Abstracts tagged "Systemic lupus erythematosus (SLE)"

Abstract Number: 2622 • 2014 ACR/ARHP Annual Meeting
Systemic LUPUS Erythematosus in Spanish Males
Anne Riveros-Frutos¹, Irma Casas², Iñigo Rúa-Figueroa³, José Maria Pego-Reigosa⁴, M. Jesús García de Yebenes⁵, Alejandro Olivé⁶, Jose Rosas⁷, Paloma Vela⁸, Monica Ibanez Barcelo⁹, Vicente Torrente¹⁰, Ivan Castellvi¹¹, Javier Narváez¹², Mireia Moreno¹³, R. Blanco Alonso¹⁴, Víctor Martínez Taboada¹⁵, Jaime Calvo-Alen¹⁶, Mª Angeles Aguirre¹⁷, Mercedes Freire¹⁸, Enrique Raya¹⁹, Celia Erausquin²⁰, Esther Uriarte²¹, Elvira Díez Álvarez²², Tomás Vázquez Rodríguez²³, Antonio Fernández Nebro²⁴, Eva Tomero²⁵, Paloma García de la Peña²⁶, Ana Sánchez Atrio²⁷, Monica Fernández de Castro²⁸, Antonio Zea²⁹, Patricia Richi³⁰, Francisco Lopez Longo³¹, María Galindo-Izquierdo³², Patricia Carreira³³, Gema Bonilla³⁴, Carlos Marras Fernández Cid³⁵, Maria Loreto Horcada³⁶, Carlos Montilla³⁷, Blanca Hernández-Cruz³⁸, José Marenco de la Fuente³⁹, Marian Gantes⁴⁰, Olaia Fernández Berrizbeitia⁴¹, Juan J. Alegre⁴², Ángela Pecondón Español⁴³, Manuel Rodríguez-Gómez⁴⁴, Victor Quevedo⁴⁵, José Hernández Beiraín⁴⁶ and Lucía Silva Fernández⁴⁷, ¹Rheumatology, Hospital Universitario Germans Trias i Pujol, Badalona, Spain, ²Preventive Medicine, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain, ³Rheumatology, Hospital Doctor Negrin, Las Palmas de Gran Canaria, Spain, ⁴Rheumatology, Hospital Meixoeiro, Vigo, Spain, ⁵Rheumatology, Research Unit of the SER, Madrid, Spain, ⁶Rheumatology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain, ⁷Rheumatology, Hospital Marina Baixa. Villajoyosa, Villajoyosa, Spain, ⁸Rheumatology, Hospital General de Alicante. Spain, Alicante, Spain, ⁹H. Son Llatzer, Palma de Mallorca, Spain, ¹⁰Rheumatology, Hospital Moisès Broggi, Barcelona, Spain, ¹¹Unitat de Reumatologia., Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, ¹²Rheumatology, Hospital Universitario de Bellvitge. Barcelona. Spain, Barcelona, Spain, ¹³Rheumatology, Hospital Parc Taulí, Sabadell, Spain, ¹⁴Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Spain, ¹⁵Rheumatology, Marqués de Valdecilla, Santander, Spain, ¹⁶Rheumatology, Hospital de Sierrallana. Torrelavega. Spain, Torrelavega, Spain, ¹⁷Rheumatology, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, ¹⁸Rheumatology, Hospital Universitario Juan Canalejo, La Coruña, Spain, ¹⁹Rheumatology, University Hospital San Cecilio, Granada, Spain, ²⁰Rheumatology, Hospital Dr, Negrín, Las Palmas Gran Canarias, Spain, ²¹Rheumatology, Hospital de Donosti, San Sebastian, Spain, ²²Rheumatology, Hospital de León. Spain, León, Spain, ²³Rheumatology, Hospital Lucus Augusti, Lugo, Spain, ²⁴Rheumatology, Hospital Carlos Haya. Malaga, Malaga, Spain, ²⁵Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, ²⁶Rheumatology, Hospital Norte Sanchinarro, Madrid, Spain, ²⁷Hospital Príncipe de Asturias, Immune System Diseases/Rheumatology department, Alcalá de Henares, Madrid, Spain, ²⁸Hospital Puerta del Hierro, Madrid, Spain, ²⁹Rheumatology, Hospital Universitario Ramon y Cajal, Madrid, Spain, ³⁰Hospital Infanta Sofía, Madrid, Spain, ³¹Rheumatology, Hospital Gregorio Marañón, Madrid, Spain, ³²Rheumatology, Hospital 12 de octubre, Madrid, Spain, ³³Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ³⁴Rheumatology, Hospital La Paz, Madrid, Spain, ³⁵Hospital Virgen de la Arrixaca, Murcia, Spain, ³⁶Rheumatology, Complejo Hospitalario de Navarra, Pamplona, Spain, ³⁷Rheumatology, Hospital Clínico Universitario de Salamanca, Salamanca, Spain, ³⁸Rheumatology, University Hospital Virgen Macarena, Sevilla, Spain, ³⁹Rheumatology, Hospital de Valme, Sevilla, Spain, ⁴⁰Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain, ⁴¹Rheumatology, Hospital de Basurto, Bilbao, Spain, ⁴²Rheumatology, Hospital Universitario Dr Peset, Valencia, Spain, ⁴³Rheumatology, Hospital Miguel Servet, Zaragoza, Spain, ⁴⁴Rheumatology, Complejo Hospitalario Universitario de Ourense, Ourense, Spain, ⁴⁵Rheumatology, Hospital de Monforte, Lugo, Spain, ⁴⁶Rheumatology, Hospital Insular de Gran Canaria, Las palmas Gran Canarias, Spain, ⁴⁷Rheumatology, Hospital Universitario de Guadalajara, Guadalajara, Spain

Background/Purpose: To describe the demographic, clinical and immunological manifestations in male patients with Systemic Lupus Erythematosus(SLE) Methods: Patients diagnosed of SLE that were in the…
Abstract Number: 1859 • 2014 ACR/ARHP Annual Meeting
Age-Specific Predictors of Mortality in SLE
