ACR Meeting Abstracts

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Abstracts tagged "Systemic lupus erythematosus (SLE)"

  • Abstract Number: 2553 • ACR Convergence 2023

    Prevalence, Determinants and Outcomes of Target Attainment in SLE Patients with Clinically Active Disease in a Large Multinational Prospective Lupus Cohort

    Yanjie Hao1, Dylan Hansen2, Rangi Kandane-Rathnayake3, Worawit Louthrenoo4, Yi-Hsing Chen5, Jiacai Cho6, Aisha Lateef6, Laniyati Hamijoyo7, Shue-Fen Luo8, Yeong-Jian J Wu9, Sandra Navarra10, Leonid Zamora10, Zhanguo Li11, Sargunan Sockalingam12, Yasuhiro Katsumata13, Masayoshi Harigai13, Zhuoli Zhang14, Madelynn Chan15, Jun Kikuchi16, Tsutomu Takeuchi17, Sang-Cheol Bae18, Fiona Goldblatt19, Sean O’Neill20, Kristine Ng21, Annie Law22, BMDB Basnayake23, Nicola Tugnet24, Sunil Kumar25, Cherica Tee26, Michael Tee26, Yoshiya Tanaka27, Chak Sing Lau28, Vera Golder3, Alberta Hoi29, Eric Morand30, Shereen Oon31 and Mandana Nikpour32, 1The University of Melbourne Department of Medicine at St Vincents Hospital Melbourne, Melbourne, Australia, 2Department of Rheumatology, St Vincent’s Hospital Melbourne, Fitzroy, Australia, 3Monash University, Department of Medicine, Sub-faculty of Clinical and Molecular Medicine, Clayton, Australia, 4Chiang Mai University Hospital, Department of Internal Medicine, Faculty of Medicine, Chiang Mai, Thailand, 5Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan, 6National University Hospital, Rheumatology Division, Department of Medicine, Singapore, Singapore, 7Padjadjaran University/Hasan Sadikin General Hospital, Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Bandung, Indonesia, 8Chang Gung University, Department of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, 9Chang Gung University, Department of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Keelung, Taiwan, 10University of Santo Tomas Hospital, Joint and Bone Center, Manila, Philippines, 11Peking University Health Science Center, Department of Rheumatology and Immunology, People's Hospital, Beijing, China, 12University of Malaya, Department of Medicine, Faculty of Medicine Building, Kuala Lumpur, Malaysia, 13Tokyo Women's Medical University, Division of Rheumatology, Department of Internal Medicine, Tokyo, Japan, 14Peking University First Hospital, Rheumatology and Immunology Department, Beijing, China, 15Tan Tock Seng Hospital, Department of Rheumatology, Allergy & Immunology, Singapore, Singapore, 16Keio University School of Medicine, Tokyo, Japan, 17Keio University School of Medicine and Saitama Medical University, Tokyo, Japan, 18Hanyang University Hospital for Rheumatic Diseases and Hanyang University Institute for Rheumatology Research, Department of Rheumatology, Seoul, South Korea, 19Royal Adelaide Hospital and Flinders Medical Centre, Adelaide, Australia, 20Department of Medicine, University of New South Wales, Kensington, Australia, 21Waitemata DHB, Auckland, New Zealand, 22Singapore General Hospital; Duke-NUS Medical School, Singapore, Singapore, 23Division of Nephrology, Teaching Hospital Kandy, Adelaide, Australia, 24Auckland District Health Board, Auckland, New Zealand, 25Middlemore Hospital, Auckland, New Zealand, 26University of the Philippines, Manila, Philippines, 27University of Occupational and Environmental Health, Kitakyushu, Japan, 28University of Hong Kong, Division of Rheumatology & Clinical Immunology, Department of Medicine, Queen Mary Hospital, Hong Kong, Hong Kong, 29Monash University, Department of Medicine, Sub-faculty of Clinical and Molecular Medicine, Melbourne, Australia, 30Monash University, Centre for Inflammatory Diseases, Melbourne, Australia, 31University of Melbourne at St Vincent’s Hospital, Departments of Rheumatology and Medicine, Fitzroy, Australia, 32The University of Melbourne at St. Vincent’s Hospital Melbourne, Departments of Medicine and Rheumatology, Melbourne, Australia

    Background/Purpose: There is increasing interest in adopting the principle of treating to target (T2T) in systemic lupus erythematosus (SLE). Remission and low disease activity states…
  • Abstract Number: 0120 • ACR Convergence 2023

