, Olga Amengual⁴ and Tatsuya Atsumi¹, ¹Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, Sapporo, Japan, ²Department of Rheumatology and Clinical Immunology, Sapporo Medical University, Sapporo, Japan, Sapporo, Japan, ³Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, Sapprp, Japan, ⁴Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Background/Purpose: Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the most severe organ manifestations in SLE and is associated with poor quality of life. We…
Abstract Number: 2604 • ACR Convergence 2024
Altered Expression of Ecto-5′-Nucleotidase (NT5E) in SLE Patients Based on Disease-associated Genotype
Mikhail Olferiev¹, Katherine Owen², Peter Lipsky³ and Mary Crow¹, ¹Hospital for Special Surgery, New York, NY, ²RILITE, Charlottesville, VA, ³AMPEL BioSolutions, Charlottesville, VA
Background/Purpose: The NT5E gene, encoding Ecto-5'-Nucleotidase/CD73, is expressed on the surface of immune system cells and is critical for converting AMP/IMP to adenosine/inosine, important immunosuppressive purine nucleosides.…
Abstract Number: PP15 • ACR Convergence 2024
Breathing Mindfully and How to Control Anxiety in Lupus Patients
Amanda Greene, Lupus Research Alliance, Los Angeles, CA
Background/Purpose: For over four decades, Systemic Lupus Erythematosus has impacted my Quality of Life.. I was diagnosed in 1983- my entire life was changed. I…
Abstract Number: 0092 • ACR Convergence 2024
A New Generation Mesenchymal Stromal Cell (MSC)-based Cell Therapy Using Design of Experiments Halts Pristane Induced Glomerulosclerosis
Hulya Bukulmez¹, Adrienne Dennis², kristine Highland³ and Steven N. Emancipator⁴, ¹MetroHealth Medical Center, Case Western Reserve, Pepper Pike, OH, ²MetroHealth Medical Center, Case Western Reserve, Cleveland, OH, ³Cleveland Clinic Foundation, Cleveland, OH, ⁴Case Western Reserve University, Cleveland, OH
Background/Purpose: MSCs, exposed to a disease-specific cytokine profile, can accurately sense the composition of the inflammatory microenvironment. We have harnessed this adaptive ability of MSCs…
Abstract Number: 0167 • ACR Convergence 2024
Epidemiology of Falls in a Diverse Cohort of Adults with SLE
Laura Plantinga¹, Charmayne M. Dunlop-Thomas², Courtney Hoge³, Jinoos Yazdany⁴ and C. Barrett Bowling⁵, ¹University of California, San Francisco, San Francisco, CA, ²Emory University School of Medicine, Department of Medicine, Division of Rheumatology, Atlanta, GA, ³Emory University, Atlanta, GA, ⁴UCSF, San Francisco, CA, ⁵Duke University, Durham, NC
Background/Purpose: While often preventable, falls are a common, costly, and serious outcome in the U.S. population: more than one in four adults ³65 years old…
Abstract Number: 0191 • ACR Convergence 2024
Beyond the Symptoms: Exploring Cognitive Bias in Lupus Diagnosis Within Primary Care
Alyssa Howren¹, Quan Le Tran¹, Sadaf Sediqi¹, Saadiya Hawa², Eleni Linos¹, Titilola Falasinnu³, Yashaar Chaichian¹ and Julia Simard¹, ¹Stanford School of Medicine, Stanford, CA, ²Weiss Memorial Hospital, Chicago, IL, ³Stanford School of Medicine, Palo Alto, CA
Background/Purpose: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune rheumatic disease whose prognosis varies by race and sex. To understand whether the cognitive processes of…
Abstract Number: 0353 • ACR Convergence 2024
Identifying Solutions to Address Racial and Ethnic Health Disparities in Lupus: A Consensus-Based Approach
Joy Buie¹, Michael Fisher¹, Hannah Tlydsley², Kristen Backor² and Karen Costenbader³, ¹Lupus Foundation of America, Washington, DC, ²Charles River Associates, San Francisco, CA, ³Brigham and Women's Hospital/ Harvard Medical School, Boston, MA
Background/Purpose: Health disparities among racial and ethnic minoritized individuals living with lupus remain a critical public health concern. Challenges related to healthcare affordability, accessibility, and…
Abstract Number: 0445 • ACR Convergence 2024
Evaluating Clinical Reasoning in Randomized Surveys of Lupus Nephritis and Preeclampsia Pregnancy Case Workups: A Clinical Conundrum
Liya Stolyar¹, Sadaf Sediqi², Richard Lafayette³, Maurice Druzin⁴, Saadiya Hawa⁵, Amanda Moyer⁶, Yashaar Chaichian² and Julia Simard², ¹Palo Alto VA Medical Center/Stanford, Stanford, CA, ²Stanford School of Medicine, Stanford, CA, ³Stanford, Stanford, CA, ⁴Stanford University School of Medicine, Stanford, CA, ⁵Weiss Memorial Hospital, Chicago, IL, ⁶Stanford University, San Bruno, CA
Background/Purpose: Systemic lupus erythematosus (SLE) pregnancy is associated with a heightened risk of adverse pregnancy outcomes, including preeclampsia. Distinguishing preeclampsia from lupus nephritis (LN) presents…
Abstract Number: 0619 • ACR Convergence 2024
Prevalence and Factors Predicting Hemophagocytic Lymphohistiocytosis in Hospitalized Patients with Systemic Lupus Erythematosus
OKEOGHENE AKPOIGBE¹, BETTINA ESCOLANO², ENOCH J ABBEY² and Amanda Sammut³, ¹New York City Health and Hospitals/Harlem in Affliation with Columbia University, NEW YORK, NY, ²New York City Health and Hospitals/Harlem in Affliation with Columbia University, NEW YORK, ³New York City Health and Hospitals/Harlem. Rheumatology Department, Chappaqua, NY
Background/Purpose: Systemic lupus erythematosus (SLE) complicated with hemophagocytic lymphohistiocystosis (HLH) can be life-threatening with mortality as high as 9.9%-10.5%. Estimates of the prevalence of HLH…

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