Dominique Ibanez¹, Dafna D. Gladman² and Murray B. Urowitz², ¹Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Mortality is 3 to 5 times greater in SLE patients then it is in the general population – especially among younger patients where it…
Abstract Number: 1652 • 2014 ACR/ARHP Annual Meeting
Biomarkers of Lupus Nephritis and Ethnic Disparities in Systemic Lupus Erythematosus
Adnan Kiani¹, Laurence S. Magder² and Michelle Petri³, ¹1830 E Monument St, Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD, ³Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Lupus nephritis eventually occurs in 50% of Caucasian SLE patients and 75% of African-Americans. African Americans have a more severe presentation of SLE and…
Abstract Number: 1595 • 2013 ACR/ARHP Annual Meeting
Electroclinical Correlates and Outcome Of Status Epilepticus In Systemic Lupus Erythematosus
Jamal Mikdashi¹, Tricia Ting² and Allan Krumholz³, ¹Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore, MD, ²Neurology, University of Maryland. School of Medicine, Baltimore, MD, ³Neurology, University fo Maryland school of Medicine, Baltimore, MD
Background/Purpose: Predictors of seizures and epilepsy in systemic lupus erythematosus (SLE) patients are well described but descriptions of status epilepticus (SE) have thus far been…
Abstract Number: 1577 • 2013 ACR/ARHP Annual Meeting
Comparison Of Clinical and Serological Manifestations Among Juvenile-, Adult-, and Late-Onset Systemic Lupus Erythematosus Patients In Korea
Dong-Jin Park¹, Ji-Hyoun Kang², Kyung-Eun Lee¹, Jeong-Won Lee², Lihui Wen¹, Tae-Jong Kim³, Yong-Wook Park¹ and Shin-Seok Lee⁴, ¹Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, ²Chonnam National University Medical School, Gwangju, South Korea, ³Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea, ⁴Dept of Int Med/Rheumatology, Chonnam National University Medical School, Gwangju, South Korea
Background/Purpose: Up to 30‑40% of patients with systemic lupus erythematosus (SLE) experience their onset prior to adulthood or at over 50 years of age. Patients…
Abstract Number: 1060 • 2013 ACR/ARHP Annual Meeting
Perinatal Risk Factors For Systemic Lupus: A Register-Based Case-Control Study
Elizabeth V. Arkema¹ and Julia F. Simard^2,3, ¹Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ²Depts of Health Research and Policy and Immunology & Rheumatology, Stanford University School of Medicine, Stanford, CA, ³Clinical Epidemiology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: One’s own fetal environment has been linked to future heart disease, breast cancer, and rheumatoid arthritis. Prior work showed that among older women in…
Abstract Number: 586 • 2013 ACR/ARHP Annual Meeting
Blood Pressure Variability and Age-Related Blood Pressure Patterns In Systemic Lupus Erythematosus
George Stojan¹, Laurence S. Magder² and Michelle Petri³, ¹Div of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD, ³Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Increased visit-to-visit blood pressure (BP) variability has been associated with an increased risk of all-cause mortality, stroke, left ventricular diastolic dysfunction, and cognitive impairment…
Abstract Number: 597 • 2013 ACR/ARHP Annual Meeting
Low Complement (C3), Male Gender and Methotrexate Use Are Associated With Noncalcified Plaque In Systemic Lupus Erythematosus
Adnan Kiani¹, Armin Zadeh², Jens Vogel-Claussen¹, Joao Lima², Laurence S. Magder³ and Michelle Petri¹, ¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Johns Hopkins University, Baltimore, MD, ³Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD
Background/Purpose: New technology (CTA) can measure non-calcified coronary plaque (NCP), which is highly unstable and prone to rupture. We quantified NCP in SLE and determined…
Abstract Number: 574 • 2013 ACR/ARHP Annual Meeting
Oral Candidiasis in Systemic Lupus Erythematosus
Monthida Fangtham, Hong Fang and Michelle Petri, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Candida is the most common opportunistic fungal infection identified in SLE. In a previous autopsy study, 14 percent of deaths in SLE patients were…
Abstract Number: 2899 • 2013 ACR/ARHP Annual Meeting
Outcome Of Incidental Silent Strokes In Systemic Lupus Erythematosus
Jamal Mikdashi, Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Silent strokes are brain infarcts that lack clinically overt stroke-like symptoms and fail to come to clinical attention. The prevalence of incidentally detected acute/subacute…
Abstract Number: 2738 • 2013 ACR/ARHP Annual Meeting
Microrna-Mediated Regulation Explains Allelic Risk Of TLR7 Variant Predisposing To Systemic Lupus Erythematosis