    Incidence and Prevalence of Systemic Lupus Erythematosus in Urban China, 2013-2017: A Nationwide Population-based Study

    Mucong Li1, Chaiquan Li2, Mengzhuo Cao3, Ke Lu2, Chanyuan Wu3, Jiuliang zhao1, Qian Wang4, Xinping Tian1, Xun Tang2, Mengtao Li1, xiaofeng Zeng4 and Pei Gao2, 1Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, 2Peking University, Beijing, China, 3Peking Union Medical College Hospital, Beijing, China, 4Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

    Background/Purpose: Systemic lupus erythematosus (SLE) is becoming a public health concern because of increasing disease and economic burdens. Epidemiological information on SLE, especially its incidence…
  • Abstract Number: 0184 • ACR Convergence 2023

    Material Need Insecurities Are Associated with Worse Patient-Reported Outcomes Among Individuals with SLE

    Donavon Sandoval-Heglund1, Eric Roberts2, Joonsuk Park2, Maria Dall'Era2, Kamil Barbour3, Cristina Lanata4, Kurt Greenlund3, Caroline Gordon5, Patti Katz6 and Jinoos Yazdany2, 1University of California San Francisco School of Medicine, La Quinta, CA, 2University of California San Francisco, San Francisco, CA, 3Centers for Disease Control and Prevention, Atlanta, GA, 4National Human Genome Research Institute, Washington, DC, 5Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, 6University of California San Francisco, San Rafael, CA

    Background/Purpose: Lower socioeconomic status is associated with greater disease activity and mortality in systemic lupus erythematosus (SLE); however, mechanisms driving this are yet to be…
  • Abstract Number: 0463 • ACR Convergence 2023

    Appropriate Preconception Care Improves Pregnancy Outcomes in SLE Patients

    Hiromi Shimada1, Rina Mino2, Risa Wakiya3, Shusaku Nakashima3, Taichi Miyagi4, Yusuke Ushio5, Koichi Sugihara6, Mao Mizusaki3, Kanako Chujo7, Ryoko Kagawa5, Hayamasa Yamaguchi5, Tomohiro Kameda3 and Hiroaki Dobashi3, 1Kagawa University, Kagawa, Japan, 2Kagawa University, Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa, Japan, 3Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan, 4Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kidagun, Japan, 5Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Miki-cho, Kita-gun, Japan, 6Kagawa University, Miki-cho, Kita-gun, Japan, 7Kagawa University, Miki, Kita District, Kagawa, Japan

    Background/Purpose: Pregnancies complicated by systemic lupus erythematosus (SLE) are known to be at high risk for adverse pregnancy outcomes (APOs). Previous studies have shown that…
  • Abstract Number: 0555 • ACR Convergence 2023

    Evaluation and Management of the “False Positive” ANA and Undifferentiated Connective Tissue Disease Amongst Rheumatologists

    Neha Gupta1, Sarah Ford2, Lane Scheiber2, Tangada Rao2 and Abhishek Nandan2, 1Virginia Commonwealth University Health Systems, Richmond, VA, 2Virginia Commonwealth University Health Systems; Veterans Affairs Medical Center, Richmond, VA

    Background/Purpose: The management of a positive anti-nuclear antibody (ANA) is one of the most common consultations in rheumatology outpatient practice. The prevalence of a positive…
  • Abstract Number: 0572 • ACR Convergence 2023

    Serum/ Urine Levels and Expression of CD163 in Lupus Nephritis

    Erdem Gurel1, Suzan Cinar2, Ozge Hurdogan3, Yasemin Ozluk3, Isin Kilicaslan4, Sibel Varelci1, Safak Mirioglu5, Yasemin Yalcinkaya6, Ahmet Gul6, Lale Ocal1, Murat Inanc6 and Bahar Artim-Esen6, 1Division of Rheumatology, Istanbul University Istanbul School of Medicine, Istanbul, Turkey, 2Department of Immunology, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey, 3Department of Pathology, Istanbul University Istanbul School of Medicine, Istanbul, Turkey, 4Department of Pathology, Istanbul University Istanbul School of Medicine, Istanbıl, Turkey, 5Division of Nephrology, Bezmialem Vakif University School of Medicine, Istanbul, Turkey, 6Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

    Background/Purpose: CD163 is a glycosylated membrane protein expressed in monocytes and macrophages that phagocytize the hemoglobin/haptoglobin complex. As a result of proinflammatory stimuli, CD163 is…
  • Abstract Number: 0590 • ACR Convergence 2023

    Comparing Safety and Efficacy of Sodium-Glucose Co-Transporter 2 Inhibitors versus Dipeptidyl Peptidase 4 Inhibitors in Patients with Systemic Lupus Erythematosus and Comorbid Type 2 Diabetes Mellitus

    Jui-En Lo1, Pin-Chia Huang2, George Tsokos3, Vasileios Kyttaris4, Karen Costenbader5 and Kevin Sheng-Kai Ma2, 1Center for Global Health, Perelman School of Medicine, Philadelphia, PA, 2Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 3Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 4BIDMC, Boston, MA, 5Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: Sodium-glucose co-transporter 2 inhibitors (SGLT2i), originally approved as oral hypoglycemic agents for type 2 diabetes (T2D), have been shown to reduce progression to end-stage…
  • Abstract Number: 0723 • ACR Convergence 2023

    Investigating the Effects and Molecular Mechanisms of TRAF5 on the Pathogenesis of SLE Associated Pulmonary Arterial Hypertension

    Xiaoyue Deng1, Junyan Qian1, Ranran Wang2, JIULIANG ZHAO3, Qian Wang4, Tianyi Yuan2, MENGTAO LI1 and Xiaofeng Zeng5, 1Peking Union Medical College Hospital, Beijing, China, 2Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, 3Beijing Union Medical College Hospital, Beijing, China, 4Peking Union Medical College, Beijing, China, 5Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

    Background/Purpose: Pulmonary arterial hypertension (PAH) is a serious complication in SLE patients, with rapid progression and poor prognosis. In China, approximately 3% of the over…
  • Abstract Number: 0848 • ACR Convergence 2023

    Performance of Serum MRP8/14, sCD14, IL-6 and Neutrophil CD64 in Isolation and in Combination for Differentiating Flare from Bacterial Infection in Febrile SLE Patients

    Kishan Majithiya1, Komal Singh1, Pankti Mehta2, Chengappa Kavadichanda3, seema Sharma1, Able Lawrence1 and Amita Aggarwal1, 1Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India, 2King George's Medical University, Mumbai, India, 3Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India

    Background/Purpose: Disease flare and infections are the major causes of fever in a patient with SLE. It is vital to differentiate between these two as…
  • Abstract Number: 0903 • ACR Convergence 2023

    Effects of Hydroxychloroquine on Maternal Outcomes in Pregnant Patients with Systemic Lupus Erythematous

    Yurilu Gonzalez1 and Irene Tan2, 1Albert Einstein Medical Center, Wyncote, PA, 2Einstein Medical Center Philadelphia, Bala Cynwyd, PA

    Background/Purpose: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease, that affects women of childbearing age. SLE is a high-risk condition in pregnant patients due…
  • Abstract Number: 0924 • ACR Convergence 2023

    Distinct Cell-Bound Complement Activation Products Associate with Disease Activity and Immune Transcriptional Signatures in SLE

    Gabriel Arguelles, Lynne Mitchell, Dennis Hourcade, John Atkinson, Elisha Roberson and Alfred Kim, Washington University School of Medicine, St. Louis, MO

    Background/Purpose: Complement plays a central role in SLE, generating an array of bioactive soluble and cell-bound complement activation products (CB-CAPs) during disease activity. Data are…
  • Abstract Number: 1094 • ACR Convergence 2023

    “Lupus Doesn’t Have Me, I Have Lupus” a Patient Centered Quality Improvement Project to Increase Medication Adherence for Patients with Lupus Nephritis

    Christopher Macko1, Patty Chen2, Roger Santos3, Nirmala Ramalingam4, Nicole Tran5 and Sijie Zheng6, 1Kaiser Oakland Internal Medicine Residency, Piedmont, CA, 2Kaiser Oakland Medical Center Department of Rheumatology, Orinda, CA, 3Kaiser East Bay Department of Pharmacy, Oakland, CA, 4Kaiser Oakland Medical Center Department of Graduate Medical Education, Oakland, CA, 5Kaiser Oakland Department of Adult and Family Medicine, Oakland, CA, 6Kaiser Oakland Medical Center Department of Nephrology, Oakland, CA

    Background/Purpose: Lupus nephritis (LN) is the most common cause of kidney injury in patients with systemic lupus erythematous (SLE) and is associated with higher morbidity…
  • Abstract Number: 1247 • ACR Convergence 2023