Yun Deng¹, Jian Zhao¹, Jennifer M. Grossman² and Betty P. Tsao¹, ¹Division of Rheumatology, Department of Medicine, David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA, ²Division of Rheumatology, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: We identified a genome-wide significant association of the TLR7 variant (rs3853839) with SLE susceptibility in multiple ancestries (Pmeta =2.0×10-19, OR =1.25), and the risk…
Abstract Number: 2505 • 2013 ACR/ARHP Annual Meeting
Higher Disease Damage Among African Americans With Familial Versus Sporadic Systemic Lupus Erythematosus
April Barnado¹, Lee Wheless², Stephanie Slan¹, Gary S. Gilkeson¹ and Diane L. Kamen¹, ¹Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ²Public Health Sciences, Medical University of South Carolina, Charleston, SC
Background/Purpose: Studies in predominantly Caucasian cohorts have found no significant clinical or serologic differences in systemic lupus erythematosus (SLE) patients with a family history of…
Abstract Number: 1583 • 2013 ACR/ARHP Annual Meeting
Serositis In Systemic Lupus Erythematosus: Prevalence, Recurrence, Treatment and Outcome
Mansour Somaily¹, Dafna D. Gladman², Dominique Ibanez² and Murray B. Urowitz², ¹Medicine, Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Serositis is one of the ACR classification criteria for SLE. Its incidence is variable in studies varying from 12 to 60%. The aim of…
Abstract Number: 1412 • 2012 ACR/ARHP Annual Meeting
Vascular Cell Adhesion Molecule (VCAM-1) and Angiostatin in Systemic Lupus Erythematosus
Adnan Kiani¹, Hong Fang¹, Tianfu Wu², Chandra Mohan³ and Michelle Petri¹, ¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Division of Rheumatology/Internal Medicine, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX, ³Internal Medicine/Division of Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX
Background/Purpose: Vascular cell adhesion molecule-1 (VCAM-1), an adhesion molecule, is involved in the progression of glomerular and tubulointerstitial injury. High levels of VCAM-1 have been…
Abstract Number: 843 • 2012 ACR/ARHP Annual Meeting
Interferon Regulatory Factor 5 Associates with Systemic Lupus Erythematosus Through Two Distinct and Independent Effects
Erin Zoller¹, Leah C. Kottyan², Bahram Namjou¹, Samuel Vaughn¹, Miranda C. Marion³, Carl D. Langefeld⁴, Marta E. Alarcon-Riquelme⁵, Juan-Manuel Anaya⁶, Elizabeth E. Brown on behalf of PROFILE⁷, Sang-Cheol Bae⁸, Jeffrey C. Edberg⁹, Patrick M. Gaffney¹⁰, Diane L. Kamen¹¹, Robert P. Kimberly¹², Chaim O. Jacob¹³, Joan T. Merrill¹⁴, Kathy Moser Sivils¹⁵, Michelle Petri¹⁶, Rosalind Ramsey-Goldman¹⁷, John D. Reveille¹⁸, Anne M. Stevens¹⁹, Betty P. Tsao²⁰, Luis M. Vila²¹, Timothy J. Vyse²² and Kenneth M. Kaufman²³, ¹Division of Rheumatology and The Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, ⁴Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ⁵Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Center for Genomics and Oncological Research Pfizer-University of Granada-Junta de Andalucia, Oklahoma City, OK, ⁶School of Medicine and Health Sciences, Universidad del Rosario. Center for Autoimmune Diseases Research (CREA), Bogotá, Colombia, ⁷University of Alabama at Birmingham, Birmingham, AL, ⁸Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ¹⁰Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹¹Department of Medicine, Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Charleston, SC, ¹²Clinical Immun & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ¹³Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA, ¹⁴Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁵Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁶Johns Hopkins University School of Medicine, Baltimore, MD, ¹⁷Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹⁸Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX, ¹⁹Pediatrics, University of Washington, Seattle, WA, ²⁰Medicine/Rheumatology, UCLA School of Medicine, Los Angeles, CA, ²¹Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, PR, ²²Medical & Molecular Genetics, King's College London, London, United Kingdom, ²³1Center for Autoimmune Genomics and Etiology and Rheumatology Division, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati, Cincinnati, OH
Background/Purpose: Powerful evidence suggests that Systemic lupus erythematous (SLE or lupus) autoimmunity is mediated by disregulation of the IRF5-NFκB signaling pathway. The interferon regulatory factor 5…

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