    Pharmacokinetic, Pharmacodynamic, and Safety Profile of Subcutaneous Belimumab in Pediatric Patients with Systemic Lupus Erythematosus: Analysis of Data from a Multicenter, Open-Label Trial

    Hermine Brunner1, Diego Oscar Viola2, Richard Dimelow3, Inmaculada Calvo Penadés4, Christel Wilkinson5, Juan Cruz Rizo Rodriguez6, Alina Boteanu7, Sylvia Kamphuis8, Kirsten Minden9, Gerd Horneff10, Jordi Anton11, Masaaki Mori12, Yuichi Yamasaki13, Jose Miyar Olaiz14, Rebecca Marino15, Andre van Maurik16, Mohamed Okily17, Emad Yanni18 and Paul WIlde19, 1Cincinnati Children's Hospital Medical Center, Division of Rheumatology, Cincinnati, OH, 2CAICI Institute, Pediatric Rheumatology, Santa Fe, Argentina, 3GlaxoSmithKline, Clinical Pharmacology Modelling and Simulation, Stevenage, United Kingdom, 4Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, València, Spain, 5GlaxoSmithKline, Clinical Statistics, Stevenage, United Kingdom, 6Centro de Alta Especialidad en Reumatologia e Investigacion del Potosi, San Luis Potosí, Mexico, 7Hospital Universitario Ramón y Cajal, Departamento de Reumatología, Madrid, Spain, 8Erasmus University Medical Center, Department of Pediatric Rheumatology, Rotterdam, Netherlands, 9Charité Universitätsmedizin Berlin, Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Berlin, Germany, 10Asklepios Klinik Sankt Augustin GmbH, Bonn, Germany, 11Hospital Sant Joan de Déu, Pediatric Rheumatology Department, Universitat de Barcelona, Barcelona, Spain, 12Tokyo Medical and Dental University Hospital, Department of Lifetime Clinical Immunology, Tokyo, Japan, 13Kagoshima University Hospital, Department of Pediatrics, Kagoshima, Japan, 14GlaxoSmithKline, Safety Evaluation and Risk Management, Brentford, United Kingdom, 15GlaxoSmithKline, Safety Evaluation and Risk Management, Durham, NC, 16GlaxoSmithKline, Clinical Pharmacology and Experimental Medicine, Brentford, United Kingdom, 17GlaxoSmithKline, Clinical Development, ImmunoInflammation, Brentford, United Kingdom, 18GlaxoSmithKline, Clinical Development, Rockville, MD, 19GlaxoSmithKline, Clinical Development, Brentford, United Kingdom

    Background/Purpose: Belimumab (BEL) is an approved treatment for SLE, in addition to standard therapy. Intravenous (IV) BEL is approved in patients (pts) ≥5 years of…
  • Abstract Number: 1446 • ACR Convergence 2023

    Glucocorticoids Use Is a Major Driver of Self-perceived Depression in Systemic Lupus Erythematosus: Insights from a Large, Prospective and Multicenter Study Using RELESSERPROS Register’s Database

    Iñigo Rúa-Figueroa1, JULIA MARTINEZ BARRIO2, Norman Jiménez3, Maria Galindo-Izquierdo4, Esther Uriarte Isacelaya5, Antonio Fernandez-Nebro6, Jaime Calvo- Alén7, SARA MANRIQUE8, Jose Rosas9, Rocío Caño-Alameda10, Javier Narvaez11, Inmaculada Ros12, Elena Aurrecoechea Aguinaga13, Vicente Torrente-Segarra14, Clara Sanguesa Gomez15, Mercedes Freire González16, Eva Tomero Muriel17, Loreto Horcada18, Clara Moriano Morales19, Mireia Moreno20, Carlota Iñíguez21, Ricardo Blanco22, Ana Pérez Gómez23, Jose Luis Andreu-Sánchez24, Sandra Garrote Corral25, Santiago Muñoz26, Gema Bonilla27, Nuria Lozano Rivas28, Carlos Montilla-Morales29, Oihane Ibarguengoitia-Barrena30, Lorena Expósito31, Elia Valls-Pascual32, Angela Pecondon-Español33, Sergio Machin34, Eva Salgado-Pérez35, Celia Erausquin36, TAREK CARLOS SALMAN MONTE37, Raúl Menor-Almagro38, Alejandro Muñoz39, Irene Altabas Gonzalez40, Jorge Juan Fragio41 and Jose-Maria Pego-Reigosa42, 1Rheumatology, Hospital de Gran Canaria Doctor Negrin, Las Palmas de Gran Canaria, Spain, 2Rheumatology, Gregorio Marañon University Hospital, Madrid, Spain, 3IIRIDIS (Investigation in Rheumatology and Immune-Mediated Diseases) Group, Galicia Sur Health Research Institute., Vigo, Spain, 4Rheumatology, University Hospital of 12 de Octubre, Madrid, Spain, 5Rheumatology, University Hospital of Donosti, San Sebastián, Spain, 6Hospital Regional Universitario de Málaga, Malaga, Spain, 7Rheumatology, Bioaraba Research Unit, Hospital Universitario Araba, Vitoria, Spain, 8Division of Rheumatology, Hospital Regional Universitario Carlos Haya, Malaga, Spain, 9Hospital Marina Baixa, Alicante, Spain, 10Rheumatology Department, Dr. Balmis University General Hospital, Alicante. Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain, 11Hospital Universitario de Bellvitge, Barcelona, Spain, 12Rheumatology Department HUSLL, Palma de Mallorca, Spain, 13Department of Rheumatology, Hospital Sierrallana, Torrelavega, Spain, 14Department of Rheumatology, Hospital de Sant Joan Despí Moises Broggi,, Sant Joan Despí, Spain, 15Severo Ochoa Hospital, Madrid, Spain, 16Rheumatology department, Complexo Hospitalario Universitario A Coruña (CHUAC). Instituto de Investigación Biomédica A Coruña (INIBIC), A Coruña, Spain, 17Rheumatology, Hospital La Princesa, Madrid, Spain, 18Hospital de Navarra, Pamplona, Spain, 19Rheumatology, Hospital Universitario de León, León, Spain, 20Parc Tauli Hospital Universitari, I3PT(UAB), Barcelona, Spain, 21Hospital Lucus Augusti, Lugo, Spain, 22Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 23Rheumatology, Hospital Principe de Asturias, Alcalá de Henares, Spain, 24Rheumatology, Hospital Universitario Puerta de Hierro, Majadahonda, Spain, 25Hospital Ramón y Cajal, Madrid, Spain, 26Hospital Infanta Sofia, Madrid, Spain, 27Department of Rheumatology, Hospital Clínico Universitario La Paz, Madrid, Spain, 28Department of Rheumatology, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain, 29Rheumatology, University Hospital of Salamanca, Salamanca, Spain, 30Galdakao-Usansolo University Hospital, Bilbao, Spain, 31Rheumatology Unit, Hospital Universitario de Canarias, San Cristóbal de La Laguna, Spain, 32Hospital Universitario Doctor Peset. Alicante, Spain., Valencia, Spain, 33Hospital Miguel Servet, Zaragoza, Spain, 34CHUIMI, Las Palmas de Gran Canaria, Spain, 35Department of Rheumatology, University Hospital of Ourense, Ourense, Spain, 36Rheumatology Department Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain, 37Hospital del Mar/Parc de Salut Mar-IMIM, Barcelona, Spain, 38Rheumatology, Hospital Jerez, Puerto De Santa María, Spain, 39Hospital universitario Virgen del Rocío, El Viso de Alcor, Spain, 40Complejo Hospitalario Universitario de Vigo, IRIDIS (Investigation in Rheumatology and Immune-Mediated Diseases) Group, Galicia Sur Health Research Institute, Vigo, Spain, 41Hospital General Universitario Valencia, Valencia, Spain, 42Rheumatology, Hospital do Meixoeiro, Vigo, Spain

    Background/Purpose: The prevalence of depression and associated factors in systemic lupus erythematosus (SLE) are not well known and there are no longitudinal studies addressing this…
  • Abstract Number: 1463 • ACR Convergence 2023

    Predictors of Cognitive Impairment in Individuals with Systemic Lupus Erythematosus

    Alexandra Lee1, Sharon Phillips2 and Leslie Crofford3, 1Meharry Medical College, Nashville, TN, 2Vanderbilt University Medical Center, Nashville, TN, 3Vanderbilt University Medical Center, Melbourne, AR

    Background/Purpose: The purpose of this study was to investigate factors associated with objective cognitive impairment in patients diagnosed with Systemic Lupus Erythematous (SLE). Subjective complaints…
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